메뉴 건너뛰기




Volumn 12, Issue 3, 2010, Pages 209-215

Therapeutic potential of microRNAs in heart failure

Author keywords

Cardiac disease; Heart failure; MicroRNA; MRNA

Indexed keywords

MESSENGER RNA; MICRORNA; MYOSIN HEAVY CHAIN ALPHA; MYOSIN HEAVY CHAIN BETA; PARVOVIRUS VECTOR; SHORT HAIRPIN RNA; SMALL INTERFERING RNA;

EID: 77956394522     PISSN: 15233782     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11886-010-0096-7     Document Type: Review
Times cited : (18)

References (35)
  • 2
    • 34547951375 scopus 로고    scopus 로고
    • MicroRNAs repress translation of m7Gppp-capped target mRNAs in vitro by inhibiting initiation and promoting deadenylation
    • Standart N, Jackson RJ: MicroRNAs repress translation of m7Gppp-capped target mRNAs in vitro by inhibiting initiation and promoting deadenylation. Genes Dev 2007, 21:1975-1982.
    • (2007) Genes Dev , vol.21 , pp. 1975-1982
    • Standart, N.1    Jackson, R.J.2
  • 3
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • Ambros V: The functions of animal microRNAs. Nature 2004, 431:350-355.
    • (2004) Nature , vol.431 , pp. 350-355
    • Ambros, V.1
  • 4
    • 0030671503 scopus 로고    scopus 로고
    • Myosin heavy chain gene expression in human heart failure
    • Nakao K, Minobe W, Roden R, et al.: Myosin heavy chain gene expression in human heart failure. J Clin Invest 1997, 100:2362-2370.
    • (1997) J Clin Invest , vol.100 , pp. 2362-2370
    • Nakao, K.1    Minobe, W.2    Roden, R.3
  • 5
    • 34247589595 scopus 로고    scopus 로고
    • Control of stressdependent cardiac growth and gene expression by a microRNA
    • This landmark paper describes a role for miR-208, embedded within one of the MHC genes, in counterregulation of the two MHC genes. This established a mechanism relating the genetic locus of a miR to its primary function
    • van Rooij E, Sutherland LB, Qi X, et al.: Control of stressdependent cardiac growth and gene expression by a microRNA. Science 2007, 316:575-579. This landmark paper describes a role for miR-208, embedded within one of the MHC genes, in counterregulation of the two MHC genes. This established a mechanism relating the genetic locus of a miR to its primary function.
    • (2007) Science , vol.316 , pp. 575-579
    • Van Rooij, E.1    Sutherland, L.B.2    Qi, X.3
  • 6
    • 70349202176 scopus 로고    scopus 로고
    • MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice
    • Callis TE, Pandya K, Seok HY, et al.: MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. J Clin Invest 2009, 119:2772-2786.
    • (2009) J Clin Invest , vol.119 , pp. 2772-2786
    • Callis, T.E.1    Pandya, K.2    Seok, H.Y.3
  • 7
    • 0026349336 scopus 로고
    • Regulation of cardiac gene expression during myocardial growth and hypertrophy: Molecular studies of an adaptive physiologic response
    • Chien KR, Knowlton KU, Zhu H, Chien S: Regulation of cardiac gene expression during myocardial growth and hypertrophy: Molecular studies of an adaptive physiologic response. FASEB J 1991, 5:3037-3046.
    • (1991) FASEB J , vol.5 , pp. 3037-3046
    • Chien, K.R.1    Knowlton, K.U.2    Zhu, H.3    Chien, S.4
  • 8
    • 49149084567 scopus 로고    scopus 로고
    • Transcriptomic biomarkers for individual risk assessment in new-onset heart failure
    • Heidecker B, Kasper EK, Wittstein IS, et al.: Transcriptomic biomarkers for individual risk assessment in new-onset heart failure. Circulation 2008, 118:238-246.
    • (2008) Circulation , vol.118 , pp. 238-246
    • Heidecker, B.1    Kasper, E.K.2    Wittstein, I.S.3
  • 9
    • 65349121886 scopus 로고    scopus 로고
    • Genomics, transcriptional profiling, and heart failure
    • Margulies KB, Bednarik DP, Dries DL: Genomics, transcriptional profiling, and heart failure. J Am Coll Cardiol 2009, 53:1752-1759.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 1752-1759
    • Margulies, K.B.1    Bednarik, D.P.2    Dries, D.L.3
  • 10
    • 49149127971 scopus 로고    scopus 로고
    • Put your chips on transcriptomics
    • Dorn GW 2nd, Matkovich SJ: Put your chips on transcriptomics. Circulation 2008, 118:216-218.
    • (2008) Circulation , vol.118 , pp. 216-218
    • Dorn II, G.W.1    Matkovich, S.J.2
  • 11
    • 77954146850 scopus 로고    scopus 로고
    • MicroRNAs in cardiovascular disease: Putative novel therapeutic targets?
    • Jan 29 [Epub ahead of print]
    • Condorelli G, Latronico MVG, Dorn GW 2nd: MicroRNAs in cardiovascular disease: Putative novel therapeutic targets? Eur Heart J 2010 Jan 29 [Epub ahead of print].
    • (2010) Eur Heart J
    • Condorelli, G.1    Latronico, M.V.G.2    Dorn II, G.W.3
  • 12
    • 33845317603 scopus 로고    scopus 로고
    • A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure
    • van Rooij E, Sutherland LB, Liu N, et al.: A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci U S A 2006, 103:18255-18260.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 18255-18260
    • Van Rooij, E.1    Sutherland, L.B.2    Liu, N.3
  • 13
    • 34547579291 scopus 로고    scopus 로고
    • MicroRNAs in the human heart: A clue to fetal gene reprogramming in heart failure
    • Thum T, Galuppo P, Wolf C, et al.: MicroRNAs in the human heart: A clue to fetal gene reprogramming in heart failure. Circulation 2007, 116:258-267.
    • (2007) Circulation , vol.116 , pp. 258-267
    • Thum, T.1    Galuppo, P.2    Wolf, C.3
  • 14
    • 36248948593 scopus 로고    scopus 로고
    • Altered microRNA expression in human heart disease
    • Ikeda S, Kong SW, Lu J, et al.: Altered microRNA expression in human heart disease. Physiol Genomics 2007, 31:367-373.
    • (2007) Physiol Genomics , vol.31 , pp. 367-373
    • Ikeda, S.1    Kong, S.W.2    Lu, J.3
  • 15
    • 48849095818 scopus 로고    scopus 로고
    • MiRNA expression in the failing human heart: Functional correlates
    • Sucharov C, Bristow MR, Port JD: MiRNA expression in the failing human heart: Functional correlates. J Mol Cell Cardiol 2008, 45:185-192.
    • (2008) J Mol Cell Cardiol , vol.45 , pp. 185-192
    • Sucharov, C.1    Bristow, M.R.2    Port, J.D.3
  • 16
    • 70350463883 scopus 로고    scopus 로고
    • Unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks
    • Naga Prasad SV, Duan ZH, Gupta MK, et al.: Unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks. J Biol Chem 2009, 284:27487-27499.
    • (2009) J Biol Chem , vol.284 , pp. 27487-27499
    • Naga Prasad, S.V.1    Duan, Z.H.2    Gupta, M.K.3
  • 17
    • 63649096271 scopus 로고    scopus 로고
    • Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support
    • This is the only study to date comparing mRNA and miR expression profiles in different stages of heart failure. It established greater sensitivity of the miR signature for clinical status
    • Matkovich SJ, Van Booven DJ, Youker KA, et al.: Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support. Circulation 2009, 119:1263-1271, This is the only study to date comparing mRNA and miR expression profiles in different stages of heart failure. It established greater sensitivity of the miR signature for clinical status.
    • (2009) Circulation , vol.119 , pp. 1263-1271
    • Matkovich, S.J.1    Van Booven, D.J.2    Youker, K.A.3
  • 18
    • 16244378559 scopus 로고    scopus 로고
    • Mixed messages: Transcription patterns in failing and recovering human myocardium
    • Margulies KB, Matiwala S, Cornejo C, et al.: Mixed messages: Transcription patterns in failing and recovering human myocardium. Circ Res 2005, 96:592-599.
    • (2005) Circ Res , vol.96 , pp. 592-599
    • Margulies, K.B.1    Matiwala, S.2    Cornejo, C.3
  • 19
    • 48749122914 scopus 로고    scopus 로고
    • Circulating micro- RNAs as stable blood-based markers for cancer detection
    • This paper established that circulating miRs are stable for extended periods of time in blood, and can be accurately measured in a manner that reflects their regulated expression in tissue. This important finding suggests that a blood test may provide the same miR expression signature information as myocardial biopsy
    • Mitchell PS, Parkin RK, Kroh EM, et al.: Circulating micro- RNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A 2008, 105:10513-10518, This paper established that circulating miRs are stable for extended periods of time in blood, and can be accurately measured in a manner that reflects their regulated expression in tissue. This important finding suggests that a blood test may provide the same miR expression signature information as myocardial biopsy.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 10513-10518
    • Mitchell, P.S.1    Parkin, R.K.2    Kroh, E.M.3
  • 20
    • 34249279050 scopus 로고    scopus 로고
    • MicroRNA-133 controls cardiac hypertrophy
    • Information in this paper indicates that synthetic miR agonists and antagonists (in the form of a complementary single strand sequence) can be useful to mimic or oppose specific miR effects in the in vivo heart
    • Care A, Catalucci D, Felicetti F, et al.: MicroRNA-133 controls cardiac hypertrophy. Nat Med 2007, 13:613-618, Information in this paper indicates that synthetic miR agonists and antagonists (in the form of a complementary single strand sequence) can be useful to mimic or oppose specific miR effects in the in vivo heart.
    • (2007) Nat Med , vol.13 , pp. 613-618
    • Care, A.1    Catalucci, D.2    Felicetti, F.3
  • 21
    • 57749121689 scopus 로고    scopus 로고
    • MicroRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart
    • Liu N, Bezprozvannaya S, Williams AH, et al.: MicroRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes Dev 2008, 22:3242-3254.
    • (2008) Genes Dev , vol.22 , pp. 3242-3254
    • Liu, N.1    Bezprozvannaya, S.2    Williams, A.H.3
  • 22
    • 0242266620 scopus 로고    scopus 로고
    • Dicer is essential for mouse development
    • Bernstein E, Kim SY, Carmell MA, et al.: Dicer is essential for mouse development. Nat Genet 2003, 35:215-217.
    • (2003) Nat Genet , vol.35 , pp. 215-217
    • Bernstein, E.1    Kim, S.Y.2    Carmell, M.A.3
  • 23
    • 41149147013 scopus 로고    scopus 로고
    • Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure
    • Chen JF, Murchison EP, Tang R, et al.: Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A 2008, 105:2111-2116.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 2111-2116
    • Chen, J.F.1    Murchison, E.P.2    Tang, R.3
  • 24
    • 55249125659 scopus 로고    scopus 로고
    • Conditional dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling
    • da Costa Martins PA, Bourajjaj M, Gladka M, et al.: Conditional dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling. Circulation 2008, 118:1567-1576.
    • (2008) Circulation , vol.118 , pp. 1567-1576
    • Da Costa Martins, P.A.1    Bourajjaj, M.2    Gladka, M.3
  • 25
    • 70349254444 scopus 로고    scopus 로고
    • Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure
    • Rao PK, Toyama Y, Chiang HR, et al.: Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ Res 2009, 105:585-594.
    • (2009) Circ Res , vol.105 , pp. 585-594
    • Rao, P.K.1    Toyama, Y.2    Chiang, H.R.3
  • 26
    • 63649117394 scopus 로고    scopus 로고
    • Long-term cardiactargeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy
    • Suckau L, Fechner H, Chemaly E, et al.: Long-term cardiactargeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy. Circulation 2009, 119:1241-1252.
    • (2009) Circulation , vol.119 , pp. 1241-1252
    • Suckau, L.1    Fechner, H.2    Chemaly, E.3
  • 27
    • 34147153781 scopus 로고    scopus 로고
    • Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2
    • Zhao Y, Ransom JF, Li A, et al.: Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell 2007, 129:303-317.
    • (2007) Cell , vol.129 , pp. 303-317
    • Zhao, Y.1    Ransom, J.F.2    Li, A.3
  • 28
    • 67749106564 scopus 로고    scopus 로고
    • MiR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy
    • Lin Z, Murtaza I, Wang K, et al.: MiR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy. Proc Natl Acad Sci U S A 2009, 106:12103-12108.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 12103-12108
    • Lin, Z.1    Murtaza, I.2    Wang, K.3
  • 29
    • 55449100829 scopus 로고    scopus 로고
    • Toward microRNA-based therapeutics for heart disease: The sense in antisense
    • van Rooij E, Marshall WS, Olson EN: Toward microRNA-based therapeutics for heart disease: The sense in antisense. Circ Res 2008, 103:919-928.
    • (2008) Circ Res , vol.103 , pp. 919-928
    • Van Rooij, E.1    Marshall, W.S.2    Olson, E.N.3
  • 30
    • 68649114571 scopus 로고    scopus 로고
    • AngiomiRs-key regulators of angiogenesis
    • Wang S, Olson EN: AngiomiRs-key regulators of angiogenesis. Curr Opin Genet Dev 2009, 19:205-211.
    • (2009) Curr Opin Genet Dev , vol.19 , pp. 205-211
    • Wang, S.1    Olson, E.N.2
  • 31
    • 48549106378 scopus 로고    scopus 로고
    • The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis
    • Wang S, Aurora AB, Johnson BA, et al.: The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell 2008, 15:261-271.
    • (2008) Dev Cell , vol.15 , pp. 261-271
    • Wang, S.1    Aurora, A.B.2    Johnson, B.A.3
  • 32
    • 66349123063 scopus 로고    scopus 로고
    • MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20
    • Ren XP, Wu J, Wang X, et al.: MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20. Circulation 2009, 119:2357-2366.
    • (2009) Circulation , vol.119 , pp. 2357-2366
    • Ren, X.P.1    Wu, J.2    Wang, X.3
  • 33
    • 65249185780 scopus 로고    scopus 로고
    • Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes
    • Rane S, He M, Sayed D, et al.: Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res 2009, 104:879-886.
    • (2009) Circ Res , vol.104 , pp. 879-886
    • Rane, S.1    He, M.2    Sayed, D.3
  • 34
    • 57749168828 scopus 로고    scopus 로고
    • MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
    • Thum T, Gross C, Fiedler J, et al.: MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 2008, 456:980-984.
    • (2008) Nature , vol.456 , pp. 980-984
    • Thum, T.1    Gross, C.2    Fiedler, J.3
  • 35
    • 51349141401 scopus 로고    scopus 로고
    • Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis
    • van Rooij E, Sutherland LB, Thatcher JE, et al.: Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci U S A 2008, 105:13027-13032.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 13027-13032
    • Van Rooij, E.1    Sutherland, L.B.2    Thatcher, J.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.