Functional interdependence and colocalization of endothelial nitric oxide synthase and heat shock protein 90 in cerebral arteries

Journal of Cerebral Blood Flow and Metabolism

Volumn 20, Issue 11, 2000, Pages 1563-1570

  Khurana, Vini G ^a   Feterik, Kristian ^b   Springett, Margaret J ^a   Eguchi, Daihiko ^b   Shah, Vijay ^a   Katusic, Zvonimir S ^a,b  

^a MAYO CLINIC   (United States)

^b DEPARTMENT OF UROLOGY   (United States)

Author keywords

Endothelium; Heat shock protein; HSP90; Nitric oxide synthase

Indexed keywords

CYCLIC GMP; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASILAR ARTERY; BRAIN ARTERY; BRAIN CIRCULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOG; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; ENZYME ACTIVATION; IMMUNOGOLD STAINING; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RADIOIMMUNOASSAY; SIGNAL TRANSDUCTION; VASOCONSTRICTION; VASOMOTOR REFLEX;

EID: 0033762055     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200011000-00006     Document Type: Article

References (26)

1. Protein A-gold and protein G-gold postembedding immunoelectron microscopy
2. Localization of heat shock proteins in mouse male germ cells: An immunoelectron microscopical study
3. Transfer and expression of recombinant nitric oxide synthase genes in the cardiovascular system
4. Expression and function of recombinant endothelial nitric oxide synthase gene in canine basilar artery
5. Heat shock response inhibits cytokine-inducible nitric oxide synthase expression in rat hepatocytes
6. Dynamic activation of endothelial nitric oxide synthase by Hsp90
7. The amino-terminal domain of heat shock protein 90 (Hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation
8. Neuroprotection at drosophila synapses conferred by prior heat-shock
9. Putative role of heat-shock protein 90 (Hsp90) in nitric oxide (NO)-mediated cerebral vasodilatation
10. Geldanamycin, an Hsp90/GRP94-binding drug, induces increased transcription of endoplasmic reticulum (ER) chaperones via the ER stress pathway
11. Stress-inducible responses and heat shock proteins: New pharmacologic targets for cytoprotection
12. Adventitial expression of recombinant endothelial nitric oxide synthase gene reverses vasoconstrictor effect of endothelin-1
13. The function of heat-shock proteins in stress tolerance: Degradation and reactivation of damaged proteins
14. Receptor-regulated translocation of endothelial nitric-oxide synthase
15. The role of the Hsp90-based chaperone system in signal transduction by nuclear receptors and receptors signaling via map kinase
16. The Hsp90-based chaperone system: Involvement in signal transduction from a variety of hormone and growth factor receptors
17. Identification and structural characterization of the ATP/ ADP-binding site in the Hsp90 molecular chaperone
18. The Hsp90 complex: A super-chaperone machine as a novel drug target
19. Hsp90 regulation of endothelial nitric oxide synthase contributes to vascular control in portal hypertension
20. Immunoreactivity for nitric oxide synthase and endothelin in the coronary and basilar arteries of renal hypertensive rats
21. Molecular chaperones: Biology and prospects for pharmacological intervention
22. Crystal structure of an Hsp90-geldanamycin complex: Targeting of a protein chaperone by an antitumor agent
23. Recent advances in the study of hsp90 structure and mechanism of action
24. Heat shock protein 90 is involved in pulsatile flow-induced dilation of rat middle cerebral artery
25. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation
26. The heat shock response inhibits inducible nitric oxide synthase gene expression by blocking Iκ-B degradation and NF-κB nuclear translocation