Effects of bezafibrate on the expression of endothelial nitric oxide synthase gene and its mechanisms in cultured bovine endothelial cells

Atherosclerosis

Volumn 187, Issue 2, 2006, Pages 265-273

  Wang, Yan ^a,a   Yang, Qi ^a   Yan, Jiang Tao ^a   Zhao, Chunxia ^a   Cianflone, Katherine ^b   Wang, Dao Wen ^a  

^a Tongji Hospital   (China)

^b MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

Bezafibrate; Endothelial cells; Endothelial nitric oxide synthase; Gene expression; PPAR ligand

Indexed keywords

BEZAFIBRATE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL CELL; ARTICLE; ATHEROGENESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; COW; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME METABOLISM; ENZYME REGULATION; GENE EXPRESSION; HEART CELL CULTURE; INCUBATION TIME; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; RNA STABILITY; SIGNAL TRANSDUCTION; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTILIPEMIC AGENTS; AORTA, THORACIC; BEZAFIBRATE; CATTLE; CELLS, CULTURED; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYPOLIPIDEMIC AGENTS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PPAR ALPHA; PROMOTER REGIONS (GENETICS); PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-AKT; RNA STABILITY; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 33745567557     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2005.09.008     Document Type: Article

References (52)

1. Kersten S., Desvergne B., and Wahli W. Roles of PPARs in health and disease. Nature 405 (2000) 421-424
2. Schoonjans K., Peinado-Onsurbe J., Lefebvre A.M., et al. PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J 15 (1996) 5336-5348
3. Bishop-Bailey D. Peroxisome proliferator-activated receptors in the cardiovascular system. Br J Pharmacol 129 (2000) 823-834
4. Brandt J.M., Djouadi F., and Kelly D.P. Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha. J Biol Chem 273 (1998) 23786-23792
5. Delerive P., De Bosscher K., Besnard S., et al. Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1. J Biol Chem 274 (1999) 32048-32054
6. Jackson S.M., Parhami F., Xi X.P., et al. Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction. Arterioscler Thromb Vasc Biol 19 (1999) 2094-2104
7. Chinetti G., Griglio S., Antonucci M., et al. Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages. J Biol Chem 273 (1998) 25573-25580
8. Marx N., Mackman N., Schonbeck U., et al. PPARalpha activators inhibit tissue factor expression and activity in human monocytes. Circulation 103 (2001) 213-219
9. Wu Z.-L., O'Kane T.M., Scott R.W., Savage M.J., and Bozyczko-Coyne D. Protein tyrosine phosphatases are up-regulated and participate in cell death induced by polyglutamine expansion. J Biol Chem 277 (2002) 44208-44213
10. Wang H., Lin L., Jiang J., et al. Up-regulation of endothelial nitric-oxide synthase by endothelium-derived hyperpolarizing factor involves mitogen-activated protein kinase and protein kinase C signaling pathways. J Pharmacol Exp Ther 307 (2003) 753-764
11. Kleinert H., Wallerath T., Euchenhofer C., Ihrig-Biedert I., Li H., and Forstermann U. Estrogens increase transcription of the human endothelial NO synthase gene: analysis of the transcription factors involved. Hypertension 31 (1998) 582-588
12. Cho D.-H., Choi Y.J., Jo S.A., and Jo I. Nitric oxide production and regulation of endothelial nitric-oxide synthase phosphorylation by prolonged treatment with troglitazone: evidence for involvement of peroxisome proliferator-activated receptor (PPAR) {gamma}-dependent and PPAR{gamma}-independent signaling pathways. J Biol Chem 279 (2004) 2499-2506
13. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 340 (1999) 115-126
14. Issemann I., and Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347 (1990) 645-650
15. Krey G., Braissant O., L'Horset F., et al. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol Endocrinol 11 (1997) 779-791
16. Inoue I., Shino K., Noji S., Awata T., and Katayama S. Expression of peroxisome proliferator-activated receptor alpha (PPAR alpha) in primary cultures of human vascular endothelial cells. Biochem Biophys Res Commun 246 (1998) 370-374
17. Staels B., Koenig W., Habib A., et al. Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators. Nature 393 (1998) 790-793
18. Chinetti G., Gbaguidi F.G., Griglio S., et al. CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors. Circulation 101 (2000) 2411-2417
19. Zhu L., Bisgaier C.L., Aviram M., and Newton R.S. 9-cis Retinoic acid induces monocyte chemoattractant protein-1 secretion in human monocytic THP-1 cells. Arterioscler Thromb Vasc Biol 19 (1999) 2105-2111
20. Delerive P., Martin-Nizard F., Chinetti G., et al. Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway. Circ Res 85 (1999) 394-402
21. Marx N., Sukhova G.K., Collins T., Libby P., and Plutzky J. PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation 99 (1999) 3125-3131
22. Shu H., Wong B., Zhou G., et al. Activation of PPARalpha or gamma reduces secretion of matrix metalloproteinase 9 but not interleukin 8 from human monocytic THP-1 cells. Biochem Biophys Res Commun 267 (2000) 345-349
23. Chinetti G., Lestavel S., Bocher V., et al. PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat Med 7 (2001) 53-58
24. Neve B.P., Corseaux D., Chinetti G., et al. PPARalpha agonists inhibit tissue factor expression in human monocytes and macrophages. Circulation 103 (2001) 207-212
25. Poynter M.E., and Daynes R.A. Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging. J Biol Chem 273 (1998) 32833-32841
26. Cayatte A.J., Palacino J.J., Horten K., and Cohen R.A. Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits. Arterioscler Thromb 14 (1994) 753-759
27. Kehrer J.P., Biswal S.S., La E., et al. Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886. Biochem J 356 (2001) 899-906
28. Desvergne B., and Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 20 (1999) 649-688
29. Vamecq J., and Latruffe N. Medical significance of peroxisome proliferator-activated receptors. Lancet 354 (1999) 141-148
30. Nishida K., Harrison D.G., Navas J.P., et al. Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase. J Clin Invest 90 (1992) 2092-2096
31. Sessa W.C., Harrison J.K., Barber C.M., et al. Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase. J Biol Chem 267 (1992) 15274-15276
32. Marsden P.A., Heng H.H., Scherer S.W., et al. Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J Biol Chem 268 (1993) 17478-17488
33. Robinson L.J., Weremowicz S., Morton C.C., and Michel T. Isolation and chromosomal localization of the human endothelial nitric oxide synthase (NOS3) gene. Genomics 19 (1994) 350-357
34. Blair A., Shaul P.W., Yuhanna I.S., Conrad P.A., and Smart E.J. Oxidized low density lipoprotein displaces endothelial nitric-oxide synthase (eNOS) from plasmalemmal caveolae and impairs eNOS activation. J Biol Chem 274 (1999) 32512-32519
35. Braam B. Renal endothelial and macula densa NOS: integrated response to changes in extracellular fluid volume. Am J Physiol 276 (1999) R1551-R1561
36. Buckley B.J., Mirza Z., and Whorton A.R. Regulation of Ca(2+)-dependent nitric oxide synthase in bovine aortic endothelial cells. Am J Physiol 269 (1995) C757-C765
37. Buga G.M., Griscavage J.M., Rogers N.E., and Ignarro L.J. Negative feedback regulation of endothelial cell function by nitric oxide. Circ Res 73 (1993) 808-812
38. Drummond G.R., Cai H., Davis M.E., Ramasamy S., and Harrison D.G. Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide. Circ Res 86 (2000) 347-354
39. Sumi D., Hayashi T., Jayachandran M., and Iguchi A. Estrogen prevents destabilization of endothelial nitric oxide synthase mRNA induced by tumor necrosis factor alpha through estrogen receptor mediated system. Life Sci 69 (2001) 1651-1660
40. Bouloumie A., Schini-Kerth V.B., and Busse R. Vascular endothelial growth factor up-regulates nitric oxide synthase expression in endothelial cells. Cardiovasc Res 41 (1999) 773-780
41. Mital S., Zhang X., Zhao G., et al. Simvastatin upregulates coronary vascular endothelial nitric oxide production in conscious dogs. Am J Physiol Heart Circ Physiol 279 (2000) H2649-H2657
42. McQuillan L.P., Leung G.K., Marsden P.A., Kostyk S.K., and Kourembanas S. Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms. Am J Physiol 267 (1994) H1921-H1927
43. Boo Y.C., Sorescu G., Boyd N., et al. Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1179 by Akt-independent mechanisms. Role of protein kinase A. J Biol Chem 277 (2002) 3388-3396
44. Govers R., and Rabelink T.J. Cellular regulation of endothelial nitric oxide synthase. Am J Physiol Renal Physiol 280 (2001) F193-F206
45. Simoncini T., Fornari L., Mannella P., et al. Novel non-transcriptional mechanisms for estrogen receptor signaling in the cardiovascular system. Interaction of estrogen receptor alpha with phosphatidylinositol 3-OH kinase. Steroids 67 (2002) 935-939
46. Gelinas D.S., Bernatchez P.N., Rollin S., Bazan N.G., and Sirois M.G. Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K, PKC and PLC pathways. Br J Pharmacol 137 (2002) 1021-1030
47. Go Y.M., Park H., Maland M.C., et al. Phosphatidylinositol 3-kinase gamma mediates shear stress-dependent activation of JNK in endothelial cells. Am J Physiol 275 (1998) H1898-H1904
48. Rieusset J., Roques M., Bouzakri K., Chevillotte E., and Vidal H. Regulation of p85alpha phosphatidylinositol-3-kinase expression by peroxisome proliferator-activated receptors (PPARs) in human muscle cells. FEBS Lett 502 (2001) 98-102
49. Bondeva T., Pirola L., Bulgarelli-Leva G., Rubio I., Wetzker R., and Wymann M.P. Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK. Science 282 (1998) 293-296
50. Hu E., Kim J.B., Sarraf P., and Spiegelman B.M. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma. Science 274 (1996) 2100-2103
51. Lazennec G., Canaple L., Saugy D., and Wahli W. Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators. Mol Endocrinol 14 (2000) 1962-1975
52. Barger P.M., Browning A.C., Garner A.N., and Kelly D.P. p38 Mitogen-activated protein kinase activates peroxisome proliferator-activated receptor alpha: a potential role in the cardiac metabolic stress response. J Biol Chem 276 (2001) 44495-44501