Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro

Drug Metabolism and Disposition

Volumn 38, Issue 10, 2010, Pages 1785-1789

  Bellemare, Judith ^a   Rouleau, Mélanie ^a   Girard, Hugo ^a   Harvey, Mario ^a   Guillemette, Chantal ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC G 418; BLASTICIDIN S; DRUG METABOLIZING ENZYME; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A10; GLUCURONOSYLTRANSFERASE 1A3; GLUCURONOSYLTRANSFERASE 1A4; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 1A7; GLUCURONOSYLTRANSFERASE 1A8; GLUCURONOSYLTRANSFERASE 1A9; GLYCOSYLTRANSFERASE; ISOPROTEIN; PROTEIN; TRANSFERASE; UDP GLUCURONOSYLTRANFERASE A1; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GLUCURONIC ACID;

ALTERNATIVE RNA SPLICING; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; COMPLEX FORMATION; DRUG METABOLISM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; EXON; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE LOCUS; GENE SEQUENCE; GLUCURONIDATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

ALTERNATIVE SPLICING; BLOTTING, WESTERN; CELL LINE; COLON; ESOPHAGUS; GLUCURONOSYLTRANSFERASE; HUMANS; IMMUNOPRECIPITATION; INTESTINE, SMALL; LIVER; MULTIENZYME COMPLEXES; PROTEIN ISOFORMS; PROTEIN MULTIMERIZATION; TRANSFECTION;

EID: 77957173109     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.110.034835     Document Type: Article

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