-
2
-
-
34547951375
-
MicroRNAs repress translation of m7Gppp-capped target mRNAs in vitro by inhibiting initiation and promoting deadenylation
-
Standart N, Jackson RJ: MicroRNAs repress translation of m7Gppp-capped target mRNAs in vitro by inhibiting initiation and promoting deadenylation. Genes Dev 2007, 21:1975-1982.
-
(2007)
Genes Dev
, vol.21
, pp. 1975-1982
-
-
Standart, N.1
Jackson, R.J.2
-
3
-
-
4644309196
-
The functions of animal microRNAs
-
Ambros V: The functions of animal microRNAs. Nature 2004, 431:350-355.
-
(2004)
Nature
, vol.431
, pp. 350-355
-
-
Ambros, V.1
-
4
-
-
0030671503
-
Myosin heavy chain gene expression in human heart failure
-
Nakao K, Minobe W, Roden R, et al.: Myosin heavy chain gene expression in human heart failure. J Clin Invest 1997, 100:2362-2370.
-
(1997)
J Clin Invest
, vol.100
, pp. 2362-2370
-
-
Nakao, K.1
Minobe, W.2
Roden, R.3
-
5
-
-
34247589595
-
Control of stressdependent cardiac growth and gene expression by a microRNA
-
This landmark paper describes a role for miR-208, embedded within one of the MHC genes, in counterregulation of the two MHC genes. This established a mechanism relating the genetic locus of a miR to its primary function
-
van Rooij E, Sutherland LB, Qi X, et al.: Control of stressdependent cardiac growth and gene expression by a microRNA. Science 2007, 316:575-579. This landmark paper describes a role for miR-208, embedded within one of the MHC genes, in counterregulation of the two MHC genes. This established a mechanism relating the genetic locus of a miR to its primary function.
-
(2007)
Science
, vol.316
, pp. 575-579
-
-
Van Rooij, E.1
Sutherland, L.B.2
Qi, X.3
-
6
-
-
70349202176
-
MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice
-
Callis TE, Pandya K, Seok HY, et al.: MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. J Clin Invest 2009, 119:2772-2786.
-
(2009)
J Clin Invest
, vol.119
, pp. 2772-2786
-
-
Callis, T.E.1
Pandya, K.2
Seok, H.Y.3
-
7
-
-
0026349336
-
Regulation of cardiac gene expression during myocardial growth and hypertrophy: Molecular studies of an adaptive physiologic response
-
Chien KR, Knowlton KU, Zhu H, Chien S: Regulation of cardiac gene expression during myocardial growth and hypertrophy: Molecular studies of an adaptive physiologic response. FASEB J 1991, 5:3037-3046.
-
(1991)
FASEB J
, vol.5
, pp. 3037-3046
-
-
Chien, K.R.1
Knowlton, K.U.2
Zhu, H.3
Chien, S.4
-
8
-
-
49149084567
-
Transcriptomic biomarkers for individual risk assessment in new-onset heart failure
-
Heidecker B, Kasper EK, Wittstein IS, et al.: Transcriptomic biomarkers for individual risk assessment in new-onset heart failure. Circulation 2008, 118:238-246.
-
(2008)
Circulation
, vol.118
, pp. 238-246
-
-
Heidecker, B.1
Kasper, E.K.2
Wittstein, I.S.3
-
9
-
-
65349121886
-
Genomics, transcriptional profiling, and heart failure
-
Margulies KB, Bednarik DP, Dries DL: Genomics, transcriptional profiling, and heart failure. J Am Coll Cardiol 2009, 53:1752-1759.
-
(2009)
J Am Coll Cardiol
, vol.53
, pp. 1752-1759
-
-
Margulies, K.B.1
Bednarik, D.P.2
Dries, D.L.3
-
10
-
-
49149127971
-
Put your chips on transcriptomics
-
Dorn GW 2nd, Matkovich SJ: Put your chips on transcriptomics. Circulation 2008, 118:216-218.
-
(2008)
Circulation
, vol.118
, pp. 216-218
-
-
Dorn II, G.W.1
Matkovich, S.J.2
-
11
-
-
77954146850
-
MicroRNAs in cardiovascular disease: Putative novel therapeutic targets?
-
Jan 29 [Epub ahead of print]
-
Condorelli G, Latronico MVG, Dorn GW 2nd: MicroRNAs in cardiovascular disease: Putative novel therapeutic targets? Eur Heart J 2010 Jan 29 [Epub ahead of print].
-
(2010)
Eur Heart J
-
-
Condorelli, G.1
Latronico, M.V.G.2
Dorn II, G.W.3
-
12
-
-
33845317603
-
A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure
-
van Rooij E, Sutherland LB, Liu N, et al.: A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci U S A 2006, 103:18255-18260.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 18255-18260
-
-
Van Rooij, E.1
Sutherland, L.B.2
Liu, N.3
-
13
-
-
34547579291
-
MicroRNAs in the human heart: A clue to fetal gene reprogramming in heart failure
-
Thum T, Galuppo P, Wolf C, et al.: MicroRNAs in the human heart: A clue to fetal gene reprogramming in heart failure. Circulation 2007, 116:258-267.
-
(2007)
Circulation
, vol.116
, pp. 258-267
-
-
Thum, T.1
Galuppo, P.2
Wolf, C.3
-
14
-
-
36248948593
-
Altered microRNA expression in human heart disease
-
Ikeda S, Kong SW, Lu J, et al.: Altered microRNA expression in human heart disease. Physiol Genomics 2007, 31:367-373.
-
(2007)
Physiol Genomics
, vol.31
, pp. 367-373
-
-
Ikeda, S.1
Kong, S.W.2
Lu, J.3
-
15
-
-
48849095818
-
MiRNA expression in the failing human heart: Functional correlates
-
Sucharov C, Bristow MR, Port JD: MiRNA expression in the failing human heart: Functional correlates. J Mol Cell Cardiol 2008, 45:185-192.
-
(2008)
J Mol Cell Cardiol
, vol.45
, pp. 185-192
-
-
Sucharov, C.1
Bristow, M.R.2
Port, J.D.3
-
16
-
-
70350463883
-
Unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks
-
Naga Prasad SV, Duan ZH, Gupta MK, et al.: Unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks. J Biol Chem 2009, 284:27487-27499.
-
(2009)
J Biol Chem
, vol.284
, pp. 27487-27499
-
-
Naga Prasad, S.V.1
Duan, Z.H.2
Gupta, M.K.3
-
17
-
-
63649096271
-
Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support
-
This is the only study to date comparing mRNA and miR expression profiles in different stages of heart failure. It established greater sensitivity of the miR signature for clinical status
-
Matkovich SJ, Van Booven DJ, Youker KA, et al.: Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support. Circulation 2009, 119:1263-1271, This is the only study to date comparing mRNA and miR expression profiles in different stages of heart failure. It established greater sensitivity of the miR signature for clinical status.
-
(2009)
Circulation
, vol.119
, pp. 1263-1271
-
-
Matkovich, S.J.1
Van Booven, D.J.2
Youker, K.A.3
-
18
-
-
16244378559
-
Mixed messages: Transcription patterns in failing and recovering human myocardium
-
Margulies KB, Matiwala S, Cornejo C, et al.: Mixed messages: Transcription patterns in failing and recovering human myocardium. Circ Res 2005, 96:592-599.
-
(2005)
Circ Res
, vol.96
, pp. 592-599
-
-
Margulies, K.B.1
Matiwala, S.2
Cornejo, C.3
-
19
-
-
48749122914
-
Circulating micro- RNAs as stable blood-based markers for cancer detection
-
This paper established that circulating miRs are stable for extended periods of time in blood, and can be accurately measured in a manner that reflects their regulated expression in tissue. This important finding suggests that a blood test may provide the same miR expression signature information as myocardial biopsy
-
Mitchell PS, Parkin RK, Kroh EM, et al.: Circulating micro- RNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A 2008, 105:10513-10518, This paper established that circulating miRs are stable for extended periods of time in blood, and can be accurately measured in a manner that reflects their regulated expression in tissue. This important finding suggests that a blood test may provide the same miR expression signature information as myocardial biopsy.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 10513-10518
-
-
Mitchell, P.S.1
Parkin, R.K.2
Kroh, E.M.3
-
20
-
-
34249279050
-
MicroRNA-133 controls cardiac hypertrophy
-
Information in this paper indicates that synthetic miR agonists and antagonists (in the form of a complementary single strand sequence) can be useful to mimic or oppose specific miR effects in the in vivo heart
-
Care A, Catalucci D, Felicetti F, et al.: MicroRNA-133 controls cardiac hypertrophy. Nat Med 2007, 13:613-618, Information in this paper indicates that synthetic miR agonists and antagonists (in the form of a complementary single strand sequence) can be useful to mimic or oppose specific miR effects in the in vivo heart.
-
(2007)
Nat Med
, vol.13
, pp. 613-618
-
-
Care, A.1
Catalucci, D.2
Felicetti, F.3
-
21
-
-
57749121689
-
MicroRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart
-
Liu N, Bezprozvannaya S, Williams AH, et al.: MicroRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes Dev 2008, 22:3242-3254.
-
(2008)
Genes Dev
, vol.22
, pp. 3242-3254
-
-
Liu, N.1
Bezprozvannaya, S.2
Williams, A.H.3
-
22
-
-
0242266620
-
Dicer is essential for mouse development
-
Bernstein E, Kim SY, Carmell MA, et al.: Dicer is essential for mouse development. Nat Genet 2003, 35:215-217.
-
(2003)
Nat Genet
, vol.35
, pp. 215-217
-
-
Bernstein, E.1
Kim, S.Y.2
Carmell, M.A.3
-
23
-
-
41149147013
-
Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure
-
Chen JF, Murchison EP, Tang R, et al.: Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A 2008, 105:2111-2116.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 2111-2116
-
-
Chen, J.F.1
Murchison, E.P.2
Tang, R.3
-
24
-
-
55249125659
-
Conditional dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling
-
da Costa Martins PA, Bourajjaj M, Gladka M, et al.: Conditional dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling. Circulation 2008, 118:1567-1576.
-
(2008)
Circulation
, vol.118
, pp. 1567-1576
-
-
Da Costa Martins, P.A.1
Bourajjaj, M.2
Gladka, M.3
-
25
-
-
70349254444
-
Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure
-
Rao PK, Toyama Y, Chiang HR, et al.: Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ Res 2009, 105:585-594.
-
(2009)
Circ Res
, vol.105
, pp. 585-594
-
-
Rao, P.K.1
Toyama, Y.2
Chiang, H.R.3
-
26
-
-
63649117394
-
Long-term cardiactargeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy
-
Suckau L, Fechner H, Chemaly E, et al.: Long-term cardiactargeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy. Circulation 2009, 119:1241-1252.
-
(2009)
Circulation
, vol.119
, pp. 1241-1252
-
-
Suckau, L.1
Fechner, H.2
Chemaly, E.3
-
27
-
-
34147153781
-
Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2
-
Zhao Y, Ransom JF, Li A, et al.: Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell 2007, 129:303-317.
-
(2007)
Cell
, vol.129
, pp. 303-317
-
-
Zhao, Y.1
Ransom, J.F.2
Li, A.3
-
28
-
-
67749106564
-
MiR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy
-
Lin Z, Murtaza I, Wang K, et al.: MiR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy. Proc Natl Acad Sci U S A 2009, 106:12103-12108.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 12103-12108
-
-
Lin, Z.1
Murtaza, I.2
Wang, K.3
-
29
-
-
55449100829
-
Toward microRNA-based therapeutics for heart disease: The sense in antisense
-
van Rooij E, Marshall WS, Olson EN: Toward microRNA-based therapeutics for heart disease: The sense in antisense. Circ Res 2008, 103:919-928.
-
(2008)
Circ Res
, vol.103
, pp. 919-928
-
-
Van Rooij, E.1
Marshall, W.S.2
Olson, E.N.3
-
30
-
-
68649114571
-
AngiomiRs-key regulators of angiogenesis
-
Wang S, Olson EN: AngiomiRs-key regulators of angiogenesis. Curr Opin Genet Dev 2009, 19:205-211.
-
(2009)
Curr Opin Genet Dev
, vol.19
, pp. 205-211
-
-
Wang, S.1
Olson, E.N.2
-
31
-
-
48549106378
-
The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis
-
Wang S, Aurora AB, Johnson BA, et al.: The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell 2008, 15:261-271.
-
(2008)
Dev Cell
, vol.15
, pp. 261-271
-
-
Wang, S.1
Aurora, A.B.2
Johnson, B.A.3
-
32
-
-
66349123063
-
MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20
-
Ren XP, Wu J, Wang X, et al.: MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20. Circulation 2009, 119:2357-2366.
-
(2009)
Circulation
, vol.119
, pp. 2357-2366
-
-
Ren, X.P.1
Wu, J.2
Wang, X.3
-
33
-
-
65249185780
-
Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes
-
Rane S, He M, Sayed D, et al.: Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res 2009, 104:879-886.
-
(2009)
Circ Res
, vol.104
, pp. 879-886
-
-
Rane, S.1
He, M.2
Sayed, D.3
-
34
-
-
57749168828
-
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
-
Thum T, Gross C, Fiedler J, et al.: MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 2008, 456:980-984.
-
(2008)
Nature
, vol.456
, pp. 980-984
-
-
Thum, T.1
Gross, C.2
Fiedler, J.3
-
35
-
-
51349141401
-
Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis
-
van Rooij E, Sutherland LB, Thatcher JE, et al.: Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci U S A 2008, 105:13027-13032.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 13027-13032
-
-
Van Rooij, E.1
Sutherland, L.B.2
Thatcher, J.E.3
|