Barriers to the successful treatment of liver disease by hepatocyte transplantation

Journal of Hepatology

Volumn 53, Issue 4, 2010, Pages 769-774

  Soltys, Kyle A ^a   Soto Gutiérrez, Alejandro ^b   Nagaya, Masaki ^b   Baskin, Kevin M ^a   Deutsch, Melvin ^b   Ito, Ryotaro ^b   Shneider, Benjamin L ^a   Squires, Robert ^a   Vockley, Jerry ^a   Guha, Chandan ^c   Roy Chowdhury, Jayanta ^c   Strom, Stephen C ^b   Platt, Jeffrey L ^d   Fox, Ira J ^b  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Hepatocyte transplantation

Indexed keywords

IMMUNOSUPPRESSIVE AGENT;

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; BLEEDING; CANCER RADIOTHERAPY; CHRONIC LIVER DISEASE; CRIGLER NAJJAR SYNDROME; CRYOPRESERVATION; HEPATOCYTE TRANSPLANTATION; HUMAN; HYPERBILIRUBINEMIA; HYPEROXALURIA; IMMUNOSUPPRESSIVE TREATMENT; LIVER CELL; LIVER CIRRHOSIS; LIVER DISEASE; LIVER FAILURE; LIVER GRAFT REJECTION; LIVER HEMANGIOMA; LIVER METABOLISM; LUNG EMBOLISM; METABOLIC DISORDER; NEPHROBLASTOMA; NONHUMAN; ORGAN DONOR; PORTAL HYPERTENSION; PORTAL VEIN; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT;

EID: 77956265180     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.05.010     Document Type: Note

References (93)

1. F. Durand, and D. Valla Assessment of the prognosis of cirrhosis: Child-Pugh versus MELD J Hepatol 42 2005 S100 S107
2. P.M. Lopez, and P. Martin Update on liver transplantation: indications, organ allocation, and long-term care Mt Sinai J Med 73 2006 1056 1066
3. M. Hagmann Biomedicine. New genetic tricks to rejuvenate ailing livers Science 287 2000 1185 1187
4. R.M. Merion When is a patient too well and when is a patient too sick for a liver transplant? Liver Transpl 10 2004 S69 S73
5. J.M. De Vree, R. Ottenhoff, P.J. Bosma, A.J. Smith, J. Aten, and R.P. Oude Elferink Correction of liver disease by hepatocyte transplantation in a mouse model of progressive familial intrahepatic cholestasis Gastroenterology 119 2000 1720 1730
6. A.A. Demetriou, J.F. Whiting, D. Feldman, S.M. Levenson, N.R. Chowdhury, and A.D. Moscioni Replacement of liver function in rats by transplantation of microcarrier-attached hepatocytes Science 233 1986 1190 1192
7. I.J. Fox, and J. Roy-Chowdhury Hepatocyte transplantation J Hepatol 40 2004 878 886
8. C.G. Groth, B. Arborgh, C. Bjorken, B. Sundberg, and G. Lundgren Correction of hyperbilirubinemia in the glucuronyltransferase-deficient rat by intraportal hepatocyte transplantation Transplant Proc 9 1977 313 316
9. N. Kobayashi, T. Fujiwara, K.A. Westerman, Y. Inoue, M. Sakaguchi, and H. Noguchi Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes Science 287 2000 1258 1262
10. J.M. Kocken, I.H. Borel Rinkes, A.M. Bijma, W.K. de Roos, E. Bouwman, and O.T. Terpstra Correction of an inborn error of metabolism by intraportal hepatocyte transplantation in a dog model Transplantation 62 1996 358 364
11. A.J. Matas, D.E. Sutherland, M.W. Steffes, S.M. Mauer, A. Sowe, and R.L. Simmons Hepatocellular transplantation for metabolic deficiencies: decrease of plasms bilirubin in Gunn rats Science 192 1976 892 894
12. J. Ribeiro, B. Nordlinger, F. Ballet, L. Cynober, C. Coudray-Lucas, and M. Baudrimont Intrasplenic hepatocellular transplantation corrects hepatic encephalopathy in portacaval-shunted rats Hepatology 15 1992 12 18
13. C. Selden, D. Calnan, N. Morgan, H. Wilcox, E. Carr, and H.J. Hodgson Histidinemia in mice: a metabolic defect treated using a novel approach to hepatocellular transplantation Hepatology 21 1995 1405 1412
14. B.G. Sommer, D.E. Sutherland, R.L. Simmons, and J.S. Najarian Hepatocellular transplantation for experimental ischemic acute liver failure in dogs J Surg Res 29 1980 319 325
15. D.E. Sutherland, M. Numata, A.J. Matas, R.L. Simmons, and J.S. Najarian Hepatocellular transplantation in acute liver failure Surgery 82 1977 124 132
16. J.C. Wiederkehr, G.T. Kondos, and R. Pollak Hepatocyte transplantation for the low-density lipoprotein receptor-deficient state: a study in the Watanabe rabbit Transplantation 50 1990 466 471
17. Y. Yoshida, Y. Tokusashi, G.H. Lee, and K. Ogawa Intrahepatic transplantation of normal hepatocytes prevents Wilson's disease in Long-Evans cinnamon rats Gastroenterology 111 1996 1654 1660
18. K.P. Ponder, S. Gupta, F. Leland, G. Darlington, M. Finegold, and J. DeMayo Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation Proc Natl Acad Sci USA 88 1991 1217 1221
19. A. Dhawan, R.R. Mitry, R.D. Hughes, S. Lehec, C. Terry, and S. Bansal Hepatocyte transplantation for inherited factor VII deficiency Transplantation 78 2004 1812 1814
20. I.J. Fox, J.R. Chowdhury, S.S. Kaufman, T.C. Goertzen, N.R. Chowdhury, and P.I. Warkentin Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation N Engl J Med 338 1998 1422 1426
21. C.M. Habibullah, I.H. Syed, A. Qamar, and Z. Taher-Uz Human fetal hepatocyte transplantation in patients with fulminant hepatic failure Transplantation 58 1994 951 952
22. S.P. Horslen, and I.J. Fox Hepatocyte transplantation Transplantation 77 2004 1481 1486
23. S.P. Horslen, T.C. McCowan, T.C. Goertzen, P.I. Warkentin, H.B. Cai, and S.C. Strom Isolated hepatocyte transplantation in an infant with a severe urea cycle disorder Pediatrics 111 2003 1262 1267
24. M. Mito, M. Kusano, and Y. Kawaura Hepatocyte transplantation in man Transplant Proc 24 1992 3052 3053
25. M. Muraca, G. Gerunda, D. Neri, M.T. Vilei, A. Granato, and P. Feltracco Hepatocyte transplantation as a treatment for glycogen storage disease type 1a Lancet 359 2002 317 318
26. E.M. Sokal, F. Smets, A. Bourgois, L. Van Maldergem, J.P. Buts, and R. Reding Hepatocyte transplantation in a 4-year-old girl with peroxisomal biogenesis disease: technique, safety, and metabolic follow-up Transplantation 76 2003 735 738
27. S.C. Strom, J.R. Chowdhury, and I.J. Fox Hepatocyte transplantation for the treatment of human disease Semin Liver Dis 19 1999 39 48
28. P.N. Newsome, J.N. Plevris, L.J. Nelson, and P.C. Hayes Animal models of fulminant hepatic failure: a critical evaluation Liver Transpl 6 2000 21 31
29. J. Terblanche, and R. Hickman Animal models of fulminant hepatic failure Dig Dis Sci 36 1991 770 774
30. D.L. Sudan, B.W. Shaw Jr., I.J. Fox, and A.N. Langnas Long-term follow-up of auxiliary orthotopic liver transplantation for the treatment of fulminant hepatic failure Surgery 122 1997 771 777 discussion 777-8
31. J. Rozga Liver support technology - an update Xenotransplantation 13 2006 380 389
32. B.M. Bilir, D. Guinette, F. Karrer, D.A. Kumpe, J. Krysl, and J. Stephens Hepatocyte transplantation in acute liver failure Liver Transpl 6 2000 32 40
33. R.A. Fisher, D. Bu, M. Thompson, J. Tisnado, U. Prasad, and R. Sterling Defining hepatocellular chimerism in a liver failure patient bridged with hepatocyte infusion Transplantation 69 2000 303 307
34. W.M. Lee, R.H. Squires Jr., S.L. Nyberg, E. Doo, and J.H. Hoofnagle Acute liver failure: summary of a workshop Hepatology 47 2008 1401 1415
35. V.R. Mas, D.G. Maluf, M. Thompson, A. Ferreira-Gonzalez, and R.A. Fisher Engraftment measurement in human liver tissue after liver cell transplantation by short tandem repeats analysis Cell Transplant 13 2004 231 236
36. Ott M, Barthold M, Alexandrova K. Clinical applications of human hepatocytes isolated under CGMP conditions. In: 40th annual meeting of the European association for the study of the liver; 2005.
37. Soriano HE. Clinical trials of liver cell transplantation in children with liver failure. In: Cell transplant society 10th anniversary congress; 2001.
38. H.E. Soriano, R.P. Wood, and D.C. Kang Hepatocellular transplantation in children with fulminant liver failure Hepatology 30 1997 239A
39. Sterling RK, Fisher RA. Liver transplantation: living donor, hepatocyte, and xenotransplantation. In: Gish R, editor. Current future treatment therapies for liver disease. Clinics in Liver Disease. Philadelphia: WB Saunders; 2001.
40. M. Mito Hepatocyte transplantation in man Cell Transplant 2 1993 65
41. N. Kobayashi, M. Ito, J. Nakamura, J. Cai, C. Gao, and J.M. Hammel Hepatocyte transplantation in rats with decompensated cirrhosis Hepatology 31 2000 851 857
42. H. Nagata, M. Ito, J. Cai, A.S. Edge, J.L. Platt, and I.J. Fox Treatment of cirrhosis and liver failure in rats by hepatocyte xenotransplantation Gastroenterology 124 2003 422 431
43. A.A. Khan, A. Habeeb, and N. Parveen Peritoneal transplantation of human fetal hepatocytes for the treatment of acute fatty liver of pregnancy: a case report Trop Gastroenterol 25 2004 141 143
44. S.C. Strom, R.A. Fisher, M.T. Thompson, A.J. Sanyal, P.E. Cole, and J.M. Ham Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure Transplantation 63 1997 559 569
45. H. Nagata, M. Ito, C. Shirota, A. Edge, T.C. McCowan, and I.J. Fox Route of hepatocyte delivery affects hepatocyte engraftment in the spleen Transplantation 76 2003 732 734
46. S.F. Badylak The extracellular matrix as a biologic scaffold material Biomaterials 28 2007 3587 3593
47. H.C. Ott, T.S. Matthiesen, S.K. Goh, L.D. Black, S.M. Kren, and T.I. Netoff Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart Nat Med 14 2008 213 221
48. B.E. Uygun, A. Soto-Gutierrez, H. Yagi, M.L. Izamis, M.A. Guzzardi, and C. Shulman Organ re-engineering: development of a transplantable recellularized liver graft using decellularized liver matrix Nat Med 16 2010 814 820
49. H. Nagata, R. Nishitai, C. Shirota, J.L. Zhang, C.A. Koch, and J. Cai Prolonged survival of porcine hepatocytes in cynomolgus monkeys Gastroenterology 132 2007 321 329
50. R. Nishitai, T.B. Plummer, and J.L. Platt Detection of albumin synthesis in transplanted porcine hepatocytes in mice Liver Transpl 8 2002 972 974
51. K. Overturf, M. al-Dhalimy, C.N. Ou, M. Finegold, and M. Grompe Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes Am J Pathol 151 1997 1273 1280
52. J.A. Rhim, E.P. Sandgren, J.L. Degen, R.D. Palmiter, and R.L. Brinster Replacement of diseased mouse liver by hepatic cell transplantation Science 263 1994 1149 1152
53. J.A. Rhim, E.P. Sandgren, R.D. Palmiter, and R.L. Brinster Complete reconstitution of mouse liver with xenogeneic hepatocytes Proc Natl Acad Sci USA 92 1995 4942 4946
54. D. Guo, T. Fu, J.A. Nelson, R.A. Superina, and H.E. Soriano Liver repopulation after cell transplantation in mice treated with retrorsine and carbon tetrachloride Transplantation 73 2002 1818 1824
55. E. Laconi, R. Oren, D.K. Mukhopadhyay, E. Hurston, S. Laconi, and P. Pani Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine Am J Pathol 153 1998 319 329
56. L.J. Peters, H.R. Withers, J.H. Cundiff, and K.A. Dicke Radiobiological considerations in the use of total-body irradiation for bone-marrow transplantation Radiology 131 1979 243 247
57. C. Guha, A. Sharma, S. Gupta, A. Alfieri, G.R. Gorla, and S. Gagandeep Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatocyte transplantation Cancer Res 59 1999 5871 5874
58. I. Dagher, T.H. Nguyen, M.T. Groyer-Picard, P. Lainas, S. Mainot, and C. Guettier Efficient hepatocyte engraftment and long-term transgene expression after reversible portal embolization in nonhuman primates Hepatology 49 2009 950 959
59. K. Yamanouchi, H. Zhou, N. Roy-Chowdhury, F. Macaluso, L. Liu, and T. Yamamoto Hepatic irradiation augments engraftment of donor cells following hepatocyte transplantation Hepatology 49 2009 258 267
60. C. Guha, B. Parashar, N.J. Deb, M. Garg, G.R. Gorla, and A. Singh Normal hepatocytes correct serum bilirubin after repopulation of Gunn rat liver subjected to irradiation/partial resection Hepatology 36 2002 354 362
61. C. Guha, K. Yamanouchi, J. Jiang, X. Wang, N. Roy-Chowdhury, and A. Santana Feasibility of hepatocyte transplantation-based therapies for primary hyperoxalurias Am J Nephrol 25 2005 161 170
62. F.A. Mettler, A.C. Upton, and W. Hendee Medical effects of ionizing radiation 2008 Saunders Philadelphia
63. L.A. Dawson, and R.K. Ten Haken Partial volume tolerance of the liver to radiation Semin Radiat Oncol 15 2005 279 283
64. J.J. Kovalic, P.R. Thomas, J.B. Beckwith, J.H. Feusner, and P.A. Norkool Hepatocellular carcinoma as second malignant neoplasms in successfully treated Wilms' tumor patients. A National Wilms' Tumor Study report Cancer 67 1991 342 344
65. T.S. Lawrence, J.M. Robertson, M.S. Anscher, R.L. Jirtle, W.D. Ensminger, and L.F. Fajardo Hepatic toxicity resulting from cancer treatment Int J Radiat Oncol Biol Phys 31 1995 1237 1248
66. S.E. Order, and S.S. Donaldson Radiation therapy of benign diseases 2nd ed. 2003 Springer New York
67. H. Zhou, J. Ding, Y. Avsar, X. Wang, J. Roy-Chowdhury, and N. Roy-Chowdhury Repopulation of individual liver lobes by transplanted hepatocytes using regiospecific hepatic irradiation cures jaundice in the Gunn rat model of Crigler-Najjar Syndrome type I Hepatology 50 2009 303A
68. R.R. Mitry, A. Dhawan, R.D. Hughes, S. Bansal, S. Lehec, and C. Terry One liver, three recipients: segment IV from split-liver procedures as a source of hepatocytes for cell transplantation Transplantation 77 2004 1614 1616
69. R.D. Hughes, R.R. Mitry, A. Dhawan, S.C. Lehec, R. Girlanda, and M. Rela Isolation of hepatocytes from livers from non-heart-beating donors for cell transplantation Liver Transpl 12 2006 713 717
70. J. Meyburg, A.M. Das, F. Hoerster, M. Lindner, H. Kriegbaum, and G. Engelmann One liver for four children: first clinical series of liver cell transplantation for severe neonatal urea cycle defects Transplantation 87 2009 636 641
71. R. Nishitai, C.A. Koch, K. Ogata, B.E. Knudsen, T.B. Plummer, and K.A. Butters Toward the survival and function of xenogeneic hepatocyte grafts Liver Transpl 11 2005 39 50
72. C. Terry, R.D. Hughes, R.R. Mitry, S.C. Lehec, and A. Dhawan Cryopreservation-induced nonattachment of human hepatocytes: role of adhesion molecules Cell Transplant 16 2007 639 647
73. B. Diener, D. Utesch, and N. Beer A method for the cryopreservation of liver parenchymal cells for studies of xenobiotics Cryobiology 30 1993 116 127
74. J.G. Hengstler, D. Utesch, P. Steinberg, K.L. Platt, B. Diener, and M. Ringel Cryopreserved primary hepatocytes as a constantly available in vitro model for evaluation of human and animal drug metabolism and enzyme induction Drug Metab Rev 32 2000 81 118
75. J. Puppi, and A. Dhawan Human hepatocyte transplantation overview Methods Mol Biol 481 2009 1 16
76. K. Tanaka, A. Soto-Gutierrez, N. Navarro-Alvarez, J.D. Rivas-Carrillo, H.S. Jun, and N. Kobayashi Functional hepatocyte culture and its application to cell therapies Cell Transplant 15 2006 855 864
77. H. Basma, A. Soto-Gutierrez, G.R. Yannam, L. Liu, R. Ito, and T. Yamamoto Differentiation and transplantation of human embryonic stem cell-derived hepatocytes Gastroenterology 136 2009 990 999
78. K. Si-Tayeb, F.K. Noto, M. Nagaoka, J. Li, M.A. Battle, and C. Duris Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells Hepatology 51 2010 297 305
79. J. Yu, K. Hu, K. Smuga-Otto, S. Tian, R. Stewart, and I.I. Slukvin Human induced pluripotent stem cells free of vector and transgene sequences Science 324 2009 797 801
80. K. Takahashi, K. Tanabe, M. Ohnuki, M. Narita, T. Ichisaka, and K. Tomoda Induction of pluripotent stem cells from adult human fibroblasts by defined factors Cell 131 2007 861 872
81. M.G. Michaels, R. Lanford, A.J. Demetris, D. Chavez, K. Brasky, and J. Fung Lack of susceptibility of baboons to infection with hepatitis B virus Transplantation 61 1996 350 351
82. J.L. Platt New directions for organ transplantation Nature 392 1998 11 17
83. J.R. Gunsalus, D.A. Brady, S.M. Coulter, B.M. Gray, and A.S. Edge Reduction of serum cholesterol in Watanabe rabbits by xenogeneic hepatocellular transplantation Nat Med 3 1997 48 53
84. R.J. Fischel, A.J. Matas, J.L. Platt, E. Perry, H. Noreen, and S.J. Shumway Cardiac xenografting in the pig-to-rhesus monkey model: manipulation of antiendothelial antibody prolongs survival J Heart Lung Transplant 11 1992 965 973 discussion 973-964
85. A.G. Katopodis, R.G. Warner, R.O. Duthaler, M.B. Streiff, A. Bruelisauer, and O. Kretz Removal of anti-Galalpha1,3Gal xenoantibodies with an injectable polymer J Clin Invest 110 2002 1869 1877
86. D. Kolber-Simonds, L. Lai, S.R. Watt, M. Denaro, S. Arn, and M.L. Augenstein Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations Proc Natl Acad Sci USA 101 2004 7335 7340
87. K. Kuwaki, C. Knosalla, K. Moran, A. Alt, A.G. Katopodis, and R.O. Duthaler Reduction of anti-Galalpha1,3Gal antibodies by infusion of types 2 and 6 gal trisaccharides conjugated to poly-l-lysine Xenotransplantation 11 2004 210 215
88. S.S. Lin, B.C. Weidner, G.W. Byrne, L.E. Diamond, J.H. Lawson, and C.W. Hoopes The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants J Clin Invest 101 1998 1745 1756
89. J.L. Platt Genetic modification of xenografts Curr Top Microbiol Immunol 278 2003 1 21
90. K. Yamada, K. Yazawa, A. Shimizu, T. Iwanaga, Y. Hisashi, and M. Nuhn Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue Nat Med 11 2005 32 34
91. H. Tsukamoto, M. Matsuoka, and S.W. French Experimental models of hepatic fibrosis: a review Semin Liver Dis 10 1990 56 65
92. C.M. Walker Comparative features of hepatitis C virus infection in humans and chimpanzees Springer Semin Immunopathol 19 1997 85 98
93. P. Ramirez, R. Chavez, M. Majado, V. Munitiz, A. Munoz, and Q. Hernandez Life-supporting human complement regulator decay accelerating factor transgenic pig liver xenograft maintains the metabolic function and coagulation in the nonhuman primate for up to 8 days Transplantation 70 2000 989 998