Lymphoid-specific transcription mediated by the conserved octamer site: Who is doing what?

Seminars in Immunology

Volumn 10, Issue 2, 1998, Pages 155-163

  Matthias, Patrick ^a  

^a FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

Author keywords

Immunoglobulin transcription; OBF 1; Oct 1; Oct 2; Octamer site

Indexed keywords

TRANSCRIPTION FACTOR;

ARTICLE; B LYMPHOCYTE; GENETIC TRANSCRIPTION; IMMUNOGLOBULIN GENE; LYMPHOID CELL; PROMOTER REGION; PROTEIN DOMAIN;

EID: 0032052935     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1006/smim.1998.0117     Document Type: Article

References (76)

1. 1. Staudt LM, Lenardo MJ (1991) Immunoglobulin gene transcription. Annu Rev Immunol 9:373-398
2. 2. Ernst P, Smale ST (1995) Combinatorial regulation of transcription II: The immunoglobulin mu heavy chain gene. Immunity 2:427-438
3. 3. Parslow TG, Blair DL, Murphy WJ, Granner DK (1984) Structure of the 5′ ends of immunoglobulin genes: A novel conserved sequence. Proc Natl Acad Sci USA 81:2650-2654
4. 4. Falkner FG, Zachau HG (1984) Correct transcription of an immunoglobulin κ gene requires an upstream fragment containing conserved sequence elements. Nature (London) 310:71-74
5. 5. Banerji J, Olson L, Schaffner W (1983) A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes. Cell 33:729-740
6. 6. Gillies SD, Morrison SL, Oi VT, Tonegawa S (1983) A tissue-specific transcription enhancer element is located in the major intron of the rearranged immunoglobulin heavy chain gene. Cell 33:717-728
7. 7. Pettersson S, Cook GP, Brüggemann M, Neuberger MS (1990) A second B cell specific enhancer 3′ of the immunoglobulin heavy chain locus. Nature (London) 344:165-168
8. 8. Dariavach P, Williams GT, Campbell K, Pettersson S, Neuberger M.S. (1991) The mouse IgH 3′ enhancer. Eur J Immunol 21:1499-1504
9. 9. Lieberson R, Giannini SL, Birshtein BK, Eckhardt LA (1991) An enhancer at the 3′ end of the mouse immunoglobulin heavy chain locus. Nucleic Acids Res 19:933-937
10. 10. Matthias P, Baltimore D (1993) The immunoglobulin heavy chain locus contains another B-cell-specific 3′ enhancer close to the alpha constant region. Mol Cell Biol 13:1547-1553
11. 11. Madisen L, Groudine M (1994) Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells. Genes Dev 8:2212-2226
12. 12. Hermanson GG, Briskin M, Sigman D, Wall R (1989) Immunoglobulin enhancer and promoter motifs 5′ of the B29 B-cell-specific gene. Proc Natl Acad Sci USA 86:7341-7345
13. 13. Thevenin C, Rieckmann P, Kozlow EJ, Kehrl JH (1992) Identification of a diverged octamer binding site important in the B cell-specific expression of the CD20 gene. Trans Assoc Am Physicians 105
14. 14. Bergman Y, Rice D, Grosschedl R, Baltimore D (1984) Two regulatory elements for immunoglobulin kappa light chain gene expression. Proc Natl Acad Sci USA 81:7041-7045
15. 15. Mason JO, Williams GT, Neuberger MS (1985) Transcription cell-type specificity is controlled by an immunoglobulin VH promoter that includes a functional consensus sequence. Cell 41:479-487
16. 16. Mizushima-Sugano J, Roeder RG (1986) Cell-type -specific transcription of an immunoglobulin k light chain promoter gene in vitro. Proc Natl Acad Sci USA 83:8511-8515
17. 17. Wirth T, Staudt L, Baltimore D (1987) An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity. Nature (London) 329:174-177
18. 18. Dreyfus M, Doyen N, Rougeon F (1987) The conserved decanucleotide from the immunoglobulin heavy chain promoter induces a very high transcriptional activity in B cells when introduced into a heterologous promoter. EMBO J 6:1685-1690
19. 19. Annweiler A Zwilling S, Hipskind RA Wirth T (1993) Analysis of transcriptional stimulation by recombinant Oct proteins in a cell-free system. J Biol Chem 268:2525-2534
20. 20. Gerster T, Matthias P, Thali M, Jiricny J, Schaffner W (1987) Cell type-specific elements of the immunoglobulin heavy chain gene enhancer. EMBO J 6:1323-1330
21. 21. Jenuwein T, Grosschedl R (1991) Complex pattern of immunoglobulin mu gene expression in normal and transgenic mice: nonoverlapping regulatory sequences govern distinct tissue specificities. Genes Dev 5:932-943
22. 22. Junker S, Nielsen V, Matthias P, Picard D (1988) Both immunoglobulin promoter and enhancer sequences are targets for suppression in myeloma-fibroblast hybrid cells. Embo J 7:3093-3098
23. 23. Junker S, Pedersen S, Schreiber E, Matthias P (1990) Extinction of an immunoglobulin kappa promoter in cell hybrids is mediated by the octamer motif and correlates with suppression of Oct-2 expression. Cell 61:467-474
24. 24. Yu H, Porton B, Shen LY, Eckhardt LA (1989) Role of the octamer motif in hybrid cell extinction of immunoglobulin gene expression: extinction is dominant in a two enhancer system. Cell 58:441-448
25. 25. Reich L, Sharir H, Ber R, Wirth T, Bergman Y, Laskov R (1996) Coordinate suppression of myeloma-specific genes and expression of fibroblast-specific genes in myeloma X fibroblast somatic cell hybrids. Somat Cell Mol Genet 22:1-20
26. 26. Junker S, Lamm M, Nielsen V, Matthias P (1997) Extinction of immunoglobulin gene expression in B cells upon fusion with HeLa cells is preceded by rapid nuclear depletion of essential transcription factors and is accompanied by widespread inactivation of genes expressed in a B cell-specific manner. J Cell Sci 110:2579-2587
27. 27. LaBella F, Sive HL, Roeder RG, Heintz N (1988) Cell-cycle regulation of a human histone H2B gene is mediated by the H2B subtype-specific consensus element. Genes Dev 2:32-39
28. 28. Carbon P, Murgo S, Ebel JP, Krol A Tebb G, Mattaj LW (1987) A common octamer motif binding protein is involved in the transcription of U6 snRNAby RNA polymerase III and U2 snRNA by RNA polymerase II. Cell 51:71-79
29. 29. Tanaka M, Grossniklaus U, Herr W, Hernandez N (1988) Activation of the U2 snRNA promoter by the octamer motif defines a new class of RNA polymerase II enhancer. Genes Dev 2:1764-1778
30. 30. Sturm RA, Das G, Herr W (1988) The ubiquitous octamerbinding protein Oct-1 contains a POU domain with a homeo box subdomain. Genes Dev 2:1582-1599
31. 31. Scheidereit C, Cromlish JA, Gerster T, Kawakami K, Bal-maceda CG, Currie RA, Roeder RG (1988) A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homeobox protein. Nature 336:551-557
32. 32. Müller MM, Ruppert S, Schaffner W, Matthias P (1988) A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells. Nature 336:544-551
33. 33. Clerc RG, Corcoran LM, LeBowitz JH, Baltimore D, Sharp PA (1988) The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains. Genes Dev 2:1570-1581
34. 34. Herr W, Sturm RA, Clerc RG, Corcoran LM, Baltimore D, Sharp PA Ingraham HA Rosenfeld MG, Finney M, Ruvkun G, Horvitz HR (1988) The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2 and Caenorhabditis elegans unc-86 gene products. Genes Dev 2:1513-1516
35. 35. Rosenfeld MG (1991) POU-domain transcription factors: pou-er-ful developmental regulators. Genes Dev 5:897-907
36. 36. Schöler HR (1991) Octamania: the POU factors in murine development. Trends Genet 7:323-329
37. 37. Wegner M, Drolet DW, Rosenfeld MG (1993) POU-domain proteins: structure and function of developmental regulators. Curr Opin Cell Biol 5:488-498
38. 38. Ryan AK, Rosenfeld MG (1997) POU domain family values: flexibility, partnerships, and developmental codes. Genes Dev 11:1207-1225
39. 39. Tanaka M, Herr W (1990) Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation. Cell 60:375-386
40. 40. Muller-Immergluck MM, Schaffner W, Matthias P (1990) Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non-lymphoid (HeLa) cells. Embo J 9:1625-1634
41. 41. Gerster T, Balmaceda CG, Roeder RG (1990) The cell type-specific octamer transcription factor OTF-2 has two domains required for the activation of transcription. Embo J 9:1635-1643
42. 42. Wirth T, Priess A, Annweiler A Zwilling S, Oeler B (1991) Multiple Oct2 isoforms are generated by alternative splicing. Nucleic Acids Res 19:43-51
43. 43. Staudt LM, Clerc RG, Singh H, LeBowitz JH, Sharp PA Baltimore D (1988) Cloning of a lymphoid-specific cDNA encoding a protein binding the regulatory octamer DNA motif. Science 241:577-580
44. 44. Miller CL, Feldbaus AL, Rooney JW, Rhodes LD, Sibley CH, Singh H (1991) Regulation and a possible stage-specific function of Oct-2 during pre-B-cell differentiation. Mol Cell Biol 11:4885-4894
45. 45. Kang SM, Tsang W, Doll S, Scherle P, Ko HS, Tran AC, Lenardo MJ, Staudt LM (1992) Induction of the POU domain transcription factor Oct-2 during T-cell activation by cognate antigen. Mol Cell Biol 12:3149-3154
46. 46. Strubin M, Newell JW, Matthias P (1995) OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins. Cell 80:497-506
47. 47. Luo Y, Roeder RG (1995) Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B. Mol Cell Biol 15:4115-4124
48. 48. Gstaiger M, Knoepfel L, Georgiev O, Schaffner W, Hovens CM (1995) A B-cell coactivator of octamer-binding transcription factors. Nature 373:360-362
49. 49. Pierani A, Heguy A, Fujii H, Roeder RG (1990) Activation of octamer-contaming promoters by either octamer-binding transcription factor 1 (OTF-1) or OTF-2 and requirement of an additional B-cell-specific component for optimal transcription of immunoglobulin promoters. Mol Cell Biol 10:6204-6215
50. 50. Luo Y, Fujii H, Gerster T, Roeder RG (1992) A novel B cell-derived coactivator potentiates the activation of immunoglobulin promoters by octamer-binding transcription factors. Cell 71:231-241
51. 51. Schubart DB, Sauter P, Massa S, Friedl EM, Schwarzenbach H, Matthias P (1996) Gene structure and characterization of the murine homologue of the B cell-specific transcriptional coactivator OBF-1. Nucleic Acids Res 24:1913-1920
52. 52. Pfisterer P, Zwilling S, Hess J, Wirth T (1995) Functional characterization of the murine homolog of the B cell-specific coactivator BOB.1/OBF.1. J Biol Chem 270:29870-29880
53. 53. Gstaiger M, Georgiev O, van Leeuwen H, van der Vliet P, Schaffner W (1996) The B cell coactivator Bobl shows DNA sequence-dependent complex formation with Oct-1/Oct-2 factors, leading to differential promoter activation. Embo J 15:2781-2790
54. 54. Babb R, Cleary MA, Herr W (1997) OCA-B is a functional analog of VP16 but targets a separate surface of the Oct-1 POU domain. Mol Cell Biol 17:7295-7305
55. 55. Cepek KL, Chasman DI, Sharp PA (1996) Sequence-specific DNA binding of the B-cell-specific coactivator OCA-B. Genes Dev 10:2079-2088
56. 56. Sauter P, Matthias P (1997) The B cell-specific coactivator OBF-1 (OCA-B, Bob-1) is inducible in T cells and its expression is dispensable for IL-2 gene induction. Immunobiology 197:293-302
57. 57. Zwilling S, Dieckmann A, Pfisterer P, Angel P, Wirth T (1997) Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells [see comments]. Science 277:221-225
58. 58. Feldbaus AL, Klug CA, Arvin KL, Singh H (1993) Targeted disruption of the Oct-2 locus in a B cell provides genetic evidence for two distinct cell type-specific pathways of octamer element-mediated gene activation. Embo J 12:2763-2772
59. 59. Corcoran L, Karvelas M, Nossal GJ, Ye ZS, Jacks T, Baltimore D (1993) Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival. Genes Dev 7:570-582
60. 60. Annweiler A, Muller-Immergluck M, Wirth T (1992) Oct2 transactivation from a remote enhancer position requires a B-cell-restricted activity. Mol Cell Biol 12:3107-3116
61. 61. Annweiler A, Zwilling S, Wirth T (1994) Functional differences between the Oct2 transactivation domains determine the transactivation potential of individual Oct2 isoforms. Nucleic Acids Res 22:4250-4258
62. 62. Friedl EM, Matthias P (1995) Transcriptional activation and repression, two properties of the lymphoid-specific transcription factor Oct-2a. Eur J Biochem 234:308-316
63. 63. Corcoran LM, Karvelas M (1994) Oct-2 is required early in T cell-independent B cell activation for G1 progression and for proliferation. Immunity 1:635-645
64. 64. Humbert PO, Corcoran LM (1997) oct-2 gene disruption eliminates the peritoneal B-1 lymphocyte lineage and attenuates B 2 cell maturation. J Immunol 159:5273-5284
65. 65. Pfisterer P, Annweiler A, Ullmer C, Corcoran LM, Wirth T (1994) Differential transactivation potential of Oct1 and Oct2 is determined by additional B cell-specific activities. Embo J 13:1655-1663
66. 66. LeBowitz JH, Kobayashi T, Staudt LM, Baltimore D, Sharp PA (1988) Octamer-binding proteins from B or heLa cells stimulate transcription of the immunoglobulin eavy chain promoter in vitro. Genes Dev 2:1227-1237
67. 67. Johnson DG, Carayannopoulos L, Capra JD, Tucker PW, Hanke JH (1990) The ubiquitous octamer-binding protein(s) is sufficient for transcription of immunoglobulin genes. Mol Cell Biol 10:982-990
68. 68. Schubart DB, Rolink A, Kosco-Vilbois MH, Botteri F, Matthias P (1996) B-cell-specific coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation. Nature 383:538-542
69. 69. Kim U, Qin XF, Gong S, Stevens S, Luo Y, Nussenzweig M, Roeder RG (1996) The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes. Nature 383:542-547
70. 70. Nielsen PJ, Georgiev O, Lorenz B, Schaffner W (1996) B lymphocytes are impaired in mice lacking the transcriptional co-activator Bob1/OCA-B/OBF1. Fur J Immunol 26:3214-3218
71. 71. Hardy RR, Carmack CE, Li YS, Hayakawa K (1994) Distinctive developmental origins and specificities of murine CD5 + B cells. Immunol Rev 137:91-118
72. 72. Hayakawa K, Hardy RR, Herzenberg LA (1986) Peritoneal Ly-1 B cells: genetic control, autoantibody production, increased lambda light chain expression. Eur J Immunol 16:450-456
73. 73. Nutt SL, Urbanek P, Rolink A, Busslinger M (1997) Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus. Genes Dev 11:476-491
74. 74. Konig H, Pfisterer P, Corcoran LM, Wirth T (1995) Identification of CD36 as the first gene dependent on the B-cell differentiation factor Oct-2. Genes Dev 9:1598-1607
75. 75. Pfisterer P, Konig H, Hess J, Lipowsky G, Haendler B, Schleuning WD, Wirth T (1996) CRISP-3, a protein with homology to plant defense proteins, is expressed in mouse B cells under the control of Oct2. Mol Cell Biol 16:6160-6168
76. 76. Hendriks RW, de BM, Maas A, Dingjan GM, Karis A, Grosveld F (1996) Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage. Embo J 15:4862-4872