Overexpression of the regulatory subunit of γ-glutamylcysteine synthetase in HeLa cells increases γ-glutamylcysteine synthetase activity and confers drug resistance

Biochemical Journal

Volumn 337, Issue 2-3, 1999, Pages 559-566

  Tipnis, Sarah R ^a   Blake, David G ^a   Shepherd, A Graeme ^a   McLellan, Lesley I ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Cadmium chloride; Cisplatin; Doxorubicin; Glutathione; Melphalan

Indexed keywords

ANTINEOPLASTIC AGENT; CADMIUM CHLORIDE; CISPLATIN; COMPLEMENTARY DNA; DOXORUBICIN; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; MALEIC ACID DIETHYL ESTER; MELPHALAN;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL STRAIN COS1; CONTROLLED STUDY; DRUG RESISTANCE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBUNIT; GENETIC TRANSFECTION; GLUTATHIONE METABOLISM; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTINEOPLASTIC AGENTS; CADMIUM CHLORIDE; CARCINOGENS; CELL LINE; CELL SURVIVAL; COS CELLS; DNA, COMPLEMENTARY; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HELA CELLS; HUMANS; MALEATES; RECOMBINANT PROTEINS;

ANIMALIA;

EID: 0033082845     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/bj3370559     Document Type: Article

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