Neuroactive steroids have multiple actions to potentiate GABAA receptors

Journal of Physiology

Volumn 558, Issue 1, 2004, Pages 59-74

  Akk, Gustav ^a   Bracamontes, John R ^a   Covey, Douglas F ^a   Evers, Alex ^a   Dao, Tim ^b   Steinbach, Joe Henry ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(3ALPHA, 5ALPHA, 17BETA) 3 HYDROXYANDROSTANE 17 CARBONITRILE; (3ALPHA, 5BETA, 17BETA) 3 HYDROXY 18 NORANDROSTANE 17 CARBONITRILE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; B 285; NEUROSTEROID; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG; (3ALPHA,5ALPHA,17BETA) 3 HYDROXYANDROSTANE 17 CARBONITRILE; (3ALPHA,5BETA,17BETA) HYDROXY 18 NORANDROSTANE 17 CARBONITRILE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA4; 4 AMINOBUTYRIC ACID A RECEPTOR BETA2; 4 AMINOBUTYRIC ACID A RECEPTOR GAMMA2; STEROID;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CELL LINE; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IC 50; INTRACELLULAR RECORDING; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; BINDING SITE; GABAERGIC SYSTEM; IC50; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; PROTEIN EXPRESSION; RECEPTOR BINDING; RECEPTOR OCCUPANCY; RECEPTOR UPREGULATION;

ANIMALS; CELL LINE; DRUG SYNERGISM; ESTRANES; GAMMA-AMINOBUTYRIC ACID; HUMANS; ION CHANNEL GATING; KIDNEY; MUTAGENESIS; NITRILES; NORANDROSTANES; RATS; RECEPTORS, GABA-A; STEROIDS;

EID: 4043104784     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2004.066571     Document Type: Article

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