Simulated microgravity increases myogenic tone in rat cerebral arteries

Journal of Applied Physiology

Volumn 85, Issue 5, 1998, Pages 1615-1621

  Geary, Greg G ^a   Krause, Diana N ^a   Purdy, Ralph E ^a   Duckles, Sue P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Hindlimb unweighting; Nitric oxide

Indexed keywords

N(G) NITROARGININE METHYL ESTER;

ANIMAL EXPERIMENT; ARTERY DIAMETER; ARTERY TONE; ARTICLE; BRAIN ARTERY; BRAIN BLOOD FLOW; CARDIOVASCULAR AUTOREGULATION; CONTROLLED STUDY; HEMODYNAMICS; MALE; MICROGRAVITY; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0031793623     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1998.85.5.1615     Document Type: Article

References (35)

1. Arbeille, P., F. Achaïbou, G. Fomina, J. M. Pottier, and M. Porcher. Regional blood flow in microgravity: adaptation and deconditioning. Med. Sci. Sports Exerc. 28: S70-S79, 1996.
2. Asano, M., K. Masuzawa-Ito, T. Matsuda, Y. Suzuki, H. Oyama, M. Shibuya, and K. Sugita. Functional role of charybdotoxin-sensitive K+ channels in the resting state of cerebral, coronary and mesenteric arteries of the dog. J. Pharmacol. Exp. Ther. 267: 1277-1285, 1993.
3. Bayliss, W. M. On the local reaction of the arterial wall to changes of internal pressure. J. Physiol. (Lond.) 28: 220-231, 1902.
4. Bevan, J. A., and R. D. Bevan. Is innervation a prime regulator of cerebral blood flow? News Physiol. Sci. 8: 149-153, 1993.
5. Bondar, R. L., F. Stein, M. S. Kassam, P. T. Dunphy, B. S. Bennett, and K. W. Johnston. Cerebral blood flow velocities by transcranial Doppler during parabolic flight. J. Clin. Pharmacol. 31: 915-919, 1991.
6. Bondar, R. L., F. Stein, M. S. Kassam, F. Stein, P. T. Dunphy, S. Fortney, and M. L. Riedesel. Simultaneous cerebrovascular and cardiovascular responses during presyncope. Stroke 26: 1794-1800, 1995.
7. Brayden, J. E., and M. T. Nelson. Regulation of arterial tone by activation of calcium-dependent potassium channels. Science 256: 532-535, 1992.
8. Buckey, J. C., L. D. Lane, and B. D. Levine. Orthostatic intolerance after spaceflight. J. Appl. Physiol. 81: 7-18, 1996.
9. D'Angelo, G., and G. A. Meininger. Transduction mechanisms involved in the regulation of myogenic activity. Hypertension 23: 1096-1105, 1994.
10. Delp, M. D., T. Holder-Binkley, M. H. Laughlin, and E. M. Hasser. Vasoconstrictor properties of rat aorta are diminished by hindlimb unweighting. J. Appl. Physiol. 75: 2620-2628, 1993.
11. Dohi, Y., M. Thiel, F. R. Bühler, and T. F. Lüscher. Activation of the endothelial L-arginine pathway in pressurized mesenteric resistance arteries: effect of age and hypertension. Hypertension 15: 170-175, 1990.
12. Dunn, C. D. R., P. C. Johnson, and R. D. Lange. Regulation of the hematopoiesis in rats exposed to antiorthostatic hypokinetic/ hypodynamia. Mechanisms of the "anemia." Aviat. Space Environ. Med. 57: 36-44, 1986.
13. Edvinsson, L., E. T. MacKenzie, and J. McCulloch. Cerebral blood flow and metabolism. In: Cerebral Blood Flow and Metabolism. New York: Raven, 1993, p. 553-580.
14. Faraci, F. M., and D. D. Heistad. Regulation of cerebral arteries and cerebral microvascular pressure. Circ. Res. 66: 8-17, 1990.
15. Folkow, B., and G. Karlström. Age-and pressure-dependent changes of systemic resistance vessels concerning the relationships between geometric design, wall distensibility, vascular reactivity and smooth muscle sensitivity. Acta Physiol. Scand. 122: 17-33, 1984.
16. Funk, W., B. Endrich, K. Messmer, and M. Intaglietta. Spontaneous arteriolar vasomotion as a determinant of peripheral vascular resistance. Int. J. Microcirc. Clin. Exp. 2: 11-25, 1983.
17. Griffith, T. M., and D. H. Edwards. Mechanisms underlying chaotic vasomotion in the isolated resistance arteries: roles of calcium and EDRF. Biorheology 30: 333-347, 1993.
18. +-pump. Acta Physiol. Scand. 150: 161-170, 1994.
19. Harder, D. R., and A. Waters. Electrical activation of arterial muscle. Int. Rev. Cytol. 89: 137-149, 1984.
20. Hargens, A. R., and D. E. Watenpaugh. Cardiovascular adaptation to spaceflight. Med. Sci. Sports Exerc. 28: 977-982, 1996.
21. Hargens, A. R., D. E. Watenpaugh, and G. A. Breit. Control of circulatory function in altered gravitational fields. Physiologist 35: S80-S83, 1992.
22. Johnson, P. C. Autoregulation of blood flow. Circ. Res. 59: 483-495, 1986.
23. Kontos, H. A., E. P. Wei, R. M. Navari, J. E. Levasseur, W. I. Rosenblum, and J. L. Patterson. Response of cerebral arteries and arterioles to acute hypotension and hypertension. Am. J. Physiol. 234 (Heart Circ. Physiol. 3): H371-H383, 1978.
24. McCarron, J. G., C. A. Crichton, P. D. Langston, A. Mackenzie, and G. L. Smith. Myogenic contraction by modulation of voltage-dependent calcium currents in isolated rat cerebral arteries. J. Physiol. (Lond.) 498: 371-379, 1997.
25. McDonald, K. S., M. D. Delp, and R. H. Fitts. Effect of hindlimb unweighting on tissue blood flow in the rat. J. Appl. Physiol. 72: 2210-2218, 1992.
26. Murison, R. C. C. Time course of plasma corticosterone under immobilization stress in rats. IRCS Med. Sci. 11: 20-21, 1983.
27. Osol, G., and W. Halpren. Myogenic properties of cerebral blood vessels from normotensive and hypertensive rats. Am. J. Physiol. 249 (Heart Circ. Physiol. 18): H914-H921, 1985.
28. Osol, G., and W. Halpren. Spontaneous vasomotion in pressurized cerebral arteries from genetically hypertensive rats. Am. J. Physiol. 254 (Heart Circ. Physiol. 23): H28-H33, 1988.
29. 2max and regional blood flow responses to exercise. J. Appl. Physiol. 66: 653-659, 1989.
30. Purdy, R. E., S. P. Duckles, D. N. Krause, K. M. Rubera, and D. Sara. Effect of simulated microgravity on vascular contractility. J. Appl. Physiol. 85: 1307-1315, 1998.
31. Sadoshima, S., M. Fujishima, F. Yoshida, S. Ibayashi, O. Shiokawa, and T. Omae. Cerebral autoregulation in young spontaneously hypertensive rats. Hypertension 7: 392-397, 1985.
32. Shellock, F. G., H. J. C. Swan, and S. A. Rubin. Early central venous pressure changes in the rat during two different levels of head-down suspension. Aviat. Space Environ. Med. 56: 791-795, 1985.
33. Thomason, D. B., D. L. Eckberg, R. L. Goble, J. J. Schelhorn, and H. C. Halliday. Device for rapid quantification of human carotid baroreceptor-cardiac reflex response. J. Appl. Physiol. 63: 130-137, 1987.
34. + channel. Circ. Res. 79: 1024-1030, 1996.
35. Wesselman, J. P. M., E. VanBavel, M. Pfaffendorf, and J. A. E. Spaan. Voltage-operated calcium channels are essential for the myogenic responsiveness of cannulated rat mesenteric small arteries. J. Vasc. Res. 33: 32-41, 1996.