Cardioprotective effects of the novel Na+/H+ exchanger-1 inhibitor KR-32560 in a perfused rat heart model of global ischemia and reperfusion: Involvement of the Akt-GSK-3β cell survival pathway and antioxidant enzyme

Archives of Pharmacal Research

Volumn 33, Issue 8, 2010, Pages 1241-1251

  Jung, In Sang ^a   Lee, Sung Hun ^a   Yang, Min Kyu ^a   Park, Jung Woo ^a   Yi, Kyu Yang ^b   Yoo, Sung Eun ^b   Kwon, Suk Hyung ^c   Chung, Hun Jong ^d   Choi, Wahn Soo ^d   Shin, Hwa Sup ^a  

^a Konkuk University   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

^c Rexgene Biotech Co Ltd   (South Korea)

^d Konkuk University School of Medicine   (South Korea)

Author keywords

Akt; Cardioprotection; GSK 3 ; KR 32560; Na+ H+ exchanger; Reperfusion

Indexed keywords

[5 (2 METHOXY 5 FLUOROPHENYL)FURAN 2 YLCARBONYL]GUANIDINE; CATALASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUTATHIONE PEROXIDASE; GLYCOGEN SYNTHASE KINASE 3BETA; GUANIDINE DERIVATIVE; KR 32560; MALONALDEHYDE; PROTEIN INHIBITOR; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE ISCHEMIA; HEART PERFUSION; HEART PROTECTION; LIPID PEROXIDATION; MALE; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; REPERFUSION INJURY; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; BLOTTING, WESTERN; CARDIOTONIC AGENTS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOGEN SYNTHASE KINASE 3; GUANIDINES; MALE; MALONDIALDEHYDE; MYOCARDIAL REPERFUSION INJURY; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SODIUM-HYDROGEN ANTIPORTER; VENTRICULAR DYSFUNCTION, LEFT;

EID: 77957300993     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-010-0815-z     Document Type: Article

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