Mechanism of potentiation of a dysfunctional epilepsy-linked mutated GABAA receptor by a neurosteroid (3α, 21-Dihydroxy-5α- pregnan-20-one): Transient kinetic investigations

Biochemistry

Volumn 49, Issue 36, 2010, Pages 7892-7901

  Ramakrishnan, Latha ^a,b   Hess, George P ^a  

^a Department of Obstetrics Gynecology   (United States)

^b ST CLOUD STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; EQUILIBRIUM CONSTANTS; PHOTOLYSIS; PULSED LASER APPLICATIONS;

CELL CURRENT; CHANNEL CLOSING; CHANNEL OPENING; HEK293 CELLS; RAPID REACTIONS; TRANSIENT KINETICS; WILD TYPES;

RATE CONSTANTS;

3ALPHA, 21 DIHYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; NEUROSTEROID; UNCLASSIFIED DRUG; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; DEOXYCORTICOSTERONE; TETRAHYDRODEOXYCORTICOSTERONE;

ARTICLE; CHANNEL GATING; EPILEPSY; GENE MUTATION; MOLECULAR DYNAMICS; PRIORITY JOURNAL; ANALOGS AND DERIVATIVES; CELL CULTURE; CHEMISTRY; GENETIC TRANSFECTION; GENETICS; HUMAN; KINETICS; METABOLISM; MUTATION; PHOTOLYSIS;

CELLS, CULTURED; DESOXYCORTICOSTERONE; EPILEPSY; HUMANS; KINETICS; MUTATION; NEUROTRANSMITTER AGENTS; PHOTOLYSIS; RECEPTORS, GABA-A; TRANSFECTION;

EID: 77956412566     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi901241g     Document Type: Article

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