Effects of 2 adenosine antagonists, quercetin and caffeine, on vigilance and mood

Journal of Clinical Psychopharmacology

Volumn 30, Issue 5, 2010, Pages 573-578

  Olson, Craig A ^a   Thornton, Jennifer A ^b   Adam, Gina E ^c   Lieberman, Harris R ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b DAVID GRANT MEDICAL CENTER   (United States)

^c U S ARMY RESEARCH INSTITUTE OF ENVIRONMENTAL MEDICINE   (United States)

Author keywords

alertness; cognitive performance; dietary supplement; fatigue; flavonoid

Indexed keywords

CAFFEINE; PLACEBO; QUERCETIN;

ABSENCE OF SIDE EFFECTS; ADULT; ALERTNESS; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG BLOOD LEVEL; DRUG EFFECT; FATIGUE; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MOOD; MOOD DISORDER; NORMAL HUMAN; PRIORITY JOURNAL; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; REACTION TIME; SCORING SYSTEM; TASK PERFORMANCE;

ADULT; AFFECT; AROUSAL; CAFFEINE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; PSYCHOMOTOR PERFORMANCE; PURINERGIC P1 RECEPTOR ANTAGONISTS; QUERCETIN; REACTION TIME; YOUNG ADULT;

EID: 77957278508     PISSN: 02710749     EISSN: None     Source Type: Journal    
DOI: 10.1097/JCP.0b013e3181ee0f79     Document Type: Article

References (58)

1. Childs E, de Wit H. Enhanced mood and psychomotor performance by a caffeine-containing energy capsule in fatigued individuals. Exp Clin Psychopharmacol. 2008;16: 13-21. (Pubitemid 351305491)
2. De Valck E, Cluydts R. Slow-release caffeine as a countermeasure to driver sleepiness induced by partial sleep deprivation. J Sleep Res. 2001;10: 203-209. (Pubitemid 32823903)
3. Smit HJ, Rogers PJ. Effects of low doses of caffeine on cognitive performance, mood and thirst in low and higher caffeine consumers. Psychopharmacology. 2000;152: 167-173.
4. Herz RS. Caffeine effects on mood and memory. Behaviour Research and Therapy. 1999;37: 869-879.
5. James JE. Acute and chronic effects of caffeine on performance, mood, headache, and sleep. Neuropsychobiology. 1998;38: 32-41.
6. Lieberman HR, Wurtman RJ, Emde GG, et al. The effects of caffeine and aspirin on mood and performance. J Clin Psychopharmacol. 1987;7: 315-320. (Pubitemid 18042931)
7. Lieberman HR, Wurtman RJ, Emde GG, et al. The effects of low doses of caffeine on human performance and mood. Psychopharmacology (Berl). 1987;92: 308-312. (Pubitemid 17100477)
8. French JA, Wainwright CJ, Booth DA. Caffeine and mood: individual differences in low-dose caffeine sensitivity. Appetite. 1994;22: 277-279. (Pubitemid 24249098)
9. Reyner LA, Horne JA. Early morning driver sleepiness: effectiveness of 200 mg caffeine. Psychophysiology. 2000;37: 251-256.
10. Snyder SH, Katims JJ, Annau Z, et al. Adenosine receptors and behavioral actions of methylxanthines. Proc Natl Acad Sci U S A. 1981;78: 3260-3264.
11. Hirsh K. Central nervous system pharmacology of the dietary methylxanthines. Progress in Clinical and Biological Research. 1984;158: 235-301.
12. El Yacoubi M, Ledent C, Menard JF, et al. The stimulant effects of caffeine on locomotor behaviour in mice are mediated through its blockade of adenosine A(2A) receptors. Br J Pharmacol. 2000;129: 1465-1473. (Pubitemid 30175720)
13. Davis JM, Zhao Z, Stock HS, et al. Central nervous system effects of caffeine and adenosine on fatigue. Am J Physiol Regul Integr Comp Physiol. 2003;284: R399-R404. (Pubitemid 36120156)
14. Fisone G, Borgkvist A, Usiello A. Caffeine as a psychomotor stimulant: mechanism of action. Cell Mol Life Sci. 2004;61: 857-872. (Pubitemid 38659659)
15. Higgins GA, Grzelak ME, Pond AJ, et al. The effect of caffeine to increase reaction time in the rat during a test of attention is mediated through antagonism of adenosine A(2A) receptors. Behavioural Brain Research. 2007;185: 32-42.
16. Fredholm BB, Arslan G, Halldner L, et al. Structure and function of adenosine receptors and their genes. Naunyn Schmiedebergs Arch Pharmacol. 2000;362: 364-374.
17. Ji XD, Melman N, Jacobson KA. Interactions of flavonoids and other phytochemicals with adenosine receptors. J Med Chem. 1996;39: 781-788. (Pubitemid 26069697)
18. Tzeng SH, Ko WC, Ko FN, et al. Inhibition of platelet-aggregation by some flavonoids. Thrombosis Research. 1991;64: 91-100.
19. Moro S, van Rhee AM, Sanders LH, et al. Flavonoid derivatives as adenosine receptor antagonists: a comparison of the hypothetical receptor binding site based on a comparative molecular field analysis model. Journal of Medicinal Chemistry. 1998;41: 46-52. (Pubitemid 28070466)
20. Alexander SP. Flavonoids as antagonists at A1 adenosine receptors. Phytother Res. 2006;20: 1009-1012.
21. Bravo L. Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev. 1998;56: 317-333.
22. Yang CS, Landau JM, Huang MT, et al. Inhibition of carcinogenesis by dietary polyphenolic compounds. Annual Review of Nutrition. 2001;21: 381-406. (Pubitemid 32695277)
23. Walle T, Walle UK, Halushka PV. Carbon dioxide is the major metabolite of quercetin in humans. Journal of Nutrition. 2001;131: 2648-2652. (Pubitemid 32947790)
24. Egert S, Wolffram S, Bosy-Westphal A, et al. Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J Nutr. 2008;138: 1615-1621.
25. Hertog MGL, Kromhout D, Aravanis C, et al. Flavonoid intake and long-term risk of coronary heart disease and cancer in the 7 countries study. Arch Intern Med. 1995;155: 381-386.
26. National Toxicology Program. Toxicology and carcinogenesis studies of quercetin (CAS No. 117-39-5) in F344/N rats (feed studies). Technical Report No. 409, NIH Publication No. 92-3140. 1992. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, National Toxicology Program, Research Triangle Park, NC.
27. Justesen U, Knuthsen P, Leth T. Quantitative analysis of flavonols, flavones, and flavanones in fruits, vegetables and beverages by high-performance liquid chromatography with photo-diode array and mass spectrometric detection. Journal of Chromatography A. 1998;799: 101-110. (Pubitemid 28161212)
28. Hertog MGL, Hollman PCH, Katan MB. Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands. Journal of Agricultural and Food Chemistry. 1992;40: 2379-2383.
29. Middleton E Jr, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev. 2000;52: 673-751.
30. Hertog MGL, Hollman PCH, Vandeputte B. Content of potentially anticarcinogenic flavonoids of tea infusions, wines, and fruit juices. Journal of Agricultural and Food Chemistry. 1993;41: 1242-1246.
31. Grippo AA, Capps K, Rougeau B, et al. Analysis of flavonoid phytoestrogens in botanical and ephedra-containing dietary supplements. Ann Pharmacother. 2007;41: 1375-1382. (Pubitemid 47311357)
32. Hollman PC, Bijsman MN, van Gameren Y, et al. The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man. Free Radic Res. 1999;31: 569-573.
33. Shoskes DA, Zeitlin SI, Shahed A, et al. Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial. Urology. 1999;54: 960-963.
34. Erlund I, Alfthan G, Siren H, et al. Validated method for the quantitation of quercetin from human plasma using high-performance liquid chromatography with electrochemical detection. J Chromatogr B Biomed Sci Appl. 1999;727: 179-189. (Pubitemid 29189290)
35. Hollman PC, de Vries JH, van Leeuwen SD, et al. Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers. Am J Clin Nutr. 1995;62: 1276-1282.
36. Hollman PC, Katan MB. Absorption, metabolism and health effects of dietary flavonoids in man. Biomed Pharmacother. 1997;51: 305-310.
37. Youdim KA, Qaiser MZ, Begley DJ, et al. Flavonoid permeability across an in situ model of the blood-brain barrier. Free Radical Biology and Medicine. 2004;36: 592-604.
38. Williamson G, Manach C. Bioavailability and bioefficacy of polyphenols in humans, II. Review of 93 intervention studies. Am J Clin Nutr. 2005;81: 243S-255S.
39. Nieman DC. Immunonutrition support for athletes. Nutrition Reviews. 2008;66: 310-320.
40. Nieman DC, Henson DA, Gross SJ, et al. Quercetin reduces illness but not immune perturbations after intensive exercise. Medicine and Science in Sports and Exercise. 2007;39: 1561-1569.
41. Erdman JW Jr, Balentine D, Arab L, et al. Flavonoids and heart health: proceedings of the ILSI North America Flavonoids Workshop, May 31-June 1, 2005, Washington, DC. J Nutr. 2007;137: 718SY737S. (Pubitemid 46397511)
42. Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol. 2008;585: 325-337.
43. Conquer JA, Maiani G, Azzini E, et al. Supplementation with quercetin markedly increases plasma quercetin concentration without effect on selected risk factors for heart disease in healthy subjects. J Nutr. 1998;128: 593-597. (Pubitemid 28188358)
44. Boyle SP, Dobson VL, Duthie SJ, et al. Absorption and DNA protective effects of flavonoid glycosides from an onion meal. Eur J Nutr. 2000;39: 213-223.
45. Chopra M, Fitzsimons PE, Strain JJ, et al. Nonalcoholic red wine extract and quercetin inhibit LDL oxidation without affecting plasma antioxidant vitamin and carotenoid concentrations. Clin Chem. 2000;46: 1162-1170. (Pubitemid 30643320)
46. McAnulty SR, McAnulty LS, Nieman DC, et al. Chronic quercetin ingestion and exercise-induced oxidative damage and inflammation. Applied Physiology Nutrition and Metabolism-Physiologie Appliquee Nutrition et Metabolisme. 2008;33: 254-262.
47. Kumar A, Goyal R. Quercetin protects against acute immobilization stress-induced behaviors and biochemical alterations in mice. Journal of Medicinal Food. 2008;11: 469-473.
48. Fine BJ, Kobrick JL, Lieberman HR, et al. Effects of caffeine or diphenhydramine on visual vigilance. Psychopharmacology (Berl). 1994;114: 233-238.
49. Frary CD, Johnson RK,Wang MQ. Food sources and intakes of caffeine in the diets of persons in the United States. J Am Diet Assoc. 2005;105: 110-113.
50. Amendola CA, Gabrieli JDE, Lieberman HR. Caffeine s effects on performance amd mood are independent of age and gender. Nutr Neuro. 1998;1: 269-280.
51. Lieberman HR, Tharion WJ, Shukitt-Hale B, et al. Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training. Sea-Air-Land. Psychopharmacology (Berl). 2002;164: 250-261. (Pubitemid 35340991)
52. Lieberman HR, Coffey B, Kobrick J. A vigilance task sensitive to the effects of stimulants, hypnotics, and environmental stress: the Scanning Visual Vigilance Test. Behavior Research Methods Instruments & Computers. 1998;30: 416-422. (Pubitemid 128685495)
53. McNair DM, Lorr M, Droppleman LF. edITS Manual for the Profile of Mood States. San Diego, CA: Educational and Industrial Testing Service, 1971.
54. Tharion WJ, Shukitt-Hale B, Coffey B, et al. The use of caffeine to enhance cognitive performance, reaction time, vigilance, rifle marksmanship, and mood states in sleep-deprived Navy SEALs (BUD/S) trainees. USARIEM Technical Report T98-4. 1997. Natick, MA, U.S. Army Research Institute of Environmental Medicine.
55. Johnson RF, Merullo DJ. Effects of caffeine and gender on vigilance and marksmanship. Proceedings of the Human Factors and Ergonomics Society (HFES Proceedings). 1996;40: 1217-1221.
56. Attwood AS, Higgs S, Terry P. Differential responsiveness to caffeine and perceived effects of caffeine in moderate and high regular caffeine consumers. Psychopharmacology (Berl). 2007;190: 469-477. (Pubitemid 46204464)
57. Johnson RF, Merullo DJ. Caffeine, Gender, and Sentry Duty: Effects of a Mild Stimulant on Vigilance and Marksmanship. Countermeasures for Battlefield Stressors. Baton Rouge, LA: Louisiana State University Press, 2004: 1-18.
58. Kamimori GH, Karyekar CS, Otterstetter R, et al. The rate of absorption and relative bioavailability of caffeine administered in chewing gum versus capsules to normal healthy volunteers. International Journal of Pharmaceutics. 2002;234: 159-167. (Pubitemid 34142621)