NMR-based metabonomic analysis of the hepatotoxicity induced by combined exposure to PCBs and TCDD in rats

Toxicology and Applied Pharmacology

Volumn 248, Issue 3, 2010, Pages 178-184

  Lu, Chunfeng ^a,b   Wang, Yimei ^a   Sheng, Zhiguo ^c   Liu, Gang ^a   Fu, Ze ^a   Zhao, Jing ^a   Zhao, Jun ^a   Yan, Xianzhong ^d   Zhu, Benzhan ^c   Peng, Shuangqing ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b JIAMUSI UNIVERSITY   (China)

^c RESEARCH CENTER FOR ECO ENVIRONMENTAL SCIENCES   (China)

^d NATIONAL CENTER OF BIOMEDICAL ANALYSIS   (China)

Author keywords

2,3,7,8 Tetrachlorodibenzo p dioxin; Combined exposure; Hepatotoxicity; Metabonomics; NMR; Polychlorinated biphenyls

Indexed keywords

2 OXOGLUTARIC ACID; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CITRIC ACID; CREATINE; ENDOCRINE DISRUPTOR; GLUCOSE; HIPPURIC ACID; ISOVALERIC ACID; LACTIC ACID; POLYCHLORINATED BIPHENYL; SUCCINIC ACID; TAURINE; TRIMETHYLAMINE OXIDE; DRUG COMBINATION; POLLUTANT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; FATTY ACID METABOLISM; HISTOPATHOLOGY; LIVER TOXICITY; MALE; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; URINALYSIS; ANIMAL; COMPARATIVE STUDY; DRUG COMBINATION; DRUG-INDUCED LIVER INJURY; METABOLISM; METABOLOMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOLOGY; POLLUTANT; PROCEDURES; RANDOMIZATION; SPRAGUE DAWLEY RAT; TOXICITY;

ANIMALS; DRUG COMBINATIONS; DRUG-INDUCED LIVER INJURY; ENVIRONMENTAL POLLUTANTS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOMICS; POLYCHLORINATED BIPHENYLS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; TETRACHLORODIBENZODIOXIN;

RATTUS;

EID: 77957232598     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.07.020     Document Type: Article

References (39)

1. Aragon A.C., Kopf P.G., Campen M.J., Huwe J.K., Walker M.K. In utero and lactational 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin exposure: effects on fetal and adult cardiac gene expression and adult cardiac and renal morphology. Toxicol. Sci. 2008, 101:321-330.
2. Azmi J., Griffin J.L., Shore R.F., Holmes E., Nicholson J.K. Chemometric analysis of biofluids following toxicant induced hepatotoxicity: a metabonomic approach to distinguish the effects of 1-naphthylisothiocyanate from its products. Xenobiotica 2005, 35:839-852.
3. Bain J.R., Stevens R.D., Wenner B.R., Ilkayeva O., Muoio D.M., Newgard C.B. Metabolomics applied to diabetes research: moving from information to knowledge. Diabetes 2009, 58:2429-2443.
4. Beckwith-Hall B.M., Nicholson J.K., Nicholls A.W., Foxall P.J., Lindon J.C., Connor S.C., Abdi M., Connelly J., Holmes E. Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effects of three model hepatotoxins. Chem. Res. Toxicol. 1998, 11:260-272.
5. Bollard M.E., Stanley E.G., Lindon J.C., Nicholson J.K., Holmes E. NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition. NMR Biomed. 2005, 18:143-162.
6. Boverhof D.R., Burgoon L.D., Tashiro C., Sharratt B., Chittim B., Harkema J.R., Mendrick D.L., Zacharewski T.R. Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice. Toxicol. Sci. 2006, 94:398-416.
7. 1H-NMR-based urine metabolic profiles of male Wistar Han rats: implications for biomarker discovery. Biomarkers 2004, 9:156-179.
8. Craig A., Cloarec O., Holmes E., Nicholson J.K., Lindon J.C. Scaling and normalization effects in NMR spectroscopic metabonomic data sets. Anal. Chem. 2006, 78:2262-2267.
9. 13C]methionine UvrB from Bacillus caldotenax reveals UvrB-domain 4 heterodimer formation in solution. J. Mol. Biol. 2007, 373:282-295.
10. Desaulniers D., Cooke G.M., Leingartner K., Soumano K., Cole J., Yang J., Wade M., Yagminas A. Effects of postnatal exposure to a mixture of polychlorinated biphenyls, p, p'-dichlorodiphenyltrichloroethane, and p-p'-dichlorodiphenyldichloroethene in prepubertal and adult female Sprague-Dawley rats. Int. J. Toxicol. 2005, 24:111-127.
11. Holmes E., Antti H. Chemometric contributions to the evolution of metabonomics: mathematical solutions to characterising and interpreting complex biological NMR spectra. Analyst 2002, 127:1549-1557.
12. Ishihara K., Katsutani N., Aoki T. A metabonomics study of the hepatotoxicants galactosamine, methylene dianiline and clofibrate in rats. Basic Clin. Pharmacol. Toxicol. 2006, 99:251-260.
13. Jordan K.W., Cheng L.L. NMR-based metabolomics approach to target biomarkers for human prostate cancer. Expert Rev. Proteomics 2007, 4:389-400.
14. Keun H.C. Metabonomic modeling of drug toxicity. Pharmacol. Ther. 2006, 109:92-106.
15. Kleno T.G., Kiehr B., Baunsgaard D., Sidelmann U.G. Combination of 'omics' data to investigate the mechanism(s) of hydrazine-induced hepatotoxicity in rats and to identify potential biomarkers. Biomarkers 2004, 9:116-138.
16. Korenaga T., Fukusato T., Ohta M., Asaoka K., Murata N., Arima A., Kubota S. Long-term effects of subcutaneously injected 2,3,7,8-tetrachlorodibenzo-p-dioxin on the liver of rhesus monkeys. Chemosphere 2007, 67:S399-S404.
17. Lewis G.D., Asnani A., Gerszten R.E. Application of metabolomics to cardiovascular biomarker and pathway discovery. J. Am. Coll. Cardiol. 2008, 52:117-123.
18. Lindon J.C., Holmes E., Bollard M.E., Stanley E.G., Nicholson J.K. Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis. Biomarkers 2004, 9:1-31.
19. Ma L. Endocrine disruptors in female reproductive tract development and carcinogenesis. Trends Endocrinol. Metab. 2009, 20:357-363.
20. Marty-Teysset C., Posthuma C., Lolkema J.S., Schmitt P., Divies C., Konings W.N. Proton motive force generation by citrolactic fermentation in Leuconostoc mesenteroides. J. Bacteriol. 1996, 178:2178-2185.
21. McGarry J.D., Foster D.W. Regulation of hepatic fatty acid oxidation and ketone body production. Annu. Rev. Biochem. 1980, 49:395-420.
22. Mortishire-Smith R.J., Skiles G.L., Lawrence J.W., Spence S., Nicholls A.W., Johnson B.A., Nicholson J.K. Use of metabonomics to identify impaired fatty acid metabolism as the mechanism of a drug-induced toxicity. Chem. Res. Toxicol. 2004, 17:165-173.
23. Nagayama J., Tsuji H., Iida T., Nakagawa R., Matsueda T., Hirakawa H., Yanagawa T., Fukushige J., Watanabe T. Immunologic effects of perinatal exposure to dioxins, PCBs and organochlorine pesticides in Japanese infants. Chemosphere 2007, 67:393-398.
24. Nicholson J.K., Lindon J.C., Holmes E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 1999, 29:1181-1189.
25. Nicholson J.K., Connelly J., Lindon J.C., Holmes E. Metabonomics: a platform for studying drug toxicity and gene function. Nat. Rev. Drug Discov. 2002, 1:153-161.
26. 1H-NMR-based metabonomics. Int. J. Cancer 2005, 113:782-788.
27. 1H NMR analysis of rat urine in relation to toxicometabonomics. Part I: dose-dependent toxic effects of bromobenzene and paracetamol. Toxicol. Sci. 2007, 98:271-285.
28. Serkova N.J., Spratlin J.L., Eckhardt S.G. NMR-based metabolomics: translational application and treatment of cancer. Curr. Opin. Mol. Ther. 2007, 9:572-585.
29. Siculella L., Sabetta S., di Summa R., Leo M., Giudetti A.M., Palmieri F., Gnoni G.V. Starvation-induced posttranscriptional control of rat liver mitochondrial citrate carrier expression. Biochem. Biophys. Res. Commun. 2002, 299:418-423.
30. Sprague C.L., Phillips L.A., Young K.M., Elfarra A.A. Species and tissue differences in the toxicity of 3-butene-1, 2-diol in male Sprague-Dawley rats and B6C3F1 mice. Toxicol. Sci. 2004, 80:3-13.
31. 1H NMR-based metabolomics. Neoplasia 2009, 11:269-276.
32. Wade M.G., Foster W.G., Younglai E.V., McMahon A., Leingartner K., Yagminas A., Blakey D., Fournier M., Desaulniers D., Hughes C.L. Effects of subchronic exposure to a complex mixture of persistent contaminants in male rats: systemic, immune, and reproductive effects. Toxicol. Sci. 2002, 67:131-143.
33. Walker N.J., Crockett P.W., Nyska A., Brix A.E., Jokinen M.P., Sells D.M., Hailey J.R., Easterling M., Haseman J.K., Yin M., Wyde M.E., Bucher J.R., Portier C.J. Dose-additive carcinogenicity of a defined mixture of "dioxin-like compounds". Environ. Health Perspect. 2005, 113:43-48.
34. Wang Q.J., Jiang Y., Wu C.Q., Zhao J.Y., Yu S.Z., Yuan B.L., Yan X.Z., Liao M.Y. Study of a novel indolin-2-ketone compound Z24 induced hepatotoxicity by NMR-spectroscopy-based metabonomics of rat urine, blood plasma, and liver extracts. Toxicol. Appl. Pharmacol. 2006, 215:71-82.
35. Waterfield C.J., Turton J.A., Scales M.D., Timbrell J.A. Investigations into the effects of various hepatotoxic compounds on urinary and liver taurine levels in rats. Arch. Toxicol. 1993, 67:244-254.
36. Webb-Robertson B.J., Lowry D.F., Jarman K.H., Harbo S.J., Meng Q.R., Fuciarelli A.F., Pounds J.G., Lee K.M. A study of spectral integration and normalization in NMR-based metabonomic analyses. J. Pharm. Biomed. Anal. 2005, 39:830-836.
37. Wu H., Zhang X., Li X., Li Z., Wu Y., Pei F. Comparison of metabolic profiles from serum from hepatotoxin-treated rats by nuclear-magnetic-resonance -spectroscopy-based metabonomic analysis. Anal. Biochem. 2005, 340:99-105.
38. Yavuz A., Tetta C., Ersoy F.F., D'intini V., Ratanarat R., De Cal M., Bonello M., Bordoni V., Salvatori G., Andrikos E., Yakupoglu G., Levin N.W., Ronco C. Uremic toxins: a new focus on an old subject. Semin. Dial. 2005, 18:203-211.
39. Yokoyama T., Banta S., Berthiaume F., Nagrath D., Tompkins R.G., Yarmush M.L. Evolution of intrahepatic carbon, nitrogen, and energy metabolism in a d-galactosamine-induced rat liver failure model. Metab. Eng. 2005, 7:88-103.