Interaction kinetic and structural dynamic analysis of ligand binding to acetylcholine-binding protein

Biochemistry

Volumn 49, Issue 37, 2010, Pages 8143-8154

  Geitmann, Matthis ^a   Retra, Kim ^b   De Kloe, Gerdien E ^b   Homan, Evert ^a   Smit, August B ^b   De Esch, Iwan J P ^b   Danielson, U Helena ^a,c  

^a Beactica   (Sweden)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; BIOSENSORS; COMPUTER SIMULATION; DYNAMIC ANALYSIS; DYNAMICS; STRUCTURAL DYNAMICS;

ACETYLCHOLINE-BINDING PROTEINS; AS-LIGANDS; CONFORMATIONAL CHANGE; DIRECT INTERACTIONS; ENCOUNTER COMPLEX; EPIBATIDINE; EXPERIMENTAL CONDITIONS; FUNCTIONAL CHARACTERISTICS; GATING MECHANISMS; INDUCED FIT; INTERACTION KINETICS; LIGAND BINDING; LIGAND-GATED ION CHANNELS; LYMNAEA STAGNALIS; MECHANISTIC MODELS; MODEL PROTEINS; QUINUCLIDINES; SMALL MOLECULES; STRUCTURAL INTERPRETATION;

LIGANDS;

ACETYLCHOLINE; ACETYLCHOLINE BINDING PROTEIN; CYSTEINE; CYSTEINE LOOP LIGAND GATED ION CHANNEL; EPIBATIDINE; NICOTINE; QUINUCLIDINE; UNCLASSIFIED DRUG; CARRIER PROTEIN; LIGAND; PROTEIN;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIGAND BINDING; LYMNAEA; NEUROTRANSMISSION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; ANIMAL; BIOPHYSICS; CHEMISTRY; METABOLISM; PHYSIOLOGY; SYNAPTIC TRANSMISSION;

LYMNAEA STAGNALIS;

ACETYLCHOLINE; ANIMALS; BIOPHYSICAL PROCESSES; CARRIER PROTEINS; LIGANDS; LYMNAEA; NICOTINE; PROTEINS; SYNAPTIC TRANSMISSION;

EID: 77956592818     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1006354     Document Type: Article

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