Endothelial role in the thoracic aorta response to hindlimb unloading in rats

Aviation Space and Environmental Medicine

Volumn 78, Issue 12, 2007, Pages 1103-1107

  Summers, Scott M ^a   Ulloa, Adolph S ^a   Purdy, Ralph E ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cardiovascular; eNOS; Hindlimb unloading; Nitric oxide; Space; Sprague Dawley; Wistar

Indexed keywords

ACETYLCHOLINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; METHYLFURTRETHONIUM; NITRIC OXIDE; NITROPRUSSIDE SODIUM; PHENYLEPHRINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM; FORCE; HEMODYNAMICS; HINDLIMB; MUSCLE CONTRACTION; NONHUMAN; RAT; THORACIC AORTA; VASCULAR SMOOTH MUSCLE;

ACETYLCHOLINE; ANIMALS; AORTA, THORACIC; ENDOTHELIUM, VASCULAR; HINDLIMB SUSPENSION; ISOMETRIC CONTRACTION; MALE; MUSCARINE; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NITROPRUSSIDE; PARASYMPATHOMIMETICS; PHENYLEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

RATTUS; RATTUS NORVEGICUS;

EID: 36749077499     PISSN: 00956562     EISSN: None     Source Type: Journal    
DOI: 10.3357/ASEM.2125.2007     Document Type: Article

References (23)

1. Ba ZF, Kuebler JF, Rue III LW, Bland KI, Wang P, Chaudry IH. Gender dimorphic tissue perfusion response after acute hemorrhage and resuscitation: role of vascular endothelial cell function. Am J Physiol Heart Circ Physiol 2003; 284:H2162-9.
2. Buckey JC, Lane LD, Levine BD, Watenpaugh DE, Wright SJ, et al. Orthostatic intolerance after spaceflight. J Appl Physiol 1996; 81:7-18.
3. Catterson AD, McCutcheon EP, Minners HA, Pollard RA. Aeromedical observations. In: Mercury Project summary including results of the fourth manned orbital flight May 15 and 16, 1963. Washington, DC: NASA; 1963:299-326.
4. Delp MD, Binkley T, Laughlin MH, Hasser EM. Vasoconstrictor properties of rat aorta are diminished by hindlimb unloading. J Appl Physiol 1993; 75:2620-8.
5. Dorofeeva NA, Shelkovnikov SA, Starshinova LA, Danilov AF, Nedoma J, Tucek S. Quest for agonist and antagonist selectivity at muscarinic receptors in guinea-pig smooth muscles and cardiac atria. Naunyn-Schmiedebergs Arch Pharmacol 1992; 346:383-90.
6. Freeman EJ, Ferrario CM, Tallant EA. Angiotensins differentially activate phospholipase D in vascular smooth muscle cells from spontaneously hypertensive and Wistar-Kyoto rats. Am J Hypertens 1995; 8:1105-11.
7. Fritsch-Yelle JM, Whitson PA, Bondar RL, Brown TE. Subnormal norepinephrine release relates to presyncope in astronauts after spaceflight. J Appl Physiol 1996; 81:2134-41.
8. Fu Q, Witkowski S, Levine BD. Vasoconstrictor reserve and sympathetic neural control of orthostasis. Circulation 2004; 110: 2931-7.
9. Hitt BA, Mazze RI, Cousins MJ, Edmunds HN, Barr GA, Trudell JA. Metabolism of isoflurane in Fischer 344 rats and man. Anesthesiology 1974; 40:62-7.
10. Hwang S, Shelkovnikov SA, Purdy RE. Simulated microgravity effects on the rat carotid and femoral arteries: role of contractile protein expression and mechanical properties of the vessel wall. J Appl Physiol 2007; 102:1595-603.
11. Ing HR, Kordik P, Williams DP. Studies on the structure-action relationships of the choline group. Br J Pharmacol Chemother 1952; 7:103-16.
12. Kauser K, Rubanyi GM. Gender difference in bioassayable endothelium-derived nitric oxide from isolated rat aortae. Am J Physiol 1994; 267(6, Pt. 2):H2311-7.
13. Ma J, Kahwaji CI, Ni Z, Vaziri ND, Purdy RE. Effects of simulated microgravity on arterial nitric oxide synthase and nitrate and nitrite content. J Appl Physiol 2003; 94:83-92.
14. Ma J, Zhang LF, Yu ZB. Effects of 14-day tail suspension on vasoreactivity of arteries from different parts of the body in rats. J Gravit Physiol 1996; 3:9-10.
15. Meek JV, Waters WW, Ziegler MG, deBlock HF, Mills PJ, et al. Mechanisms of post spaceflight orthostatic hypotension: low alphal-adrenergic receptor responses before flight and central autonomic dysregulation postflight. Am J Physiol Heart Circ Physiol 2004; 286:H1486-95.
16. Mendelsohn ME, Karas RH. The protective effects of estrogen on the cardiovascular system. N Engl J Med 1999; 340:1801-11.
17. Moffitt JA, Foley CM, Schadt JC, Laughlin MH, Hasser EM. Attenuated baroreflex control of sympathetic nerve activity after cardiovascular deconditioning in rats. Am J Physiol 1998; 274:R1397-405.
18. Morey-Holton ER, Globus RK. Hindlimb unloading rodent model: technical aspects. J Appl Physiol 2002; 92:1367-77.
19. Owens GK, Rabinovitch PS, Schwartz SM. Smooth muscle cell hypertrophy versus hyperplasia in hypertension. Proc Natl Acad Sci USA 1981; 78:7759-63.
20. Purdy RE, Duckies SP, Krause DN, Rubera KM, Sara D. Effect of simulated microgravity on vascular contractility. J Appl Physiol 1998; 85:1307-15.
21. Sangha DS, Vaziri ND, Ding Y, Purdy RE. Vascular hyporesponsiveness in simulated microgravity: role of nitric oxide-dependent mechanisms. J Appl Physiol 2000; 88:507-17.
22. Summers SM, Ulloa AS, Purdy RE. Simulated microgravity in Wistar rats markedly increases vasoconstrictor capacity in endothelium denuded thoracic aorta(Abstract). Gravit Space Biol Bull 2005; 19:10.
23. Wilkerson MK, Muller-Delp J, Colleran PN, Delp MD. Effects of hindlimb unloading on rat cerebral, splenic, and mesenteric resistance artery morphology. J Appl Physiol 1999; 87:2115-21.