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Volumn 31, Issue 9, 2010, Pages 1612-1619

Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility

(34)  Lascorz, Jesús a   Försti, Asta a,b   Chen, Bowang a   Buch, Stephan c   Steinke, Verena d   Rahner, Nils d   Holinski Feder, Elke e   Morak, Monika e   Schackert, Hans K f   Görgens, Heike f   Schulmann, Karsten g   Goecke, Timm h   Kloor, Matthias i   Engel, Cristoph j   Büttner, Reinhard d   Kunkel, Nelli a   Weires, Marianne a   Hoffmeister, Michael a   Pardini, Barbara k   Naccarati, Alessio k   more..


Author keywords

[No Author keywords available]

Indexed keywords

CASEIN KINASE II; INHIBIN A; MITOGEN ACTIVATED PROTEIN KINASE; MYOSIN III; ZINC FINGER PROTEIN;

EID: 77956281205     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgq146     Document Type: Article
Times cited : (49)

References (60)
  • 1
    • 56449107092 scopus 로고    scopus 로고
    • Recent advances in colorectal cancer genetics and diagnostics
    • Cheah,P.Y. (2009) Recent advances in colorectal cancer genetics and diagnostics. Crit. Rev. Oncol. Hematol., 69, 45-55.
    • (2009) Crit. Rev. Oncol. Hematol. , vol.69 , pp. 45-55
    • Cheah, P.Y.1
  • 2
    • 0034644185 scopus 로고    scopus 로고
    • Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland
    • Lichtenstein,P. et al. (2000) Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland. N. Engl. J. Med., 343, 78-85.
    • (2000) N. Engl. J. Med. , vol.343 , pp. 78-85
    • Lichtenstein, P.1
  • 3
    • 33846332027 scopus 로고    scopus 로고
    • Explaining the familial colorectal cancer risk associated with mismatch repair (MMR)-deficient and MMR-stable tumors
    • Aaltonen,L. et al. (2007) Explaining the familial colorectal cancer risk associated with mismatch repair (MMR)-deficient and MMR-stable tumors. Clin. Cancer Res., 13, 356-361.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 356-361
    • Aaltonen, L.1
  • 4
    • 42649124305 scopus 로고    scopus 로고
    • Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21
    • Tenesa,A. et al. (2008) Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat. Genet., 40, 631-637.
    • (2008) Nat. Genet. , vol.40 , pp. 631-637
    • Tenesa, A.1
  • 5
    • 34547498546 scopus 로고    scopus 로고
    • A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21
    • Tomlinson,I. et al. (2007) A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nat. Genet., 39, 984-988.
    • (2007) Nat. Genet. , vol.39 , pp. 984-988
    • Tomlinson, I.1
  • 6
    • 34547092701 scopus 로고    scopus 로고
    • Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24
    • Zanke,B.W. et al. (2007) Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nat. Genet., 39, 989-994.
    • (2007) Nat. Genet. , vol.39 , pp. 989-994
    • Zanke, B.W.1
  • 7
    • 35648937584 scopus 로고    scopus 로고
    • A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk
    • Broderick,P. et al. (2007) A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk. Nat. Genet., 39, 1315-1317.
    • (2007) Nat. Genet. , vol.39 , pp. 1315-1317
    • Broderick, P.1
  • 8
    • 37549072226 scopus 로고    scopus 로고
    • Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk
    • Jaeger,E. et al. (2008) Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk. Nat. Genet., 40, 26-28.
    • (2008) Nat. Genet. , vol.40 , pp. 26-28
    • Jaeger, E.1
  • 9
    • 42649136554 scopus 로고    scopus 로고
    • A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
    • Tomlinson,I.P. et al. (2008) A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Nat. Genet., 40, 623-630.
    • (2008) Nat. Genet. , vol.40 , pp. 623-630
    • Tomlinson, I.P.1
  • 10
    • 56749176944 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
    • Houlston,R.S. et al. (2008) Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Nat. Genet., 40, 1426-1435.
    • (2008) Nat. Genet. , vol.40 , pp. 1426-1435
    • Houlston, R.S.1
  • 11
    • 49649105031 scopus 로고    scopus 로고
    • Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk
    • Berndt,S.I. et al. (2008) Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk. Hum. Mol. Genet., 17, 2665-2672.
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 2665-2672
    • Berndt, S.I.1
  • 12
    • 60549116326 scopus 로고    scopus 로고
    • Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21
    • Curtin,K. et al. (2009) Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21. Cancer Epidemiol. Biomarkers Prev., 18, 616-621.
    • (2009) Cancer Epidemiol. Biomarkers Prev. , vol.18 , pp. 616-621
    • Curtin, K.1
  • 13
    • 39449118229 scopus 로고    scopus 로고
    • A common 8q24 variant and the risk of colon cancer: a population-based case-control study
    • Li,L. et al. (2008) A common 8q24 variant and the risk of colon cancer: a population-based case-control study. Cancer Epidemiol. Biomarkers Prev., 17, 339-342.
    • (2008) Cancer Epidemiol. Biomarkers Prev. , vol.17 , pp. 339-342
    • Li, L.1
  • 14
    • 71049186073 scopus 로고    scopus 로고
    • Association between an 8q24 locus and the risk of colorectal cancer in Japanese
    • Matsuo,K. et al. (2009) Association between an 8q24 locus and the risk of colorectal cancer in Japanese. BMC Cancer, 9, 379.
    • (2009) BMC Cancer , vol.9 , pp. 379
    • Matsuo, K.1
  • 15
    • 72749099050 scopus 로고    scopus 로고
    • Enrichment of low penetrance susceptibility loci in a Dutch familial colorectal cancer cohort
    • Middeldorp, A. et al. (2009) Enrichment of low penetrance susceptibility loci in a Dutch familial colorectal cancer cohort. Cancer Epidemiol. Biomarkers Prev., 18, 3062-3067.
    • (2009) Cancer Epidemiol. Biomarkers Prev. , vol.18 , pp. 3062-3067
    • Middeldorp, A.1
  • 16
    • 56049119387 scopus 로고    scopus 로고
    • Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer
    • Pittman,A.M. et al. (2008) Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer. Hum. Mol. Genet., 17, 3720-3727.
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 3720-3727
    • Pittman, A.M.1
  • 17
    • 37049032569 scopus 로고    scopus 로고
    • Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: results from the Colon Cancer Family Registry
    • Poynter,J.N. et al. (2007) Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: results from the Colon Cancer Family Registry. Cancer Res., 67, 11128-11132.
    • (2007) Cancer Res. , vol.67 , pp. 11128-11132
    • Poynter, J.N.1
  • 18
    • 58149386907 scopus 로고    scopus 로고
    • Investigation of the colorectal cancer susceptibility region on chromosome 8q24.21 in a large German case-control sample
    • Schafmayer,C. et al. (2009) Investigation of the colorectal cancer susceptibility region on chromosome 8q24.21 in a large German case-control sample. Int. J. Cancer, 124, 75-80.
    • (2009) Int. J. Cancer , vol.124 , pp. 75-80
    • Schafmayer, C.1
  • 19
    • 76749121394 scopus 로고    scopus 로고
    • Increased risk of colon cancer associated with a genetic polymorphism of SMAD7
    • Slattery,M.L. et al. (2010) Increased risk of colon cancer associated with a genetic polymorphism of SMAD7. Cancer Res., 70, 1479-1485.
    • (2010) Cancer Res. , vol.70 , pp. 1479-1485
    • Slattery, M.L.1
  • 20
    • 67349245787 scopus 로고    scopus 로고
    • New insights into the aetiology of colorectal cancer from genome-wide association studies
    • Tenesa,A. et al. (2009) New insights into the aetiology of colorectal cancer from genome-wide association studies. Nat. Rev. Genet., 10, 353-358.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 353-358
    • Tenesa, A.1
  • 21
    • 61949237323 scopus 로고    scopus 로고
    • Surveying the genomic landscape of colorectal cancer
    • Hemminki,K. et al. (2009) Surveying the genomic landscape of colorectal cancer. Am. J. Gastroenterol., 104, 789-790.
    • (2009) Am. J. Gastroenterol. , vol.104 , pp. 789-790
    • Hemminki, K.1
  • 22
    • 0142063079 scopus 로고    scopus 로고
    • Polygenic inheritance of breast cancer: implications for design of association studies
    • Antoniou,A.C. et al. (2003) Polygenic inheritance of breast cancer: implications for design of association studies. Genet. Epidemiol., 25, 190-202.
    • (2003) Genet. Epidemiol. , vol.25 , pp. 190-202
    • Antoniou, A.C.1
  • 23
    • 53349108674 scopus 로고    scopus 로고
    • Family-based samples can play an important role in genetic association studies
    • Lange,E.M. et al. (2008) Family-based samples can play an important role in genetic association studies. Cancer Epidemiol. Biomarkers Prev., 17, 2208-2214.
    • (2008) Cancer Epidemiol. Biomarkers Prev. , vol.17 , pp. 2208-2214
    • Lange, E.M.1
  • 24
    • 65949104586 scopus 로고    scopus 로고
    • Genomewide association studies and human disease
    • Hardy,J. et al. (2009) Genomewide association studies and human disease. N. Engl. J. Med., 360, 1759-1768.
    • (2009) N. Engl. J. Med. , vol.360 , pp. 1759-1768
    • Hardy, J.1
  • 25
    • 34250876250 scopus 로고    scopus 로고
    • Genetic investigation of DNA-repair pathway genes PMS2, MLH1, MSH2, MSH6, MUTYH, OGG1 and MTH1 in sporadic colon cancer
    • Schafmayer,C. et al. (2007) Genetic investigation of DNA-repair pathway genes PMS2, MLH1, MSH2, MSH6, MUTYH, OGG1 and MTH1 in sporadic colon cancer. Int. J. Cancer, 121, 555-558.
    • (2007) Int. J. Cancer , vol.121 , pp. 555-558
    • Schafmayer, C.1
  • 26
    • 22944433733 scopus 로고    scopus 로고
    • Spectrum and frequencies of mutations in MSH2 and MLH1 identified in 1,721 German families suspected of hereditary nonpolyposis colorectal cancer
    • Mangold,E. et al. (2005) Spectrum and frequencies of mutations in MSH2 and MLH1 identified in 1,721 German families suspected of hereditary nonpolyposis colorectal cancer. Int. J. Cancer, 116, 692-702.
    • (2005) Int. J. Cancer , vol.116 , pp. 692-702
    • Mangold, E.1
  • 27
    • 33344470090 scopus 로고    scopus 로고
    • PopGen: population-based recruitment of patients and controls for the analysis of complex genotype-phenotype relationships
    • Krawczak,M. et al. (2006) PopGen: population-based recruitment of patients and controls for the analysis of complex genotype-phenotype relationships. Community Genet., 9, 55-61.
    • (2006) Community Genet. , vol.9 , pp. 55-61
    • Krawczak, M.1
  • 28
    • 54849184900 scopus 로고    scopus 로고
    • Ten recently identified associations between nsSNPs and colorectal cancer could not be replicated in German families
    • Frank,B. et al. (2008) Ten recently identified associations between nsSNPs and colorectal cancer could not be replicated in German families. Cancer Lett., 271, 153-157.
    • (2008) Cancer Lett. , vol.271 , pp. 153-157
    • Frank, B.1
  • 29
    • 0034884907 scopus 로고    scopus 로고
    • Study of Health In Pomerania (SHIP): a health examination survey in an east German region: objectives and design
    • John,U. et al. (2001) Study of Health In Pomerania (SHIP): a health examination survey in an east German region: objectives and design. Soz. Praventivmed., 46, 186-194.
    • (2001) Soz. Praventivmed. , vol.46 , pp. 186-194
    • John, U.1
  • 30
    • 33746129686 scopus 로고    scopus 로고
    • Does a negative screening colonoscopy ever need to be repeated?
    • Brenner,H. et al. (2006) Does a negative screening colonoscopy ever need to be repeated? Gut, 55, 1145-1150.
    • (2006) Gut , vol.55 , pp. 1145-1150
    • Brenner, H.1
  • 31
    • 66149128387 scopus 로고    scopus 로고
    • Genetic variation in adipokine genes and risk of colorectal cancer
    • Pechlivanis,S. et al. (2009) Genetic variation in adipokine genes and risk of colorectal cancer. Eur. J. Endocrinol., 160, 933-940.
    • (2009) Eur. J. Endocrinol. , vol.160 , pp. 933-940
    • Pechlivanis, S.1
  • 32
    • 42349112088 scopus 로고    scopus 로고
    • Genome-wide association studies for complex traits: consensus, uncertainty and challenges
    • McCarthy,M.I. et al. (2008) Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat. Rev. Genet., 9, 356-369.
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 356-369
    • McCarthy, M.I.1
  • 33
    • 34548292504 scopus 로고    scopus 로고
    • PLINK: a tool set for whole-genome association and population-based linkage analyses
    • Purcell,S. et al. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet., 81, 559-575.
    • (2007) Am. J. Hum. Genet. , vol.81 , pp. 559-575
    • Purcell, S.1
  • 34
    • 65549126774 scopus 로고    scopus 로고
    • Genetic structure of Europeans: a view from the North-East
    • Nelis,M. et al. (2009) Genetic structure of Europeans: a view from the North-East. PLoS One, 4, e5472.
    • (2009) PLoS One , vol.4
    • Nelis, M.1
  • 35
    • 56749182096 scopus 로고    scopus 로고
    • Lung cancer susceptibility locus at 5p15.33
    • McKay,J.D. et al. (2008) Lung cancer susceptibility locus at 5p15.33. Nat. Genet., 40, 1404-1406.
    • (2008) Nat. Genet. , vol.40 , pp. 1404-1406
    • McKay, J.D.1
  • 36
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature, 447, 661-678.
    • Nature , vol.447 , pp. 661-678
  • 37
    • 34347408099 scopus 로고    scopus 로고
    • Problems with genome-wide association studies
    • Williams,S.M. et al. (2007) Problems with genome-wide association studies. Science, 316, 1840-1842.
    • (2007) Science , vol.316 , pp. 1840-1842
    • Williams, S.M.1
  • 38
    • 33749993417 scopus 로고    scopus 로고
    • The consensus coding sequences of human breast and colorectal cancers
    • Sjoblom,T. et al. (2006) The consensus coding sequences of human breast and colorectal cancers. Science, 314, 268-274.
    • (2006) Science , vol.314 , pp. 268-274
    • Sjoblom, T.1
  • 39
    • 36248962105 scopus 로고    scopus 로고
    • The genomic landscapes of human breast and colorectal cancers
    • Wood,L.D. et al. (2007) The genomic landscapes of human breast and colorectal cancers. Science, 318, 1108-1113.
    • (2007) Science , vol.318 , pp. 1108-1113
    • Wood, L.D.1
  • 40
    • 63049105067 scopus 로고    scopus 로고
    • A transposon-based genetic screen in mice identifies genes altered in colorectal cancer
    • Starr,T.K. et al. (2009) A transposon-based genetic screen in mice identifies genes altered in colorectal cancer. Science, 323, 1747-1750.
    • (2009) Science , vol.323 , pp. 1747-1750
    • Starr, T.K.1
  • 41
    • 13444269543 scopus 로고    scopus 로고
    • Haploview: analysis and visualization of LD and haplotype maps
    • Barrett,J.C. et al. (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics, 21, 263-265.
    • (2005) Bioinformatics , vol.21 , pp. 263-265
    • Barrett, J.C.1
  • 42
    • 67649584052 scopus 로고    scopus 로고
    • Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder
    • Holmans,P. et al. (2009) Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder. Am. J. Hum. Genet., 85, 13-24.
    • (2009) Am. J. Hum. Genet. , vol.85 , pp. 13-24
    • Holmans, P.1
  • 43
    • 58149194611 scopus 로고    scopus 로고
    • ConsensusPathDB-a database for integrating human functional interaction networks
    • Kamburov,A. et al. (2009) ConsensusPathDB-a database for integrating human functional interaction networks. Nucleic Acids Res., 37, D623-D628.
    • (2009) Nucleic Acids Res , vol.37
    • Kamburov, A.1
  • 44
    • 67849130563 scopus 로고    scopus 로고
    • ToppGene Suite for gene list enrichment analysis and candidate gene prioritization
    • Chen,J. et al. (2009) ToppGene Suite for gene list enrichment analysis and candidate gene prioritization. Nucleic Acids Res., 37, W305-W311.
    • (2009) Nucleic Acids Res , vol.37
    • Chen, J.1
  • 45
    • 17844368327 scopus 로고    scopus 로고
    • The MAPK signalling pathways and colorectal cancer
    • Fang,J.Y. et al. (2005) The MAPK signalling pathways and colorectal cancer. Lancet Oncol., 6, 322-327.
    • (2005) Lancet Oncol. , vol.6 , pp. 322-327
    • Fang, J.Y.1
  • 46
    • 67349166946 scopus 로고    scopus 로고
    • Detecting gene-gene interactions that underlie human diseases
    • Cordell,H.J. (2009) Detecting gene-gene interactions that underlie human diseases. Nat. Rev. Genet., 10, 392-404.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 392-404
    • Cordell, H.J.1
  • 47
    • 0034973569 scopus 로고    scopus 로고
    • Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer
    • Ritchie,M.D. et al. (2001) Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. Am. J. Hum. Genet., 69, 138-147.
    • (2001) Am. J. Hum. Genet. , vol.69 , pp. 138-147
    • Ritchie, M.D.1
  • 48
    • 70349694160 scopus 로고    scopus 로고
    • Sonic hedgehog signaling proteins and ATP-binding cassette G2 are aberrantly expressed in diffuse large B-cell lymphoma
    • Kim,J.E. et al. (2009) Sonic hedgehog signaling proteins and ATP-binding cassette G2 are aberrantly expressed in diffuse large B-cell lymphoma. Mod. Pathol., 22, 1312-1320.
    • (2009) Mod. Pathol. , vol.22 , pp. 1312-1320
    • Kim, J.E.1
  • 49
    • 36248953744 scopus 로고    scopus 로고
    • Hedgehog signaling pathway is inactive in colorectal cancer cell lines
    • Chatel,G. et al. (2007) Hedgehog signaling pathway is inactive in colorectal cancer cell lines. Int. J. Cancer, 121, 2622-2627.
    • (2007) Int. J. Cancer , vol.121 , pp. 2622-2627
    • Chatel, G.1
  • 50
    • 53849112604 scopus 로고    scopus 로고
    • Integrative approach for differentially overexpressed genes in gastric cancer by combining large-scale gene expression profiling and network analysis
    • Takeno, A. et al. (2008) Integrative approach for differentially overexpressed genes in gastric cancer by combining large-scale gene expression profiling and network analysis. Br. J. Cancer, 99, 1307-1315.
    • (2008) Br. J. Cancer , vol.99 , pp. 1307-1315
    • Takeno, A.1
  • 51
    • 38449105399 scopus 로고    scopus 로고
    • Identification of molecular targets in head and neck squamous cell carcinomas based on genome-wide gene expression profiling
    • Shimizu,S. et al. (2007) Identification of molecular targets in head and neck squamous cell carcinomas based on genome-wide gene expression profiling. Oncol. Rep., 18, 1489-1497.
    • (2007) Oncol. Rep. , vol.18 , pp. 1489-1497
    • Shimizu, S.1
  • 52
    • 46849098205 scopus 로고    scopus 로고
    • Multiple loci with different cancer specificities within the 8q24 gene desert
    • Ghoussaini,M. et al. (2008) Multiple loci with different cancer specificities within the 8q24 gene desert. J. Natl Cancer Inst., 100, 962-966.
    • (2008) J. Natl Cancer Inst. , vol.100 , pp. 962-966
    • Ghoussaini, M.1
  • 53
    • 68149180901 scopus 로고    scopus 로고
    • The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer
    • Pomerantz,M.M. et al. (2009) The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. Nat. Genet., 41, 882-884.
    • (2009) Nat. Genet. , vol.41 , pp. 882-884
    • Pomerantz, M.M.1
  • 54
    • 68149170044 scopus 로고    scopus 로고
    • The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling
    • Tuupanen,S. et al. (2009) The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling. Nat. Genet., 41, 885-890.
    • (2009) Nat. Genet. , vol.41 , pp. 885-890
    • Tuupanen, S.1
  • 55
    • 23944469845 scopus 로고    scopus 로고
    • Recent developments in genomewide association scans: a workshop summary and review
    • Thomas,D.C. et al. (2005) Recent developments in genomewide association scans: a workshop summary and review. Am. J. Hum. Genet., 77, 337-345.
    • (2005) Am. J. Hum. Genet. , vol.77 , pp. 337-345
    • Thomas, D.C.1
  • 56
    • 62549085618 scopus 로고    scopus 로고
    • Human genetic variation and its contribution to complex traits
    • Frazer,K.A. et al. (2009) Human genetic variation and its contribution to complex traits. Nat. Rev. Genet., 10, 241-251.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 241-251
    • Frazer, K.A.1
  • 57
    • 70349956433 scopus 로고    scopus 로고
    • Finding the missing heritability of complex diseases
    • Manolio,T.A. et al. (2009) Finding the missing heritability of complex diseases. Nature, 461, 747-753.
    • (2009) Nature , vol.461 , pp. 747-753
    • Manolio, T.A.1
  • 58
    • 55549147191 scopus 로고    scopus 로고
    • Personal genomes: the case of the missing heritability
    • Maher,B. (2008) Personal genomes: the case of the missing heritability. Nature, 456, 18-21.
    • (2008) Nature , vol.456 , pp. 18-21
    • Maher, B.1
  • 59
    • 58549112996 scopus 로고    scopus 로고
    • Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
    • Huang da,W. et al. (2009) Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res., 37, 1-13.
    • (2009) Nucleic Acids Res. , vol.37 , pp. 1-13
    • Huang da, W.1
  • 60
    • 40849147041 scopus 로고    scopus 로고
    • EGFR antagonists in cancer treatment
    • Ciardiello,F. et al. (2008) EGFR antagonists in cancer treatment. N. Engl. J. Med., 358, 1160-1174.
    • (2008) N. Engl. J. Med. , vol.358 , pp. 1160-1174
    • Ciardiello, F.1


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