In vivo relevance of two critical levels for NAD(P)H:quinone oxidoreductase (NQO1)-mediated cellular protection against electrophile toxicity found in vitro

Toxicology in Vitro

Volumn 20, Issue 5, 2006, Pages 594-600

  de Haan, Laura H J ^a   Pot, Gerda K ^a   Aarts, Jac M M J G ^a   Rietjens, Ivonne M C M ^a   Alink, Gerrit M ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Cytotoxicity; Menadione; NQO1; Threshold levels

Indexed keywords

2,6 DICHLOROPHENOL; 3 INDOLEMETHANOL; GUAIACOL; MENADIONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE);

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CHEMICAL MODIFICATION; COLON; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME MECHANISM; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; KIDNEY; LIVER; LUNG; MOUSE; NONHUMAN; SMALL INTESTINE; TISSUE LEVEL;

ANIMALS; CELL LINE; CHO CELLS; CRICETINAE; CYTOPROTECTION; FEMALE; HUMANS; MICE; NAD(P)H DEHYDROGENASE (QUINONE); NADPH DEHYDROGENASE; VITAMIN K 3;

EID: 33744546476     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2005.10.005     Document Type: Article

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