Post-LASIK tear dysfunction and dysesthesia

Ocular Surface

Volumn 8, Issue 3, 2010, Pages 135-145

  Nettune, Gregory R ^a   Pflugfelder, Stephen C ^a  

^a CULLEN EYE INSTITUTE   (United States)

Author keywords

Confocal microscopy; Corneal innervation; Dry eye; Hyperesthesia; Laser in situ keratomileusis (LASIK); Laser subepithelial keratomileusis (LASEK); Photorefractive keratectomy (PRK); Precorneal tear film; Surface ablation; Tear dysfunction syndrome; Thin flap LASIK

Indexed keywords

ARTIFICIAL TEAR; ASCORBIC ACID; CALCITONIN GENE RELATED PEPTIDE; CYCLOSPORIN; INTERLEUKIN 6; OMEGA 3 FATTY ACID; PLATELET DERIVED GROWTH FACTOR BB; SUBSTANCE P; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; VASCULOTROPIN;

BLINKING; BLOOD AUTOTRANSFUSION; CELL DENSITY; CONFOCAL MICROSCOPY; CONJUNCTIVA DISEASE; CONTACT LENS; CORNEA; DENERVATION; DRY EYE; DYSESTHESIA; ETHNICITY; EYE INFLAMMATION; EYELID DISEASE; GOBLET CELL; HUMAN; HYPEROSMOLARITY; HYPESTHESIA; KERATOMILEUSIS; LACRIMAL GLAND DISEASE; LACRIMATION; LACRIMATION DISORDER; LASER EPITHELIAL KERATOMILEUSIS; MEIBOMIAN GLAND; NERVE INJURY; NEURITIS; NEUROLOGIC DISEASE; NEUROPATHIC PAIN; PATHOPHYSIOLOGY; PHACOEMULSIFICATION; PHOTOREFRACTIVE KERATECTOMY; POSTMENOPAUSE; POSTOPERATIVE CARE; PREOPERATIVE PERIOD; PREOPERATIVE TREATMENT; PROTEIN BLOOD LEVEL; REINNERVATION; REVIEW; RISK FACTOR; SCHIRMER TEST; SEBACEOUS GLAND DISEASE; SOFT CONTACT LENS; SURGICAL INJURY; TEAR DYSFUNCTION; TEAR FILM; VISUAL DISORDER; VISUAL PROSTHESIS;

EID: 77957316164     PISSN: 15420124     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1542-0124(12)70224-0     Document Type: Review

References (105)

1. Duffey RJ, Leaming D. US trends in refractive surgery: 2004 ISRS/AAO survey. J Refract Surg 2005;21:742-8
2. Solomon KD, Fernandez de Castro LE, Sandoval HP, et al. LASIK world literature review: quality of life and patient satisfaction. Ophthalmology 2009;116:691-701
3. Toda I. LASIK and the ocular surface. Cornea 2008;27 Suppl 1:S70-6
4. Albietz JM, Lenton LM, McLennan SG. Chronic dry eye and regression after laser in situ keratomileusis for myopia. J Cataract Refract Surg 2004;30:675-84
5. Behrens A, Doyle JJ, Stern L, et al. Dystunctional tear syndrome: a Delphi approach to treatment recommendations. Cornea 2006;25:900-7 (Pubitemid 44763848)
6. (No authors listed). The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop 2007. Ocul Surf 2007;5:75-92 (Pubitemid 351902651)
7. Pflugfelder SC, Beuerman RW, Stern ME (eds): Dry eye and ocular surface disorders. New York, NY, Marcel Dekker, 2004
8. Rosenthal P, Baran I, Jacobs DS. Corneal pain without stain. Is it real? Ocul Surf 2009;7:28-40
9. Muller LJ, Marfurt CF, Kruse F, Tervo TM. Corneal nerves: structure, contents and function. Exp Eye Res 2003;76:521-42 (Pubitemid 36411929)
10. Belmonte C. Eye dryness sensations after refractive surgery: impaired tear secretion or "phantom" cornea? J Refrac Surg 2007;23:598-602
11. Hart WM (ed). Adler's physiology of the eye. St Louis, MO, Mosby Year Book, 1992, ed 9
12. Rodriguez-Prats JL, Hamdi IM, Rodriguez AE, et al. Effect of suction ring application during LASIK on goblet cell density. J Refract Surg 2007;23:559-62
13. Albietz JM, Lenton LM, McLennan SG. Effect of laser in situ keratomileusis for hyperopia on tear film and ocular surface. J Refract Surg 2002;18:113-23
14. Albietz JM, Lenton LM, McLennan SG. The effect of ocular surface management on myopic LASIK outcomes. Adv Exp Med Biol 2002;506:711-7
15. Battat L, Macri A, Dursun D, Pflugfelder SC. Effects of laser in situ keratomileusis on tear production, clearance, and the ocular surface. Ophthalmology 2001;108:1230-5 (Pubitemid 32568132)
16. De Paiva CS, Chen Z, Koch DD. The incidence and risk factors for developing dry eye after myopic LASIK. Am J Ophthalmol 2006;141:438-45 (Pubitemid 43265946)
17. Donnenfeld ED, Solomon K, Perry HD, et al. The effect of hinge position on corneal sensation and dry eye after LASIK. Ophthalmology 2003;110:1023-9 (Pubitemid 36560506)
18. Benitez-del-Castillo JM, del Rio T, Iradier T, et al. Decrease in tear secretion and corneal sensitivity after laser in situ keratomileusis. Cornea 2001; 20:30-2 (Pubitemid 32038151)
19. Toda I, Asano-Kato N, Komai-Hori Y, Tsubota K. Dry eye after laser in situ keratomileusis. Am J Ophthalmol 2001;132:1-7
20. Yu EY, Leung A, Rao S, Lam DS. Effects of laser in situ keratomileusis on tear stability. Ophthalmology 2000;107:2131-5
21. Lee JB, Ryu CH, Kim J, et al. Comparison of tear secretion and tear film instability after photorefractive keratectomy and laser in situ keratomileusis. J Cataract Refract Surg 2000;26:1326-31
22. Long Q, Chu R, Zhou X, et al. Correlation between TGF-B1 in tears and corneal haze following LASeK and epi-LASIK. J Refract Surg 2006;22: 708-12
23. Vesaluoma M, Teppo AM, Grönhagen-Riska C, Tervo T. Release of TGF-beta 1 and VEGF in tears following photorefractive keratectomy. Curr Eye Res 1997;16:19-25
24. Vesaluoma M, Teppo AM, Gronhagen-Riska C, Tervo T. Platelet-derived growth factor-BB (PDGF-BB) in tear fluid: a potential modulator of corneal wound healing following photorefractive keratectomy. Curr Eye Res 1997;16: 825-31
25. Vesaluoma M, Teppo AM, Grönhagen-Riska C, Tervo T. Increased release of tumour necrosis factor-alpha in human tear fluid after excimer laser induced corneal wound. . Br J Ophthalmol 1997;81:145-9
26. Malecaze F, Simorre V, Chollet P et al. Interleukin-6 in tear fluid after photorefrac tive keratectomy and its effects on keratocytes in culture. Cornea 1997;16: 580-87 (Pubitemid 27381613)
27. Bilgihan A, Bilgihan K, Toklu Y et al. Ascorbic acid levels in human tears after photorefractive keratectomy, transepithelial photorefractive keratectomy, and laser in situ keratomileusis. J Cataract Refract Surg 2001;27:585-8 (Pubitemid 36987480)
28. Darwish T, Brahma A, Efron N, O'Donnell C. Subbasal nerve regeneration after LASEK measured by confocal microscopy. J Refract Surg 2007;23:709-15 (Pubitemid 47424677)
29. Marfurt CF, Cox J, Deek S, Dvorscak L. Anatomy of the human corneal innervations. Exp Eye Res 2010;90:478-92
30. Mian SI, Shtein RM, Nelson A, Musch DC. Effect of hinge position on corneal sensation and dry eye after laser in situ keratomileusis using a femtosecond laser. J Cataract Refract Surg 2007;33:1190-4 (Pubitemid 46951011)
31. Vroman DT, Sandoval HP, Fernández de Castro LE, et al. Effect of hinge location on corneal sensation and dry eye after laser in situ keratomileusis for myopia. J Cataract Refract Surg 2005;31:1881-7
32. Kumano Y, Matsui H, Zushi I, et al. Recovery of corneal sensation after myopic correction by laser in situ keratomileusis with a nasal or superior hinge. J Cataract Refract Surg 2003;29:757-61
33. Donnenfeld ED, Ehrenhaus M, et al. Effect of hinge width on corneal sensation and dry eye after laser in situ keratomileusis. J Cataract Refract Surg 2004;30:790-7
34. Nassaralla BA, Mcleod SD, Nasaralla JJ Jr. Effect of myopic LASIK on human corneal sensitivity. Ophthalmology 2003;110:497-502
35. Kim WS, Kim JS. Changes in corneal sensitivity following laser in situ keratomileusis. J Cataract Refract Surg 1999;25:368-73
36. Shoja MR, Besharati MR. Dry eye after LASIK for myopia: incidence and risk factors. Eur J Ophthalmol 2007;17:1-6
37. Tuisku IS, Lindbohm N, Wilson SE. Dry eye and corneal sensitivity after high myopic LASIK. J Cataract Refract Surg 2007;23:338-42
38. Bragheeth MA, Dua HS. Corneal sensation after myopic and hyperopic LASIK: clinical and confocal microscopic study. Br J Ophthalmol 2005;89:580-5
39. Bourcier T, Acosta MC, Borderie V, et al. Decreased corneal sensitivity in patients with dry eye. Invest Ophthalmol Vis Sci 2005;46:2341-5 (Pubitemid 43119478)
40. Perez-Santonja JJ, Sakla HF, Cardona C, et al. Corneal sensitivity after photorefractive keratectomy and laser in situ keratomileusis for low myopia. Am J Ophthalmol 1999;127:497-504 (Pubitemid 29215758)
41. Gallar J, Acosta MC, Moilanen JA, et al. Recovery of corneal sensitivity to mechanical and chemical stimulation after laser in situ keratomileusis. J Refract Surg 2004;20:229-35 (Pubitemid 38657012)
42. Patel S, Perez-Santonja JJ, Alio JL, Murphy PJ. Corneal sensitivity and some properties of the tear film after laser in situ keratomileusis. J Refract Surg 2001;17:17-24
43. Salamao MQ, Ambrosio R, Wilson SE. Dry eye associated with laser insitu keratomileusis: Mechanical microkeratome versus femtosecond laser. J Cataract Refract Surg 2009; 35:1756-60
44. Barequet IS, Hirsh A, Levinger S. Effect of thin femtosecond LASIK flaps on corneal sensitivity and tear function. J Refr Surg 2008;24:897-902
45. Toda I, Asano-Kato N, Hori-Komai Y, Tsubota K. Laser-assisted in situ keratomileusis for patients with dry eye. Arch Ophthalmol 2002;120:1024-8 (Pubitemid 34856069)
46. Konomi K, Chen LL, Tarko RS, et al. Preoperative characteristics and a potential mechanism of chronic dry eye after LASIK. Invest Ophthalmol Vis Sci 2008;49:168-74
47. Patel SV, McLaren JW, Hodge DO, Bourne WM. Confocal microscopy in vivo in corneas of long-term contact lens wearers. Invest Ophthalmol Vis Sci 2002;43:995-1003
48. Albietz JM, Lenton LM, McLennan SG. Dry eye after LASIK: comparison of outcomes for asian and caucasian eyes. Clin Exp Optom 2005;88:89-96
49. Situ P, Simpson TL, Fonn D, Jones LW. Conjunctival and corneal pneumatic sensitivity is associated with signs and symptoms of ocular dryness. Invest Ophthalmol Vis Sci 2008;49:2971-6
50. Nakamori K, Odawara M, Nakajima T, et al. Blinking is controlled primarily by ocular surface conditions. Am J Ophthalmol 1997;124:24-30 (Pubitemid 27298986)
51. Wilson SE, Ambrosio R. Laser in situ keratomileusis-induced neurotrophic epitheliopathy. Am J Ophthalmol 2001;132:405-6
52. Wilson SE. Laser in situ keratomileusis-induced (presumed) neurotrophic epitheliopathy. Ophthalmology 2001;108:1082-7
53. Erie JC, Mclaren JW, Hodge DO, Bourne WM. Recovery of corneal subbasal nerve density after PRK and LASIK. Am J Ophthalmol 2005;140:1059-64
54. Lee SJ, Jin KK, Kyung YS, et al. Comparison of corneal nerve regeneration and sensitivity between LASIK and laser epithelial keratomileusis (LASEK). Am J Ophthalmol 2006;141:1009-15
55. Lee BH, McLaren JW, Erie JC, et al. Reinnervation in the cornea after LASIK. Invest Ophthalmol Vis Sci 2002;43:3660-4
56. Moilanen JA, Holopainen JM, Tervo TM. Corneal recovery after lasik for high myopia: a 2-year prospective confocal microscopy study. Br J Ophthalmol 2008;92:1397-1402
57. Calvillo MP, McLaren JW, Hodge DO, Bourne WM. Corneal reinnervation after LASIK: prospective 3-year longitudinal study. Invest Ophthalmol Vis Sci 2004;45:3991-6
58. Linna TU, Vesaluoma MH, Perez-Santonja JJ, et al. Effect of myopic LASIK on corneal sensitivity and morphology of subbasal nerves. Invest Ophthalmol Vis Sci 2000;41:393-7
59. Stapleton F, Hayward KB, Bachand N, et al. Evaluation of corneal sensitivity to mechanical and chemical stimuli after LASIK: a pilot study. Eye Contact Lens 2006;32:88-93 (Pubitemid 44510053)
60. Stachs O, Zhivov A, Kraak R, et al. Structural-functional correlations of corneal innervation after LASIK and penetrating keratoplasty. J Refrac Surg 2010;26:159-67
61. Pflugfelder SC, Beuerman RW, Stern ME. Dry eye and ocular surface disorders. New York, NY, Informa Healthcare, 2004
62. Pflugfelder SC, Jones D, Ji Z, et al. Altered cytokine balanace in the tear fluid and conjunctiva of patients with Sjogren's syndrome keratoconjunctivitis sicca. Curr Eye Res 1999;19:201-11 (Pubitemid 29500267)
63. Pflugfelder SC, de Paiva CS, Tong L, et al. Stress-activated protein kinases signaling pathways in dry eye and ocular surface disease. Ocul Surf 2005;3:S154-7
64. Liu H, Begley C, Chen M, et al. A link between tear instability and hyperosmolarity in dry eye. Invest Ophthalmol Vis Sci 2009;50:3671-9
65. Yeh S, Song XJ, Farley W, et al. Apoptosis of ocular surface cells in experimentally induced dry eye. Invest Ophthalmol Vis Sci 2003;44:124-9 (Pubitemid 36134264)
66. Avunduk AM, Avunduk MC, Varnell ED, Kaufman HE. The comparison of efficacies of topical corticosteroids and nonsteroidal anti-inflammatory drops on dry eye patients: a clinical and immunocytochemical study. Am J Ophthalmol 2003;136:593-602
67. Pflugfelder SC, de Paiva CS, Villareal AL, Stern ME. Effects of sequential artificial tear and cyclosporine emulsion therapy on conjunctival goblet cell density and transforming growth factor-beta2 production. Cornea 2008;27:64-9
68. Solomon R, Donnenfeld ED, Perry HD. The effects of LASIK on the ocular surface. Ocul Surf 2004;2:34-44
69. Belmonte C, Acosta MC, Schmelz M, Gallar J. Measurement of corneal sensitivity to mechanical and chemical stimuli with a CO2 esthesiometer. Invest Ophthalmol Vis Sci 1999;40:513-9 (Pubitemid 29063850)
70. Pflugfelder SC, Tseng SC, Sanabria O, et al. Evaluation of subjective assessments and objective diagnostic tests for diagnosing tear-film disorders known to cause ocular irritation. Cornea 1998;17:38-56
71. Xu KP, Yagi Y, Tsubota K. Decrease in corneal sensitivity and change in tear function in dry eye. Cornea 1996;15:235-9
72. Benitez-del-Castillo JM, Acosta MC, Wassfi MA, et al. Relation between corneal innervations with confocal microscopy and corneal sensitivity with noncontact esthesiometry in patients with dry eye. Invest Ophthalmol Vis Sci 2007;48:173-81
73. Adatia FA, Michaeli-Cohen A, Naor J, et al. Correlation between corneal sensitivity, subjective dry eye symptoms and corneal staining in Sjogren syndrome. Can J Ophthalmol 2004;39:767-71
74. Gilbard JP, Rossi SR. Tear film and ocular surface changes in a rabbit model of neurotrophic keratitis. Ophthalmology 1990;97:308-12
75. Afonso AA, Monroy D, Stern ME, et al, Correlation of tear fluorescein clearance and Schirmer test scores with ocular irritation symptoms. Ophthalmology 1999;106:803-10 (Pubitemid 30194326)
76. de Paiva CS, Pflugfelder SC. Corneal epitheliopathy of dry eye induces hyperesthesia to mechanical air jet stimulation. Am J Ophthalmol 2004;137:109-15
77. Belmonte C, Acosta MC, Gallar J. Neural basis of sensation in intact and injured corneas. Exp Eye Res 2004;78:513-25 (Pubitemid 38183329)
78. Patel DV, McGhee CN. In vivo laser scanning confocal microscopy confirms that the human corneal sub-basal nerve plexus is a highly dynamic structure. Invest Ophthalmol Vis Sci 2008;49:3409-12
79. Benitez del Catillo JM, Wasfy MA, Fernandez C, Garcia-Sanchez A. An in vivo confocal masked study on corneal epithelium and subbasal nerves in patients with dry eyes. Invest Ophthalmol Vis Sci 2004;45:3030-5 (Pubitemid 39121832)
80. Villani E, Galimberti D, Viola F, et al. The cornea in Sjogren's syndrome: an in vivo confocal study. Invest Ophthalmol Vis Sci 2007;48:2017-22 (Pubitemid 351261269)
81. Zhang M, Chen J, Luo L, et al. Altered corneal nerves in aqueous tear deficiency viewed by in vivo confocal microscopy. Cornea 2005;24:818-24
82. Kallinikos P, Berhanu M, O'Donnell C, et al. Corneal nerve tortuosity in diabetic patients with neuropathy. Invest Ophthalmol Vis Sci 2004;45:418-22
83. Kunert KS, Tisdale AS, Gipson IK. Goblet cell numbers and epithelial proliferation in the conjunctiva of patients with dry eye syndrome treated with cyclosporine. Arch Ophthalmol 2002;120:330-7
84. Peyman GA, Sanders DR, Batlle JF, et al. Cyclosporine 0.05% ophthalmic preparation to aid recovery from loss of corneal sensitivity after LASIK. J Refract Surg 2008;24:337-43
85. Rao K, Leveque C, Pflugfelder SC. Corneal nerve regeneration in neurotrophic keratopathy following autologous plasma therapy: an in vivo confocal study. Br J Ophthalmol 2010;94:584-91
86. Lambiase A, Rama P, Bonini S, et al. Topical treatment with nerve growth factor for corneal neurotrophic ulcers. N Engl J Med 1998;338:1174-80 (Pubitemid 28180745)
87. Bonini S, Lambiase A, Rama P, et al. Topical treatment with nerve growth factor for neurotrophic keratitis. Ophthalmology 2000;107:1347-51
88. Aloe L, Tirasse P, Lambiase A. A topical application of nerve growth factor as a pharmacological tool for human corneal and skin ulcers. Pharmacol Res 2008;57:253-8
89. Esquenazi S, Bazan HE, Bui V, et al. Topical combination of NGF and DHA increases rabbit corneal nerve regeneration after photorefractive keratectomy. Invest Ophthalmol Vis Sci 2005;46:3121-7 (Pubitemid 44264296)
90. Zagon IS, Klocek MS, Sassani JW, et al. Dry eye reversal and corneal sensation restoration with topical naltrexone in diabetes mellitus. Arch Ophthalmol. 2009;127:1468-73
91. Nishida T, Ohashi Y, Awata T, et al. Fibronectin, a new therapy for corneal trophic ulcer. Arch Ophthalmol 1983;101:1046-8 (Pubitemid 13067497)
92. Nishida T, Chikama T, Morishige N, et al. Persistent epithelial defects due to neurotrophic keratopathy treated with a substance P-derived peptide and insulin-like growth factor 1. Jpn J Ophthalmol 2007;51:442-7
93. Toda I, Asano-Kato N, Hori-Komai Y, Tsubota K. Ocular surface treatment before laser in situ keratomileusis in patients with severe dry eye. J Refract Surg 2004;20:270-5
94. Chen KH, Wen-Ming H, Shui-Mei L, et al. Laser-assisted subepithelial keratectomy for dry eye associated with soft contact lenses. J Cataract Refract Surg 2005;31:2299-2305
95. Matsui H, Kumano Y, Zushi I, et al. Corneal sensation after correction of myopia by photorefractive keratectomy and laser in situ keratomileusis. J Cataract Refract Surg 2001:27:370-3
96. Hovanesian JA, Shah SS, Maloney RK. Symptoms of dry eye and recurrent erosion syndrome after refractive surgery. J Cataract Refract Surg 2001;27:577-84
97. Slade SG, Durrie DS, Binder PS. A prospective, contralateral eye study comparing thin-flap LASIK (sub-bowman keratomileusis) with photorefractive keratectomy. Ophthalmology 2009;116:1075-82
98. Rajan MS, Jaycock P, O'Brart D, et al. A long-term study of photorefractive keratectomy. Ophthalmology 2004;111:1813-24
99. Herrmann WA, Shah CP, von Mohrenfels CW, et al. Tear film function and corneal sensation in the early postoperative period after LASEK for the correction of myopia. Graefes Arch Clin Exp Ophthalmol 2005;243:911-6
100. Darwish T, Brahma A, O'Donnell C, Efron N. Subbasal nerve fiber regeneration after LASIK and LASEK assessed by noncontact esthesiometry and in vivo confocal microscopy: prospective study. J Cataract Refract Surg 2007;33:1515-21 (Pubitemid 47299183)
101. Kim JH, Chung JL, Kang SY, et al. Change in corneal sensitivity and corneal nerve after cataract surgery. Cornea 2009;28:S20-5
102. Sanders DR, Vukich JA, Doney K, et al. U.S. food and Drug Administration clinical trial of the implantable contact lens for moderate to high myopia. Ophthalmology 2003;110:255-66 (Pubitemid 36184328)
103. Toda I, Kato-Asano N, Hori-Komai Y, Tsubota K. Dry eye after LASIK enhancement by flap lifting. J Refract Surg 2006;22:358-62
104. Lim T, Yang S, Kim MJ, Tchah H. Comparison of the intralase femtosecond laser and mechanical microkeratome for laser in situ keratomileusis. Am J Ophthalmol 2006;141:833-9
105. McDonald MB. Conductive keratoplasty: a radiofrequency-based technique for the correction of hyperopia. Trans Am Ophthalmol Soc 2005;103:512-36