Oxidative DNA damage contributes to the toxic activity of propylparaben in mammalian cells

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 702, Issue 1, 2010, Pages 86-91

  Martín, José Manuel Pérez ^a   Peropadre, Ana ^a   Herrero, Óscar ^a   Freire, Paloma Fernández ^a   Labrador, Verónica ^a   Hazen, María José ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Cell cycle arrest; Cytotoxicity; DNA damage; Oxidative stress; Propylparaben

Indexed keywords

DOUBLE STRANDED DNA; PROPYL PARABEN;

ANIMAL CELL; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA STRAND BREAKAGE; DRUG SAFETY; GENOTOXICITY; IMMUNODETECTION; MITOSIS; NONHUMAN; OXIDATION; PRIORITY JOURNAL; VERO CELL;

ANIMALS; CELL CYCLE; CELL PROLIFERATION; CERCOPITHECUS AETHIOPS; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; FOOD PRESERVATIVES; MITOTIC INDEX; OXIDATIVE STRESS; PARABENS; PRESERVATIVES, PHARMACEUTICAL; VERO CELLS;

CERCOPITHECUS AETHIOPS; MAMMALIA;

EID: 77956445163     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2010.07.012     Document Type: Article

References (54)

1. Soni M., Carabin I., Burdock G. Safety assessment of esters of p-hydroxybenzoic acid (parabens). Food. Chem. Toxicol. 2005, 43:985-1015.
2. Canosa P., Rodríguez I., Rubí E., Bollaín M., Cela R. Optimisation of a solid-phase microextraction method for the determination of parabens in water samples at the low ng per litre level. J. Chromatogr. A 2006, 1124:3-10.
3. Lee H., Peart T., Svoboda M. Determination of endocrine-disrupting phenols, acidic pharmaceuticals, and personal-care products in sewage by solid-phase extraction and gas chromatography-mass spectrometry. J. Chromatogr. A 2005, 1094:122-129.
4. Benijts T., Lambert W., De Leenheer A. Analysis of multiple endocrine disruptors in environmental waters via wide-spectrum solid-phase extraction and dual-polarity ionization LC-ion trap-MS/MS. Anal. Chem. 2004, 76:704-711.
5. Kasprzyk-Hordern B., Dinsdale R.M., Guwy A.J. The occurrence of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs in surface water in South Wales, UK. Water Res. 2008, 42:3498-3518.
6. Canosa P., Rodriguez I., Rubi E., Cela R. Determination of Parabens and Triclosan in indoor dust using matrix solid-phase dispersion and gas chromatography with tandem mass spectrometry. Anal. Chem. 2007, 79:1675-1681.
7. Makino T. Female reproductive tract and mammary disorders caused by endocrine disruptor. Jpn. Med. Assoc. J. 2003, 46:93-96.
8. Ye X., Kuklenyik Z., Bishop A., Needham L., Calafat A. Quantification of the urinary concentrations of parabens in humans by on-line solid phase extraction-high performance liquid chromatography-isotope dilution tandem mass spectrometry. J. Chromatogr. B 2006, 844:53-59.
9. Darbre P., Aljarrah A., Miller W., Coldham N., Sauer M., Pope G. Concentrations of parabens in human breast tumours. J. Appl. Toxicol. 2004, 24:5-13.
10. Darbre P., Harvey P. Paraben esters: review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks, J. Appl. Toxicol. 2008, 28:561-578.
11. Soni M., Burdock G., Taylor S., Greenberg N. Safety assessment of propyl paraben: a review of the published literature. Food. Chem. Toxicol. 2001, 39:513-532.
12. JECFA Evaluation of certain food additives and contaminants. Sixty-seventh report of the joint FAO/WHO Expert committee on Food Additives, WHO Technical Report Series 940 2007.
13. Ukelis U., Kramer P.-J., Olejniczak K., Mueller S.O. Replacement of in vivo acute oral toxicity studies by in vitro cytotoxicity methods: Opportunities, limits and regulatory status, Regul. Toxicol. Pharmacol. 2008, 51:108-118.
14. Xu J., Ma M., Purcell W.M. Characterization of some cytotoxic endpoints using rat liver and HepG2 spheroids as in vitro models and their application in hepatotoxicity studies. I. Glucose metabolism and enzyme release as cytotoxic markers. Toxicol. Appl. Pharmacol. 2003, 189:100-111.
15. Bhogal N., Grindon C., Combes R., Balls M. Toxicity testing: creating a revolution based on new technologies. Trends Biotechnol. 2005, 23:299-307.
16. Fotakis G., Timbrell J.A. In vitro cytotoxicity assays: Comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride. Toxicol. Lett. 2006, 160:171-177.
17. Fernández Freire P., Peropadre A., Pérez Martín J.M., Herrero O., Hazen M.J. An integrated cellular model to evaluate cytotoxic effects in mammalian cell lines. Toxicol. In vitro 2009, 23:1553-1558.
18. Borenfreund E., Puerner J. Toxicity determined in vitro by morphological alterations and neutral red absorption. Toxicol. Lett. 1985, 24:119-124.
19. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65:55-63.
20. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
21. Yarborough A., Zhang Y.-J., Hsu T.-M., Santella R.M. Immunoperoxidase detection of 8-hydroxydeoxyguanosine in aflatoxin B1-treated rat liver and human oral mucosal cells. Cancer Res. 1996, 56:683-688.
22. Nakagawa Y., Moldéus P. Mechanisms of p-hydroxybenzoate ester-induced mitochondrial dysfunction and cytotoxicity in isolated rat hepatocytes. Biochem. Pharmacol. 1998, 55:1907-1914.
23. Nakagawa Y., Moore G. Role of mitochondrial membrane permeability transition in p-hydroxybenzoate ester-induced cytotoxicity in rat hepatocytes. Biochem. Pharmacol. 1999, 58:811-816.
24. Panicker L. Effect of propyl paraben on the dipalmitoyl phosphatidic acid vesicles. J. Colloid Interface Sci. 2007, 311:407-416.
25. Panicker L. Interaction of propyl paraben with dipalmitoyl phosphatidylcholine bilayer: A differential scanning calorimetry and nuclear magnetic resonance study. Colloids Surf. B Biointerf. 2008, 61:145-152.
26. Shackelford R., Kaufmann W., Paules R. Cell cycle control, checkpoint mechanisms, and genotoxic stress, Environ. Health Perspect. 1999, 107:5-24.
27. Houtgraaf J., Versmissen J., van der Giessen W. A concise review of DNA damage checkpoints and repair in mammalian cells. Cardiovasc. Revasc. Med. 2006, 7:165-172.
28. Abraham R. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 2001, 15:2177-2196.
29. Rich T., Allen R.L., Wyllie A.H. Defying death after DNA damage. Nature 2000, 407:777-783.
30. Rouse J., Jackson S.P. Interfaces between the detection, signaling, and repair of DNA damage. Science 2002, 297:547-551.
31. Zhou B.S., Elledge S.J. The DNA damage response: putting checkpoints in perspective. Nature 2000, 408:433-439.
32. Downs J.A., Allard S., Jobin-Robitaille O., Javaheri A., Auger A., Bouchard N., Kron S.J., Jackson S.P., Côté J. Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites. Mol. Cell 2004, 16:979-990.
33. Shroff R., Arbel-Eden A., Pilch D., Ira G., Bonner W.M., Petrini J.H., Haber J.E., Lichten M. Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break. Curr. Biol. 2004, 14:1703-1711.
34. Ünal E., Arbel-Eden A., Sattler U., Shroff R., Lichten M., Haber J.E., Koshland D. DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain. Mol. Cell 2004, 16:991-1002.
35. D.C. van Gent, J.H.J. Hoeijmakers, R. Kanaar, Chromosomal stability and the DNA double-stranded break connection, 2 (2001) 196-206.
36. Tayama S., Nakagawa Y., Tayama K. Genotoxic effects of environmental estrogen-like compounds in CHO-K1 cells. Mutat. Res. 2008, 649:114-125.
37. Kulkarni A., Das K. Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation. Am. J. Physiol. Lung Cell. Mol. Physiol. 2008, 294:998-1006.
38. Tanaka T., Halicka H., Huang X., Traganos F., Darzynkiewicz Z. Constitutive histone H2AX phosphorylation and ATM activation, the reporters of damage by endogenous oxidants. Cell Cycle 2006, 5:1940-1945.
39. Kasai H. Analysis of a form of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis. Mutat. Res. 1997, 387:147-163.
40. Valavanidis A., Vlachogianni T., Fiotakis C. 8-hydroxy-2ó-deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis. J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev. 2009, 27:120-139.
41. Nishizawa C., Takeshita K., Ueda J., Nakanishi I., Suzuki K., Ozawa T. Reaction of para-hydroxybenzoic acid esters with singlet oxygen in the presence of glutathione produces glutathione conjugates of hydroquinone, potent inducers of oxidative stress. Free Radic. Res. 2006, 40:233-240.
42. Handa O., Kokura S., Adachi S., Takagi T., Naito Y., Tanigawa T., Yoshida N., Yoshikawa T. Methylparaben potentiates UV-induced damage of skin keratinocytes. Toxicology 2006, 227:62-72.
43. Asnani V., Verma R. Aqueous ginger extract ameliorates paraben induced cytotoxicity. Acta Pol. Pharm. 2006, 63:117-119.
44. Asnani V., Verma R. Antioxidative effect of rhizome of Zinziber officinale on paraben induced lipid peroxidation: an in vitro study. Acta Pol. Pharm. 2007, 64:35-37.
45. Asnani V., Verma R. Ameliorative effects of ginger extract on paraben-induced lipid peroxidation in the liver of mice. Acta Pol. Pharm. 2009, 66:225-228.
46. M.D. Evans, M. Dizdaroglu, M.S. Cooke, Oxidative DNA damage and disease: induction, repair and significance, 567 (2004) 1-61.
47. M. Valko, C.J. Rhodes, J. Moncol, M. Izakovic, M. Mazur, Free radicals, metals and antioxidants in oxidative stress-induced cancer, 160 (2006) 1-40.
48. Bonner W.M., Redon C.E., Dickey J.S., Nakamura A.J., Sedelnikova O.A., Solier S., Pommier Y. γ-H2AX and cancer. Nat. Rev. Cancer 2008, 8:957-967.
49. Chowdhury D., Keogh M.-C., Ishii H., Peterson C.L., Buratowski S., Lieberman J. γ-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Mol. Cell 2005, 20:801-809.
50. Baure J., Izadi A., Suarez V., Giedzinski E., Cleaver J.E., Fike J.R., Limoli C.L. Histone H2AX phosphorylation in response to changes in chromatin structure induced by altered osmolarity. Mutagenesis 2009, 24:161-167.
51. Suzuki M., Suzuki K., Kodama S., Watanabe M. Phosphorylated histone H2AX foci persist on rejoined mitotic chromosomes in normal human diploid cells exposed to ionizing radiation. Radiat. Res. 2006, 165:269-276.
52. Cadet J., Delatour T., Douki T., Gasparutto D., Pouget J.P., Ravanat J.L., Sauvaigo S. Hydroxyl Radicals and DNA Base Damage 1999, vol. 424. pp. 9-21.
53. Cooke M.S., Evans M.D., Dizdaroglu M., Lunec J. Oxidative DNA Damage: Mechanisms, Mutation, And Disease 2003, vol. 17. pp. 1195-1214.
54. Manderville R. Ambident reactivity of phenoxyl radicals in DNA adduction. Can. J. Chem. 2005, 83:1261-1267.