Sensitive determination of 20(S)-protopanaxadiol in rat plasma using HPLC-APCI-MS: Application of pharmacokinetic study in rats

Journal of Pharmaceutical and Biomedical Analysis

Volumn 48, Issue 5, 2008, Pages 1476-1480

  Ren, Hong can ^a   Sun, Jian guo ^a   Wang, Guang ji ^a   A, Ji Ye ^a   Xie, Hai tang ^a   Zha, Wei bin ^a   Yan, Bei ^a   Sun, Fen zhi ^a   Hao, Hai ping ^a   Gu, Sheng hua ^a   Sheng, Long sheng ^a   Shao, Feng ^b   Shi, Jian ^a   Zhou, Fang ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Jiangsu Simcere Pharmaceutical R and D Co Ltd   (China)

Author keywords

20(S) Protopanaxadiol; Bioavailability; Ginsenoside; HPLC APCI MS; Pharmacokinetics

Indexed keywords

ANTINEOPLASTIC AGENT; GINSENOSIDE; GINSENOSIDE RG 3; GINSENOSIDE RH 2; PANAXADIOL; PROTOPANAXADIOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CALIBRATION; COMPARTMENT MODEL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG STABILITY; DRUG STRUCTURE; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION MONITORING; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE ANALYSIS; RAT; REACTION OPTIMIZATION; RELIABILITY; SINGLE DRUG DOSE; STANDARD; TIME TO MAXIMUM PLASMA CONCENTRATION; VALIDATION PROCESS;

ADMINISTRATION, ORAL; ANIMALS; ANTICARCINOGENIC AGENTS; AREA UNDER CURVE; ATMOSPHERIC PRESSURE; BIOLOGICAL AVAILABILITY; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GUIDELINES AS TOPIC; HALF-LIFE; INJECTIONS, INTRAVENOUS; MALE; MASS SPECTROMETRY; METABOLIC CLEARANCE RATE; MOLECULAR STRUCTURE; QUALITY CONTROL; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SAPOGENINS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 58249128088     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2008.09.045     Document Type: Article

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