Characterization of an ultra-conserved putative cis-regulatory module at the mammalian telomerase reverse transcriptase gene

DNA and Cell Biology

Volumn 29, Issue 9, 2010, Pages 499-508

  Tran, Diana A ^a   Wong, Terence C ^a   Schep, Alicia N ^a   Drewell, Robert A ^a  

^a HARVEY MUDD COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE REVERSE TRANSCRIPTASE; TELOMERASE;

ARTICLE; BINDING SITE; BIOINFORMATICS; CANCER CELL CULTURE; CELL LINEAGE; CONTROLLED STUDY; FIBROBLAST; GENE EXPRESSION; GENE IDENTIFICATION; HELA CELL; HEMATOPOIESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MAMMAL; NONHUMAN; PRIMATE; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; TRANSCRIPTION INITIATION; TRANSIENT TRANSFECTION; ANIMAL; BIOLOGY; DOG; ENHANCER REGION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; GENOME; HELA CELL LINE; MOLECULAR EVOLUTION; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; RAT;

EUKARYOTA; MAMMALIA; PRIMATES;

ANIMALS; BASE SEQUENCE; COMPUTATIONAL BIOLOGY; CONSERVED SEQUENCE; DOGS; ENHANCER ELEMENTS, GENETIC; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, REPORTER; GENOME; HELA CELLS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; PRIMATES; RATS; TELOMERASE; TRANSCRIPTION, GENETIC;

EID: 77956375106     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/dna.2009.0994     Document Type: Article

References (52)

1. Atchison, M.L. (1988). Enhancers: mechanisms of action and cell specificity. Annu Rev Cell Biol 4, 127-153.
2. Banerji, J., Rusconi, S., and Schaffner, W. (1981). Expression of a b-globin gene is enhanced by remote SV40 DNA sequences. Cell 27, 299-308.
3. Bejerano, G., Pheasant, M., Makunin, I., Stephen, S., Kent, W.J., Mattick, J.S., and Haussler, D. (2004). Ultraconserved elements in the human genome. Science 304, 1321-1325.
4. Bell, A.C., West, A.G., and Felsenfeld, G. (1999). The protein CTCF is required for the enhancer blocking activity of vertebrate insulators. Cell 98, 387-396.
5. Blackburn, E.H. (2001). Switching and signaling at the telomere. Cell 106, 661-673.
6. Bodnar, A.G., Ouellette, M., Frolkis, M., Holt, S.E., Chiu, C.P., Morin, G.B., Harley, C.B., Shay, J.W., Lichtsteiner, S., and Wright, W.E. (1998). Extension of life-span by introduction of telomerase into normal human cells. Science 279, 349-352.
7. Chebel, A., Rouault, J.P., Urbanowicz, I., Baseggio, L., Chien, W.W., Salles, G., and Ffrench, M. (2009). Transcriptional activation of hTERT, the human telomerase reverse transcriptase, by nuclear factor of activated T cells. J Biol Chem 284, 35725-35734.
8. Cong, Y.S., and Bacchetti, S. (2000). Histone deacetylation is involved in the transcriptional repression of hTERT in normal human cells. J Biol Chem 275, 35665-35668.
9. Cong, Y.S., Wen, J., and Bacchetti, S. (1999). The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter. Hum Mol Genet 8, 137-142.
10. Doetzlhofer, A., Rotheneder, H., Lagger, G., Koranda, M., Kurtev, V., Brosch, G., Wintersberger, E., and Seiser, C. (1999). Histone deacetylase 1 can repress transcription by binding to Sp1. Mol Cell Biol 19, 5504-5511.
11. Drewell, R.A., Arney, K.L., Arima, T., Barton, S.C., Brenton, J.D., and Surani, M.A. (2002). Novel conserved elements upstream of the H19 gene are transcribed and act as mesodermal enhancers. Development 129, 1205-1213.
12. Engelhardt, M., Kumar, R., Albanell, J., Pettengell, R., Han, W., and Moore, M.A.S. (1997). Telomerase regulation, cell cycle, and telomere stability in primitive hematopoietic cells. Blood 90, 182-193.
13. Feng, J., Funk, W.D., Wang, S.S., Weinrich, S.L., Avilion, A.A., Chiu, C.P., Adams, R.R., Chang, E., Allsopp, R.C., Yu, J., Le, S., West, M.D., Harley, C.B., Andrews, W.H., Greider, C.W., and Villeponteau, B. (1995). The RNA component of human telomerase. Science 269, 1236-1241.
14. Fourel, G., Magdinier, F., and Gilson, E. (2004). Insulator dynamics and the setting of chromatin domains. Bioessays 26, 523-532.
15. Friedman, A.D. (2007). Transcriptional control of granulocyte and monocyte development. Oncogene 26, 6816-6828.
16. Garcia, J.F., Roncador, G., Garcia, J.F., Sanz, A.I., Maestre, L., Lucas, E., Montes-Moreno, S., Fernandez Victoria, R., Martinez-Torrecuadrara, J.L., Marafioti, T., Mason, D.Y., and Piris, M.A. (2006). PRDM1/BLIMP-1 expression in multiple B and T-cell lymphoma. Haematologica 91, 467-474.
17. Hardison, R.C., Oeltjen, J., and Miller, W. (1997). Long humanmouse sequence alignments reveal novel regulatory elements: a reason to sequence the mouse genome. Genome Res 7, 959-966.
18. Harley, C.B., Futcher, A.B., and Greider, C.W. (1990). Telomeres shorten during ageing of human fibroblasts. Nature 345, 458-460.
19. Harrington, L., Zhou, W., McPhail, T., Oulton, R., Yeung, D.S., Mar, V., Bass, M.B., and Robinson, M.O. (1997). Human telomerase contains evolutionarily conserved catalytic and structural subunits. Genes Dev 11, 3109-3115.
20. Harris, M.B., Mostecki, J., and Rothman, P.B. (2005). Repression of an interleukin-4-responsive promoter requires cooperative BCL-6 function. J Biol Chem 280, 13114-13121.
21. Ivankovic, M., Cukusic, A., Gotic, I., Skrobot, N., Matijasic, M., Polancec, D., and Rubelj, I. (2007). Telomerase activity in HeLa cervical carcinoma cell line proliferation. Biogerontology 8, 163-172.
22. Jiang, P., Wu, H., Wang, W., Ma, W., Sun, X., and Lu, Z. (2007). MiPred:classification of real and pseudo microRNA precursors using random forest prediction model with combined features. Nucleic Acids Res 35, W339-W344.
23. Kanaya, T., Kyo, S., Hamada, K., Takakura, M., Kitagawa, Y., Harada, H., and Inoue, M. (2000). Adenoviral expression of p53 represses telomerase activity through downregulation of human telomerase reverse transcriptase transcription. Clin Cancer Res 6, 1239-1247.
24. Kilian, A., Bowtell, D.D., Abud, H.E., Hime, G.R., Venture, D.J., Keese, P.K., Duncan, E.L., Reddel, R.R., and Jefferson, R.A. (1997). Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types. Hum Mol Genet 6, 2011-2019.
25. Kyo, S., Takakura, M., Taira, T., Kanaya, T., Itoh, H., Yutsudo, M., Ariga, H., and Inoue, M. (2000). Sp1 cooperates with c-Myc to activiate transcription of the human telomerase reverse transcriptase gene (hTERT). Nucleic Acids Res 28, 669-677.
26. Lettice, L.A., Heaney, S.J., Purdie, L.A., Li, L., de Beer, P., Oostra, B.A., Goode, D., Elgar, G., Hill, R.E., and de Graaff, E. (2003). A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly. Hum Mol Genet 12, 1725-1735.
27. Li, L., He, S., Sun, J.M., and Davie, J.R. (2004). Gene regulation by Sp1 and Sp3. Biochem. Cell Biol 82, 460-471.
28. Lindsey, J., McGill, N.I., Lindsey, L.A., Green, D.K., and Cooke, H.J. (1991). In vivo loss of telomeric repeats with age in humans. Mutat Res 256, 45-48.
29. Lingner, J., Hughes, T.R., Shevchenko, A., Mann, M., Lundblad, V., and Cech, T.R. (1997). Reverse transcriptase motifs in the catalytic subunit telomerase. Science 276, 561-567.
30. Loots, G.G., Locksley, R.M., Blankespoor, C.M., Wang, Z.E., Miller, W., Rubin, E.M., and Frazer, K.A. (2000). Identification of a coordinate regulator of interleukins 4, 13, and 5 by crossspecies sequence comparisons. Science 288, 136-140.
31. Martin, N., Patel, S., and Segre, J.A. (2004). Long-range comparison of human and mouse Sprr loci to identify conserved noncoding sequences involved in coordinate regulation. Genome Res 14, 2430-2438.
32. Matthias, P. (1998). Lymphoid-specific transcription mediated by the conserved octamer site: who is doing what? Semin Immunol 10, 155-163.
33. Meyerson, M., Counter, C.M., Eaton, E.N., Ellisen, L.W., Steiner, P., Caddle, S.D., Ziaugra, L., Beijersbergen, R.L., Davidoff, M.J., Liu, Q., Bacchetti, S., Haber, D.A., and Weinberg, R.A. (1997). hEST2, the putattive human telomerase catalytic subunit gene, is upregulated in tumor cells and during immortalization. Cell 90, 785-795.
34. Nobrega, M.A., Ovcharenko, I., Afzal, V., and Rubin, E.M. (2003). Scanning human gene deserts for long-range enhancers. Science 302, 413.
35. Oeltjen, J.C., Malley, T.M., Muzny, D.M., Miller, W., Gibbs, R.A., and Belmont, J.W. (1997). Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains. Genome Res 7, 315-329.
36. Quandt, K., Freche, K., Karas, H., Wingender, E., and Werner, T. (1995). MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res 23, 4878-4884.
37. Remenyi, A., Scholer, H.R., and Wilmanns, M. (2004). Combinatorial control of gene expression. Nat Struct Mol Biol 11, 812-815.
38. Ritchie, W., Theodule, F.X., and Gautheret, D. (2008). Mireval: a web tool for simple microRNA prediction in genome sequences. Bioinformatics 24, 1394-1396.
39. Shay, J.W., and Bacchetti, S. (1997). A survey of telomerase activity in human cancer. Eur J Cancer 33, 787-791.
40. Shay, J.W., and Wright, W.E. (2000). Hayflick, his limit, and cellular ageing. Nat Rev Mol Cell Biol 1, 72-76.
41. Staal, F.J., and Sen, J.M. (2008). The canonical Wnt signaling pathway plays an important role in lymphopoiesis and hematopoiesis. Eur J Immunol 38, 1788-1794.
42. Takakura, M., Kyo, S., Kanaya, T., Hirano, H., Takeda, J., Yutsudo, M., and Inoue, M. (1999). Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res 59, 551-557.
43. Tamura, T., Yanai, H., Savitsky, D., and Taniguchi, T. (2008). The IRF family transcription factors in immunity and oncogenesis. Annu Rev Immunol 26, 535-584.
44. Valenzuela, H.F., and Effros, R.B. (2002). Divergent telomerase and CD28 expression patterns in human CD4 and CD8 T cells following repeated encounters with the same antigenic stimulus. Clin Immunol 105, 117-125.
45. Valenzuela, L., Dhillon, N., Dubey, R.N., Gartenberg, M.R., and Kamakaka, R.T. (2008). Long-range communication between the silencers of HMR. Mol Cell Biol 28, 1924-1935.
46. Woolfe, A., Goodson, M., Goode, D.K., Snell, P., McEwen, G.K., Vavouri, T., Smith, S.F., North, P., Callaway, H., Kelly, K., Walter, K., Abnizova, I., Gilks, W., Edwards, Y.J., Cooke, J.E., and Elgar, G. (2005). Highly conserved non-coding sequences are associated with vertebrate development. PLoS Biol 3, e7.
47. Wright, W.E., Pereira-Smith, O.M., and Shay, J.W. (1989). Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts. Mol Cell Biol 9, 3088-3092.
48. Wright, W.E., Piatyszek, M.A., Rainey, W.E., Bryd, W., and Shay, J.W. (1996). Telomerase activity in human germline and embryonic tissues and cells. Dev Genet 18, 173-179.
49. Wu, K.J., Grandori, C., Amacker, M., Simon-Vermont, N., Polack, A., Lingner, J., and Dalla-Favera, R. (1999). Direct activation of TERT transcription by c-MYC. Nat Genet 21, 220-224.
50. Xu, D., Popov, N., Hou, M., Wang, Q., Bjorkholm, M., Gruber, A., Menkel, A.R., and Henriksson, M. (2001). Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells. Proc Natl Acad Sci 98, 3826-3831.
51. Xu, D., Wang, Q., Gruber, A., Bjorkholm, M., Chen, Z., Zaid, A., Selivanova, G., Peterson, C., Wiman, K.G., and Pisa, P. (2000). Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells. Oncogene 19, 5123-5133.
52. Yang, J., Chang, E., Cherry, A.M., Bangs, C.D., Oei, Y., Bodnar, A., Bronstein, A., Chiu, C.P., and Herron, G.S. (1999). Human endothelial cell life extension by telomerase expression. J Biol Chem 274, 26141-26148.