RNA oxidation: A contributing factor or an epiphenomenon in the process of neurodegeneration

Free Radical Research

Volumn 42, Issue 9, 2008, Pages 773-777

  Kong, Qiongman ^a   Shan, Xiu ^a   Chang, Yueming ^a   Tashiro, Hirofumi ^a   Lin, Chien Liang Glenn ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

ALS; Alzheimer's disease; Neurodegeneration; Oxidative damage; Oxidative stress; RNA oxidation

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; MESSENGER RNA; MICRORNA; RIBOSOME RNA; TRANSFER RNA;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; DEGENERATIVE DISEASE; EPILEPSY; HUMAN; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RNA TRANSLATION; SPINAL CORD INJURY;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; HUMANS; MICE; NEURODEGENERATIVE DISEASES; OXIDANTS; OXIDATIVE STRESS; OXYGEN; RATS; REACTIVE OXYGEN SPECIES; RNA; RNA, MESSENGER; RNA, RIBOSOMAL;

EID: 57349196835     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.1080/10715760802311187     Document Type: Article

References (36)

1. Lin, MT and Beal, MF. (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature, 443, pp. 787-795.
2. Juurlink, BH and Paterson, PG. (1998) Review of oxidative stress in brain and spinal cord injury: Suggestions for pharmacological and nutritional management strategies. J Spinal Cord Med, 21, pp. 309-334.
3. Patel, M. (2004) Mitochondrial dysfunction and oxidative stress: Cause and consequence of epileptic seizures. Free Radic Biol Med, 37, pp. 1951-1962.
4. Fiala, ES, Conaway, CC and Mathis, JE. (1989) Oxidative DNA and RNA damage in the livers of Sprague- Dawley rats treated with the hepatocarcinogen 2-nitropropane. Cancer Res, 49, pp. 5518-5522.
5. Wamer, WG, Yin, JJ and Wei, RR. (1997) Oxidative damage to nucleic acids photosensitized by titanium dioxide. Free Radic Biol Med, 23, pp. 851-858.
6. Nunomura, A., Perry, G., Pappolla, MA, Wade, R., Hirai, K., Chiba, S. and Smith, MA. (1999) RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. J Neurosci, 19, pp. 1959-1964.
7. Zhang, J., Perry, G., Smith, MA, Robertson, D., Olson, SJ, Graham, DG and Montine, TJ. (1999) Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons. Am J Pathol, 154, pp. 1423-1429.
8. Nunomura, A., Perry, G., Pappolla, MA, Friedland, RP, Hirai, K., Chiba, S. and Smith, MA. (2000) Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome. J Neuropathol Exp Neurol, 59, pp. 1011-1017.
9. Nunomura, A., Chiba, S., Kosaka, K., Takeda, A., Castellani, RJ, Smith, MA and Perry, G. (2002) Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies. Neuroreport, 13, pp. 2035-2039.
10. Guentchev, M., Siedlak, SL, Jarius, C., Tagliavini, F., Castellani, RJ, Perry, G., Smith, MA and Budka, H. (2002) Oxidative damage to nucleic acids in human prion disease. Neurobiol Dis, 9, pp. 275-281.
11. Petersen, RB, Siedlak, SL, Lee, HG, Kim, YS, Nunomura, A., Tagliavini, F., Ghetti, B., Cras, P., Moreira, PI, Castellani, RJ, Guentchev, M., Budka, H., Ironside, JW, Gambetti, P., Smith, MA and Perry, G. (2005) Redox metals and oxidative abnormalities in human prion diseases. Acta Neuropathol (Berl), 110, pp. 232-238.
12. Hayashi, M., Arai, N., Satoh, J., Suzuki, H., Katayama, K., Tamagawa, K. and Morimatsu, Y. (2002) Neurodegenerative mechanisms in subacute sclerosing panencephalitis. J Child Neurol, 17, pp. 725-730.
13. Hayashi, M., Araki, S., Kohyama, J., Shioda, K. and Fukatsu, R. (2005) Oxidative nucleotide damage and superoxide dismutase expression in the brains of xeroderma pigmentosum group A and Cockayne syndrome. Brain Dev, 27, pp. 34-38.
14. Lin, CL, Chang, Y., Shan, X., Lai, L. and Tian, G. (2007) Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS. Soc Neurosci Abstr, 489, p. 17.
15. Abe, T., Tohgi, H., Isobe, C., Murata, T. and Sato, C. (2002) Remarkable increase in the concentration of 8- hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease. J Neurosci Res, 70, pp. 447-450.
16. Abe, T., Isobe, C., Murata, T., Sato, C. and Tohgi, H. (2003) Alteration of 8-hydroxyguanosine concentrations in the cerebrospinal fluid and serum from patients with Parkinson's disease. Neurosci Lett, 336, pp. 105-108.
17. Nunomura, A., Perry, G., Aliev, G., Hirai, K., Takeda, A., Balraj, EK, Jones, PK, Ghanbari, H., Wataya, T., Shimohama, S., Chiba, S., Atwood, CS, Petersen, RB and Smith, MA. (2001) Oxidative damage is the earliest event in Alzheimer disease. J Neuropathol Exp Neurol, 60, pp. 759-767.
18. Nunomura, A., Chiba, S., Lippa, CF, Cras, P., Kalaria, RN, Takeda, A., Honda, K., Smith, MA and Perry, G. (2004) Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease. Neurobiol Dis, 17, pp. 108-113.
19. Ding, Q., Markesbery, WR, Chen, Q., Li, F. and Keller, JN. (2005) Ribosome dysfunction is an early event in Alzheimer's disease. J Neurosci, 25, pp. 9171-9175.
20. Shan, X., Chang, Y. and Lin, CL. (2007) Messenger RNA oxidation is an early event preceding cell death and causes reduced protein expression. FASEB J, 21, pp. 2753-2764.
21. Shan, X., Tashiro, H. and Lin, CL. (2003) The identification and characterization of oxidized RNAs in Alzheimer's disease. J Neurosci, 23, pp. 4913-4921.
22. Shan, X. and Lin, CL. (2006) Quantification of oxidized RNAs in Alzheimer's disease. Neurobiol Aging, 27, pp. 657-662.
23. Cao, X., Yeo, G., Muotri, AR, Kuwabara, T. and Gage, FH. (2006) Noncoding RNAs in the mammalian central nervous system. Annu Rev Neurosci, 29, pp. 77-103.
24. Honda, K., Smith, MA, Zhu, X., Baus, D., Merrick, WC, Tartakoff, AM, Hattier, T., Harris, PL, Siedlak, SL, Fujioka, H., Liu, Q., Moreira, PI, Miller, FP, Nunomura, A., Shimohama, S. and Perry, G. (2005) Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron. J Biol Chem, 280, pp. 20978-20986.
25. Gajewski, E., Rao, G., Nackerdien, Z. and Dizdaroglu, M. (1990) Modification of DNA bases in mammalian chromatin by radiation-generated free radicals. Biochemistry, 29, pp. 7876-7882.
26. Demple, B. and Harrison, L. (1994) Repair of oxidative damage to DNA: enzymology and biology. Annu Rev Biochem, 63, pp. 915-948.
27. Yanagawa, H., Ogawa, Y. and Ueno, M. (1992) Redox ribonucleosides. Isolation and characterization of 5- hydroxyuridine, 8-hydroxyguanosine, and 8-hydroxyadenosine from Torula yeast RNA. J Biol Chem, 267, pp. 13320-13326.
28. Tanaka, M., Chock, PB and Stadtman, ER. (2007) Oxidized messenger RNA induces translation errors. Proc Natl Acad Sci USA, 104, pp. 66-71.
29. Ding, Q., Martin, S., Dimayuga, E., Bruce-Keller, AJ and Keller, JN. (2006) LMP2 knock-out mice have reduced proteasome activities and increased levels of oxidatively damaged proteins. Antioxid Redox Signal, 8, pp. 130-135.
30. Ding, Q., Dimayuga, E. and Keller, JN. (2007) Oxidative stress alters neuronal RNA- and protein-synthesis: Implications for neural viability. Free Radic Res, 41, pp. 903-910.
31. Ishibashi, T., Hayakawa, H., Ito, R., Miyazawa, M., Yamagata, Y. and Sekiguchi, M. (2005) Mammalian enzymes for preventing transcriptional errors caused by oxidative damage. Nucleic Acids Res, 33, pp. 3779-3784.
32. Taddei, F., Hayakawa, H., Bouton, M., Cirinesi, A., Matic, I., Sekiguchi, M. and Radman, M. (1997) Counteraction by MutT protein of transcriptional errors caused by oxidative damage. Science, 278, pp. 128-130.
33. Hayakawa, H., Kuwano, M. and Sekiguchi, M. (2001) Specific binding of 8-oxoguanine-containing RNA to polynucleotide phosphorylase protein. Biochemistry, 40, pp. 9977-9982.
34. Hayakawa, H., Uchiumi, T., Fukuda, T., Ashizuka, M., Kohno, K., Kuwano, M. and Sekiguchi, M. (2002) Binding capacity of human YB-1 protein for RNA containing 8-oxoguanine. Biochemistry, 41, pp. 12739-12744.
35. Aas, PA, Otterlei, M., Falnes, PO, Vägbø, CB, Skorpen, F., Akbari, M., Sundheim, O., Bjørås, M., Slupphaug, G., Seeberg, E. and Krokan, HE. (2003) Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature, 421, pp. 859-863.
36. Bellacosa, A. and Moss, EG. (2003) RNA repair: Damage control. Curr Biol, 13, pp. R482-R484.