Decisive role of apurinic/apyrimidinic endonuclease/Ref-1 in initiation of cell death

Molecular and Cellular Neuroscience

Volumn 45, Issue 3, 2010, Pages 267-276

  Cho, Kyoung Joo ^a   Kim, Hyun Jeong ^a   Park, Soo Chul ^a   Kim, Hyun Woo ^a   Kim, Gyung Whan ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

Adenovirus; APE small peptide; APE Ref 1; Neutral antibody; SiRNA; TAT mediated transduction

Indexed keywords

ANTIBODY; CASPASE 3; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; KAINIC ACID; PROTEIN; REDOX EFFECTOR FACTOR 1;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; APYRIMIDINIC SITE; ARTICLE; CELL DEATH; CELL FATE; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; EXCISION REPAIR; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NERVE INJURY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL;

ADENOVIRIDAE; ANIMALS; CELL DEATH; DNA DAMAGE; DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; HIPPOCAMPUS; HUMANS; KAINIC ACID; MALE; MICE; NEURONS; PEPTIDES; RNA, SMALL INTERFERING;

ADENOVIRIDAE;

EID: 77956615040     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mcn.2010.07.001     Document Type: Article

References (39)

1. Barzilai A., Biton S., Shiloh Y. The role of the DNA damage response in neuronal development, organization and maintenance. DNA Repair (Amst) 2008, 7:1010-1027.
2. Ben-Ari Y., Cossart R. Kainate, a double agent that generates seizures: two decades of progress. Trends Neurosci. 2000, 23:580-587.
3. Bernstein C., Bernstein H., Payne C.M., Garewal H. DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis. Mutat. Res. 2002, 511:145-178.
4. Borsello T., Clarke P.G., Hirt L., Vercelli A., Repici M., Schorderet D.F., Bogousslavsky J., Bonny C. A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. Nat. Med. 2003, 9:1180-1186.
5. Brasnjevic I., Hof P.R., Steinbusch H.W., Schmitz C. Accumulation of nuclear DNA damage or neuron loss: molecular basis for a new approach to understanding selective neuronal vulnerability in neurodegenerative diseases. DNA Repair (Amst) 2008, 7:1087-1097.
6. Caldecott K.W. Mammalian DNA single-strand break repair: an X-ra(y)ted affair. Bioessays 2001, 23:447-455.
7. Demple B., Sung J.S. Molecular and biological roles of Ape1 protein in mammalian base excision repair. DNA Repair (Amst) 2005, 4:1442-1449.
8. Dirnagl U., Iadecola C., Moskowitz M.A. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 1999, 22:391-397.
9. Evans A.R., Limp-Foster M., Kelley M.R. Going APE over ref-1. Mutat. Res. 2000, 461:83-108.
10. Fishel M.L., Vasko M.R., Kelley M.R. DNA repair in neurons: So if they don't divide what's to repair?. Mutat. Res. 2007, 614:24-36.
11. Fung H., Demple B. A vital role for Ape1/Ref1 protein in repairing spontaneous DNA damage in human cells. Mol. Cell 2005, 17:463-470.
12. Gomez J.A., Gama V., Yoshida T., Sun W., Hayes P., Leskov K., Boothman D., Matsuyama S. Bax-inhibiting peptides derived from Ku70 and cell-penetrating pentapeptides. Biochem. Soc. Trans. 2007, 35:797-801.
13. Heo K., Cho Y.J., Cho K.J., Kim H.W., Kim H.J., Shin H.Y., Lee B.I., Kim G.W. Minocycline inhibits caspase-dependent and -independent cell death pathways and is neuroprotective against hippocampal damage after treatment with kainic acid in mice. Neurosci. Lett. 2006, 398:195-200.
14. Jeon B.H., Gupta G., Park Y.C., Qi B., Haile A., Khanday F.A., Liu Y.X., Kim J.M., Ozaki M., White A.R., Berkowitz D.E., Irani K. Apurinic/apyrimidinic endonuclease 1 regulates endothelial NO production and vascular tone. Circ. Res. 2004, 95:902-910.
15. Kaneto H., Nakatani Y., Miyatsuka T., Kawamori D., Matsuoka T.A., Matsuhisa M., Kajimoto Y., Ichijo H., Yamasaki Y., Hori M. Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide. Nat. Med. 2004, 10:1128-1132.
16. Kim G.W., Copin J.C., Kawase M., Chen S.F., Sato S., Gobbel G.T., Chan P.H. Excitotoxicity is required for induction of oxidative stress and apoptosis in mouse striatum by the mitochondrial toxin, 3-nitropropionic acid. J. Cereb. Blood Flow Metab. 2000, 20:119-129.
17. Kim G.W., Lewen A., Copin J., Watson B.D., Chan P.H. The cytosolic antioxidant, copper/zinc superoxide dismutase, attenuates blood-brain barrier disruption and oxidative cellular injury after photothrombotic cortical ischemia in mice. Neuroscience 2001, 105:1007-1018.
18. Kim H.W., Cho K.J., Lee B.I., Kim H.J., Kim G.W. Post-ischemic administration of peptide with apurinic/apyrimidinic endonuclease activity inhibits induction of cell death after focal cerebral ischemia/reperfusion in mice. Neurosci. Lett. 2009, 460:166-169.
19. Kim H.W., Cho K.J., Park S.C., Kim H.J., Kim G.W. The adenoviral vector-mediated increase in apurinic/apyrimidinic endonuclease inhibits the induction of neuronal cell death after transient ischemic stroke in mice. Brain Res. 2009, 1274:1-10.
20. Lan J., Henshall D.C., Simon R.P., Chen J. Formation of the base modification 8-hydroxyl-2'-deoxyguanosine and DNA fragmentation following seizures induced by systemic kainic acid in the rat. J. Neurochem. 2000, 74:302-309.
21. Lee B.I., Chan P.H., Kim G.W. Metalloporphyrin-based superoxide dismutase mimic attenuates the nuclear translocation of apoptosis-inducing factor and the subsequent DNA fragmentation after permanent focal cerebral ischemia in mice. Stroke 2005, 36:2712-2717.
22. Lindsay M.A. Peptide-mediated cell delivery: application in protein target validation. Curr. Opin. Pharmacol. 2002, 2:587-594.
23. Lomax M.E., Cunniffe S., O'Neill P. Efficiency of repair of an abasic site within DNA clustered damage sites by mammalian cell nuclear extracts. Biochemistry 2004, 43:11017-11026.
24. Martin L.J. DNA damage and repair: relevance to mechanisms of neurodegeneration. J. Neuropathol. Exp. Neurol. 2008, 67:377-387.
25. Martin L.J., Liu Z., Pipino J., Chestnut B., Landek M.A. Molecular Regulation of DNA Damage-Induced Apoptosis in Neurons of Cerebral Cortex. Cereb. Cortex 2008.
26. Martin L.J., Pan Y., Price A.C., Sterling W., Copeland N.G., Jenkins N.A., Price D.L., Lee M.K. Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J. Neurosci. 2006, 26:41-50.
27. McMurray C.T. To die or not to die: DNA repair in neurons. Mutat. Res. 2005, 577:260-274.
28. Nazarkina Zh K., Khodyreva S.N., Marsin S., Radicella J.P., Lavrik O.I. Study of interaction of XRCC1 with DNA and proteins of base excision repair by photoaffinity labeling technique. Biochemistry (Mosc) 2007, 72:878-886.
29. Neema M., Navarro-Quiroga I., Chechlacz M., Gilliams-Francis K., Liu J., Lamonica K., Lin S.L., Naegele J.R. DNA damage and nonhomologous end joining in excitotoxicity: neuroprotective role of DNA-PKcs in kainic acid-induced seizures. Hippocampus 2005, 15:1057-1071.
30. Patel M., Li Q.Y. Age dependence of seizure-induced oxidative stress. Neuroscience 2003, 118:431-437.
31. Ramana C.V., Boldogh I., Izumi T., Mitra S. Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:5061-5066.
32. Rich T., Allen R.L., Wyllie A.H. Defying death after DNA damage. Nature 2000, 407:777-783.
33. Song Y.J., Lee J.Y., Joo H.K., Kim H.S., Lee S.K., Lee K.H., Cho C.H., Park J.B., Jeon B.H. Tat-APE1/ref-1 protein inhibits TNF-alpha-induced endothelial cell activation. Biochem. Biophys. Res. Commun. 2008, 368(1):68-73.
34. Spalloni A., Pascucci T., Albo F., Ferrari F., Puglisi-Allegra S., Zona C., Bernardi G., Longone P. Altered vulnerability to kainate excitotoxicity of transgenic-Cu/Zn SOD1 neurones. NeuroReport 2004, 15:2477-2480.
35. Tell G., Damante G., Caldwell D., Kelley M.R. The intracellular localization of APE1/Ref-1: more than a passive phenomenon?. Antioxid. Redox Signal. 2005, 7:367-384.
36. Vasko M.R., Guo C., Kelley M.R. The multifunctional DNA repair/redox enzyme Ape1/Ref-1 promotes survival of neurons after oxidative stress. DNA Repair (Amst) 2005, 4:367-379.
37. Xanthoudakis S., Miao G.G., Curran T. The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains. Proc. Natl. Acad. Sci. U. S. A. 1994, 91:23-27.
38. Zhivotovsky B., Kroemer G. Apoptosis and genomic instability. Nat. Rev. Mol. Cell Biol. 2004, 5:752-762.
39. Zhu H., Zhang L.B. Detection of Coxsackie B virus IgM antibody in myocarditis patients by Mac ELISA. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2000, 14:370-372.