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Volumn 70, Issue 13, 2010, Pages 1429-1436

Immunohistochemical examination of the mTORC1 pathway in high grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinomas (PCa): A tissue microarray study (TMA)

Author keywords

Immunohistochemistry; MTOR; MTORC1; RAPTOR; Tissue microarray

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PROTEIN P70; PROTEIN S6; PROTEIN SUBUNIT; RIBOSOME PROTEIN; S6 KINASE; MTORC1 PROTEIN, HUMAN; PROTEIN; PROTEIN KINASE B; RAPTOR PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

EID: 77956625396     PISSN: 02704137     EISSN: 10970045     Source Type: Journal    
DOI: 10.1002/pros.21178     Document Type: Article
Times cited : (17)

References (34)
  • 3
    • 0027229645 scopus 로고
    • Prostate cancer: Screening, diagnosis, and management
    • Garnick MB,. Prostate cancer: Screening, diagnosis, and management. Ann Intern Med 1993; 118 (10): 804 -818.
    • (1993) Ann Intern Med , vol.118 , Issue.10 , pp. 804-818
    • Garnick, M.B.1
  • 4
    • 33747842237 scopus 로고    scopus 로고
    • Interphase FSH analysis of PTEN in histolofical sections show genoimic deletions in 68% of primary prostate cancer and 23% of high-grade prostatic intra-epithelial neoplasias
    • Yashimoto M, Cutz J, Nuin PA, Joshua AM, Bayani J, Evan AJ, Zielenksa M, Squire JA,. Interphase FSH analysis of PTEN in histolofical sections show genoimic deletions in 68% of primary prostate cancer and 23% of high-grade prostatic intra-epithelial neoplasias. Cancer Genet Cytogenet 2006; 169: 128 -137.
    • (2006) Cancer Genet Cytogenet , vol.169 , pp. 128-137
    • Yashimoto, M.1    Cutz, J.2    Nuin, P.A.3    Joshua, A.M.4    Bayani, J.5    Evan, A.J.6    Zielenksa, M.7    Squire, J.A.8
  • 9
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM,. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004; 14: 1296 -1302.
    • (2004) Curr Biol , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1    Ali, S.M.2    Kim, D.H.3    Guertin, D.A.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 10
    • 0033607531 scopus 로고    scopus 로고
    • Immunopurified mammalian target of rapamycin phosphorylates and activates p70 s6 kinase alpha in vitro
    • Isotani S, Hara K, Tokunga C, Inoue H, Avruch J, Yonezawa K,. Immunopurified mammalian target of rapamycin phosphorylates and activates p70 s6 kinase alpha in vitro. J Biol Chem 1999; 274: 34493 -34498.
    • (1999) J Biol Chem , vol.274 , pp. 34493-34498
    • Isotani, S.1    Hara, K.2    Tokunga, C.3    Inoue, H.4    Avruch, J.5    Yonezawa, K.6
  • 11
    • 0035312747 scopus 로고    scopus 로고
    • Regulation of translation initiation by FRAP/mTOR
    • Gingras A, Raught B, Sonenberg N,. Regulation of translation initiation by FRAP/mTOR. Genes Dev 2001; 15: 807 -826.
    • (2001) Genes Dev , vol.15 , pp. 807-826
    • Gingras, A.1    Raught, B.2    Sonenberg, N.3
  • 12
    • 0035200856 scopus 로고    scopus 로고
    • Amino acid-induced translation of TOP mRNAs is fully dependenton phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation
    • Tang H, Hornstein E, Stolovich M, Levy G, Livingstone M, Templeton D, Avruch J, Meyuhas O,. Amino acid-induced translation of TOP mRNAs is fully dependenton phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation. Mol Cell Biol 2001; 21 (24): 8671 -8683.
    • (2001) Mol Cell Biol , vol.21 , Issue.24 , pp. 8671-8683
    • Tang, H.1    Hornstein, E.2    Stolovich, M.3    Levy, G.4    Livingstone, M.5    Templeton, D.6    Avruch, J.7    Meyuhas, O.8
  • 14
    • 33746637660 scopus 로고    scopus 로고
    • Current development of mTOR inhibitors as anticancer agents
    • Faivre S, Kroemer G, Raymond E,. Current development of mTOR inhibitors as anticancer agents. Nature Rev Drug Discov 2006; 5: 671 -688.
    • (2006) Nature Rev Drug Discov , vol.5 , pp. 671-688
    • Faivre, S.1    Kroemer, G.2    Raymond, E.3
  • 16
    • 66449106340 scopus 로고    scopus 로고
    • Increased AKT S478 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumoral cell response to PI3K/mTOR inhibition
    • Breuleux M, Klopfenstein M, Stephan C, Doughty CA, Barys L, Maira SM, Kwiatkowski D, Lane HA,. Increased AKT S478 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumoral cell response to PI3K/mTOR inhibition. Mol Cancer Ther 2009; 8: 742 -753.
    • (2009) Mol Cancer Ther , vol.8 , pp. 742-753
    • Breuleux, M.1    Klopfenstein, M.2    Stephan, C.3    Doughty, C.A.4    Barys, L.5    Maira, S.M.6    Kwiatkowski, D.7    Lane, H.A.8
  • 17
    • 23844438209 scopus 로고    scopus 로고
    • Activation of AKT and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition
    • Sun SY, Rosenberg LM, Wang X, Zhou Z, Yue P, Fu H, Khuri FR,. Activation of AKT and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res 2005; 65 (16): 7052 -7058.
    • (2005) Cancer Res , vol.65 , Issue.16 , pp. 7052-7058
    • Sun, S.Y.1    Rosenberg, L.M.2    Wang, X.3    Zhou, Z.4    Yue, P.5    Fu, H.6    Khuri, F.R.7
  • 18
    • 38049187096 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: Rationale for therapeutic inhibition of both pathways
    • Tamburini J, Chapuis N, Bardet V, Park S, Sujobert P, Willems L, Ifrah N, Dreyfus F, Mayeux P, Lacombe C, Bouscary D,. Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: Rationale for therapeutic inhibition of both pathways. Blood 2008; 111 (1): 379 -382.
    • (2008) Blood , vol.111 , Issue.1 , pp. 379-382
    • Tamburini, J.1    Chapuis, N.2    Bardet, V.3    Park, S.4    Sujobert, P.5    Willems, L.6    Ifrah, N.7    Dreyfus, F.8    Mayeux, P.9    Lacombe, C.10    Bouscary, D.11
  • 19
    • 33947538050 scopus 로고    scopus 로고
    • Rapamycin induced feedback activation of AKT signaling through an IGF-1R-dependant mechanism
    • Wan X, Harkavy B, Shen N, Grohar P, Helman LJ,. Rapamycin induced feedback activation of AKT signaling through an IGF-1R-dependant mechanism. Oncogene 2007; 26: 1932 -1940.
    • (2007) Oncogene , vol.26 , pp. 1932-1940
    • Wan, X.1    Harkavy, B.2    Shen, N.3    Grohar, P.4    Helman, L.J.5
  • 21
    • 27644534999 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade
    • Shi Y, Yan H, Frost P, Gera J, Lichtenstein A,. Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade. Mol Cancer Ther 2005; 10: 1533 -1540.
    • (2005) Mol Cancer Ther , vol.10 , pp. 1533-1540
    • Shi, Y.1    Yan, H.2    Frost, P.3    Gera, J.4    Lichtenstein, A.5
  • 23
    • 78349290007 scopus 로고    scopus 로고
    • Morphoproteomic conformation of a constitutively activated mTOR pathway in high grade prostatic intraepithelial neoplasia and prostate cancer
    • Brown RE, Zotalis G, Zhang PL, Zhao B,. Morphoproteomic conformation of a constitutively activated mTOR pathway in high grade prostatic intraepithelial neoplasia and prostate cancer. Int J Clin Exp Pathol 2008; 1: 333 -342.
    • (2008) Int J Clin Exp Pathol , vol.1 , pp. 333-342
    • Brown, R.E.1    Zotalis, G.2    Zhang, P.L.3    Zhao, B.4
  • 26
    • 34447296448 scopus 로고    scopus 로고
    • Comparison of annexin II, p63 and a-methylacyl-CoA racemase immunoreactivity in prostatic tissue: A tissue microarray study
    • Stewart J, Fleshner N, Cole H, Sweet J,. Comparison of annexin II, p63 and a-methylacyl-CoA racemase immunoreactivity in prostatic tissue: A tissue microarray study. J Clin Pathol 2007; 60: 773 -780.
    • (2007) J Clin Pathol , vol.60 , pp. 773-780
    • Stewart, J.1    Fleshner, N.2    Cole, H.3    Sweet, J.4
  • 28
    • 38349056675 scopus 로고    scopus 로고
    • Hypoxia regulates TSC1/2-Mtor signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling
    • DeYoung MP, Horak P, Sofer A, Sgroi D, Ellisen LW,. Hypoxia regulates TSC1/2-Mtor signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Gene Dev 2008; 22: 239 -251.
    • (2008) Gene Dev , vol.22 , pp. 239-251
    • Deyoung, M.P.1    Horak, P.2    Sofer, A.3    Sgroi, D.4    Ellisen, L.W.5
  • 29
    • 0034331255 scopus 로고    scopus 로고
    • Increasing levels of hypoxia in prostate carcinoma correlate significantly with increasing clinical stage and patient age an Eppendorf pO2 study
    • Movsas B, Chapman JD, Greenberg RE, Hanlon AL, Horwitz EM, Pinover WH, Stobbe C, Hanks GE,. Increasing levels of hypoxia in prostate carcinoma correlate significantly with increasing clinical stage and patient age an Eppendorf pO2 study. Cancer 2000; 89 (9): 2018 -2024.
    • (2000) Cancer , vol.89 , Issue.9 , pp. 2018-2024
    • Movsas, B.1    Chapman, J.D.2    Greenberg, R.E.3    Hanlon, A.L.4    Horwitz, E.M.5    Pinover, W.H.6    Stobbe, C.7    Hanks, G.E.8
  • 34
    • 21244458013 scopus 로고    scopus 로고
    • Structure of s6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site
    • Ali SM, Sabatini DM,. Structure of s6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site. J Biol Chem 2005; 280 (20): 19445 -19448.
    • (2005) J Biol Chem , vol.280 , Issue.20 , pp. 19445-19448
    • Ali, S.M.1    Sabatini, D.M.2


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