Corneal reinnervation after LASIK: Prospective 3-year longitudinal study

Investigative Ophthalmology and Visual Science

Volumn 45, Issue 11, 2004, Pages 3991-3996

  Calvillo, Martha P ^a   McLaren, Jay W ^a   Hodge, David O ^a   Bourne, William M ^a,b  

^a Mayo Clinic   (United States)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; CONFOCAL MICROSCOPY; CORNEA EPITHELIUM; CORNEA SURGERY; FEMALE; HUMAN; KERATOMILEUSIS; LONGITUDINAL STUDY; MALE; MYOPIA; NERVE FUNCTION; ORIENTATION; PHOTOREFRACTIVE KERATECTOMY; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; REINNERVATION; SENSORY NERVE; STROMA CELL; TRIGEMINAL NERVE;

ADULT; CORNEA; CORNEAL STROMA; FEMALE; HUMANS; KERATOMILEUSIS, LASER IN SITU; LONGITUDINAL STUDIES; MALE; MICROSCOPY, CONFOCAL; MYOPIA; NERVE FIBERS; NERVE REGENERATION; OPHTHALMIC NERVE; PROSPECTIVE STUDIES; SURGICAL FLAPS;

EID: 6944233580     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.04-0561     Document Type: Article

References (34)

1. Mensher JH. Corneal nerves. Surv Ophthalmol. 1974;19:1-18.
2. Donnenfeld ED, Solomon K, Perry HD, et al. The effect of hinge position on corneal sensation and dry eye after LASIK. Ophthalmology. 2003;110:1023-1029.
3. Benitez-del-Castillo JM, del-Rio T, Iradier T, Hernandez JL, Castillo A, Garcia-Sanchez J. Decrease in tear secretion and corneal sensitivity after laser in situ keratomileusis. Cornea. 2001;20:30-32.
4. Auran JD, Koester CJ, Kleiman NJ, et al. Scanning slit confocal microscopic observation of cell morphology and movement within the normal human anterior cornea. Ophthalmology. 1995;102:33-41.
5. Linna TU, Vesaluoma MH, Perez-Santonja JJ, Petroll WM, Alio JL, Tervo TM. Effect of myopic LASIK on corneal sensitivity and morphology of subbasal nerves. Invest Ophthalmol Vis Sci. 2000;41:393-397.
6. Perez-Gomez I, Efron N. Change to corneal morphology after refractive surgery (myopic laser in situ keratomileusis) as viewed with a confocal microscope. Optom Vis Sci. 2003;80:690-697.
7. Slowik C, Somodi S, Richter A, Guthoff R. Assessment of corneal alterations following laser in situ keratomileusis by confocal slit scanning microscopy. Ger J Ophthalmol. 1997;5:526-531.
8. Kauffmann T, Bodanowitz S, Hesse L, Kroll P. Corneal reinnervation after photorefractive keratectomy and laser in situ keratomileusis: an in vivo study with a confocal videomicroscope. Ger J Ophthalmol. 1997;5:508-512.
9. Lee BH, McLaren JW, Erie JC, Hodge DO, Bourne WM. Reinnervation in the cornea after LASIK. Invest Ophthalmol Vis Sci. 2002;43:3660-3664.
10. Kanellopoulos A, Pallikaris I, Donnefeld E, Detorakis S, Koufala K, Perry HD. Comparison of corneal sensation following photorefractive keratectomy and laser in situ keratomileusis. J Cataract Refract Surg. 1997;23:34-38.
11. Kumano Y, Matsui H, Zushi I, et al. Recovery of corneal sensation after myopic correction by laser in situ keratomileusis with a nasal or superior hinge. J Cataract Refract Surg. 2003;29:757-761.
12. Perez-Santonja JJ, Sakla JF, Cardona C, Chipont E, Alió J. Corneal sensitivity after photorefractive keratectomy and laser in situ keratomileusis for low myopia. Am J Ophthalmol. 1999;127:497-504.
13. Patel SV, McLaren JW, Hodge DO, Bourne WM. Normal human keratocyte density and corneal thickness measurement by using confocal microscopy in vivo. Invest Ophthalmol Vis Sci. 2001;42:333-339.
14. Oliveira-Soto L, Efron N. Morphology of corneal nerves using confocal microscopy. Cornea. 2001;20:374-384.
15. McLaren JW, Nau CB, Erie JC, Bourne WM. Corneal thickness measurement by confocal microscopy, ultrasound, and scanning slit methods. Am J Ophthalmol. 2004;137:1011-1020.
16. Latvala T, Barraquer-Coll C, Tervo K, Tervo T. Corneal wound healing and nerve morphology after excimer laser in situ keratomileusis in human eyes. J Refract Surg. 1996;12:677-683.
17. Anderson NJ, Edelhauser HF, Sharara N, et al. Histologic and ultrastructural findings in human corneas after successful laser in situ keratomileusis. Arch Opbthalmol. 2002;120:288-293.
18. Murphy PJ, Patel S, Marshall J. A new noncontact corneal aesthesiometer (NCCA). Ophthalmic Physiol Opt. 1996;16:101-107.
19. Murphy PJ, Lawrenson JG, Patel S, Marshall J. Reliability of the noncontact corneal aesthesiometer and its comparison with the Cochet-Bonnet aesthesiometer. Ophthalmic Physiol Opt. 1998;18:532-539.
20. 2 esthesiometer. Invest Ophthalmol Vis Sci. 1999;40:513-519.
21. Mitooka K, Ramirez M, Maguire LJ, et al. Keratocyte density of central human cornea after laser in situ keratomileusis. Am J Ophthalmol. 2002;133:307-314.
22. Jacot JL, Glover JP, Robison WG Jr. Computer analysis of corneal innervation density using a novel double stain in rat corneal whole mounts. J Anat. 1997;191:191-199.
23. Rosenberg ME, Tervo TM, Immonen IJ, Müller LJ, Gronhagen-Riska C, Vesaluoma MH. Corneal structure and sensitivity in type 1 diabetes mellitus. Invest Ophthalmol Vis Sci. 2000;41:2915-2921.
24. Grupcheva C, Wong T, Riley A, McGhee C. Assessing the subbasal nerve plexus of the living healthy human cornea by in vivo confocal microscopy. Clin Exp Ophthalmol. 2002;30:187-190.
25. Oliveira-Soto L, Efron N. Assessing the cornea by in vivo confocal microscopy. Clin Exp Ophthalmol. 2003;32:83-86.
26. Erie JC, Nau CB, McLaren JM, Hodge DO, Bourne WM. Long-term keratocyte deficits in the corneal stroma after LASIK. Ophthalmology. 2004;111:1356-1361.
27. Müller L, Pels L, Vrensen GFJM. Ultrastructural organization of human corneal nerves. Invest Ophthalmol Vis Sci. 1996;37:476-488.
28. Erie JC. Corneal wound healing after photorefractive keratectomy: a 3-year confocal microscopic study. Trans Am Ophthalmol Soc. 2003;101:287-328.
29. Tervo T, Vannas A, Tervo K, Holden BA. Histochemical evidence of limited reinnervation of human corneal grafts. Acta Ophthalmol. 1985;63:207-214.
30. Rao GN, John T, Ishida N, Aquarella JV. Recovery of corneal sensitivity in grafts following penetrating keratoplasty. Ophthalmology. 1985;92:1408-1411.
31. Bourne WM. Cellular changes in transplanted human corneas. Cornea. 2001;20:560-569.
32. Müller L, Vrensen GFJM, Pels L, Nunes-Cardozo B, Willekens B. Architecture of human corneal nerves. Invest Ophthalmol Vis Sci. 1997;38:985-994.
33. Müller LJ, Marfurt CF, Kruse F, Tervo TMT. Corneal nerves: structure, contents and function. Exp Eye Res. 2003;76:521-542.
34. rd ed. Orlando: Academic Press; 1984:1-158.