CD117-positive cells in adult human heart are localized in the subepicardium, and their activation is associated with laminin-1 and α6 integrin expression

Stem Cells

Volumn 26, Issue 7, 2008, Pages 1723-1731

  Castaldo, Clotilde ^a   Di Meglio, Franca ^a   Nurzynska, Daria ^a   Romano, Gianpaolo ^b   Maiello, Ciro ^b   Bancone, Ciro ^b   Müller, Patrick ^c   Böhm, Michael ^c   Cotrufo, Maurizio ^b   Montagnani, Stefania ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b MONALDI HOSPITAL   (Italy)

^c SAARLAND UNIVERSITY   (Germany)

Author keywords

Cardiac CD117 positive cells; Extracellular matrix; Heart failure; Laminin

Indexed keywords

ALPHA6 INTEGRIN; LAMININ 1; MEROSIN; SMALL INTERFERING RNA; STEM CELL FACTOR RECEPTOR;

APOPTOSIS; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; EXTRACELLULAR MATRIX; GENETIC TRANSFECTION; HEART DEVELOPMENT; HEART MUSCLE CELL; HEART RATE; HUMAN; ISCHEMIC HEART DISEASE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

ADULT; EPITHELIUM; FEMALE; GENE EXPRESSION REGULATION; HEART; HUMANS; INTEGRIN ALPHA6; LAMININ; MALE; MESODERM; MYOCARDIUM; PERICARDIUM; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS C-KIT; RNA, SMALL INTERFERING;

EID: 55049116647     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2007-0732     Document Type: Article

References (33)

1. Moretti A, Caron L, Nakano A et al. Multipotent embryonic Isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell 2006;127:1151-1165.
2. Kattman SJ, Huber TL, Keller GM. Multipotent Flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages. Dev Cell 2006;11:723-732.
3. Wu SM, Fujiwara Y, Cibulsky SM et al. Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell 2006;127:1137-1150.
4. Beltrami AP, Barlucchi L, Torella D et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 2003;114:763-776.
5. Oh H, Bradfute SB, Gallardo TD et al. Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction. Proc Natl Acad Sci U S A 2003;100:12313-12318.
6. Messina E, De Angelis L, Frati G et al. Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ Res 2004;95:911-921.
7. Limana F, Germani A, Zacheo A et al. Exogenous high-mobility group box 1 protein induces myocardial regeneration after infarction via enhanced cardiac c-kit+ cell proliferation and differentiation. Circ Res 2005;97:e73-e83.
8. Miner JH, Yurchenco PD. Laminin functions in tissue morphogenesis. Annu Rev Cell Dev Biol 2004;20:255-284.
9. De Arcangelis A, Neuville P, Boukamel R et al. Inhibition of laminin alpha 1-chain expression leads to alteration of basement membrane assembly and cell differentiation. J Cell Biol 1996;133:417-430.
10. Jones KJ, Morgan G, Johnston H et al. The expanding phenotype of laminin α2 chain (merosin) abnormalities: Case series and review. J Med Genet 2001;38:649-657.
11. Giancotti FG, Tarone G. Positional control of cell fate through joint integrin/receptor protein kinase signaling. Annu Rev Cell Dev Biol 2003;19:173-206.
12. Ross RS, Borg TK. Integrins and the myocardium. Circ Res 2001;88:1112-1119.
13. Dowling J, Yu QC, Fuchs E. β4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. J Cell Biol 1996;134:559-572.
14. Rabinovitz I, Mercurio AM. The integrin α6β4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin-containing motility structures. J Cell Biol 1997;139:1873-1884.
15. Thiery JP, Sleeman JP. Complex networks orchestrate epithelial- mesenchymal transitions. Nat Rev Mol Cell Biol 2006;7:131-142.
16. Morabito CJ, Dettman RW, Kattan J et al. Positive and negative regulation of epicardial-mesenchymal transformation during avian heart development. Dev Biol 2001;234:204-215.
17. Wada AM, Smith TK, Osler ME et al. Epicardial/mesothelial cell line retains vasculogenic potential of embryonic epicardium. Circ Res 2003;92:525-531.
18. van Tuyn J, Atsma DE, Winter EM et al. Epicardial cells of human adults can undergo an epithelial-to-mesenchymal transition and obtain characteristics of smooth muscle cells in vitro. STEM CELLS 2007;25:271-278.
19. Freshney RI. Primary culture. In: Freshney RI. Culture of Animal Cells. 4th ed. New York: Wiley-Liss 2000:149-177.
20. Ekblom P, Lonai P, Talts JF. Expression and biological role of laminin-1. Matrix Biol 2003;22:35-47.
21. Bearzi C, Rota M, Hosoda T et al. Human cardiac stem cells. Proc Natl Acad Sci U S A 2007;104:14068-14073.
22. Wessels A, Perez-Pomares JM. The epicardium and epicardially derived cells (EPDCs) as cardiac stem cells. Anat Rec A Discov Mol Cell Evol Biol 2004;276:43-57.
23. Urbanek K, Quaini F, Tasca G et al. Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy. Proc Natl Acad Sci U S A 2003;100:10440-10445.
24. Urbanek K, Cesselli D, Rota M et al. Stem cell niches in the adult mouse heart. Proc Natl Acad Sci U S A 2006;103:9226-9231.
25. Dettman RW, Pae SH, Morabito C et al. Inhibition of a4-integrin stimulates epicardial-mesenchymal transformation and alters migration and cell fate of epicardially derived mesenchyme. Dev Biol 2003;257:315-328.
26. Yang JT, Rayburn H, Hynes RO. Cell adhesion events mediated by α4 integrins are essential in placental and cardiac development. Development 1995;121:549-560.
27. Sengbusch JK, He W, Pinco KA et al. Dual functions of alpha4beta1 integrin in epicardial development: Initial migration and long-term attachment. J Cell Biol 2002;157:873-882.
28. Maitra N, Flink IL, Bahl JJ et al. Expression of alpha and beta integrins during terminal differentiation of cardiomyocytes. Cardiovasc Res 2000;47:715-725.
29. Sasaki T, Giltay R, Talts U et al. Expression and distribution of laminin alpha1 and alpha2 chains in embryonic and adult mouse tissues: An immunochemical approach. Exp Cell Res 2002;275:185-199.
30. Schuger L, Skubitz AP, Zhang J et al. Laminin alpha1 chain synthesis in the mouse developing lung: Requirement for epithelial-mesenchymal contact and possible role in bronchial smooth muscle development. J Cell Biol 1997;139:553-562.
31. Kikkawa Y, Mochizuki Y, Miner JH et al. Transient expression of laminin alpha1 chain in regenerating murine liver: Restricted localization of laminin chains and nidogen-1. Exp Cell Res 2005;305:99-109.
32. Yurchenco PD, Cheng YS, Campbell K et al. Loss of basement membrane, receptor and cytoskeletal lattices in a laminin-2 deficient muscular dystrophy. J Cell Sci 2004;117:735-742.
33. Schéele S, Nystrom A, Durbeej M et al. Laminin isoforms in development and disease. J Mol Med 2007;85:825-836.