Apurinic/apyrmidinic endonuclease 1 regulates endothelial NO production and vascular tone

Circulation Research

Volumn 95, Issue 9, 2004, Pages 902-910

  Jeon, Byeong Hwa ^a,b   Gupta, Gaurav ^a   Park, Young Chul ^a,c   Qi, Bing ^a   Haile, Azeb ^a   Khanday, Firdous A ^a   Liu, Yan Xia ^a   Kim, Jin Man ^b   Ozaki, Michitaka ^d   White, Anthony R ^a   Berkowitz, Dan E ^a   Irani, Kaikobad ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Chungnam National University   (South Korea)

^c Pusan National University   (South Korea)

^d HOKKAIDO UNIVERSITY   (Japan)

Author keywords

eNOS; H ras; Hypertension; Redox

Indexed keywords

DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; AKT1 PROTEIN, HUMAN; AKT1 PROTEIN, RAT; APEX1 PROTEIN, MOUSE; CALCIUM; HRAS PROTEIN, HUMAN; INDUCIBLE NITRIC OXIDE SYNTHASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NOS3 PROTEIN, HUMAN; NOS3 PROTEIN, MOUSE; NOS3 PROTEIN, RAT; ONCOPROTEIN; PROTEIN P21; PROTEIN SERINE THREONINE KINASE;

ANIMAL TISSUE; ARTICLE; BLOOD VESSEL TONE; ENDOTHELIUM CELL; ENZYME ACTIVITY; HYPERTENSION; NONHUMAN; ONCOGENE H RAS; OXIDATION REDUCTION STATE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; THORACIC AORTA; ANIMAL; AORTA; BIOSYNTHESIS; BLOOD PRESSURE; CATTLE; CELL CULTURE; CHEMISTRY; CYTOLOGY; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; HUMAN; MALE; METABOLISM; MOUSE; MOUSE MUTANT; ONCOGENE RAS; OXIDATION REDUCTION REACTION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS; UMBILICAL VEIN; VASCULAR ENDOTHELIUM; VASCULAR RESISTANCE; VASOCONSTRICTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; AORTA; BLOOD PRESSURE; CALCIUM; CATTLE; CELLS, CULTURED; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GENES, RAS; HUMANS; HYPERTENSION; MALE; MICE; MICE, KNOCKOUT; MUTAGENESIS, SITE-DIRECTED; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; OXIDATION-REDUCTION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS P21(RAS); RATS; TRANSFECTION; UMBILICAL VEINS; VASCULAR RESISTANCE; VASOCONSTRICTION;

EID: 7244248654     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000146947.84294.4c     Document Type: Article

References (25)

1. Negishi H, Ikeda K, Kuga S, Noguchi T, Kanda T, Njelekela M, Liu L, Miki T, Nara Y, Sato T, Mashalla Y, Mtabaji J, Yamori Y. The relation of oxidative DNA damage to hypertension and other cardiovascular risk factors in Tanzania. J Hypertens. 2001;19:529-533.
2. Martinet W, Knaapen MW, De Meyer GR, Herman AG, Kockx MM. Elevated levels of oxidative DNA damage and DNA repair enzymes in human atherosclerotic plaques. Circulation. 2002;106:927-932.
3. Xanthoudakis S, Miao GG, Curran T. The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains. Proc Natl Acad Sci U S A. 1994;91:23-27.
4. Walker LJ, Robson CN, Black E, Gillespie D, Hickson ID. Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding. Mol Cell Biol. 1993; 13:5370-5376.
5. Ozaki M, Haga S, Zhang HQ, Irani K, Suzuki S. Inhibition of hypoxia/ reoxygenation-induced oxidative stress in HGF-stimulated antiapoptotic signaling: role of PI3-K and Akt kinase upon rac1. Cell Death Differ. 2003;10:508-515.
6. Deshpande SS, Qi B, Park YC, Irani K. Constitutive activation of rac1 results in mitochondrial oxidative stress and induces premature endothelial cell senescence. Arterioscler Thromb Vasc Biol. 2003;23:e1-6.
7. Xanthoudakis S, Smeyne RJ, Wallace JD, Curran T. The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice. Proc Natl Acad Sci U S A. 1996;93:8919-8923.
8. Cheo DL, Meira LB, Burns DK, Reis AM, Issac T, Friedberg EC. Ultraviolet B radiation-induced skin cancer in mice defective in the Xpc, Trp53, and Apex (HAP1) genes: genotype-specific effects on cancer predisposition and pathology of tumors. Cancer Res. 2000;60: 1580-1584.
9. Kelm M, Preik-Steinhoff H, Preik M, Strauer BE. Serum nitrite sensitively reflects endothelial NO formation in human forearm vasculature: evidence for biochemical assessment of the endothelial L-arginine-NO pathway. Cardiovasc Res. 1999;41:765-772.
10. Wang HD, Xu S, Johns DG, Du Y, Quinn MT, Cayatte AJ, Cohen RA. Role of NADPH oxidase in the vascular hypertrophic and oxidative stress response to angiotensin II in mice. Circ Res. 2001;88:947-953.
11. Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K. Franke TF, Papapetropoulos A, Sessa WC. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature. 1999;399: 597-601.
12. Garcia-Cardena G, Fan R, Shah V, Sorrentino R, Cirino G, Papapetropoulos A, Sessa WC. Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature. 1998;392:821-824.
13. Angkeow P, Deshpande SS, Qi B, Liu YX, Park YC, Jeon BH, Ozaki M, Irani K. Redox factor-1: an extra-nuclear role in the regulation of endothelial oxidative stress and apoptosis. Cell Death Differ. 2002;9:717-725.
14. Lee W, Keller EB. Regulatory elements mediating transcription of the human Ha-ras gene. J Mol Biol. 1991;220:599-611.
15. Damante G, Filetti S, Rapoport B. The functional activity of the rat c-Ha-ras promoter requires the coordinate involvement of multiple elements. FEBS Lett. 1987;225:264-268.
16. Lowndes NF, Paul J, Wu J, Allan M. c-Ha-ras gene bidirectional promoter expressed in vitro: location and regulation. Mol Cell Biol. 1989;9:3758-3770.
17. Trimble WS, Hozumi N. Deletion analysis of the c-Ha-ras oncogene promoter. FEBS Lett. 1987;219:70-74.
18. Bloomfield KL, Osborne SA, Kennedy DD, Clarke FM, Tonissen KF. Thioredoxin-mediated redox control of the transcription factor Sp1 and regulation of the thioredoxin gene promoter. Gene. 2003;319:107-116.
19. Meira LB, Devaraj S, Kisby GE, Burns DK, Daniel RL, Hammer RE, Grundy S, Jialal I, Friedberg EC. Heterozygosity for the mouse Apex gene results in phenotypes associated with oxidative stress. Cancer Res. 2001;61:5552-5557.
20. Cracowski JL, Camus L, Durand T, Devillier P, Guy A, Hardy G, Stanke-Labesque F, Rossi JC, Bessard G. Response of rat thoracic aorta to F(2)-isoprostane metabolites. J Cardiovasc Pharmacol. 2002;39: 396-403.
21. Cho HJ, Jeong HG, Lee JS, Woo ER, Hyun JW, Chung MH, You HJ. Oncogenic H-Ras enhances DNA repair through the Ras/phosphatidylinositol 3-kinase/Rac1 pathway in NIH3T3 cells. Evidence for association with reactive oxygen species. J Biol Chem. 2002;277:19358-19366.
22. Vaziri ND, Ni Z, Oveisi F, Trnavsky-Hobbs DL. Effect of antioxidant therapy on blood pressure and NO synthase expression in hypertensive rats. Hypertension. 2000;36:957-964.
23. Chin SY, Pandey KN, Shi SJ, Kobori H, Moreno C, Navar LG. Increased activity and expression of Ca(2+)-dependent NOS in renal cortex of Ang II-infused hypertensive rats. Am J Physiol. 1999;277:F797-804.
24. Drummond GR, Cai H, Davis ME, Ramasamy S, Harrison DG. Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide. Circ Res. 2000;86:347-354.
25. Okazaki T, Zajac JD, Igarashi T, Ogata E, Kronenberg HM. Negative regulatory elements in the human parathyroid hormone gene. J Biol Chem. 1991;266:21903-21910.