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Volumn 92, Issue 2, 2010, Pages 219-230

Pathogenesis of diffuse large B cell lymphoma

Author keywords

Diffuse large B cell lymphoma; Oncogenic pathways; Pathogenesis

Indexed keywords

B LYMPHOCYTE RECEPTOR; BORTEZOMIB; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE; MICRORNA; PROTEIN BCL 2; PROTEIN P53; STAT PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 5;

EID: 77956933850     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12185-010-0602-0     Document Type: Review
Times cited : (25)

References (84)
  • 2
    • 68749087282 scopus 로고    scopus 로고
    • Gene expression profiling in lymphoma diagnosis and management
    • 10.1016/j.beha.2009.05.001 19698928 1:CAS:528:DC%2BD1MXhtVegs7bM
    • J Iqbal Z Liu, et al. 2009 Gene expression profiling in lymphoma diagnosis and management Best Pract Res Clin Haematol 22 2 191 210 10.1016/j.beha.2009.05.001 19698928 1:CAS:528:DC%2BD1MXhtVegs7bM
    • (2009) Best Pract Res Clin Haematol , vol.22 , Issue.2 , pp. 191-210
    • Iqbal, J.1    Liu, Z.2
  • 5
    • 51649111684 scopus 로고    scopus 로고
    • Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways
    • 10.1073/pnas.0804295105 18765795
    • G Lenz GW Wright, et al. 2008 Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways Proc Natl Acad Sci USA 105 36 13520 13525 10.1073/pnas.0804295105 18765795
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.36 , pp. 13520-13525
    • Lenz, G.1    Wright, G.W.2
  • 6
    • 75749096130 scopus 로고    scopus 로고
    • Cancer genome sequencing: A review
    • 10.1093/hmg/ddp396 19808792 1:CAS:528:DC%2BD1MXhtlCqu7nM
    • ER Mardis RK Wilson 2009 Cancer genome sequencing: a review Hum Mol Genet 18 R2 R163 R168 10.1093/hmg/ddp396 19808792 1:CAS:528:DC%2BD1MXhtlCqu7nM
    • (2009) Hum Mol Genet , vol.18 , Issue.R2
    • Mardis, E.R.1    Wilson, R.K.2
  • 7
    • 53649106195 scopus 로고    scopus 로고
    • Next-generation DNA sequencing
    • 10.1038/nbt1486 18846087 1:CAS:528:DC%2BD1cXht1aisrzK
    • J Shendure H Ji 2008 Next-generation DNA sequencing Nat Biotechnol 26 10 1135 1145 10.1038/nbt1486 18846087 1:CAS:528:DC%2BD1cXht1aisrzK
    • (2008) Nat Biotechnol , vol.26 , Issue.10 , pp. 1135-1145
    • Shendure, J.1    Ji, H.2
  • 8
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • 10.1016/j.cell.2009.01.002 19167326 1:CAS:528:DC%2BD1MXhs1Kiuro%3D
    • DP Bartel 2009 MicroRNAs: target recognition and regulatory functions Cell 136 2 215 233 10.1016/j.cell.2009.01.002 19167326 1:CAS:528: DC%2BD1MXhs1Kiuro%3D
    • (2009) Cell , vol.136 , Issue.2 , pp. 215-233
    • Bartel, D.P.1
  • 9
    • 60149103676 scopus 로고    scopus 로고
    • The centrality of RNA
    • 10.1016/j.cell.2009.02.007 19239877 1:CAS:528:DC%2BD1MXkvFGksLo%3D
    • PA Sharp 2009 The centrality of RNA Cell 136 4 577 580 10.1016/j.cell.2009.02.007 19239877 1:CAS:528:DC%2BD1MXkvFGksLo%3D
    • (2009) Cell , vol.136 , Issue.4 , pp. 577-580
    • Sharp, P.A.1
  • 10
    • 33845242919 scopus 로고    scopus 로고
    • MicroRNAs: Regulators of gene expression and cell differentiation
    • DOI 10.1182/blood-2006-01-030015
    • RA Shivdasani 2006 MicroRNAs: regulators of gene expression and cell differentiation Blood 108 12 3646 3653 10.1182/blood-2006-01-030015 16882713 1:CAS:528:DC%2BD28Xht1Kgs77K (Pubitemid 44864540)
    • (2006) Blood , vol.108 , Issue.12 , pp. 3646-3653
    • Shivdasani, R.A.1
  • 12
    • 42449141513 scopus 로고    scopus 로고
    • MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia
    • 10.1182/blood-2007-07-098749 18187662 1:CAS:528:DC%2BD1cXjvVamtbY%3D
    • R Garzon S Volinia, et al. 2008 MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia Blood 111 6 3183 3189 10.1182/blood-2007-07-098749 18187662 1:CAS:528:DC%2BD1cXjvVamtbY%3D
    • (2008) Blood , vol.111 , Issue.6 , pp. 3183-3189
    • Garzon, R.1    Volinia, S.2
  • 13
    • 65549112644 scopus 로고    scopus 로고
    • Differentiation stage-specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas
    • 10.1182/blood-2008-10-184077 19047678 1:CAS:528:DC%2BD1MXlt1yjsLk%3D
    • R Malumbres KA Sarosiek, et al. 2009 Differentiation stage-specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas Blood 113 16 3754 3764 10.1182/blood-2008-10-184077 19047678 1:CAS:528:DC%2BD1MXlt1yjsLk%3D
    • (2009) Blood , vol.113 , Issue.16 , pp. 3754-3764
    • Malumbres, R.1    Sarosiek, K.A.2
  • 14
    • 66549101276 scopus 로고    scopus 로고
    • Patterns of microRNA expression characterize stages of human B-cell differentiation
    • 10.1182/blood-2008-09-178186 19202128 1:CAS:528:DC%2BD1MXnvVyqtbc%3D
    • J Zhang DD Jima, et al. 2009 Patterns of microRNA expression characterize stages of human B-cell differentiation Blood 113 19 4586 4594 10.1182/blood-2008-09-178186 19202128 1:CAS:528:DC%2BD1MXnvVyqtbc%3D
    • (2009) Blood , vol.113 , Issue.19 , pp. 4586-4594
    • Zhang, J.1    Jima, D.D.2
  • 21
    • 0037229674 scopus 로고    scopus 로고
    • Microarray reveals differences in both tumors and vascular specific gene expression in de novo CD5+ and CD5- diffuse large B-cell lymphomas
    • 12517778 1:CAS:528:DC%2BD3sXjvFKmtA%3D%3D
    • T Kobayashi M Yamaguchi, et al. 2003 Microarray reveals differences in both tumors and vascular specific gene expression in de novo CD5+ and CD5- diffuse large B-cell lymphomas Cancer Res 63 1 60 66 12517778 1:CAS:528:DC%2BD3sXjvFKmtA%3D%3D
    • (2003) Cancer Res , vol.63 , Issue.1 , pp. 60-66
    • Kobayashi, T.1    Yamaguchi, M.2
  • 22
    • 77956939958 scopus 로고    scopus 로고
    • Clinicopathologic characteristics and treatment outcome of the addition of rituximab to chemotherapy for CD5-positive in comparison with CD5-negative diffuse large B-cell lymphoma
    • Niitsu, N., M. Okamoto, et al. Clinicopathologic characteristics and treatment outcome of the addition of rituximab to chemotherapy for CD5-positive in comparison with CD5-negative diffuse large B-cell lymphoma. Ann Oncol. 2010
    • (2010) Ann Oncol.
    • Niitsu, N.1    Okamoto, M.2
  • 23
    • 48749115803 scopus 로고    scopus 로고
    • De novo CD5+ diffuse large B-cell lymphoma: Results of a detailed clinicopathological review in 120 patients
    • 10.3324/haematol.12810 18556402
    • M Yamaguchi N Nakamura, et al. 2008 De novo CD5+ diffuse large B-cell lymphoma: results of a detailed clinicopathological review in 120 patients Haematologica 93 8 1195 1202 10.3324/haematol.12810 18556402
    • (2008) Haematologica , vol.93 , Issue.8 , pp. 1195-1202
    • Yamaguchi, M.1    Nakamura, N.2
  • 24
    • 3042594986 scopus 로고    scopus 로고
    • BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma
    • 15215171 1:CAS:528:DC%2BD2cXmtFygsbo%3D
    • J Iqbal WG Sanger, et al. 2004 BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma Am J Pathol 165 1 159 166 15215171 1:CAS:528:DC%2BD2cXmtFygsbo%3D
    • (2004) Am J Pathol , vol.165 , Issue.1 , pp. 159-166
    • Iqbal, J.1    Sanger, W.G.2
  • 26
    • 40449102602 scopus 로고    scopus 로고
    • G.O.D.'s Holy Grail: Discovery of the RAG proteins
    • 18096995 1:CAS:528:DC%2BD2sXhsVGjur%2FN
    • VL Brandt DB Roth 2008 G.O.D.'s Holy Grail: discovery of the RAG proteins J Immunol 180 1 3 4 18096995 1:CAS:528:DC%2BD2sXhsVGjur%2FN
    • (2008) J Immunol , vol.180 , Issue.1 , pp. 3-4
    • Brandt, V.L.1    Roth, D.B.2
  • 27
    • 63649110740 scopus 로고    scopus 로고
    • Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates
    • 10.1016/j.molcel.2009.03.009 19362533 1:CAS:528:DC%2BD1MXls1Srs7Y%3D
    • L Deriano TH Stracker, et al. 2009 Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates Mol Cell 34 1 13 25 10.1016/j.molcel.2009.03.009 19362533 1:CAS:528:DC%2BD1MXls1Srs7Y%3D
    • (2009) Mol Cell , vol.34 , Issue.1 , pp. 13-25
    • Deriano, L.1    Stracker, T.H.2
  • 28
    • 1942421722 scopus 로고    scopus 로고
    • RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination
    • DOI 10.1016/S0092-8674(04)00301-0, PII S0092867404003010
    • GS Lee MB Neiditch, et al. 2004 RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination Cell 117 2 171 184 10.1016/S0092-8674(04) 00301-0 15084256 1:CAS:528:DC%2BD2cXjsFyrurg%3D (Pubitemid 38496238)
    • (2004) Cell , vol.117 , Issue.2 , pp. 171-184
    • Lee, G.S.1    Neiditch, M.B.2    Salus, S.S.3    Roth, D.B.4
  • 29
    • 76749171752 scopus 로고    scopus 로고
    • Mechanisms of chromosomal rearrangement in the human genome
    • 10.1186/1471-2164-11-S1-S1 20158866 1:CAS:528:DC%2BC3cXit1entr4%3D
    • AG Tsai MR Lieber 2010 Mechanisms of chromosomal rearrangement in the human genome BMC Genomics 11 Suppl 1 S1 10.1186/1471-2164-11-S1-S1 20158866 1:CAS:528:DC%2BC3cXit1entr4%3D
    • (2010) BMC Genomics , vol.11 , Issue.SUPPL. 1 , pp. 1
    • Tsai, A.G.1    Lieber, M.R.2
  • 31
    • 72249096210 scopus 로고    scopus 로고
    • Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation
    • 10.1158/0008-5472.CAN-09-1110 19903857 1:CAS:528:DC%2BD1MXhtl2rsbfK
    • G Cattoretti J Mandelbaum, et al. 2009 Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation Cancer Res 69 22 8686 8692 10.1158/0008-5472.CAN-09-1110 19903857 1:CAS:528:DC%2BD1MXhtl2rsbfK
    • (2009) Cancer Res , vol.69 , Issue.22 , pp. 8686-8692
    • Cattoretti, G.1    Mandelbaum, J.2
  • 33
    • 39149099085 scopus 로고    scopus 로고
    • Two levels of protection for the B cell genome during somatic hypermutation
    • DOI 10.1038/nature06547, PII NATURE06547
    • M Liu JL Duke, et al. 2008 Two levels of protection for the B cell genome during somatic hypermutation Nature 451 7180 841 845 10.1038/nature06547 18273020 1:CAS:528:DC%2BD1cXhvVyms78%3D (Pubitemid 351253166)
    • (2008) Nature , vol.451 , Issue.7180 , pp. 841-845
    • Liu, M.1    Duke, J.L.2    Richter, D.J.3    Vinuesa, C.G.4    Goodnow, C.C.5    Kleinstein, S.H.6    Schatz, D.G.7
  • 35
    • 11344293560 scopus 로고    scopus 로고
    • The biology of human lymphoid malignancies revealed by gene expression profiling
    • DOI 10.1016/S0065-2776(05)87005-1, PII S0065277605870051
    • LM Staudt S Dave 2005 The biology of human lymphoid malignancies revealed by gene expression profiling Adv Immunol 87 163 208 10.1016/S0065-2776(05) 87005-1 16102574 1:CAS:528:DC%2BD1cXhsVOru7o%3D (Pubitemid 41135900)
    • (2005) Advances in Immunology , vol.87 , pp. 163-208
    • Staudt, L.M.1    Dave, S.2
  • 36
    • 57149089307 scopus 로고    scopus 로고
    • Stromal gene signatures in large-B-cell lymphomas
    • 10.1056/NEJMoa0802885 19038878 1:CAS:528:DC%2BD1cXhsVehtbvF
    • G Lenz G Wright, et al. 2008 Stromal gene signatures in large-B-cell lymphomas N Engl J Med 359 22 2313 2323 10.1056/NEJMoa0802885 19038878 1:CAS:528:DC%2BD1cXhsVehtbvF
    • (2008) N Engl J Med , vol.359 , Issue.22 , pp. 2313-2323
    • Lenz, G.1    Wright, G.2
  • 37
    • 0026472154 scopus 로고
    • Role of rel family genes in normal and malignant lymphoid cell growth
    • 1451115 1:STN:280:DyaK3s%2Fot1Krsw%3D%3D
    • TD Gilmore 1992 Role of rel family genes in normal and malignant lymphoid cell growth Cancer Surv 15 69 87 1451115 1:STN:280:DyaK3s%2Fot1Krsw%3D%3D
    • (1992) Cancer Surv , vol.15 , pp. 69-87
    • Gilmore, T.D.1
  • 39
    • 66649127621 scopus 로고    scopus 로고
    • Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma
    • 10.1038/nature07968 19412164 1:CAS:528:DC%2BD1MXltlSrsLs%3D
    • M Compagno WK Lim, et al. 2009 Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma Nature 459 7247 717 721 10.1038/nature07968 19412164 1:CAS:528:DC%2BD1MXltlSrsLs%3D
    • (2009) Nature , vol.459 , Issue.7247 , pp. 717-721
    • Compagno, M.1    Lim, W.K.2
  • 40
    • 70350504882 scopus 로고    scopus 로고
    • TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas
    • 10.1182/blood-2008-12-194852 19608751 1:CAS:528:DC%2BD1MXht1Wktr3M
    • K Honma S Tsuzuki, et al. 2009 TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas Blood 114 12 2467 2475 10.1182/blood-2008-12-194852 19608751 1:CAS:528:DC%2BD1MXht1Wktr3M
    • (2009) Blood , vol.114 , Issue.12 , pp. 2467-2475
    • Honma, K.1    Tsuzuki, S.2
  • 41
    • 73949114883 scopus 로고    scopus 로고
    • Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma
    • 19897720 1:CAS:528:DC%2BD1MXhsFGjtL3F
    • S Hailfinger G Lenz, et al. 2009 Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma Proc Natl Acad Sci USA 106 47 19946 19951 19897720 1:CAS:528:DC%2BD1MXhsFGjtL3F
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.47 , pp. 19946-19951
    • Hailfinger, S.1    Lenz, G.2
  • 42
    • 67650398258 scopus 로고    scopus 로고
    • Differential efficacy of bortezomib plus chemotherapy within molecular subtypes of diffuse large B-cell lymphoma
    • 10.1182/blood-2009-01-199679 19380866 1:CAS:528:DC%2BD1MXnslSmurs%3D
    • K Dunleavy S Pittaluga, et al. 2009 Differential efficacy of bortezomib plus chemotherapy within molecular subtypes of diffuse large B-cell lymphoma Blood 113 24 6069 6076 10.1182/blood-2009-01-199679 19380866 1:CAS:528:DC%2BD1MXnslSmurs%3D
    • (2009) Blood , vol.113 , Issue.24 , pp. 6069-6076
    • Dunleavy, K.1    Pittaluga, S.2
  • 43
    • 0037099752 scopus 로고    scopus 로고
    • Alternative translocation breakpoint cluster region 5′ to BCL-6 in B-cell non-Hodgkin's lymphoma
    • 12124346 1:CAS:528:DC%2BD38XlsV2lsbk%3D
    • MP Butler S Iida, et al. 2002 Alternative translocation breakpoint cluster region 5′ to BCL-6 in B-cell non-Hodgkin's lymphoma Cancer Res 62 14 4089 4094 12124346 1:CAS:528:DC%2BD38XlsV2lsbk%3D
    • (2002) Cancer Res , vol.62 , Issue.14 , pp. 4089-4094
    • Butler, M.P.1    Iida, S.2
  • 44
    • 37549015263 scopus 로고    scopus 로고
    • Germinal centres: Role in B-cell physiology and malignancy
    • 10.1038/nri2217 18097447 1:CAS:528:DC%2BD2sXhsVKrsLnI
    • U Klein R Dalla-Favera 2008 Germinal centres: role in B-cell physiology and malignancy Nat Rev Immunol 8 1 22 33 10.1038/nri2217 18097447 1:CAS:528:DC%2BD2sXhsVKrsLnI
    • (2008) Nat Rev Immunol , vol.8 , Issue.1 , pp. 22-33
    • Klein, U.1    Dalla-Favera, R.2
  • 45
    • 77649222742 scopus 로고    scopus 로고
    • Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells
    • 10.1182/blood-2009-06-227017 19965633 1:CAS:528:DC%2BC3cXhvFOitrY%3D
    • K Basso M Saito, et al. 2010 Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells Blood 115 5 975 984 10.1182/blood-2009-06-227017 19965633 1:CAS:528:DC%2BC3cXhvFOitrY%3D
    • (2010) Blood , vol.115 , Issue.5 , pp. 975-984
    • Basso, K.1    Saito, M.2
  • 46
    • 53049097048 scopus 로고    scopus 로고
    • BCL6-mediated attenuation of DNA damage sensing triggers growth arrest and senescence through a p53-dependent pathway in a cell context-dependent manner
    • 10.1074/jbc.M803490200 18524763 1:CAS:528:DC%2BD1cXpsVKmsLk%3D
    • SM Ranuncolo L Wang, et al. 2008 BCL6-mediated attenuation of DNA damage sensing triggers growth arrest and senescence through a p53-dependent pathway in a cell context-dependent manner J Biol Chem 283 33 22565 22572 10.1074/jbc.M803490200 18524763 1:CAS:528:DC%2BD1cXpsVKmsLk%3D
    • (2008) J Biol Chem , vol.283 , Issue.33 , pp. 22565-22572
    • Ranuncolo, S.M.1    Wang, L.2
  • 47
    • 0038243177 scopus 로고    scopus 로고
    • Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma
    • DOI 10.1182/blood-2002-11-3387
    • L Pasqualucci A Migliazza, et al. 2003 Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma Blood 101 8 2914 2923 10.1182/blood-2002-11-3387 12515714 1:CAS:528:DC%2BD3sXjtFCqsbw%3D (Pubitemid 36857975)
    • (2003) Blood , vol.101 , Issue.8 , pp. 2914-2923
    • Pasqualucci, L.1    Migliazza, A.2    Basso, K.3    Houldsworth, J.4    Chaganti, R.S.K.5    Dalla-Favera, R.6
  • 48
    • 34548237299 scopus 로고    scopus 로고
    • A Signaling Pathway Mediating Downregulation of BCL6 in Germinal Center B Cells Is Blocked by BCL6 Gene Alterations in B Cell Lymphoma
    • DOI 10.1016/j.ccr.2007.08.011, PII S153561080700236X
    • M Saito J Gao, et al. 2007 A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma Cancer Cell 12 3 280 292 10.1016/j.ccr.2007.08.011 17785208 1:CAS:528:DC%2BD2sXhtVKqsbrO (Pubitemid 47333420)
    • (2007) Cancer Cell , vol.12 , Issue.3 , pp. 280-292
    • Saito, M.1    Gao, J.2    Basso, K.3    Kitagawa, Y.4    Smith, P.M.5    Bhagat, G.6    Pernis, A.7    Pasqualucci, L.8    Dalla-Favera, R.9
  • 49
    • 19344368745 scopus 로고    scopus 로고
    • Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice
    • DOI 10.1016/j.ccr.2005.03.037, PII S1535610805001261
    • G Cattoretti L Pasqualucci, et al. 2005 Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice Cancer Cell 7 5 445 455 10.1016/j.ccr.2005.03.037 15894265 1:CAS:528: DC%2BD2MXkslyitLw%3D (Pubitemid 40719128)
    • (2005) Cancer Cell , vol.7 , Issue.5 , pp. 445-455
    • Cattoretti, G.1    Pasqualucci, L.2    Ballon, G.3    Tam, W.4    Nandula, S.V.5    Shen, Q.6    Mo, T.7    Murty, V.V.8    Dalla-Favera, R.9
  • 50
    • 71549121697 scopus 로고    scopus 로고
    • A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas
    • 10.1038/nm.2059 19966776 1:CAS:528:DC%2BD1MXhsFWksb3N
    • LC Cerchietti EC Lopes, et al. 2009 A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas Nat Med 15 12 1369 1376 10.1038/nm.2059 19966776 1:CAS:528: DC%2BD1MXhsFWksb3N
    • (2009) Nat Med , vol.15 , Issue.12 , pp. 1369-1376
    • Cerchietti, L.C.1    Lopes, E.C.2
  • 52
    • 42649120075 scopus 로고    scopus 로고
    • Regulation and functions of Blimp-1 in T and B lymphocytes
    • DOI 10.1146/annurev.immunol.26.021607.090241
    • G Martins K Calame 2008 Regulation and functions of Blimp-1 in T and B lymphocytes Annu Rev Immunol 26 133 169 10.1146/annurev.immunol.26.021607.090241 18370921 1:CAS:528:DC%2BD1cXltlWksb8%3D (Pubitemid 351600373)
    • (2008) Annual Review of Immunology , vol.26 , pp. 133-169
    • Martins, G.1    Calame, K.2
  • 54
    • 33646569453 scopus 로고    scopus 로고
    • Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas
    • DOI 10.1182/blood-2005-09-3778
    • W Tam M Gomez, et al. 2006 Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas Blood 107 10 4090 4100 10.1182/blood-2005-09-3778 16424392 1:CAS:528:DC%2BD28XkvFWgsrc%3D (Pubitemid 43726818)
    • (2006) Blood , vol.107 , Issue.10 , pp. 4090-4100
    • Tam, W.1    Gomez, M.2    Chadburn, A.3    Lee, J.W.4    Chan, W.C.5    Knowles, D.M.6
  • 55
    • 43549097394 scopus 로고    scopus 로고
    • Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-{kappa}B pathways in subtypes of diffuse large B-cell lymphoma
    • 10.1182/blood-2007-09-111948 18160665 1:CAS:528:DC%2BD1cXktlWmtrw%3D
    • LT Lam G Wright, et al. 2008 Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-{kappa}B pathways in subtypes of diffuse large B-cell lymphoma Blood 111 7 3701 3713 10.1182/blood-2007-09-111948 18160665 1:CAS:528:DC%2BD1cXktlWmtrw%3D
    • (2008) Blood , vol.111 , Issue.7 , pp. 3701-3713
    • Lam, L.T.1    Wright, G.2
  • 56
    • 15244350510 scopus 로고    scopus 로고
    • Biallelic mutation SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line
    • DOI 10.1182/blood-2004-09-3701
    • I Melzner AJ Bucur, et al. 2005 Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line Blood 105 6 2535 2542 10.1182/blood-2004-09-3701 15572583 1:CAS:528:DC%2BD2MXisFSktbY%3D (Pubitemid 40387056)
    • (2005) Blood , vol.105 , Issue.6 , pp. 2535-2542
    • Melzner, I.1    Bucur, A.J.2    Bruderlein, S.3    Dorsch, K.4    Hasel, C.5    Barth, T.F.E.6    Leithauser, F.7    Moller, P.8
  • 58
    • 0038239874 scopus 로고    scopus 로고
    • Regulation of cytokine receptor signaling by SOCS1
    • DOI 10.1034/j.1600-065X.2003.00020.x
    • S Ilangumaran R Rottapel 2003 Regulation of cytokine receptor signaling by SOCS1 Immunol Rev 192 196 211 10.1034/j.1600-065X.2003.00020.x 12670405 1:CAS:528:DC%2BD3sXjsVOntLw%3D (Pubitemid 36613333)
    • (2003) Immunological Reviews , vol.192 , pp. 196-211
    • Ilangumaran, S.1    Rottapel, R.2
  • 59
    • 69849087246 scopus 로고    scopus 로고
    • Recurrent mutations of the STAT6 DNA binding domain in primary mediastinal B-cell lymphoma
    • 10.1182/blood-2009-03-209759 19423726 1:CAS:528:DC%2BD1MXhtVSgsbfE
    • O Ritz C Guiter, et al. 2009 Recurrent mutations of the STAT6 DNA binding domain in primary mediastinal B-cell lymphoma Blood 114 6 1236 1242 10.1182/blood-2009-03-209759 19423726 1:CAS:528:DC%2BD1MXhtVSgsbfE
    • (2009) Blood , vol.114 , Issue.6 , pp. 1236-1242
    • Ritz, O.1    Guiter, C.2
  • 60
    • 33748308794 scopus 로고    scopus 로고
    • JAK signaling globally counteracts heterochromatic gene silencing
    • DOI 10.1038/ng1860, PII NG1860
    • S Shi HC Calhoun, et al. 2006 JAK signaling globally counteracts heterochromatic gene silencing Nat Genet 38 9 1071 1076 10.1038/ng1860 16892059 1:CAS:528:DC%2BD28XovVWjtrw%3D (Pubitemid 44325935)
    • (2006) Nature Genetics , vol.38 , Issue.9 , pp. 1071-1076
    • Shi, S.1    Calhoun, H.C.2    Xia, F.3    Li, J.4    Le, L.5    Li, W.X.6
  • 61
    • 41349110211 scopus 로고    scopus 로고
    • SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma
    • DOI 10.1182/blood-2007-07-100115
    • L Chen S Monti, et al. 2008 SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma Blood 111 4 2230 2237 10.1182/blood-2007-07-100115 18006696 1:CAS:528:DC%2BD1cXisVeit78%3D (Pubitemid 351451430)
    • (2008) Blood , vol.111 , Issue.4 , pp. 2230-2237
    • Chen, L.1    Monti, S.2    Juszczynski, P.3    Daley, J.4    Chen, W.5    Witzig, T.E.6    Habermann, T.M.7    Kutok, J.L.8    Shipp, M.A.9
  • 62
    • 33646492861 scopus 로고    scopus 로고
    • Cutting edge: Constitutive B cell receptor signaling is critical for basal growth of B lymphoma
    • 16670274 1:CAS:528:DC%2BD28XktVWgtr4%3D
    • M Gururajan CD Jennings, et al. 2006 Cutting edge: constitutive B cell receptor signaling is critical for basal growth of B lymphoma J Immunol 176 10 5715 5719 16670274 1:CAS:528:DC%2BD28XktVWgtr4%3D
    • (2006) J Immunol , vol.176 , Issue.10 , pp. 5715-5719
    • Gururajan, M.1    Jennings, C.D.2
  • 63
    • 73849145729 scopus 로고    scopus 로고
    • Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
    • 10.1038/nature08638 20054396 1:CAS:528:DC%2BC3cXhvFCitw%3D%3D
    • RE Davis VN Ngo, et al. 2010 Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma Nature 463 7277 88 92 10.1038/nature08638 20054396 1:CAS:528:DC%2BC3cXhvFCitw%3D%3D
    • (2010) Nature , vol.463 , Issue.7277 , pp. 88-92
    • Davis, R.E.1    Ngo, V.N.2
  • 64
    • 77951002653 scopus 로고    scopus 로고
    • Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia
    • 10.1182/blood-2009-08-236471 19965662 1:CAS:528:DC%2BC3cXksFOhs70%3D
    • JW Friedberg J Sharman, et al. 2010 Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia Blood 115 13 2578 2585 10.1182/blood-2009-08-236471 19965662 1:CAS:528:DC%2BC3cXksFOhs70%3D
    • (2010) Blood , vol.115 , Issue.13 , pp. 2578-2585
    • Friedberg, J.W.1    Sharman, J.2
  • 65
    • 54049126176 scopus 로고    scopus 로고
    • Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: An international collaborative study
    • 10.1182/blood-2008-01-129783 18559976 1:CAS:528:DC%2BD1cXht1Omur7N
    • KH Young K Leroy, et al. 2008 Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study Blood 112 8 3088 3098 10.1182/blood-2008-01-129783 18559976 1:CAS:528:DC%2BD1cXht1Omur7N
    • (2008) Blood , vol.112 , Issue.8 , pp. 3088-3098
    • Young, K.H.1    Leroy, K.2
  • 67
    • 67650472752 scopus 로고    scopus 로고
    • The significance of TP53 in lymphoid malignancies: Mutation prevalence, regulation, prognostic impact and potential as a therapeutic target
    • 10.1111/j.1365-2141.2009.07739.x 19500100 1:CAS:528:DC%2BD1MXhtValurrJ
    • KJ Cheung DE Horsman, et al. 2009 The significance of TP53 in lymphoid malignancies: mutation prevalence, regulation, prognostic impact and potential as a therapeutic target Br J Haematol 146 3 257 269 10.1111/j.1365-2141.2009. 07739.x 19500100 1:CAS:528:DC%2BD1MXhtValurrJ
    • (2009) Br J Haematol , vol.146 , Issue.3 , pp. 257-269
    • Cheung, K.J.1    Horsman, D.E.2
  • 68
    • 0033521621 scopus 로고    scopus 로고
    • Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53
    • DOI 10.1093/emboj/18.1.22
    • R Honda H Yasuda 1999 Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53 EMBO J 18 1 22 27 10.1093/emboj/18.1.22 9878046 1:CAS:528:DyaK1MXntVOguw%3D%3D (Pubitemid 29005019)
    • (1999) EMBO Journal , vol.18 , Issue.1 , pp. 22-27
    • Honda, R.1    Yasuda, H.2
  • 72
    • 37549008310 scopus 로고    scopus 로고
    • Widespread microRNA repression by Myc contributes to tumorigenesis
    • 10.1038/ng.2007.30 18066065 1:CAS:528:DC%2BD1cXhtVyqtQ%3D%3D
    • TC Chang D Yu, et al. 2008 Widespread microRNA repression by Myc contributes to tumorigenesis Nat Genet 40 1 43 50 10.1038/ng.2007.30 18066065 1:CAS:528:DC%2BD1cXhtVyqtQ%3D%3D
    • (2008) Nat Genet , vol.40 , Issue.1 , pp. 43-50
    • Chang, T.C.1    Yu, D.2
  • 73
    • 33745198159 scopus 로고    scopus 로고
    • FAS death domain deletions and cellular FADD-like interleukin 1beta converting enzyme inhibitory protein (long) overexpression: Alternative mechanisms for deregulating the extrinsic apoptotic pathway in diffuse large B-cell lymphoma subtypes
    • 10.1158/1078-0432.CCR-06-0076 16740746 1:CAS:528:DC%2BD28XltFyju7c%3D
    • H Takahashi F Feuerhake, et al. 2006 FAS death domain deletions and cellular FADD-like interleukin 1beta converting enzyme inhibitory protein (long) overexpression: alternative mechanisms for deregulating the extrinsic apoptotic pathway in diffuse large B-cell lymphoma subtypes Clin Cancer Res 12 11 Pt 1 3265 3271 10.1158/1078-0432.CCR-06-0076 16740746 1:CAS:528:DC%2BD28XltFyju7c%3D
    • (2006) Clin Cancer Res , vol.12 , Issue.11 PART 1 , pp. 3265-3271
    • Takahashi, H.1    Feuerhake, F.2
  • 75
    • 23744515285 scopus 로고    scopus 로고
    • Stem cell factor promotes mast cell survival via inactivation of FOXO3a-mediated transcriptional induction and MEK-regulated phosphorylation of the proapoptotic protein Bim
    • DOI 10.1182/blood-2004-12-4792
    • C Moller J Alfredsson, et al. 2005 Stem cell factor promotes mast cell survival via inactivation of FOXO3a-mediated transcriptional induction and MEK-regulated phosphorylation of the proapoptotic protein Bim Blood 106 4 1330 1336 10.1182/blood-2004-12-4792 15855272 1:CAS:528:DC%2BD2MXosVejt74%3D (Pubitemid 41129597)
    • (2005) Blood , vol.106 , Issue.4 , pp. 1330-1336
    • Moller, C.1    Alfredsson, J.2    Engstrom, M.3    Wootz, H.4    Xiang, Z.5    Lennartsson, J.6    Jonsson, J.-I.7    Nilsson, G.8
  • 79
    • 38549167908 scopus 로고    scopus 로고
    • Immunosuppressive mechanisms in human tumors: Why we still cannot cure cancer
    • 10.1016/j.imlet.2007.11.012 18164076 1:CAS:528:DC%2BD1cXhtl2isrg%3D
    • S Gross P Walden 2008 Immunosuppressive mechanisms in human tumors: why we still cannot cure cancer Immunol Lett 116 1 7 14 10.1016/j.imlet.2007.11.012 18164076 1:CAS:528:DC%2BD1cXhtl2isrg%3D
    • (2008) Immunol Lett , vol.116 , Issue.1 , pp. 7-14
    • Gross, S.1    Walden, P.2
  • 80
    • 53549102755 scopus 로고    scopus 로고
    • The tumor microenvironment and its role in promoting tumor growth
    • 10.1038/onc.2008.271 18836471 1:CAS:528:DC%2BD1cXhtF2msbbK
    • TL Whiteside 2008 The tumor microenvironment and its role in promoting tumor growth Oncogene 27 45 5904 5912 10.1038/onc.2008.271 18836471 1:CAS:528:DC%2BD1cXhtF2msbbK
    • (2008) Oncogene , vol.27 , Issue.45 , pp. 5904-5912
    • Whiteside, T.L.1
  • 81
    • 0029869855 scopus 로고    scopus 로고
    • Cellular and molecular bases of B-cell clonal expansions
    • 8722194
    • R Dolcetti M Boiocchi 1996 Cellular and molecular bases of B-cell clonal expansions Clin Exp Rheumatol 14 Suppl 14 S3 S13 8722194
    • (1996) Clin Exp Rheumatol , vol.14 , Issue.SUPPL. 14
    • Dolcetti, R.1    Boiocchi, M.2
  • 82
    • 0030894985 scopus 로고    scopus 로고
    • Maintenance of human germinal center B cells in vitro
    • JD Pound J Gordon 1997 Maintenance of human germinal center B cells in vitro Blood 89 3 919 928 9028323 1:CAS:528:DyaK2sXptVKmuw%3D%3D (Pubitemid 27121285)
    • (1997) Blood , vol.89 , Issue.3 , pp. 919-928
    • Pound, J.D.1    Gordon, J.2
  • 83
  • 84
    • 37549055122 scopus 로고    scopus 로고
    • Prognostic significance of VEGF, VEGF receptors, and microvessel density in diffuse large B cell lymphoma treated with anthracycline-based chemotherapy
    • 10.1038/labinvest.3700697 17998899 1:CAS:528:DC%2BD1cXhtVyhug%3D%3D
    • D Gratzinger S Zhao, et al. 2008 Prognostic significance of VEGF, VEGF receptors, and microvessel density in diffuse large B cell lymphoma treated with anthracycline-based chemotherapy Lab Invest 88 1 38 47 10.1038/labinvest. 3700697 17998899 1:CAS:528:DC%2BD1cXhtVyhug%3D%3D
    • (2008) Lab Invest , vol.88 , Issue.1 , pp. 38-47
    • Gratzinger, D.1    Zhao, S.2


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