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Volumn 49, Issue 5, 2010, Pages 719-727

Epithelial-mesenchymal transition of epicardial mesothelium is a source of cardiac CD117-positive stem cells in adult human heart

Author keywords

Cardiac regeneration; Cardiac stem cells; CD117 positive cells; Epicardially derived cells; Epicardium; Epithelial mesenchymal transition

Indexed keywords

ALPHA4 INTEGRIN; BETA CATENIN; CYTOKERATIN 5; CYTOKERATIN 6; EPICARDIN; MESSENGER RNA; PODOPLANIN; PROTEIN ZO1; STEM CELL FACTOR RECEPTOR; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN;

EID: 77957232737     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2010.05.013     Document Type: Article
Times cited : (62)

References (44)
  • 1
    • 20744439516 scopus 로고    scopus 로고
    • The mesenchymal cell, its role in the embryo, and the remarkable signalling mechanisms that create it
    • Hay E.D. The mesenchymal cell, its role in the embryo, and the remarkable signalling mechanisms that create it. Dev Dyn 2005, 233:706-720.
    • (2005) Dev Dyn , vol.233 , pp. 706-720
    • Hay, E.D.1
  • 2
    • 41549162752 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states in development and disease
    • Baum B., Settleman J., Quinlan M.P. Transitions between epithelial and mesenchymal states in development and disease. Semin Cell Dev Biol 2008, 19(3):294-308. 10.1016/j.semcdb.2008.02.001.
    • (2008) Semin Cell Dev Biol , vol.19 , Issue.3 , pp. 294-308
    • Baum, B.1    Settleman, J.2    Quinlan, M.P.3
  • 3
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery J.P. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002, 2:442-454.
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 4
    • 58149394173 scopus 로고    scopus 로고
    • MEKK3 initiates transforming growth factor beta 2-dependent epithelial-to-mesenchymal transition during endocardial cushion morphogenesis
    • Stevens M.V., Broka D.M., Parker P., Rogowitz E., Vaillancourt R.R., Camenisch T.D. MEKK3 initiates transforming growth factor beta 2-dependent epithelial-to-mesenchymal transition during endocardial cushion morphogenesis. Circ Res 2008, 103(12):1430-1440.
    • (2008) Circ Res , vol.103 , Issue.12 , pp. 1430-1440
    • Stevens, M.V.1    Broka, D.M.2    Parker, P.3    Rogowitz, E.4    Vaillancourt, R.R.5    Camenisch, T.D.6
  • 5
    • 0032518298 scopus 로고    scopus 로고
    • Common epicardial origin of coronary vascular smooth muscle, perivascular fibroblasts, and intermyocardial fibroblasts in the avian heart
    • Dettman R.W., Denetclaw W., Ordahl C.P., Bristow J. Common epicardial origin of coronary vascular smooth muscle, perivascular fibroblasts, and intermyocardial fibroblasts in the avian heart. Dev Biol 1998, 193(2):169-181. 10.1006/dbio.1997.8801.
    • (1998) Dev Biol , vol.193 , Issue.2 , pp. 169-181
    • Dettman, R.W.1    Denetclaw, W.2    Ordahl, C.P.3    Bristow, J.4
  • 6
    • 46449138664 scopus 로고    scopus 로고
    • Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart
    • Zhou B., Ma Q., Rajagopal S., Wu S.M., Domian I., Rivera-Feliciano J., et al. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature 2008, 454(7200):109-113.
    • (2008) Nature , vol.454 , Issue.7200 , pp. 109-113
    • Zhou, B.1    Ma, Q.2    Rajagopal, S.3    Wu, S.M.4    Domian, I.5    Rivera-Feliciano, J.6
  • 7
    • 0026633108 scopus 로고
    • Role of epicardial mesothelial cells in the modification of phenotype and function of adult rat ventricular myocytes in primary coculture
    • Eid H., Larson D.M., Springhorn J.P., Attawia M.A., Nayak R.C., Smith T.W., et al. Role of epicardial mesothelial cells in the modification of phenotype and function of adult rat ventricular myocytes in primary coculture. Circ Res 1992, 71(1):40-50.
    • (1992) Circ Res , vol.71 , Issue.1 , pp. 40-50
    • Eid, H.1    Larson, D.M.2    Springhorn, J.P.3    Attawia, M.A.4    Nayak, R.C.5    Smith, T.W.6
  • 9
    • 41449094683 scopus 로고    scopus 로고
    • Lives of a heart cell: tracing the origins of cardiac progenitors
    • Martin-Puig S., Wang Z., Chien K.R. Lives of a heart cell: tracing the origins of cardiac progenitors. Cell Stem Cell 2008, 2(4):320-331.
    • (2008) Cell Stem Cell , vol.2 , Issue.4 , pp. 320-331
    • Martin-Puig, S.1    Wang, Z.2    Chien, K.R.3
  • 10
    • 0346690330 scopus 로고    scopus 로고
    • The epicardium and epicardially derived cells (EPDCs) as cardiac stem cells
    • Wessels A., Pérez-Pomares J.M. The epicardium and epicardially derived cells (EPDCs) as cardiac stem cells. Anat Rec A Discov Mol Cell Evol Biol 2004, 276(1):43-57.
    • (2004) Anat Rec A Discov Mol Cell Evol Biol , vol.276 , Issue.1 , pp. 43-57
    • Wessels, A.1    Pérez-Pomares, J.M.2
  • 11
    • 0037459362 scopus 로고    scopus 로고
    • Epicardial/mesothelial cell line retains vasculogenic potential of embryonic epicardium
    • Wada A.M., Smith T.K., Osler M.E., Reese D.E., Bader D.M. Epicardial/mesothelial cell line retains vasculogenic potential of embryonic epicardium. Circ Res 2003, 92(5):525-531.
    • (2003) Circ Res , vol.92 , Issue.5 , pp. 525-531
    • Wada, A.M.1    Smith, T.K.2    Osler, M.E.3    Reese, D.E.4    Bader, D.M.5
  • 12
    • 33846918187 scopus 로고    scopus 로고
    • Epicardial cells of human adults can undergo an epithelial-to-mesenchymal transition and obtain characteristics of smooth muscle cells in vitro
    • van Tuyn J., Atsma D.E., Winter E.M., van der Velde-van Dijke I., Pijnappels D.A., Bax N.A., et al. Epicardial cells of human adults can undergo an epithelial-to-mesenchymal transition and obtain characteristics of smooth muscle cells in vitro. Stem Cells 2007, 25(2):271-278.
    • (2007) Stem Cells , vol.25 , Issue.2 , pp. 271-278
    • van Tuyn, J.1    Atsma, D.E.2    Winter, E.M.3    van der Velde-van Dijke, I.4    Pijnappels, D.A.5    Bax, N.A.6
  • 13
    • 55049116647 scopus 로고    scopus 로고
    • CD117-positive cells in adult human heart are localized in the subepicardium, and their activation is associated with laminin-1 and alpha6 integrin expression
    • Castaldo C., Di Meglio F., Nurzynska D., Romano G., Maiello C., Bancone C., et al. CD117-positive cells in adult human heart are localized in the subepicardium, and their activation is associated with laminin-1 and alpha6 integrin expression. Stem Cells 2008, 26(7):1723-1731.
    • (2008) Stem Cells , vol.26 , Issue.7 , pp. 1723-1731
    • Castaldo, C.1    Di Meglio, F.2    Nurzynska, D.3    Romano, G.4    Maiello, C.5    Bancone, C.6
  • 14
    • 0029905001 scopus 로고    scopus 로고
    • Cardiogel: a biosynthetic extracellular matrix for cardiomyocyte culture
    • VanWinkle W.B., Snuggs M.B., Buja L.M. Cardiogel: a biosynthetic extracellular matrix for cardiomyocyte culture. In Vitro Cell Dev Biol Anim 1996, 32(8):478-485.
    • (1996) In Vitro Cell Dev Biol Anim , vol.32 , Issue.8 , pp. 478-485
    • VanWinkle, W.B.1    Snuggs, M.B.2    Buja, L.M.3
  • 15
    • 0020467073 scopus 로고
    • The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells
    • Moll R., Franke W.W., Schiller D.L., Geiger B., Krepler R. The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell 1982, 31(1):11-24.
    • (1982) Cell , vol.31 , Issue.1 , pp. 11-24
    • Moll, R.1    Franke, W.W.2    Schiller, D.L.3    Geiger, B.4    Krepler, R.5
  • 16
    • 58149384424 scopus 로고    scopus 로고
    • Beta-catenin downregulation attenuates ischemic cardiac remodeling through enhanced resident precursor cell differentiation
    • Zelarayan L.C., Noack C., Sekkali B., Kmecova J., Gehrke C., Renger A., et al. Beta-catenin downregulation attenuates ischemic cardiac remodeling through enhanced resident precursor cell differentiation. Proc Natl Acad Sci USA 2008, 105(50):19762-19767.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.50 , pp. 19762-19767
    • Zelarayan, L.C.1    Noack, C.2    Sekkali, B.3    Kmecova, J.4    Gehrke, C.5    Renger, A.6
  • 17
    • 0031874067 scopus 로고    scopus 로고
    • Epicardin: a novel basic helix-loop-helix transcription factor gene expressed in epicardium, branchial arch myoblasts, and mesenchyme of developing lung, gut, kidney, and gonads
    • Robb L., Mifsud L., Hartley L., Biben C., Copeland N.G., Gilbert D.J., et al. Epicardin: a novel basic helix-loop-helix transcription factor gene expressed in epicardium, branchial arch myoblasts, and mesenchyme of developing lung, gut, kidney, and gonads. Dev Dyn 1998, 213(1):105-113.
    • (1998) Dev Dyn , vol.213 , Issue.1 , pp. 105-113
    • Robb, L.1    Mifsud, L.2    Hartley, L.3    Biben, C.4    Copeland, N.G.5    Gilbert, D.J.6
  • 18
    • 27844557346 scopus 로고    scopus 로고
    • Bves modulates epithelial integrity through an interaction at the tight junction
    • Osler M.E., Chang M.S., Bader D.M. Bves modulates epithelial integrity through an interaction at the tight junction. J Cell Sci 2005, 118(Pt 20):4667-4678.
    • (2005) J Cell Sci , vol.118 , Issue.PART 20 , pp. 4667-4678
    • Osler, M.E.1    Chang, M.S.2    Bader, D.M.3
  • 19
    • 0037447925 scopus 로고    scopus 로고
    • Inhibition of alpha4-integrin stimulates epicardial-mesenchymal transformation and alters migration and cell fate of epicardially-derived mesenchyme
    • Dettman R.W., Pae S.H., Morabito C., Bristow J. Inhibition of alpha4-integrin stimulates epicardial-mesenchymal transformation and alters migration and cell fate of epicardially-derived mesenchyme. Dev Biol 2003, 257(2):315-328. 10.1016/S0012-1606(03)00064-2.
    • (2003) Dev Biol , vol.257 , Issue.2 , pp. 315-328
    • Dettman, R.W.1    Pae, S.H.2    Morabito, C.3    Bristow, J.4
  • 20
    • 0025894092 scopus 로고
    • Cadherin cell adhesion receptors as a morphogenetic regulator
    • Takeichi M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science 1991, 251(5000):1451-1455.
    • (1991) Science , vol.251 , Issue.5000 , pp. 1451-1455
    • Takeichi, M.1
  • 22
    • 0024508983 scopus 로고
    • Changing patterns of cytokeratins and vimentin in the early chick embryo
    • Page M. Changing patterns of cytokeratins and vimentin in the early chick embryo. Development 1989, 105(1):97-107.
    • (1989) Development , vol.105 , Issue.1 , pp. 97-107
    • Page, M.1
  • 23
    • 0141481986 scopus 로고    scopus 로고
    • Tie-2-dependent activation of RhoA and Rac1 participates in endothelial cell motility triggered by angiopoietin-1
    • Cascone I., Audero E., Giraudo E., Napione L., Maniero F., Philips M.R., et al. Tie-2-dependent activation of RhoA and Rac1 participates in endothelial cell motility triggered by angiopoietin-1. Blood 2003, 102(7):2482-2490.
    • (2003) Blood , vol.102 , Issue.7 , pp. 2482-2490
    • Cascone, I.1    Audero, E.2    Giraudo, E.3    Napione, L.4    Maniero, F.5    Philips, M.R.6
  • 24
    • 40849088002 scopus 로고    scopus 로고
    • Cardiac malformations and myocardial abnormalities in podoplanin knockout mouse embryos: correlation with abnormal epicardial development
    • Mahtab E.A., Wijffels M.C., Van Den Akker N.M., Hahurij N.D., Lie-Venema H., Wisse L.J., et al. Cardiac malformations and myocardial abnormalities in podoplanin knockout mouse embryos: correlation with abnormal epicardial development. Dev Dyn 2008, 237(3):847-857.
    • (2008) Dev Dyn , vol.237 , Issue.3 , pp. 847-857
    • Mahtab, E.A.1    Wijffels, M.C.2    Van Den Akker, N.M.3    Hahurij, N.D.4    Lie-Venema, H.5    Wisse, L.J.6
  • 26
    • 0345516018 scopus 로고    scopus 로고
    • Epicardium-derived cells contribute a novel population to the myocardial wall and the atrioventricular cushions
    • Gittenberger-de Groot A.C., Vrancken Peeters M.P., Mentink M.M., Gourdie R.G., Poelmann R.E. Epicardium-derived cells contribute a novel population to the myocardial wall and the atrioventricular cushions. Circ Res 1998, 82(10):1043-1052.
    • (1998) Circ Res , vol.82 , Issue.10 , pp. 1043-1052
    • Gittenberger-de Groot, A.C.1    Vrancken Peeters, M.P.2    Mentink, M.M.3    Gourdie, R.G.4    Poelmann, R.E.5
  • 27
    • 26244458018 scopus 로고    scopus 로고
    • TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
    • Kasai H., Allen J.T., Mason R.M., Kamimura T., Zhang Z. TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Resp Res 2005, 6:56.
    • (2005) Resp Res , vol.6 , pp. 56
    • Kasai, H.1    Allen, J.T.2    Mason, R.M.3    Kamimura, T.4    Zhang, Z.5
  • 28
    • 33644975212 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces loss of epithelial character and smooth muscle cell differentiation in epicardial cells
    • Compton L.A., Potash D.A., Mundell N.A., Barnett J.V. Transforming growth factor-beta induces loss of epithelial character and smooth muscle cell differentiation in epicardial cells. Dev Dyn 2006, 235(1):82-93.
    • (2006) Dev Dyn , vol.235 , Issue.1 , pp. 82-93
    • Compton, L.A.1    Potash, D.A.2    Mundell, N.A.3    Barnett, J.V.4
  • 29
    • 39749130550 scopus 로고    scopus 로고
    • Primary and immortalized mouse epicardial cells undergo differentiation in response to TGFbeta
    • Austin A.F., Compton L.A., Love J.D., Brown C.B., Barnett J.V. Primary and immortalized mouse epicardial cells undergo differentiation in response to TGFbeta. Dev Dyn 2008, 237(2):366-376.
    • (2008) Dev Dyn , vol.237 , Issue.2 , pp. 366-376
    • Austin, A.F.1    Compton, L.A.2    Love, J.D.3    Brown, C.B.4    Barnett, J.V.5
  • 30
    • 0034798707 scopus 로고    scopus 로고
    • Leaving the neighborhood: molecular mechanisms involved during epithelial-mesenchymal transition
    • Savagner P. Leaving the neighborhood: molecular mechanisms involved during epithelial-mesenchymal transition. BioEssays 2001, 23:912-923.
    • (2001) BioEssays , vol.23 , pp. 912-923
    • Savagner, P.1
  • 31
    • 59049086079 scopus 로고    scopus 로고
    • Epithelial cells within the human pancreas do not coexpress mesenchymal antigens: epithelial-mesenchymal transition is an artifact of cell culture
    • Seeberger K.L., Eshpeter A., Rajotte R.V., Korbutt G.S. Epithelial cells within the human pancreas do not coexpress mesenchymal antigens: epithelial-mesenchymal transition is an artifact of cell culture. Lab Invest 2009, 89(2):110-121.
    • (2009) Lab Invest , vol.89 , Issue.2 , pp. 110-121
    • Seeberger, K.L.1    Eshpeter, A.2    Rajotte, R.V.3    Korbutt, G.S.4
  • 32
    • 0030475911 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transformations in early avian heart development
    • Markwald R., Eisenberg C., Eisenberg L., Trusk T., Sugi Y. Epithelial-mesenchymal transformations in early avian heart development. Acta Anat (Basel) 1996, 156(3):173-186.
    • (1996) Acta Anat (Basel) , vol.156 , Issue.3 , pp. 173-186
    • Markwald, R.1    Eisenberg, C.2    Eisenberg, L.3    Trusk, T.4    Sugi, Y.5
  • 33
    • 78650017839 scopus 로고    scopus 로고
    • Epicardial cells are missing from the surface of hearts with ischemic cardiomyopathy: a useful clue about the self-renewal potential of the adult human heart?
    • Electronic publication, Jan 26
    • Di Meglio F., Castaldo C., Nurzynska D., Romano V., Miraglia R., Montagnani S. Epicardial cells are missing from the surface of hearts with ischemic cardiomyopathy: a useful clue about the self-renewal potential of the adult human heart?. Int J Cardiol Jan 26 2009, Electronic publication. 10.1016/j.ijcard.2008.12.137.
    • (2009) Int J Cardiol
    • Di Meglio, F.1    Castaldo, C.2    Nurzynska, D.3    Romano, V.4    Miraglia, R.5    Montagnani, S.6
  • 34
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • Thiery J.P., Sleeman J.P. Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 2006, 7(2):131-142.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , Issue.2 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 35
    • 76449096904 scopus 로고    scopus 로고
    • Prognostic significance of epithelial-mesenchymal transition in malignant pleural mesothelioma
    • Schramm A., Opitz I., Thies S., Seifert B., Moch H., Weder W., et al. Prognostic significance of epithelial-mesenchymal transition in malignant pleural mesothelioma. Eur J Cardiothorac Surg 2010, 37(3):566-572.
    • (2010) Eur J Cardiothorac Surg , vol.37 , Issue.3 , pp. 566-572
    • Schramm, A.1    Opitz, I.2    Thies, S.3    Seifert, B.4    Moch, H.5    Weder, W.6
  • 36
    • 67650996754 scopus 로고    scopus 로고
    • Biomarkers for epithelial-mesenchymal transitions
    • Zeisberg M., Neilson E.G. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 2009, 119(6):1429-1437.
    • (2009) J Clin Invest , vol.119 , Issue.6 , pp. 1429-1437
    • Zeisberg, M.1    Neilson, E.G.2
  • 37
    • 44649178243 scopus 로고    scopus 로고
    • Characterization of key mechanisms in transmigration and invasion of mesenchymal stem cells
    • Steingen C., Brenig F., Baumgartner L., Schmidt J., Schmidt A., Bloch W. Characterization of key mechanisms in transmigration and invasion of mesenchymal stem cells. J Mol Cell Cardiol 2008, 44(6):1072-1084. 10.1016/j.yjmcc.2008.03.010.
    • (2008) J Mol Cell Cardiol , vol.44 , Issue.6 , pp. 1072-1084
    • Steingen, C.1    Brenig, F.2    Baumgartner, L.3    Schmidt, J.4    Schmidt, A.5    Bloch, W.6
  • 38
    • 24644487312 scopus 로고    scopus 로고
    • TGF-beta and epithelial-to-mesenchymal transitions
    • Zavadil J., Böttinger E.P. TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 2005, 24(37):5764-5774.
    • (2005) Oncogene , vol.24 , Issue.37 , pp. 5764-5774
    • Zavadil, J.1    Böttinger, E.P.2
  • 39
    • 0035861541 scopus 로고    scopus 로고
    • Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity
    • Bhowmick N.A., Zent R., Ghiassi M., McDonnell M., Moses H.L. Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity. J Biol Chem 2001, 276(50):46707-46713.
    • (2001) J Biol Chem , vol.276 , Issue.50 , pp. 46707-46713
    • Bhowmick, N.A.1    Zent, R.2    Ghiassi, M.3    McDonnell, M.4    Moses, H.L.5
  • 40
    • 64049087261 scopus 로고    scopus 로고
    • Derivation of epicardium-derived progenitor cells (EPDCs) from adult epicardium
    • Smart N., Riley P.R. Derivation of epicardium-derived progenitor cells (EPDCs) from adult epicardium. Curr Protoc Stem Cell Biol 2009, 8:2C.2.1-9.
    • (2009) Curr Protoc Stem Cell Biol , vol.8
    • Smart, N.1    Riley, P.R.2
  • 41
    • 10744228523 scopus 로고    scopus 로고
    • Adult cardiac stem cells are multipotent and support myocardial regeneration
    • Beltrami A.P., Barlucchi L., Torella D., Baker M., Limana F., Chimenti S., et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 2003, 114(6):763-776.
    • (2003) Cell , vol.114 , Issue.6 , pp. 763-776
    • Beltrami, A.P.1    Barlucchi, L.2    Torella, D.3    Baker, M.4    Limana, F.5    Chimenti, S.6
  • 42
    • 47949083823 scopus 로고    scopus 로고
    • Evolution of the c-kit-positive cell response to pathological challenge in the myocardium
    • Fransioli J., Bailey B., Gude N.A., Cottage C.T., Muraski J.A., Emmanuel G., et al. Evolution of the c-kit-positive cell response to pathological challenge in the myocardium. Stem Cells 2008, 26(5):1315-1324.
    • (2008) Stem Cells , vol.26 , Issue.5 , pp. 1315-1324
    • Fransioli, J.1    Bailey, B.2    Gude, N.A.3    Cottage, C.T.4    Muraski, J.A.5    Emmanuel, G.6
  • 43
    • 24644480749 scopus 로고    scopus 로고
    • Molecular requirements for epithelial-mesenchymal transition during tumor progression
    • Huber M.A., Kraut N., Beug H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol 2005, 17(5):548-558. 10.1016/j.ceb.2005.08.001.
    • (2005) Curr Opin Cell Biol , vol.17 , Issue.5 , pp. 548-558
    • Huber, M.A.1    Kraut, N.2    Beug, H.3
  • 44
    • 34548126504 scopus 로고    scopus 로고
    • Preservation of left ventricular function and attenuation of remodeling after transplantation of human epicardium-derived cells into the infarcted mouse heart
    • Winter E.M., Grauss R.W., Hogers B., van Tuyn J., van der Geest R., Lie-Venema H., et al. Preservation of left ventricular function and attenuation of remodeling after transplantation of human epicardium-derived cells into the infarcted mouse heart. Circulation 2007, 116(8):917-927.
    • (2007) Circulation , vol.116 , Issue.8 , pp. 917-927
    • Winter, E.M.1    Grauss, R.W.2    Hogers, B.3    van Tuyn, J.4    van der Geest, R.5    Lie-Venema, H.6


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