Mechanism-based discovery of small molecules that prevent noncompetitive inhibition by cocaine and MK-801 mediated by two different sites on the nicotinic acetylcholine receptor

Biochemistry

Volumn 43, Issue 31, 2004, Pages 10149-10156

  Chen, Yongli ^a   Banerjee, Anamitro ^a,b   Hess, George P ^a  

^a Department of Obstetrics Gynecology   (United States)

^b UNIVERSITY OF NORTH DAKOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELL MEMBRANES; DRUG DOSAGE; NEUROLOGY; ORGANIC COMPOUNDS; PROTEINS;

CELL CURRENT; COCAINE; ORGANIC MOLECULES; THEREPEUTIC AGENTS;

REACTION KINETICS;

CARBACHOL; COCAINE; DIZOCILPINE; ECGONINE; MEMBRANE PROTEIN; NICOTINIC RECEPTOR;

ANIMAL CELL; ARTICLE; FETUS; INHIBITION KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BINDING, COMPETITIVE; CELL LINE; COCAINE; DIZOCILPINE MALEATE; KINETICS; NEURAL INHIBITION; NICOTINIC ANTAGONISTS; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; RECEPTORS, NICOTINIC;

ANIMALIA; MAMMALIA;

EID: 3543144801     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi049590u     Document Type: Article

References (33)

1. Kandel, E. R., Schwartz, J. H., and Jessell, T. M. (2000) Principles of Neural Science, 4th ed., McGraw-Hill, New York.
2. Edmonds, B., Gibb, A. J., and Colquhoun, D. (1995) Mechanisms of activation of muscle nicotinic acetylcholine receptors and the time course of endplate currents, Annu. Rev. Physiol. 57, 469-493.
3. Crick, F. H. C. (1994) The Astonishing Hypothesis. The Scientific Search for the Soul, Macmillan, New York.
4. Amador, M., and Dani, J. A. (1991) MK-801 inhibition of nicotinic acetylcholine receptor channels, Synapse 7, 207-215.
5. Nishimura, M., Sato, K., Okada, T., Schloss, P., Shimada, S., and Tohyama, M. (1998) MK-801 blocks monoamine transporters expressed in HEK cells, FEBS Lett. 423, 376-380.
6. Kuhar, M. J., Ritz, M. C., and Boja, J. W. (1991) The dopamine hypothesis of the reinforcing properties of cocaine, Trends Neurosci. 14, 299-302.
7. Neher, E., and Steinbach, J. H. (1978) Local anaesthetics transiently block currents through single acetylcholine-receptor channels, J. Physiol. 277, 153-176.
8. Arias, H. R., Kem, W. R., Trudell, J. R., and Blanton, M. P. (2003) Unique general anesthetic binding sites within distinct conformational states of the nicotinic acetylcholine receptor, Int. Rev. Neurobiol. 54, 1-50.
9. Carroll, F. I., Howell, L. L., and Kuhar, M. J. (1999) Pharmacotherapies for treatment of cocaine abuse: Preclinical aspects, J. Med. Chem. 42, 2721-2736.
10. Schubert, D., Harris, A. J., Devine, E. E., and Heinemann, S. (1974) Characterization of a unique muscle cell line, J. Cell. Biol. 61, 398-413.
11. Rockhold, R. W., Surrett, R. S., Acuff, C. G., Zhang, T., and Hoskins, B., Ho, I. K. (1992) Antagonism of the toxicity of cocaine by MK-801: Differential effects in spontaneously hypertensive and Wistar-Kyoto rats, Neuropharmacology 31, 1269-1277.
12. Karler, R., Calder, L. D., Chaudhry, I. A., and Turkanis, S. A. (1989) Blockade of "reverse tolerance" to cocaine and amphetamine by MK-801, Life Sci. 45, 599-606.
13. Lathers, C. M., Tyau, L. S., Spino, M. M., and Agarwal, L. (1988) Cocaine-induced seizures, arrhythmias, and sudden death, J. Clin. Pharmacol. 28, 584-593.
14. Udgaonkar, J. B., and Hess, G. P. (1987) Chemical kinetic measurements of a mammalian acetylcholine receptor by a fast-reaction technique, Proc. Natl. Acad. Sci. U.S.A. 84, 8758-8762.
15. Milburn, T., Matsubara, N., Billington, A. P., Udgaonkar, J. B., Walker, J. W., Carpenter, B. K., Webb, W. W., Marque, J., Denk, W., McCray, J. A., and Hess, G. P. (1989) Synthesis, photochemistry, and biological activity of a caged photolabile acetylcholine receptor ligand, Biochemistry 28, 49-55.
16. Hess, G. P., and Grewer, C. (1998) Development and application of caged ligands for neurotransmitter receptors in transient kinetic and neuronal circuit mapping studies, Methods Enzymol. 291, 443-473.
17. Grewer, C., and Hess, G. P. (1999) On the mechanism of inhibition of the nicotinic acetylcholine receptor by the anticonvulsant MK-801 investigated by laser-pulse photolysis in the microsecond-to-millisecond time region, Biochemistry 38, 7837-7846.
18. Ulrich, H., Ippolito, J. E., Pagan, O. R., Eterovic, V. A., Hann, R. M., Shi, H., Lis, J. T., Eldefrawi, M. E., and Hess, G. P. (1998) In vitro selection of RNA molecules that displace cocaine from the membrane-bound nicotinic acetylcholine receptor, Proc. Natl. Acad. Sci. U.S.A. 95, 14051-14056.
19. Hess, G. P., Ulrich, H., Breitinger, H., Niu, L., Gameiro, A., Grewer, C., Ippolito, J. E., Lee, S., Jayaraman, V., Srivastava, S., and Coombs, S. E. (2000) Mechanism-based discovery of ligands that counteract inhibition of the nicotinic acetylcholine receptor by cocaine and MK-801, Proc. Natl. Acad. Sci. U.S.A. 97, 13895-13900.
20. Szczwinska, K., Ferchmin, P. A., Hann, R. M., and Eterovic, V. A. (1992) Electric organ polyamines and their effects on the acetylcholine receptor, Cell. Mol. Neurobiol. 12, 95-106.
21. Jayaraman, V., Usherwood, P. N., and Hess, G. P. (1999) Inhibition of nicotinic acetylcholine receptor by philanthotoxin-343: Kinetic investigations in the microsecond time region using a laser-pulse photolysis technique, Biochemistry 38, 11406-11414.
22. 3H1 cells: Characterized by laser-pulse photolysis in the microsecond-to-millisecond time region, Biochemistry 32, 3831-3835.
23. Niu, L., Abood, L. G., and Hess, G. P. (1995) Cocaine: Mechanism of inhibition of a muscle acetylcholine receptor studied by a laser-pulse photolysis technique, Proc. Natl. Acad. Sci. U.S.A. 92, 12008-12012.
24. Hess, G. P., Gameiro, A. M., Schoenfeld, R. C., Chen, Y., Ulrich, H., Nye, J. A., Sit, B., Carroll, F. I., and Ganem, B. (2003) Reversing the action of non-competitive inhibitors (MK-801 and cocaine) on a protein (nicotinic acetylcholine receptor) mediated reaction, Biochemistry 42, 6106-6114.
25. Singh, S. (2000) Chemistry, design, and structure-activity relationship of cocaine antagonists, Chem. Rev. 100, 925-1024.
26. Carroll, F. I., Kotian, P., Dehghani, A., Gray, J. L., Kuzemko, M. A., Parham, K. A., Abraham, P., Lewin, A. H., Boja, J. W., and Kuhar, M. J. (1995) Cocaine and 3 β-(4′-substituted phenyl)-tropane-2 β carboxylic acid ester and amide analogues. New high-affinity and selective compounds for the dopamine transporter, J. Med. Chem. 38, 379-388.
27. Lerner-Marmarosh, N., Carroll, F. I., and Abood, L. G. (1995) Antagonism of nicotine's action by cocaine analogs, Life Sci. 56, PL67-PL70.
28. Krivoshein, A. V., and Hess, G. P. (2004) Mechanism-based approach to the successful prevention of cocaine inhibition of the neuronal (α3β4) nicotinic acetylcholine receptor, Biochemitry 43, 481-489.
29. Hamill, O. P., Marty, A., Neher, E., Sakmann, B., and Sigworth, F. J. (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches, Pfluegers Arch. 391, 85-100.
30. Krishtal, O. A., and Pidoplichko, V. I. (1980) A receptor for protons in the nerve cell membrane, Neuroscience 5, 2325-2327.
31. Niu, L., Grewer, C., and Hess, G. P. (1996) Chemical kinetic investigation of neurotransmitter receptor on a cell surface in the μs time region, Tech. Protein Chem. 7, 139-149.
32. Hess, G. P., Udgaonkar, J. B., and Olbricht, W. L. (1987) Chemical kinetic measurements of transmembrane processes using rapid reaction techniques: Acetylcholine receptor, Annu. Rev. Biophys. Biophys. Chem. 16, 506-534.
33. What America's users spend on illegal drugs, Office of National Drug Control Policy, Rockville, MD, website: www.whitehousedrugpolicy.gov.