-
1
-
-
0036157392
-
Cancer statistics, 2002
-
Jemal A, Thomas A, Murray T, Thun M,. Cancer statistics, 2002. Cancer J Clin 2002; 52: 23 -47.
-
(2002)
Cancer J Clin
, vol.52
, pp. 23-47
-
-
Jemal, A.1
Thomas, A.2
Murray, T.3
Thun, M.4
-
2
-
-
0035119805
-
Significance of high-grade prostatic intraepithelial neoplasia in needle biopsy specimens
-
Prange W, Erbersdobler A, Hammerer P, Graefen M, Hautmann SH, Hautmann RE, Huland RP,. Significance of high-grade prostatic intraepithelial neoplasia in needle biopsy specimens. Urology 2001; 57 (30): 486 -490.
-
(2001)
Urology
, vol.57
, Issue.30
, pp. 486-490
-
-
Prange, W.1
Erbersdobler, A.2
Hammerer, P.3
Graefen, M.4
Hautmann, S.H.5
Hautmann, R.E.6
Huland, R.P.7
-
3
-
-
0027229645
-
Prostate cancer: Screening, diagnosis, and management
-
Garnick MB,. Prostate cancer: Screening, diagnosis, and management. Ann Intern Med 1993; 118 (10): 804 -818.
-
(1993)
Ann Intern Med
, vol.118
, Issue.10
, pp. 804-818
-
-
Garnick, M.B.1
-
4
-
-
33747842237
-
Interphase FSH analysis of PTEN in histolofical sections show genoimic deletions in 68% of primary prostate cancer and 23% of high-grade prostatic intra-epithelial neoplasias
-
Yashimoto M, Cutz J, Nuin PA, Joshua AM, Bayani J, Evan AJ, Zielenksa M, Squire JA,. Interphase FSH analysis of PTEN in histolofical sections show genoimic deletions in 68% of primary prostate cancer and 23% of high-grade prostatic intra-epithelial neoplasias. Cancer Genet Cytogenet 2006; 169: 128 -137.
-
(2006)
Cancer Genet Cytogenet
, vol.169
, pp. 128-137
-
-
Yashimoto, M.1
Cutz, J.2
Nuin, P.A.3
Joshua, A.M.4
Bayani, J.5
Evan, A.J.6
Zielenksa, M.7
Squire, J.A.8
-
5
-
-
18044381192
-
Rheb binds and regulates Mtor kinase
-
Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J,. Rheb binds and regulates Mtor kinase. Cell Biol 2005; 15: 702 -713.
-
(2005)
Cell Biol
, vol.15
, pp. 702-713
-
-
Long, X.1
Lin, Y.2
Ortiz-Vega, S.3
Yonezawa, K.4
Avruch, J.5
-
6
-
-
0037178786
-
MTOR interacts with RAPTOR to form a nutrient-sensitive complex that signals to the cell growth machinery
-
Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM,. mTOR interacts with RAPTOR to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002; 110: 163 -175.
-
(2002)
Cell
, vol.110
, pp. 163-175
-
-
Kim, D.H.1
Sarbassov, D.D.2
Ali, S.M.3
King, J.E.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
7
-
-
0037178781
-
Raptor, a binding partner of target ofrapamycin (TOR), mediates TOR action
-
Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S, Tokunaga C, Avruch J, Yonezawa K,. Raptor, a binding partner of target ofrapamycin (TOR), mediates TOR action. Cell 2002; 110: 177 -189.
-
(2002)
Cell
, vol.110
, pp. 177-189
-
-
Hara, K.1
Maruki, Y.2
Long, X.3
Yoshino, K.4
Oshiro, N.5
Hidayat, S.6
Tokunaga, C.7
Avruch, J.8
Yonezawa, K.9
-
8
-
-
0036753494
-
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
-
Loewwith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, Bonenfant D, Oppliger W, Jenoe P, Hall MN,. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 2002; 10: 457 -468.
-
(2002)
Mol Cell
, vol.10
, pp. 457-468
-
-
Loewwith, R.1
Jacinto, E.2
Wullschleger, S.3
Lorberg, A.4
Crespo, J.L.5
Bonenfant, D.6
Oppliger, W.7
Jenoe, P.8
Hall, M.N.9
-
9
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM,. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004; 14: 1296 -1302.
-
(2004)
Curr Biol
, vol.14
, pp. 1296-1302
-
-
Sarbassov, D.D.1
Ali, S.M.2
Kim, D.H.3
Guertin, D.A.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
10
-
-
0033607531
-
Immunopurified mammalian target of rapamycin phosphorylates and activates p70 s6 kinase alpha in vitro
-
Isotani S, Hara K, Tokunga C, Inoue H, Avruch J, Yonezawa K,. Immunopurified mammalian target of rapamycin phosphorylates and activates p70 s6 kinase alpha in vitro. J Biol Chem 1999; 274: 34493 -34498.
-
(1999)
J Biol Chem
, vol.274
, pp. 34493-34498
-
-
Isotani, S.1
Hara, K.2
Tokunga, C.3
Inoue, H.4
Avruch, J.5
Yonezawa, K.6
-
11
-
-
0035312747
-
Regulation of translation initiation by FRAP/mTOR
-
Gingras A, Raught B, Sonenberg N,. Regulation of translation initiation by FRAP/mTOR. Genes Dev 2001; 15: 807 -826.
-
(2001)
Genes Dev
, vol.15
, pp. 807-826
-
-
Gingras, A.1
Raught, B.2
Sonenberg, N.3
-
12
-
-
0035200856
-
Amino acid-induced translation of TOP mRNAs is fully dependenton phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation
-
Tang H, Hornstein E, Stolovich M, Levy G, Livingstone M, Templeton D, Avruch J, Meyuhas O,. Amino acid-induced translation of TOP mRNAs is fully dependenton phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation. Mol Cell Biol 2001; 21 (24): 8671 -8683.
-
(2001)
Mol Cell Biol
, vol.21
, Issue.24
, pp. 8671-8683
-
-
Tang, H.1
Hornstein, E.2
Stolovich, M.3
Levy, G.4
Livingstone, M.5
Templeton, D.6
Avruch, J.7
Meyuhas, O.8
-
13
-
-
7944235758
-
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
-
Jacinto E, Loewith R, Schmidt A, Lin S, Rüegg MA, Hall A, Hall MN,. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 2004; 11: 1122 -1128.
-
(2004)
Nat Cell Biol
, vol.11
, pp. 1122-1128
-
-
Jacinto, E.1
Loewith, R.2
Schmidt, A.3
Lin, S.4
Rüegg, M.A.5
Hall, A.6
Hall, M.N.7
-
14
-
-
33746637660
-
Current development of mTOR inhibitors as anticancer agents
-
Faivre S, Kroemer G, Raymond E,. Current development of mTOR inhibitors as anticancer agents. Nature Rev Drug Discov 2006; 5: 671 -688.
-
(2006)
Nature Rev Drug Discov
, vol.5
, pp. 671-688
-
-
Faivre, S.1
Kroemer, G.2
Raymond, E.3
-
15
-
-
33750510023
-
A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas
-
Duran I, Kortmansky J, Singh D, Hirte H, Kocha W, Goss G, Le L, Oza A, Nicklee T, Ho J, Birle D, Pond GR, Arboine D, Dancey J, Aviel-Ronen S, Tsao MS, Hedley D, Siu LL,. A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas. Br J Cancer 2006; 95: 1148 -1154.
-
(2006)
Br J Cancer
, vol.95
, pp. 1148-1154
-
-
Duran, I.1
Kortmansky, J.2
Singh, D.3
Hirte, H.4
Kocha, W.5
Goss, G.6
Le, L.7
Oza, A.8
Nicklee, T.9
Ho, J.10
Birle, D.11
Pond, G.R.12
Arboine, D.13
Dancey, J.14
Aviel-Ronen, S.15
Tsao, M.S.16
Hedley, D.17
Siu, L.L.18
-
16
-
-
66449106340
-
Increased AKT S478 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumoral cell response to PI3K/mTOR inhibition
-
Breuleux M, Klopfenstein M, Stephan C, Doughty CA, Barys L, Maira SM, Kwiatkowski D, Lane HA,. Increased AKT S478 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumoral cell response to PI3K/mTOR inhibition. Mol Cancer Ther 2009; 8: 742 -753.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 742-753
-
-
Breuleux, M.1
Klopfenstein, M.2
Stephan, C.3
Doughty, C.A.4
Barys, L.5
Maira, S.M.6
Kwiatkowski, D.7
Lane, H.A.8
-
17
-
-
23844438209
-
Activation of AKT and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition
-
Sun SY, Rosenberg LM, Wang X, Zhou Z, Yue P, Fu H, Khuri FR,. Activation of AKT and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res 2005; 65 (16): 7052 -7058.
-
(2005)
Cancer Res
, vol.65
, Issue.16
, pp. 7052-7058
-
-
Sun, S.Y.1
Rosenberg, L.M.2
Wang, X.3
Zhou, Z.4
Yue, P.5
Fu, H.6
Khuri, F.R.7
-
18
-
-
38049187096
-
Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: Rationale for therapeutic inhibition of both pathways
-
Tamburini J, Chapuis N, Bardet V, Park S, Sujobert P, Willems L, Ifrah N, Dreyfus F, Mayeux P, Lacombe C, Bouscary D,. Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: Rationale for therapeutic inhibition of both pathways. Blood 2008; 111 (1): 379 -382.
-
(2008)
Blood
, vol.111
, Issue.1
, pp. 379-382
-
-
Tamburini, J.1
Chapuis, N.2
Bardet, V.3
Park, S.4
Sujobert, P.5
Willems, L.6
Ifrah, N.7
Dreyfus, F.8
Mayeux, P.9
Lacombe, C.10
Bouscary, D.11
-
19
-
-
33947538050
-
Rapamycin induced feedback activation of AKT signaling through an IGF-1R-dependant mechanism
-
Wan X, Harkavy B, Shen N, Grohar P, Helman LJ,. Rapamycin induced feedback activation of AKT signaling through an IGF-1R-dependant mechanism. Oncogene 2007; 26: 1932 -1940.
-
(2007)
Oncogene
, vol.26
, pp. 1932-1940
-
-
Wan, X.1
Harkavy, B.2
Shen, N.3
Grohar, P.4
Helman, L.J.5
-
20
-
-
32944457518
-
MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
-
O'Reilly KE, Rojo F, She QB, Solit D, Mills GB, Smith D, Lane H, Hofmann F, Hicklin DJ, Ludwig DL, Baselga J, Rosen N,. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 2006; 66: 1500 -1508.
-
(2006)
Cancer Res
, vol.66
, pp. 1500-1508
-
-
O'Reilly, K.E.1
Rojo, F.2
She, Q.B.3
Solit, D.4
Mills, G.B.5
Smith, D.6
Lane, H.7
Hofmann, F.8
Hicklin, D.J.9
Ludwig, D.L.10
Baselga, J.11
Rosen, N.12
-
21
-
-
27644534999
-
Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade
-
Shi Y, Yan H, Frost P, Gera J, Lichtenstein A,. Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade. Mol Cancer Ther 2005; 10: 1533 -1540.
-
(2005)
Mol Cancer Ther
, vol.10
, pp. 1533-1540
-
-
Shi, Y.1
Yan, H.2
Frost, P.3
Gera, J.4
Lichtenstein, A.5
-
22
-
-
51349164790
-
Inhibition of the MTORC1 pathway leads to MAPK pathway activation through a PI3K-dependant feedback loop in human cancer
-
Carracedo A, Ma L, Teruya-Feldstein J, Rojo F, Salmena L, Alimonti A, Egia A, Sasaki AT, Thomas G, Kozma SC, Papa A, Nardella C, Cantley LC, Baselga J, Pandolfi PP,. Inhibition of the MTORC1 pathway leads to MAPK pathway activation through a PI3K-dependant feedback loop in human cancer. J Clin Invest 2008; 118: 3065 -3074.
-
(2008)
J Clin Invest
, vol.118
, pp. 3065-3074
-
-
Carracedo, A.1
Ma, L.2
Teruya-Feldstein, J.3
Rojo, F.4
Salmena, L.5
Alimonti, A.6
Egia, A.7
Sasaki, A.T.8
Thomas, G.9
Kozma, S.C.10
Papa, A.11
Nardella, C.12
Cantley, L.C.13
Baselga, J.14
Pandolfi, P.P.15
-
23
-
-
78349290007
-
Morphoproteomic conformation of a constitutively activated mTOR pathway in high grade prostatic intraepithelial neoplasia and prostate cancer
-
Brown RE, Zotalis G, Zhang PL, Zhao B,. Morphoproteomic conformation of a constitutively activated mTOR pathway in high grade prostatic intraepithelial neoplasia and prostate cancer. Int J Clin Exp Pathol 2008; 1: 333 -342.
-
(2008)
Int J Clin Exp Pathol
, vol.1
, pp. 333-342
-
-
Brown, R.E.1
Zotalis, G.2
Zhang, P.L.3
Zhao, B.4
-
24
-
-
51349111250
-
Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model
-
Kinkade CW, Castillo-Martin M, Puzio-Kuter A, Yan J, Foster TH, Gao H, Sun Y, Ouyang X, Gerald WL, Cordon-Cardo C, Abate-Shen C,. Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model. J Clin Invest 2008; 118 (9): 3051 -3064.
-
(2008)
J Clin Invest
, vol.118
, Issue.9
, pp. 3051-3064
-
-
Kinkade, C.W.1
Castillo-Martin, M.2
Puzio-Kuter, A.3
Yan, J.4
Foster, T.H.5
Gao, H.6
Sun, Y.7
Ouyang, X.8
Gerald, W.L.9
Cordon-Cardo, C.10
Abate-Shen, C.11
-
25
-
-
0031822837
-
Tissue microarrays for high-throughput molecular profiling of tumour specimens
-
Kononen J, Bubendorf L, Kallionimeni A, Brlund M, Schraml P, Leighton S, Torhorst J, Mihatsch MJ, Sauter G, Kallionimeni O,. Tissue microarrays for high-throughput molecular profiling of tumour specimens. Nature Med 1998; 4: 844 -847.
-
(1998)
Nature Med
, vol.4
, pp. 844-847
-
-
Kononen, J.1
Bubendorf, L.2
Kallionimeni, A.3
Brlund, M.4
Schraml, P.5
Leighton, S.6
Torhorst, J.7
Mihatsch, M.J.8
Sauter, G.9
Kallionimeni, O.10
-
26
-
-
34447296448
-
Comparison of annexin II, p63 and a-methylacyl-CoA racemase immunoreactivity in prostatic tissue: A tissue microarray study
-
Stewart J, Fleshner N, Cole H, Sweet J,. Comparison of annexin II, p63 and a-methylacyl-CoA racemase immunoreactivity in prostatic tissue: A tissue microarray study. J Clin Pathol 2007; 60: 773 -780.
-
(2007)
J Clin Pathol
, vol.60
, pp. 773-780
-
-
Stewart, J.1
Fleshner, N.2
Cole, H.3
Sweet, J.4
-
27
-
-
10044276783
-
Regulation of mTOR function in response to hypoxia by REDD1 and TSC1/TSC2 tumor suppressor complex
-
Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, Hafen E, Witters LA, Ellisen LW, Kaelin WG, Jr,. Regulation of mTOR function in response to hypoxia by REDD1 and TSC1/TSC2 tumor suppressor complex. Gene Dev 2004; 18: 2893 -2904.
-
(2004)
Gene Dev
, vol.18
, pp. 2893-2904
-
-
Brugarolas, J.1
Lei, K.2
Hurley, R.L.3
Manning, B.D.4
Reiling, J.H.5
Hafen, E.6
Witters, L.A.7
Ellisen, L.W.8
Kaelin Jr., W.G.9
-
28
-
-
38349056675
-
Hypoxia regulates TSC1/2-Mtor signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling
-
DeYoung MP, Horak P, Sofer A, Sgroi D, Ellisen LW,. Hypoxia regulates TSC1/2-Mtor signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Gene Dev 2008; 22: 239 -251.
-
(2008)
Gene Dev
, vol.22
, pp. 239-251
-
-
Deyoung, M.P.1
Horak, P.2
Sofer, A.3
Sgroi, D.4
Ellisen, L.W.5
-
29
-
-
0034331255
-
Increasing levels of hypoxia in prostate carcinoma correlate significantly with increasing clinical stage and patient age an Eppendorf pO2 study
-
Movsas B, Chapman JD, Greenberg RE, Hanlon AL, Horwitz EM, Pinover WH, Stobbe C, Hanks GE,. Increasing levels of hypoxia in prostate carcinoma correlate significantly with increasing clinical stage and patient age an Eppendorf pO2 study. Cancer 2000; 89 (9): 2018 -2024.
-
(2000)
Cancer
, vol.89
, Issue.9
, pp. 2018-2024
-
-
Movsas, B.1
Chapman, J.D.2
Greenberg, R.E.3
Hanlon, A.L.4
Horwitz, E.M.5
Pinover, W.H.6
Stobbe, C.7
Hanks, G.E.8
-
30
-
-
0032403263
-
Increased expression of hypoxia inducible factor-1 a in a rat and human prostate cancer
-
Zhong H, Agani F, Baccala AA, Laughner E,., Rioseco-Camacho N, Isaacs WB, Simons JW, Semenza GL,. Increased expression of hypoxia inducible factor-1 a in a rat and human prostate cancer. Cancer Res 1998; 58: 5280 -5284.
-
(1998)
Cancer Res
, vol.58
, pp. 5280-5284
-
-
Zhong, H.1
Agani, F.2
Baccala, A.A.3
Laughner, E.4
Rioseco-Camacho, N.5
Isaacs, W.B.6
Simons, J.W.7
Semenza, G.L.8
-
31
-
-
0034798395
-
2 study
-
2 study. Am J Clin Oncol 2001; 24 (5): 458 -461.
-
(2001)
Am J Clin Oncol
, vol.24
, Issue.5
, pp. 458-461
-
-
Movsas, B.1
Chapman, D.J.2
Hanlon, A.L.3
Horwitz, E.M.4
Pinover, W.H.5
Greenberg, R.E.6
Stobbe, C.7
Hanks, G.E.8
-
32
-
-
0036554734
-
Immunohistochemical demonstration of phospho-Akt in high gleason grade prostate cancer
-
Malik SN, Brattain M, Ghosh PM, Troyer DA, Prihoda T, Bedolla R, Kreisberg JI,. Immunohistochemical demonstration of phospho-Akt in high gleason grade prostate cancer. Clin Cancer Res 2002; 1168 (8): 1168 -1171.
-
(2002)
Clin Cancer Res
, vol.1168
, Issue.8
, pp. 1168-1171
-
-
Malik, S.N.1
Brattain, M.2
Ghosh, P.M.3
Troyer, D.A.4
Prihoda, T.5
Bedolla, R.6
Kreisberg, J.I.7
-
33
-
-
77954894110
-
Rictor is a novel target of p70 S6 kinase-1
-
Treins C, Warne PH, Magnuson MA, Pende M, Downward J,. Rictor is a novel target of p70 S6 kinase-1. Oncogene 2009; 1 -14.
-
(2009)
Oncogene
, pp. 1-14
-
-
Treins, C.1
Warne, P.H.2
Magnuson, M.A.3
Pende, M.4
Downward, J.5
-
34
-
-
21244458013
-
Structure of s6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site
-
Ali SM, Sabatini DM,. Structure of s6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site. J Biol Chem 2005; 280 (20): 19445 -19448.
-
(2005)
J Biol Chem
, vol.280
, Issue.20
, pp. 19445-19448
-
-
Ali, S.M.1
Sabatini, D.M.2
|