Effects of sequential artificial tear and cyclosporine emulsion therapy on conjunctival goblet cell density and transforming growth factor-β2 production

Cornea

Volumn 27, Issue 1, 2008, Pages 64-69

  Pflugfelder, Stephen C ^a   De Paiva, Cintia S ^a   Villarreal, Arturo L ^a   Stern, Michael E ^b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b ALLERGAN INC   (United States)

Author keywords

Conjunctiva; Cyclosporine; Dry eye disease; Goblet cell density

Indexed keywords

CYCLOSPORIN; EYE DROPS; IMMUNOSUPPRESSIVE AGENT; MUCIN; MUCIN 5AC; TRANSFORMING GROWTH FACTOR BETA2;

ADULT; AGED; ARTICLE; BIOSYNTHESIS; CELL COUNT; CHRONIC DISEASE; CONJUNCTIVA; DRUG EFFECT; DRY EYE; EMULSION; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GOBLET CELL; HUMAN; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY;

ADULT; AGED; CELL COUNT; CHRONIC DISEASE; CONJUNCTIVA; CYCLOSPORINE; DRY EYE SYNDROMES; EMULSIONS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GOBLET CELLS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MIDDLE AGED; MUCINS; OPHTHALMIC SOLUTIONS; TRANSFORMING GROWTH FACTOR BETA2;

EID: 40449107048     PISSN: 02773740     EISSN: 15364798     Source Type: Journal    
DOI: 10.1097/ICO.0b013e318158f6dc     Document Type: Article

References (29)

1. Stern ME, Beuerman RW, Fox RI, et al. The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea. 1998; 17:584-589. (Pubitemid 28511901)
2. Pflugfelder SC. Antiinflammatory therapy for dry eye. Am J Ophthalmol. 2004;137:337-342. (Pubitemid 38221009)
3. Tseng SC. Staging of conjunctival squamous metaplasia by impression cytology. Ophthalmology. 1985;92:728-733. (Pubitemid 15059999)
4. Nelson JD. Impression cytology. Cornea. 1988;7:71-81.
5. Pflugfelder SC, Tseng SC, Yoshino K, et al. Correlation of goblet cell density and mucosal epithelial membrane mucin expression with rose bengal staining in patients with ocular irritation. Ophthalmology. 1997; 104:223-235. (Pubitemid 27088097)
6. Albietz JM, Bruce AS. The conjunctival epithelium in dry eye subtypes: effect of preserved and non-preserved topical treatments. Curr Eye Res. 2001;22:8-18. (Pubitemid 32679487)
7. Murube J, Rivas L. Impression cytology on conjunctiva and cornea in dry eye patients establishes a correlation between squamous metaplasia and dry eye clinical severity. Eur J Ophthalmol. 2003;13:115-127. (Pubitemid 36433854)
8. Zhao H, Jumblatt JE,Wood TO, et al. Quantification of MUC5AC protein in human tears. Cornea. 2001;20:873-877. (Pubitemid 33029489)
9. Argueso P, Balaram M, Spurr-Michaud S, et al. Decreased levels of the goblet cell mucin MUC5AC in tears of patients with Sjogren syndrome. Invest Ophthalmol Vis Sci. 2002;43:1004-1011. (Pubitemid 34258267)
10. Gupta A, Monroy D, Ji Z, et al. Transforming growth factor beta-1 and beta-2 in human tear fluid. Curr Eye Res. 1996;15:605-614. (Pubitemid 26276535)
11. Yoshino K, Garg R, Monroy D, et al. Production and secretion of transforming growth factor beta (TGF-b) by the human lacrimal gland. Curr Eye Res. 1996;15:615-624. (Pubitemid 26276536)
12. Nelson JD, Farris RL. Sodium hyaluronate and polyvinyl alcohol artificial tear preparations. A comparison in patients with keratoconjunctivitis sicca. Arch Ophthalmol. 1988;106:484-487.
13. Sall K, Stevenson OD, Mundorf TK, et al. Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye. Ophthalmology. 2000;107: 631-639. (Pubitemid 30191329)
14. Kunert KS, Tisdale AS, Gipson IK. Goblet cell numbers and epithelial proliferation in the conjunctiva of patients with dry eye syndrome treated with cyclosporine. Arch Ophthalmol. 2002;120:330-337. (Pubitemid 34250055)
15. Schiffman RM, Christianson MD, Jacobsen G, et al. Reliability and validity of the Ocular Surface Disease Index. Arch Ophthalmol. 2000;118: 615-621. (Pubitemid 30327337)
16. De Paiva CS, Pflugfelder SC. Diagnostic approaches to lacrimal keratoconjunctivitis. In: Pflugfelder SC, Beuerman RW, Stern ME, eds. Dry Eye and the Ocular Surface. New York: Marcel Dekker; 2004:269- 308.
17. Lemp MA. Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. CLAO J. 1995;21:221-232.
18. Wei ZG, Sun TT, Lavker RM. Rabbit conjunctival and corneal epithelial cells belong to two separate lineages. Invest Ophthalmol Vis Sci. 1996;37: 523-533. (Pubitemid 26077672)
19. Wei ZG, Lin T, Sun TT, et al. Clonal analysis of the in vivo differentiation potential of keratinocytes. Invest Ophthalmol Vis Sci. 1997;38:753-761. (Pubitemid 27143146)
20. Kunert KS, Tisdale AS, Stern ME, et al. Analysis of topical cyclosporine treatment of patients with dry eye syndrome: effect on conjunctival lymphocytes. Arch Ophthalmol. 2000;118:1489-1496.
21. Stern ME, Gao J, Schwalb TA, et al. Conjunctival T-cell subpopulations in Sjogren's and non-Sjogren's patients with dry eye. Invest Ophthalmol Vis Sci. 2002;43:2609-2614. (Pubitemid 34809449)
22. Niederkorn JY, Stern ME, Pflugfelder SC, et al. Desiccating stress induces T cell-mediated Sjogren's syndrome-like lacrimal keratoconjunctivitis. J Immunol. 2006;176:3950-3957. (Pubitemid 44264372)
23. Wei L, Debets R, Hegmans JJ, et al. IL-1 beta and IFN-gamma induce the regenerative epidermal phenotype of psoriasis in the transwell skin organ culture system. IFN-gamma up-regulates the expression of keratin 17 and keratinocyte transglutaminase via endogenous IL-1 production. J Pathol. 1999;187:358-364. (Pubitemid 29064164)
24. dePaiva CS, De Paiva CS, Villarreal AL, et al. Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferongamma. Invest Ophthalmol Vis Sci. 2007;48:2553-2560. (Pubitemid 351261205)
25. Matsuda S, Koyasu S. Mechanisms of action of cyclosporine. Immunopharmacology. 2000;47:119-125. (Pubitemid 30394535)
26. Brignole F, Pisella PJ, De Saint Jean M, et al. Flow cytometric analysis of inflammatory markers in KCS: 6-month treatment with topical cyclosporin A. Invest Ophthalmol Vis Sci. 2001;42:90-95. (Pubitemid 32059414)
27. Strong B, Farley W, Stern ME, et al. Topical cyclosporine inhibits conjunctival epithelial apoptosis in experimental murine keratoconjunctivitis sicca. Cornea. 2005;24:80-85. (Pubitemid 40053499)
28. Li MO,Wan YY, Flavell RA. T cell-produced transforming growth factorbeta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity. 2007;26:579-591. (Pubitemid 46756347)
29. Stern ME, Pflugfelder SC. Inflammation in dry eye. Ocul Surf. 2004;2: 124-130. (Pubitemid 41263879)