메뉴 건너뛰기




Volumn 67, Issue 18, 2010, Pages 3131-3137

Bacterial aging: From mechanistic basis to evolutionary perspective

(1)  Ksia̧zek, Krzysztof a  

a NONE

Author keywords

Asymmetric division; Bacterial aging; Conditional senescence; Protein aggregates; Stationary phase

Indexed keywords

AGING; BACTERIAL CELL; BACTERIAL GROWTH; BACTERIAL METABOLISM; BACTERIAL REPRODUCTION; BACTERIAL SURVIVAL; BACTERIUM TRANSFORMATION; CELL AGING; CELL DIVISION; DNA DAMAGE; GROWTH CURVE; HUMAN; HUMAN VERSUS NONHUMAN DATA; LIFE CYCLE; MOLECULAR EVOLUTION; NONHUMAN; OXIDATIVE STRESS; REVIEW; SENESCENCE; BACTERIUM; CYTOLOGY; EVOLUTION; GROWTH, DEVELOPMENT AND AGING; TIME;

EID: 77956639274     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-010-0417-4     Document Type: Review
Times cited : (19)

References (45)
  • 1
    • 34548186667 scopus 로고    scopus 로고
    • Cellular senescence: When bad things happen to good cells
    • DOI 10.1038/nrm2233, PII NRM2233
    • J Campisi F d'Adda di Fagagna 2007 Cellular senescence: when bad things happen to good cells Nat Rev Mol Cell Biol 8 729 740 1:CAS:528: DC%2BD2sXpsVartLg%3D 10.1038/nrm2233 17667954 (Pubitemid 47312822)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.9 , pp. 729-740
    • Campisi, J.1    D'Adda Di Fagagna, F.2
  • 3
    • 0034124042 scopus 로고    scopus 로고
    • Replicative ageing and senescence in Saccharomyces cerevisiae and the impact on brewing fermentations
    • 1:CAS:528:DC%2BD3cXjsFersbs%3D 10832629
    • CD Powell SM Van Zandycke DE Quain KA Smart 2000 Replicative ageing and senescence in Saccharomyces cerevisiae and the impact on brewing fermentations Microbiology 146 1023 1034 1:CAS:528:DC%2BD3cXjsFersbs%3D 10832629
    • (2000) Microbiology , vol.146 , pp. 1023-1034
    • Powell, C.D.1    Van Zandycke, S.M.2    Quain, D.E.3    Smart, K.A.4
  • 4
    • 74049119294 scopus 로고    scopus 로고
    • Fission yeast and other yeasts as emergent models to unravel cellular aging in eukaryotes
    • 19875745
    • AE Roux P Chartrand G Ferbeyre LA Rokeach 2010 Fission yeast and other yeasts as emergent models to unravel cellular aging in eukaryotes J Gerontol A Biol Sci Med Sci 65 1 8 19875745
    • (2010) J Gerontol A Biol Sci Med Sci , vol.65 , pp. 1-8
    • Roux, A.E.1    Chartrand, P.2    Ferbeyre, G.3    Rokeach, L.A.4
  • 5
    • 14544270263 scopus 로고    scopus 로고
    • Alternatives to binary fission in bacteria
    • DOI 10.1038/nrmicro1096
    • ER Angert 2005 Alternatives to binary fission in bacteria Nat Rev Microbiol 3 214 224 1:CAS:528:DC%2BD2MXhslGjtLc%3D 10.1038/nrmicro1096 15738949 (Pubitemid 40298221)
    • (2005) Nature Reviews Microbiology , vol.3 , Issue.3 , pp. 214-224
    • Angert, E.R.1
  • 6
    • 2642593025 scopus 로고    scopus 로고
    • Crystal structure of the bacterial cell-division protein FtsZ
    • DOI 10.1038/34472
    • J Lowe LA Amos 1998 Crystal structure of the bacterial cell-division protein FtsZ Nature 391 203 206 1:CAS:528:DyaK1cXmt1KisA%3D%3D 10.1038/34472 9428770 (Pubitemid 28092483)
    • (1998) Nature , vol.391 , Issue.6663 , pp. 203-206
    • Lowe, J.1    Amos, L.A.2
  • 7
    • 33846246039 scopus 로고    scopus 로고
    • Bacterial Cell Division: The Mechanism and Its Precison
    • DOI 10.1016/S0074-7696(06)53002-5, PII S0074769606530025, A Survey of Cell Biology
    • E Harry L Monahan L Thompson 2006 Bacterial cell division: the mechanism and its precision Int Rev Cytol 253 27 94 1:CAS:528:DC%2BD2sXmtFKlsro%3D 10.1016/S0074-7696(06)53002-5 17098054 (Pubitemid 46107114)
    • (2006) International Review of Cytology , vol.253 , pp. 27-94
    • Harry, E.1    Monahan, L.2    Thompson, L.3
  • 9
    • 77749327485 scopus 로고    scopus 로고
    • Getting in the loop: Regulation of development in Caulobacter crescentus
    • 1:CAS:528:DC%2BC3cXkvFOlu7k%3D 10.1128/MMBR.00040-09 20197497
    • PD Curtis YV Brun 2010 Getting in the loop: regulation of development in Caulobacter crescentus Microbiol Mol Biol Rev 74 13 41 1:CAS:528: DC%2BC3cXkvFOlu7k%3D 10.1128/MMBR.00040-09 20197497
    • (2010) Microbiol Mol Biol Rev , vol.74 , pp. 13-41
    • Curtis, P.D.1    Brun, Y.V.2
  • 10
    • 0038724020 scopus 로고    scopus 로고
    • Senescence in a bacterium with asymmetric division
    • DOI 10.1126/science.1083532
    • M Ackermann SC Stearns U Jenal 2003 Senescence in a bacterium with asymmetric division Science 300 1920 1:CAS:528:DC%2BD3sXkvVGgsbw%3D 10.1126/science.1083532 12817142 (Pubitemid 36734592)
    • (2003) Science , vol.300 , Issue.5627 , pp. 1920
    • Ackermann, M.1    Stearns, S.C.2    Jenal, U.3
  • 11
    • 13944272143 scopus 로고    scopus 로고
    • Aging and death in an organism that reproduces by morphologically symmetric division
    • DOI 10.1371/journal.pbio.0030045, e45
    • EJ Stewart R Madden G Paul F Taddei 2005 Aging and death in an organism that reproduces by morphologically symmetric division PLoS Biol 3 0295 0300 1:CAS:528:DC%2BD2MXhslags7k%3D 10.1371/journal.pbio.0030045 (Pubitemid 40412649)
    • (2005) PLoS Biology , vol.3 , Issue.2 , pp. 0295-0300
    • Stewart, E.J.1    Madden, R.2    Paul, G.3    Taddei, F.4
  • 13
    • 0027383520 scopus 로고
    • The stationary phase of the bacterial life cycle
    • 1:CAS:528:DyaK2cXktV2i 10.1146/annurev.mi.47.100193.004231 8257118
    • R Kolter DA Siegele A Tormo 1993 The stationary phase of the bacterial life cycle Annu Rev Microbiol 47 855 874 1:CAS:528:DyaK2cXktV2i 10.1146/annurev.mi.47.100193.004231 8257118
    • (1993) Annu Rev Microbiol , vol.47 , pp. 855-874
    • Kolter, R.1    Siegele, D.A.2    Tormo, A.3
  • 15
    • 0033168858 scopus 로고    scopus 로고
    • DNA protection by stress-induced biocrystallization
    • DOI 10.1038/21918
    • SG Wolf D Frenkiel T Arad SE Finkel R Kolter A Minsky 1999 DNA protection by stress-induced biocrystallization Nature 400 83 85 1:CAS:528: DyaK1MXksFehsrk%3D 10.1038/21918 10403254 (Pubitemid 29315116)
    • (1999) Nature , vol.400 , Issue.6739 , pp. 83-85
    • Wolf, S.G.1    Frenkiel, D.2    Arad, T.3    Finkeil, S.E.4    Kolter, R.5    Minsky, A.6
  • 16
    • 1942455714 scopus 로고    scopus 로고
    • RMF inactivates ribosomes by covering the peptidyl transferase centre and entrance of peptide exit tunnel
    • DOI 10.1111/j.1356-9597.2004.00723.x
    • H Yoshida H Yamamoto T Uchiumi A Wada 2004 RMF inactivates ribosomes by covering the peptidyl transferase centre and entrance of peptide exit tunnel Genes Cells 9 271 278 1:CAS:528:DC%2BD2cXjsVGqurk%3D 10.1111/j.1356-9597.2004. 00723.x 15066119 (Pubitemid 38514865)
    • (2004) Genes to Cells , vol.9 , Issue.4 , pp. 271-278
    • Yoshida, H.1    Yamamoto, H.2    Uchiumi, T.3    Wada, A.4
  • 17
    • 0025769570 scopus 로고
    • Growth phase-regulated expression of bolA and morphology of stationary-phase Escherichia coli cells are controlled by the novel sigma factor sigma S
    • 1:CAS:528:DyaK3MXmt1Cqsbo%3D 1648559
    • R Lange R Hengge-Aronis 1991 Growth phase-regulated expression of bolA and morphology of stationary-phase Escherichia coli cells are controlled by the novel sigma factor sigma S J Bacteriol 173 4474 4481 1:CAS:528: DyaK3MXmt1Cqsbo%3D 1648559
    • (1991) J Bacteriol , vol.173 , pp. 4474-4481
    • Lange, R.1    Hengge-Aronis, R.2
  • 18
    • 0031784284 scopus 로고    scopus 로고
    • The ftsQ1p gearbox promoter of Escherichia coli is a major sigma S- dependent promoter in the ddlB-ftsA region
    • DOI 10.1046/j.1365-2958.1998.01077.x
    • M Ballesteros S Kusano A Ishihama M Vicente 1998 The ftsQ1p gearbox promoter of Escherichia coli is a major sigma S-dependent promoter in the ddlB-ftsA region Mol Microbiol 30 419 430 1:CAS:528:DyaK1cXntFOrt70%3D 10.1046/j.1365-2958.1998.01077.x 9791185 (Pubitemid 28480191)
    • (1998) Molecular Microbiology , vol.30 , Issue.2 , pp. 419-430
    • Ballesteros, M.1    Kusano, S.2    Ishihama, A.3    Vicente, M.4
  • 19
    • 70349321700 scopus 로고    scopus 로고
    • D-amino acids govern stationary phase cell wall remodeling in bacteria
    • 1:CAS:528:DC%2BD1MXhtFanurrE 10.1126/science.1178123 19762646
    • H Lam DC Oh F Cava CN Takacs J Clardy MA de Pedro MK Waldor 2009 D-amino acids govern stationary phase cell wall remodeling in bacteria Science 325 1552 1555 1:CAS:528:DC%2BD1MXhtFanurrE 10.1126/science.1178123 19762646
    • (2009) Science , vol.325 , pp. 1552-1555
    • Lam, H.1    Oh, D.C.2    Cava, F.3    Takacs, C.N.4    Clardy, J.5    De Pedro, M.A.6    Waldor, M.K.7
  • 20
    • 0014294940 scopus 로고
    • Phospholipid alterations during growth of Escherichia coli
    • 1:CAS:528:DyaF1cXktFKqtr8%3D 4876126
    • JE Cronan Jr 1968 Phospholipid alterations during growth of Escherichia coli J Bacteriol 95 2054 2061 1:CAS:528:DyaF1cXktFKqtr8%3D 4876126
    • (1968) J Bacteriol , vol.95 , pp. 2054-2061
    • Cronan Jr., J.E.1
  • 21
    • 0025978756 scopus 로고
    • The molecular basis of carbon-starvation-induced general resistance in Escherichia coli
    • 1:CAS:528:DyaK3MXpslynuw%3D%3D 10.1111/j.1365-2958.1991.tb01819.x 2014002
    • A Matin 1991 The molecular basis of carbon-starvation-induced general resistance in Escherichia coli Mol Microbiol 5 3 10 1:CAS:528: DyaK3MXpslynuw%3D%3D 10.1111/j.1365-2958.1991.tb01819.x 2014002
    • (1991) Mol Microbiol , vol.5 , pp. 3-10
    • Matin, A.1
  • 22
    • 0033802161 scopus 로고    scopus 로고
    • Sorting out bacterial viability with optical tweezers
    • 1:CAS:528:DC%2BD3cXmvVyrsbs%3D 10.1128/JB.182.19.5551-5555.2000 10986260
    • M Ericsson D Hanstorp P Hagberg J Enger T Nystrom 2000 Sorting out bacterial viability with optical tweezers J Bacteriol 182 5551 5555 1:CAS:528:DC%2BD3cXmvVyrsbs%3D 10.1128/JB.182.19.5551-5555.2000 10986260
    • (2000) J Bacteriol , vol.182 , pp. 5551-5555
    • Ericsson, M.1    Hanstorp, D.2    Hagberg, P.3    Enger, J.4    Nystrom, T.5
  • 23
    • 0037385854 scopus 로고    scopus 로고
    • Conditional senescence in bacteria: Death of the immortals
    • DOI 10.1046/j.1365-2958.2003.03385.x
    • T Nystrom 2003 Conditional senescence in bacteria: death of the immortals Mol Microbiol 48 17 23 1:CAS:528:DC%2BD3sXislOrsLo%3D 10.1046/j.1365-2958.2003. 03385.x 12657042 (Pubitemid 36411465)
    • (2003) Molecular Microbiology , vol.48 , Issue.1 , pp. 17-23
    • Nystrom, T.1
  • 24
    • 0035253719 scopus 로고    scopus 로고
    • Cellular senescence as a tumor-protection mechanism: The essential role of counting
    • DOI 10.1016/S0959-437X(00)00163-5
    • WE Wright JW Shay 2001 Cellular senescence as a tumor-protection mechanism: the essential role of counting Curr Opin Genet Dev 11 98 103 1:CAS:528:DC%2BD3MXhtFSntbs%3D 10.1016/S0959-437X(00)00163-5 11163158 (Pubitemid 32119285)
    • (2001) Current Opinion in Genetics and Development , vol.11 , Issue.1 , pp. 98-103
    • Wright, W.E.1    Shay, J.W.2
  • 25
    • 0035114576 scopus 로고    scopus 로고
    • Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions
    • DOI 10.1101/gad.859201
    • RD Ramirez CP Morales BS Herbert JM Rohde C Passons JW Shay WE Wright 2001 Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions Genes Dev 15 398 403 1:CAS:528:DC%2BD3MXhvVOju7s%3D 10.1101/gad.859201 11230148 (Pubitemid 32187001)
    • (2001) Genes and Development , vol.15 , Issue.4 , pp. 398-403
    • Ramirez, R.D.1    Morales, C.P.2    Herbert, B.-S.3    Rohde, J.M.4    Passons, C.5    Shay, J.W.6    Wright, W.E.7
  • 26
    • 71049114356 scopus 로고    scopus 로고
    • Network analysis of the transcriptional pattern of young and old cells of Escherichia coli during lag phase
    • 10.1186/1752-0509-3-108 19917103
    • C Pin MD Rolfe M Munoz-Cuevas JC Hinton MW Peck NJ Walton J Baranyi 2009 Network analysis of the transcriptional pattern of young and old cells of Escherichia coli during lag phase BMC Syst Biol 3 108 10.1186/1752-0509-3-108 19917103
    • (2009) BMC Syst Biol , vol.3 , pp. 108
    • Pin, C.1    Rolfe, M.D.2    Munoz-Cuevas, M.3    Hinton, J.C.4    Peck, M.W.5    Walton, N.J.6    Baranyi, J.7
  • 27
    • 38649135397 scopus 로고    scopus 로고
    • Existence of abnormal protein aggregates in healthy Escherichia coli cells
    • DOI 10.1128/JB.01603-07
    • E Maisonneuve L Fraysse D Moinier S Dukan 2008 Existence of abnormal protein aggregates in healthy Escherichia coli cells J Bacteriol 190 887 893 1:CAS:528:DC%2BD1cXhsFSgsr0%3D 10.1128/JB.01603-07 18039765 (Pubitemid 351170932)
    • (2008) Journal of Bacteriology , vol.190 , Issue.3 , pp. 887-893
    • Maisonneuve, E.1    Fraysse, L.2    Moinier, D.3    Dukan, S.4
  • 29
    • 51549087767 scopus 로고    scopus 로고
    • Protein aggregates: An aging factor involved in cell death
    • 1:CAS:528:DC%2BD1cXhtFSrsrfN 10.1128/JB.00736-08 18621895
    • E Maisonneuve B Ezraty S Dukan 2008 Protein aggregates: an aging factor involved in cell death J Bacteriol 190 6070 6075 1:CAS:528:DC%2BD1cXhtFSrsrfN 10.1128/JB.00736-08 18621895
    • (2008) J Bacteriol , vol.190 , pp. 6070-6075
    • Maisonneuve, E.1    Ezraty, B.2    Dukan, S.3
  • 30
    • 38049090214 scopus 로고    scopus 로고
    • DNA replication stress, genome instability and aging
    • 1:CAS:528:DC%2BD1cXisFyrtw%3D%3D 10.1093/nar/gkm1059 18055498
    • WC Burhans M Weinberger 2007 DNA replication stress, genome instability and aging Nucleic Acids Res 35 7545 7556 1:CAS:528:DC%2BD1cXisFyrtw%3D%3D 10.1093/nar/gkm1059 18055498
    • (2007) Nucleic Acids Res , vol.35 , pp. 7545-7556
    • Burhans, W.C.1    Weinberger, M.2
  • 31
    • 33646056352 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and cell senescence: Cause or consequence?
    • 1:CAS:528:DC%2BD28Xjtlals7w%3D 10.1089/rej.2006.9.64 16608398
    • JF Passos T Von Zglinicki G Saretzki 2006 Mitochondrial dysfunction and cell senescence: cause or consequence? Rejuvenation Res 9 64 68 1:CAS:528:DC%2BD28Xjtlals7w%3D 10.1089/rej.2006.9.64 16608398
    • (2006) Rejuvenation Res , vol.9 , pp. 64-68
    • Passos, J.F.1    Von Zglinicki, T.2    Saretzki, G.3
  • 32
    • 0041867968 scopus 로고    scopus 로고
    • The free-radical hypothesis of aging goes prokaryotic
    • DOI 10.1007/s00018-003-2310-X
    • T Nystrom 2003 The free-radical hypothesis of aging goes prokaryotic Cell Mol Life Sci 60 1333 1341 1:STN:280:DC%2BD3svgsVGmsA%3D%3D 10.1007/s00018-003- 2310-X 12943222 (Pubitemid 36900517)
    • (2003) Cellular and Molecular Life Sciences , vol.60 , Issue.7 , pp. 1333-1341
    • Nystrom, T.1
  • 33
    • 0032213238 scopus 로고    scopus 로고
    • Bacterial senescence: Stasis results in increased and differential oxidation of cytoplasmic proteins leading to developmental induction of the heat shock regulon
    • 1:CAS:528:DyaK1cXns1aju7g%3D 10.1101/gad.12.21.3431 9808629
    • S Dukan T Nystrom 1998 Bacterial senescence: stasis results in increased and differential oxidation of cytoplasmic proteins leading to developmental induction of the heat shock regulon Genes Dev 12 3431 3441 1:CAS:528: DyaK1cXns1aju7g%3D 10.1101/gad.12.21.3431 9808629
    • (1998) Genes Dev , vol.12 , pp. 3431-3441
    • Dukan, S.1    Nystrom, T.2
  • 34
    • 0026020230 scopus 로고
    • Identification of a central regulator of stationary-phase gene expression in Escherichia coli
    • 1:CAS:528:DyaK3MXhtFGqt7g%3D 10.1111/j.1365-2958.1991.tb01825.x 1849609
    • R Lange R Hengge-Aronis 1991 Identification of a central regulator of stationary-phase gene expression in Escherichia coli Mol Microbiol 5 49 59 1:CAS:528:DyaK3MXhtFGqt7g%3D 10.1111/j.1365-2958.1991.tb01825.x 1849609
    • (1991) Mol Microbiol , vol.5 , pp. 49-59
    • Lange, R.1    Hengge-Aronis, R.2
  • 35
    • 0033543618 scopus 로고    scopus 로고
    • Oxidative stress defense and deterioration of growth-arrested Escherichia coli cells
    • DOI 10.1074/jbc.274.37.26027
    • S Dukan T Nystrom 1999 Oxidative stress defense and deterioration of growth-arrested Escherichia coli cells J Biol Chem 274 26027 26032 1:CAS:528:DyaK1MXmtVKmt70%3D 10.1074/jbc.274.37.26027 10473549 (Pubitemid 29437043)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.37 , pp. 26027-26032
    • Dukan, S.1    Nystrom, T.2
  • 36
    • 0029018721 scopus 로고
    • Metabolic sources of hydrogen peroxide in aerobically growing Escherichia coli
    • 1:CAS:528:DyaK2MXmt1yqsrw%3D 10.1074/jbc.270.23.13681 7775420
    • B Gonzalez-Flecha B Demple 1995 Metabolic sources of hydrogen peroxide in aerobically growing Escherichia coli J Biol Chem 270 13681 13687 1:CAS:528:DyaK2MXmt1yqsrw%3D 10.1074/jbc.270.23.13681 7775420
    • (1995) J Biol Chem , vol.270 , pp. 13681-13687
    • Gonzalez-Flecha, B.1    Demple, B.2
  • 38
    • 33645999557 scopus 로고
    • Oxygen poisoning and x-irradiation: A mechanism in common
    • 1:CAS:528:DyaG2cXlsl2huw%3D%3D 10.1126/science.119.3097.623 13156638
    • R Gerschman DL Gilbert SW Nye P Dwyer WO Fenn 1954 Oxygen poisoning and x-irradiation: a mechanism in common Science 119 623 626 1:CAS:528: DyaG2cXlsl2huw%3D%3D 10.1126/science.119.3097.623 13156638
    • (1954) Science , vol.119 , pp. 623-626
    • Gerschman, R.1    Gilbert, D.L.2    Nye, S.W.3    Dwyer, P.4    Fenn, W.O.5
  • 39
    • 0017986804 scopus 로고
    • The suppression of defective translation by ppGpp and its role in the stringent response
    • 10.1016/0092-8674(78)90241-6 357011
    • PH O'Farrell 1978 The suppression of defective translation by ppGpp and its role in the stringent response Cell 14 545 557 10.1016/0092-8674(78)90241-6 357011
    • (1978) Cell , vol.14 , pp. 545-557
    • O'Farrell, P.H.1
  • 40
    • 0032536184 scopus 로고    scopus 로고
    • Growth phase dependent stop codon read through and shift of translation reading frame in Escherichia coli
    • DOI 10.1016/S0014-5793(97)01570-6, PII S0014579397015706
    • AM Wenthzel M Stancek LA Isaksson 1998 Growth phase dependent stop codon readthrough and shift of translation reading frame in Escherichia coli FEBS Lett 421 237 242 1:CAS:528:DyaK1cXislygsg%3D%3D 10.1016/S0014-5793(97)01570-6 9468314 (Pubitemid 28045762)
    • (1998) FEBS Letters , vol.421 , Issue.3 , pp. 237-242
    • Wenthzel, A.-M.K.1    Stancek, M.2    Isaksson, L.A.3
  • 41
    • 0035903569 scopus 로고    scopus 로고
    • Bacterial senescence: Protein oxidation in non-proliferating cells is dictated by the accuracy of the ribosomes
    • DOI 10.1093/emboj/20.18.5280
    • M Ballesteros A Fredriksson J Henriksson T Nystrom 2001 Bacterial senescence: protein oxidation in non-proliferating cells is dictated by the accuracy of the ribosomes EMBO J 20 5280 5289 1:CAS:528:DC%2BD3MXns1Ghs7c%3D 10.1093/emboj/20.18.5280 11566891 (Pubitemid 32910922)
    • (2001) EMBO Journal , vol.20 , Issue.18 , pp. 5280-5289
    • Ballesteros, M.1    Fredriksson, A.2    Henriksson, J.3    Nystrom, T.4
  • 42
    • 0029051426 scopus 로고
    • Oxidative DNA damage and senescence of human diploid fibroblast cells
    • 1:CAS:528:DyaK2MXls1alu78%3D 10.1073/pnas.92.10.4337 7753808
    • Q Chen A Fischer JD Reagan LJ Yan BN Ames 1995 Oxidative DNA damage and senescence of human diploid fibroblast cells Proc Natl Acad Sci USA 92 4337 4341 1:CAS:528:DyaK2MXls1alu78%3D 10.1073/pnas.92.10.4337 7753808
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4337-4341
    • Chen, Q.1    Fischer, A.2    Reagan, J.D.3    Yan, L.J.4    Ames, B.N.5
  • 43
    • 0018698517 scopus 로고
    • The evolution of ageing and longevity
    • 1:STN:280:DyaL3c%2FnvFykug%3D%3D 10.1098/rspb.1979.0083 42059
    • TB Kirkwood R Holliday 1979 The evolution of ageing and longevity Proc R Soc Lond B Biol Sci 205 531 546 1:STN:280:DyaL3c%2FnvFykug%3D%3D 10.1098/rspb.1979.0083 42059
    • (1979) Proc R Soc Lond B Biol Sci , vol.205 , pp. 531-546
    • Kirkwood, T.B.1    Holliday, R.2
  • 44
    • 13944262937 scopus 로고    scopus 로고
    • Understanding the odd science of aging
    • DOI 10.1016/j.cell.2005.01.027
    • TB Kirkwood 2005 Understanding the odd science of aging Cell 120 437 447 1:CAS:528:DC%2BD2MXitVWntbk%3D 10.1016/j.cell.2005.01.027 15734677 (Pubitemid 40269759)
    • (2005) Cell , vol.120 , Issue.4 , pp. 437-447
    • Kirkwood, T.B.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.