Conjunctival and corneal pneumatic sensitivity is associated with signs and symptoms of ocular dryness

Investigative Ophthalmology and Visual Science

Volumn 49, Issue 7, 2008, Pages 2971-2976

  Situ, Ping ^a   Simpson, Trefford L ^a   Fonn, Desmond ^a   Jones, Lyndon W ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DYE; FLUORESCEIN; PHENOLSULFONPHTHALEIN;

ADULT; AGED; ARTICLE; COMPUTER SYSTEM; CONJUNCTIVA; CONTROLLED STUDY; COOLING; CORNEA; DISEASE ASSOCIATION; DRY EYE; EYE EXAMINATION; EYE IRRITATION; FEMALE; HUMAN; HYPERESTHESIA; MAJOR CLINICAL STUDY; MALE; NON INVASIVE MEASUREMENT; PNEUMATIC TOOL; PRIORITY JOURNAL; QUESTIONNAIRE; RETINA PIGMENT EPITHELIOPATHY; ROOM TEMPERATURE; SCORING SYSTEM; SENSITIVITY ANALYSIS; SENSORY DYSFUNCTION; STAINING; STIMULUS; SYMPTOM; TEAR FILM; TEMPERATURE SENSITIVITY; VISUAL THRESHOLD; AIR; COLD; COMPUTER ASSISTED DIAGNOSIS; CORNEA EPITHELIUM; EYE DISEASE; LACRIMAL FLUID; METABOLISM; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; STIMULATION; VISUAL SYSTEM EXAMINATION;

ADULT; AGED; AGED, 80 AND OVER; AIR; COLD; CONJUNCTIVA; CORNEA; DIAGNOSIS, COMPUTER-ASSISTED; DIAGNOSTIC TECHNIQUES, OPHTHALMOLOGICAL; DRY EYE SYNDROMES; EPITHELIUM, CORNEAL; EYE DISEASES; FEMALE; HUMANS; HYPERESTHESIA; MALE; MIDDLE AGED; PHYSICAL STIMULATION; TEARS;

EID: 48249142768     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-1734     Document Type: Article

References (45)

1. Lemp MA, Baudouin C, Baum J, et al. The definition and classification of dry eye disease: Report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop, 2007. Ocul Surf. 2007;5:75-92. (Pubitemid 351902651)
2. Stern ME, Beuerman RW, Fox RI, Gao J, Mircheff AK, Pflugfelder SC. The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea. 1998;17:584-589. (Pubitemid 28511901)
3. Stern ME, Gao J, Siemasko KF, Beuerman RW, Pflugfelder SC. The role of the lacrimal functional unit in the pathophysiology of dry eye. Exp Eye Res. 2004;78:409-416. (Pubitemid 38183319)
4. Dartt DA. Control of mucin production by ocular surface epithelial cells. Exp Eye Res. 2004;78:173-185. (Pubitemid 38077225)
5. Dartt DA. Interaction of EGF family growth factors and neurotransmitters in regulating lacrimal gland secretion. Exp Eye Res. 2004; 78:337-345. (Pubitemid 38183310)
6. Beuerman RW, Mircheff A, Pflugfelder SC, Stern ME. The lacrimal functional unit. In: Pflugfelder SC, Beuerman RW, Stern ME, eds. Dry Eye and Ocular Surface Disorders. New York, Basel, Switzerland: Marcel Dekker, Inc.; 2004:11-39.
7. Mathers WD. Why the eye becomes dry: a cornea and lacrimal gland feedback model. CLAO J. 2000;26:159-165. (Pubitemid 30490877)
8. Rolando M, Zierhut M. The ocular surface and tear film and their dysfunction in dry eye disease. Surv Ophthalmol. 2001;45(suppl 2):S203-S210. (Pubitemid 33052379)
9. Belmonte C, Acosta MC, Gallar J. Neural basis of sensation in intact and injured corneas. Exp Eye Res. 2004;78:513-525. (Pubitemid 38183329)
10. Belmonte C, Tervo T. Pain in and around the eye. In: McMahon S, Koltzenburg M, eds. Wall and Melzack's Textbook of Pain. 5th ed. London: Elsevier Science; 2005:887-901.
11. Belmonte C. Eye dryness sensations after refractive surgery: impaired tear secretion or "phantom" cornea? J Refract Surg. 2007; 23:598-602.
12. Benitez-del-Castillo JM, Acosta MC, Wassfi MA, et al. Relation between corneal innervation with confocal microscopy and corneal sensitivity with noncontact esthesiometry in patients with dry eye. Invest Ophthalmol Vis Sci. 2007;48:173-181. (Pubitemid 47251400)
13. Bourcier T, Acosta MC, Borderie V, et al. Decreased corneal sensitivity in patients with dry eye. Invest Ophthalmol Vis Sci. 2005; 46:2341-2345. (Pubitemid 43119478)
14. de Paiva CS, Pflugfelder SC. Corneal epitheliopathy of dry eye induces hyperesthesia to mechanical air jet stimulation. Am J Ophthalmol. 2004;137:109-115. (Pubitemid 38045195)
15. Pflugfelder SC, Tseng SC, Sanabria O, et al. Evaluation of subjective assessments and objective diagnostic tests for diagnosing tear-film disorders known to cause ocular irritation. Cornea. 1998;17:38-56. (Pubitemid 28047008)
16. Xu KP, Yagi Y, Tsubota K. Decrease in corneal sensitivity and change in tear function in dry eye. Cornea. 1996;15:235-239. (Pubitemid 26123061)
17. Schiffman RM, Christianson MD, Jacobsen G, Hirsch JD, Reis BL. Reliability and validity of the Ocular Surface Disease Index. Arch Ophthalmol. 2000;118:615-621. (Pubitemid 30327337)
18. Bron AJ, Evans VE, Smith JA. Grading of corneal and conjunctival staining in the context of other dry eye tests. Cornea. 2003;22: 640-650. (Pubitemid 37175145)
19. Belmonte C, Acosta MC, Schmelz M, Gallar J. Measurement of corneal sensitivity to mechanical and chemical stimulation with a CO2 esthesiometer. Invest Ophthalmol Vis Sci. 1999;40:513-519. (Pubitemid 29063850)
20. Situ P, Simpson TL, Fonn D. Eccentric variation of corneal sensitivity to pneumatic stimulation at different temperatures and with CO2. Exp Eye Res. 2007;85:400-405. (Pubitemid 47259057)
21. du Toit R, Vega JA, Fonn D, Simpson T. Diurnal variation of corneal sensitivity and thickness. Cornea. 2003;22:205-209.
22. Feng Y, Simpson TL. Characteristics of human corneal psychophysical channels. Invest Ophthalmol Vis Sci. 2004;45:3005-3010. (Pubitemid 39121829)
23. Murphy PJ, Morgan PB, Patel S, Marshall J. Corneal surface temperature change as the mode of stimulation of the non-contact corneal aesthesiometer. Cornea. 1999;18:333-342. (Pubitemid 29205561)
24. Murphy PJ, Patel S, Morgan PB, Marshall J. The minimum stimulus energy required to produce a cooling sensation in the human cornea. Ophthalmic Physiol Opt. 2001;21:407-410. (Pubitemid 32680940)
25. Murphy PJ, Armstrong E, Woods LA. A comparison of corneal and conjunctival sensitivity to a thermally cooling stimulus. Adv Exp Med Biol. 2002;506:719-722. (Pubitemid 36307742)
26. Stapleton F, Tan M, Papas E, et al. Corneal and conjunctival sensitivity to air stimuli. Br J Ophthalmol. 2004;88:1547-1551. (Pubitemid 39573595)
27. Vega JA, Simpson TL, Fonn D. A noncontact pneumatic esthesiometer for measurement of ocular sensitivity: a preliminary report. Cornea. 1999;18:675-681. (Pubitemid 29522040)
28. Gescheider GA. Psychophysics: the Fundamentals. 3rd ed. Mahwah, NJ: Lawrence Erlbaum Associates; 2004:45-72.
29. Slinker BK, Glantz SA. Multiple regression for physiological data analysis: the problem of multicollinearity. Am J Physiol Regul Integ Comp Physiol. 1985;249:R1-T12. (Pubitemid 15243826)
30. Bron AJ, Bron AJ, Abelson MB, et al. Methodologies to diagnose and monitor dry eye disease: report of the Diagnostic Methodology Subcommittee of the International Dry Eye WorkShop, 2007. Ocul Surf. 2007;5:108-152. (Pubitemid 351902653)
31. Dartt DA. Regulation of mucin and fluid secretion by conjunctival epithelial cells. Prog Retin Eye Res. 2002;21:555-576. (Pubitemid 35341511)
32. Bron AJ, Tiffany JM, Gouveia SM, Yokoi N, Voon LW. Functional aspects of the tear film lipid layer. Exp Eye Res. 2004;78:347-360. (Pubitemid 38183311)
33. Belmonte C, Garcia-Hirschfeld J, Gallar J. Neurobiology of ocular pain. Prog Retin Eye Res. 1997;16:117-156. (Pubitemid 27051174)
34. Cervero F, Laird JMA. One pain or many pains? News Physiol Sci. 1991;6:268-273.
35. Pflugfelder SC, Solomon A, Dursun D, Li DQ. Dry eye and delayed tear clearance: "a call to arms." Adv Exp Med Biol. 2002;506:739-743.
36. Ferreira SH, Lorenzetti BB, Bristow AF, Poole S. Interleukin-1 beta as a potent hyperalgesic agent antagonized by a tripeptide analogue. Nature. 1988;334:698-700. (Pubitemid 18197566)
37. Richardson JD, Vasko MR. Cellular mechanisms of neurogenic inflammation. J Pharmacol Exp Ther. 2002;302:839-845. (Pubitemid 34920202)
38. Julius D, McCleskey EW. Cellular and molecular properties of primary afferent neurons. In: McMahon S, Koltzenburg M, eds. Wall and Melzack's Textbook of Pain. 5th ed. London: Elsevier Science; 2005:35-48.
39. Devor M. Sodium channels and mechanisms of neuropathic pain. J Pain. 2006;7(suppl 1):S3-S12. (Pubitemid 43106683)
40. Amir R, Argoff CE, Bennett GJ, et al. The role of sodium channels in chronic inflammatory and neuropathic pain. J Pain. 2006; 7(suppl 3):S1-S29.
41. Rizzo MA, Kocsis JD, Waxman SG. Mechanisms of paresthesiae, dysesthesiae, and hyperesthesiae: role of Na+ channel heterogeneity. Eur Neurol. 1996;36:3-12.
42. Adatia FA, Michaeli-Cohen A, Naor J, Caffery B, Bookman A, Slomovic AR. Correlation between corneal sensitivity, subjective dry eye symptoms and corneal staining in Sjogren syndrome. Can J Ophthalmol. 2004;39:767-771. (Pubitemid 40115579)
43. Lin PY, Cheng CY, Hsu WM, et al. Association between symptoms and signs of dry eye among an elderly chinese population in Taiwan: The Shihpai Eye Study. Invest Ophthalmol Vis Sci. 2005; 46:1593-1598. (Pubitemid 44843591)
44. Nichols KK, Nichols JJ, Mitchell GL. The lack of association between signs and symptoms in patients with dry eye disease. Cornea. 2004;23:762-770. (Pubitemid 39447304)
45. Schein OD, Tielsch JM, Munoz B, Bandeen-Roche K, West S. Relation between signs and symptoms of dry eye in the elderly: a population-based perspective. Ophthalmology. 1997;104:1395-1401. (Pubitemid 28116804)