Early changes in vasoreactivity after simulated microgravity are due to an upregulation of the endothelium-dependent nitric oxide/cGMP pathway

European Journal of Applied Physiology

Volumn 110, Issue 2, 2010, Pages 395-404

  White, Anthony R ^a   Ryoo, Sungwoo ^a   Bugaj, Lukasz ^a   Attarzadeh, David O ^a   Thiyagarajan, Srikanth ^a   Chen, Kexun ^a   Attwater, Sarah ^c   Abbot, Bryce ^c   Li, Dechun ^a   Champion, Hunter C ^b   Shoukas, Artin A ^a   Nyhan, Daniel ^a   Hare, Joshua M ^d   Berkowitz, Dan E ^a   Tuday, Eric C ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNITED STATES NAVAL ACADEMY   (United States)

^d UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Aorta; Endothelium; Hindlimb unweighting; Microgravity; Vascular

Indexed keywords

CAV PROTEIN, RAT; CAVEOLIN 1; CELL RECEPTOR; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENZYME INHIBITOR; GUANYLATE CYCLASE; HEAT SHOCK PROTEIN 90; NITRIC OXIDE; NOS3 PROTEIN, RAT; SERINE; SOLUBLE GUANYLYL CYCLASE; VASOCONSTRICTOR AGENT; VASODILATOR AGENT;

ANIMAL; AORTA; ARTICLE; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; IMMOBILIZATION; MALE; METABOLISM; PHOSPHORYLATION; RAT; SECOND MESSENGER; TIME; VASCULAR ENDOTHELIUM; VASOCONSTRICTION; VASODILATATION; WEIGHTLESSNESS;

ANIMALS; AORTA; CAVEOLIN 1; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; ENZYME INHIBITORS; GUANYLATE CYCLASE; HINDLIMB SUSPENSION; HSP90 HEAT-SHOCK PROTEINS; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SECOND MESSENGER SYSTEMS; SERINE; TIME FACTORS; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASODILATION; VASODILATOR AGENTS; WEIGHTLESSNESS SIMULATION;

EID: 77956617696     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-010-1514-7     Document Type: Article

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