Alternative-splicing forms of the major phase II conjugating UGT1A gene negatively regulate glucuronidation in human carcinoma cell lines

Pharmacogenomics Journal

Volumn 10, Issue 5, 2010, Pages 431-441

  Bellemare, J ^a   Rouleau, M ^a   Harvey, M ^a   Tteu B ^b   Guillemette, C ^a,c  

^a Université Laval   (Canada)

^b LAVAL UNIVERSITY   (Canada)

^c UNIVERSITÉ LAVAL   (Canada)

Author keywords

alternative splicing; dominant negative; glucuronidation; xenobiotics

Indexed keywords

GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A; MESSENGER RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ARTICLE; CANCER CELL CULTURE; COLON CANCER; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SUBSTRATE; EXON; GENE FUNCTION; GLUCURONIDATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTESTINE CRYPT; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

ALTERNATIVE SPLICING; BLOTTING, WESTERN; CELL LINE, TUMOR; COLON; COLONIC NEOPLASMS; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; IMMUNOHISTOCHEMISTRY; METABOLIC DETOXICATION, PHASE II; MICROSOMES, LIVER; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUBSTRATE SPECIFICITY;

EID: 77957140215     PISSN: 1470269X     EISSN: 14731150     Source Type: Journal    
DOI: 10.1038/tpj.2009.64     Document Type: Article

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