Post-ischemic administration of peptide with apurinic/apyrimidinic endonuclease activity inhibits induction of cell death after focal cerebral ischemia/reperfusion in mice

Neuroscience Letters

Volumn 460, Issue 2, 2009, Pages 166-169

  Kim, Hyun Woo ^a   Cho, Kyoung Joo ^a   Lee, Byung I ^a   Kim, Hyun jeong ^a   Kim, Gyung W ^a  

^a Kyung Hee University Hospital   (South Korea)

Author keywords

Apurinic apyrimidinic endonuclease redox factor 1 (APE Ref 1); DNA repair; Stroke; Transient focal cerebral ischemia

Indexed keywords

REDOX EFFECTOR FACTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; DNA DAMAGE; ENZYME ASSAY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REPERFUSION INJURY;

ANALYSIS OF VARIANCE; ANIMALS; BRAIN ISCHEMIA; CASPASE 3; CELL DEATH; DISEASE MODELS, ANIMAL; DNA BREAKS, SINGLE-STRANDED; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; ENDODEOXYRIBONUCLEASES; ENDORIBONUCLEASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; MALE; MICE; MICE, INBRED C57BL; PEPTIDES; REPERFUSION INJURY; TETRAZOLIUM SALTS; TIME FACTORS;

EID: 67349287046     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.05.062     Document Type: Article

References (16)

1. Borsello T., Clarke P.G., Hirt L., Vercelli A., Repici M., Schorderet D.F., Bogousslavsky J., and Bonny C. A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. Nat. Med. 9 (2003) 1180-1186
2. Chang M.L., Yang J., Kem S., Klaidman L., Sugawara T., Chan P.H., and Adams Jr. J.D. Nicotinamide and ketamine reduce infarct volume and DNA fragmentation in rats after brain ischemia and reperfusion. Neurosci. Lett. 322 (2002) 137-140
3. Chang Y.Y., Fujimura M., Morita-Fujimura Y., Kim G.W., Huang C.Y., Wu H.S., Kawase M., Copin J.C., and Chan P.H. Neuroprotective effects of an antioxidant in cortical cerebral ischemia: prevention of early reduction of the apurinic/apyrimidinic endonuclease DNA repair enzyme. Neurosci. Lett. 277 (1999) 61-64
4. Evans A.R., Limp-Foster M., and Kelley M.R. Going APE over ref-1. Mutat. Res. 461 (2000) 83-108
5. Fujimura M., Morita-Fujimura Y., Kawase M., and Chan P.H. Early decrease of apurinic/apyrimidinic endonuclease expression after transient focal cerebral ischemia in mice. J. Cereb. Blood Flow Metab. 19 (1999) 495-501
6. Izumi T., Brown D.B., Naidu C.V., Bhakat K.K., Macinnes M.A., Saito H., Chen D.J., and Mitra S. Two essential but distinct functions of the mammalian abasic endonuclease. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 5739-5743
7. Kaneto H., Nakatani Y., Miyatsuka T., Kawamori D., Matsuoka T.A., Matsuhisa M., Kajimoto Y., Ichijo H., Yamasaki Y., and Hori M. Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide. Nat. Med. 10 (2004) 1128-1132
8. Kawase M., Fujimura M., Morita-Fujimura Y., and Chan P.H. Reduction of apurinic/apyrimidinic endonuclease expression after transient global cerebral ischemia in rats: implication of the failure of DNA repair in neuronal apoptosis. Stroke 30 (1999) 441-448 discussion 449
9. Kilic U., Kilic E., Dietz G.P., and Bahr M. Intravenous TAT-GDNF is protective after focal cerebral ischemia in mice. Stroke 34 (2003) 1304-1310
10. Kim G.W., Kondo T., Noshita N., and Chan P.H. Manganese superoxide dismutase deficiency exacerbates cerebral infarction after focal cerebral ischemia/reperfusion in mice: implications for the production and role of superoxide radicals. Stroke 33 (2002) 809-815
11. Kim G.W., Noshita N., Sugawara T., and Chan P.H. Early decrease in DNA repair proteins, Ku70 and Ku86, and subsequent DNA fragmentation after transient focal cerebral ischemia in mice. Stroke 32 (2001) 1401-1407
12. Lee B.I., Chan P.H., and Kim G.W. Metalloporphyrin-based superoxide dismutase mimic attenuates the nuclear translocation of apoptosis-inducing factor and the subsequent DNA fragmentation after permanent focal cerebral ischemia in mice. Stroke 36 (2005) 2712-2717
13. Seki S., Ikeda S., Watanabe S., Hatsushika M., Tsutsui K., Akiyama K., and Zhang B. A mouse DNA repair enzyme (APEX nuclease) having exonuclease and apurinic/apyrimidinic endonuclease activities: purification and characterization. Biochim. Biophys. Acta 1079 (1991) 57-64
14. Tsuchiya D., Hong S., Kayama T., Panter S.S., and Weinstein P.R. Effect of suture size and carotid clip application upon blood flow and infarct volume after permanent and temporary middle cerebral artery occlusion in mice. Brain Res. 970 (2003) 131-139
15. Walton M., Lawlor P., Sirimanne E., Williams C., Gluckman P., and Dragunow M. Loss of Ref-1 protein expression precedes DNA fragmentation in apoptotic neurons. Brain Res. Mol. Brain Res. 44 (1997) 167-170
16. Zhu C., Wang X., Hagberg H., and Blomgren K. Correlation between caspase-3 activation and three different markers of DNA damage in neonatal cerebral hypoxia-ischemia. J. Neurochem. 75 (2000) 819-829