Novel conserved elements upstream of the H19 gene are transcribed and act as mesodermal enhancers

Development

Volumn 129, Issue 5, 2002, Pages 1205-1213

  Drewell, Robert A ^a   Arney, Katherine L ^a   Arima, Takahiro ^a   Barton, Sheila C ^a   Brenton, James D ^a   Azim Surani, M ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Enhancer; Genomic imprinting; H19; HUC; Igf2; Mouse

Indexed keywords

CIS ACTING ELEMENT; PROTEIN H19; REGULATOR PROTEIN; SOMATOMEDIN B; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; DNA METHYLATION; ENDODERM; ENHANCER REGION; GENE EXPRESSION; GENE SEQUENCE; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; GENOME IMPRINTING; HUMAN; HUMAN TISSUE; MESODERM; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REGULATORY MECHANISM; REPORTER GENE; SEQUENCE HOMOLOGY; TRANSGENE;

ANIMALS; BASE SEQUENCE; CONSERVED SEQUENCE; ENHANCER ELEMENTS (GENETICS); GENE SILENCING; GENOMIC IMPRINTING; INSULIN-LIKE GROWTH FACTOR II; MESODERM; MICE; RNA, UNTRANSLATED; TRANSCRIPTION, GENETIC;

ANIMALIA; MAMMALIA;

EID: 0036333582     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Imprinting of Igf2 and H19, from a 130 kb YAC transgene
2. Appropriate expression of the mouse H19 gene utilises three or more distinct enhancer regions spread over more than 130 kb
3. A skeletal muscle-specific mouse Igf2 repressor lies 40 kb downstream of the gene
4. Detecting conserved regulatory elements with the model genome of the Japanese puffer fish, Fugu rubripes
5. A novel imprinted gene, HYMAI, is located within an imprinted domain on human chromosome 6 containing ZAC
6. A conserved imprinting control region at the HYMAI/ZAC domain is implicated in transient neonatal diabetes mellitus
7. Epigenetic reprogramming of the genome- from the germline to the embryo and back again
8. Intergenic transcription and transinduction of the human beta-globin locus
9. Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
10. A silencer element identified in Drosophila is required for imprinting of H19 reporter transgenes in mice
11. Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19
12. Distant liaisons: Long-range enhancer-promoter interactions in Drosophila
13. Deletion of a silencer element disrupts H19 imprinting independently of a DNA methylation epigenetic switch
14. A 5′ differentially methylated sequence and the 3′-flanking region are necessary for H19 transgene imprinting
15. The role of insulator elements in defining domains of gene expression
16. Chromatin conformation of the H19 epigenetic mark
17. CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus
18. Expression of a human placental alkaline phosphatase gene in transfected cells: Use as a reporter for studies of gene expression
19. Comparative genomic sequencing identifies novel tissue-specific enhancers and sequence elements for methylation-sensitive factors implicated in Igf2/H19 imprinting
20. A transcriptional insulator at the imprinted H19/Igf2 locus
21. Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive
22. Parental allele-specific chromatin configuration in a boundary-imprinting-control element upstream of the mouse H19 gene
23. An enhancer deletion affects both H19 and Igf2 expression
24. Identification of a coordinate regulator of interleukins 4, 13 and 5 by cross-species sequence comparison
25. Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2
26. Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain
27. Deletion of the H19 transcription unit reveals the existence of a putative imprinting control element
28. Parental imprinting: Potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene
29. Transvection in the Drosophila Abd-B domain: Extensive upstream sequences are involved in anchoring distant cis-regulatory regions to the promoter
30. H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis-acting regulatory region upstream of H19
31. Imprinting and the initiation of gene silencing in the germ line
32. Delta-like and Gtl2, are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12
33. Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2
34. Detection of messenger RNA by in situ hybridisation to tissue sections and whole mounts
35. Imprinted expression of the Igf2r gene depends on an intronic CpG island
36. Characterisation of the transvection mediating region of the abdominal-B locus in Drosophila