An in vivo confocal masked study on corneal epithelium and subbasal nerves in patients with dry eye

Investigative Ophthalmology and Visual Science

Volumn 45, Issue 9, 2004, Pages 3030-3035

  Benítez Del Castillo, José M ^a,b   Wasfy, Mohamed A S ^a   Fernandez, Cristina ^a   Garcia Sanchez, Julian ^a  

^a HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^b NONE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ANALYSIS OF VARIANCE; ARTICLE; CONFOCAL MICROSCOPY; CORNEA EPITHELIUM; CORNEA STROMA; DRY EYE; FEMALE; HUMAN; HUMAN EXPERIMENT; INNERVATION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SCHIRMER TEST; SJOEGREN SYNDROME; VOLUNTEER;

ADULT; AGED; ANALYSIS OF VARIANCE; CELL COUNT; CORNEA; DRY EYE SYNDROMES; FEMALE; HUMANS; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; NERVOUS SYSTEM; REPRODUCIBILITY OF RESULTS; SINGLE-BLIND METHOD; SJOGREN'S SYNDROME;

EID: 4344646570     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.04-0251     Document Type: Article

References (26)

1. Mathers WD. Why the eye becomes dry: a cornea and lacrimal gland feedback model. CLAO J. 2000;26:159-165.
2. Lemp MA. Report of the National Eye Institute/Industry workshop on clinical trials in dry eye. CLAO J. 1995;21:221-232.
3. Rosenberg ME, Tervo TM, Immonen IJ, Muller LJ, Gronhagen-Riska C, Vesaluoma MH. Corneal structure and sensitivity in type 1 diabetes mellitus. Invest Ophthalmol Vis Sci. 2000;41:2915-2921.
4. Patel SV, McLaren JW, Hodge DO, Bourne WM. Confocal microscopy in vivo in corneas of long-term contact lens wearers. Invest Ophthalmol Vis Sci. 2002;43:995-1003.
5. Linna TU, Vesaluoma MH, Perez-Santonja JJ, Petroll WM, Alio JL, Tervo TM. Effect of myopic LASIK on corneal sensitivity and morphology of subbasal nerves. Invest Ophthalmol Vis Sci. 2000;41:393-397.
6. Benitez del Castillo JM, del Rio MT, Iradier MT, et al. Decrease in tear secretion and corneal sensitivity after laser in situ keratomileusis. Cornea. 2001;20:30-32.
7. Stern ME, Beuerman RW, Fox RI, Gao J, Mircheff AK, Pflugfelder SC. The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea. 1998;17:584-589.
8. Muller LJ, Vresen GFJM, Pels L, Cardozo BN, Willekens B. Architecture of human corneal nerves. Invest Ophthalmol Vis Sci. 1997;38:985-994.
9. Muller LJ, Marfurt CF, Kruse F, Tervo TM. Corneal nerves: structure, contents and function. Exp Eye Res. 2003;76:521-542.
10. Vitali C, Bombardieri S, Jonsson R, and the European Study Group on classification criteria for Sjögren's syndrome: classification criteria for Sjögren's syndrome - a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis. 2002;61:554-558.
11. Donate J, Benitez del Castillo JM, Fernandez C, Garcia Sanchez J. Validación de un cuestionario para diagnostico del ojo seco. Arch Soc Esp Oftalmol. 2002;77:493-500.
12. van Bijsterveld OP. Diagnostic test in the sicca syndrome. Arch Ophthalmol. 1969;82:10-14.
13. Mustonen RK, McDonald MB, Srivannaboon S, Tan AL, Doubrava W, Kim CK. Normal human corneal cell populations evaluated by in vivo scanning slit confocal microscopy. Cornea. 1998;17:485-492.
14. Cavanagh HD, Petroll WM, Alizadeh H, He YG, McCulley JP, Jester JV. Clinical and diagnostic use of in vivo confocal microscopy in patients with corneal disease. Ophthalmology. 1993;100:1444-1454.
15. Grupcheva CN, Wong T, Riley AF, McGhee CHJ. Assessing the sub-basal nerve plexus of the living healthy human cornea by in vivo confocal microscopy. Clin Exp Ophthalmol. 2002;30:187-190.
16. Oliveira-Soto L, Efron N. Morphology of corneal nerves using confocal microscopy. Cornea. 2001;20:374-384.
17. Jones MA, Marfurt CF. Peptidergic innervation of the rat cornea. Exp Eye Res. 1998;66:421-435.
18. Beckers HJM, Klooster J, Vrensen GFJM, Lamers WPMA. Substance P in rat corneal and iridal nerves: an ultrastructural immunohistochemical study. Ophthalmic Res. 1993;25:192-200.
19. Garcia-Hirschfeld J, Lopez-Briones L, Belmonte C. Neurotrophic influences on corneal epithelial cells. Exp Eye Res. 1994;59:597-605.
20. Baker KS, Anderson SC, Romanowski EG, Thoft RA, SundarRaj N. Trigeminal ganglion neurons affect corneal epithelial phenotype: influence on type VII collagen expression in vitro. Invest Ophthalmol Vis Sci. 1993;34:137-144.
21. Murphy CJ, Marfurt CF, McDermott A, et al. Spontaneous chronic corneal epithelial defects in dogs: clinical features, innervation and effect of topical SP with or without IGF-1. Invest Ophthalmol Vis Sci. 2001;42:2252-2261.
22. Tuominen ISJ, Konttinen YT, Vesaluoma MH, Moilanen JAO, Helinto M, Tervo TM. Corneal innervation and morphology in primary Sjögren's syndrome. Invest Ophthalmol Vis Sci. 2003;44:2545-2549.
23. Xu KP, Yagi Y, Tsboa K. Decrease in corneal sensitivity and change in tear function in dry eye. Cornea. 1996;15:235-239.
24. Millidot M. The influence of age on the sensation of the cornea. Invest Ophthalmol. 1977;16:241-244.
25. Kaplan JG, Rosenberg R, Reinitz E, Buchbinder S, Schaumburg HH. Invited review: peripheral neuropathy in Sjögren's syndrome. Muscle Nerve. 1990;13:570-579.
26. Brown S, Lambert S, Reid T, Murphy C. Neurotrophic and anhidrotic keratopathy treated with substance P and insulin-like growth factor-1. Arch Ophthalmol. 1997;115:926-927.