New directions for organ transplantation

Nature

Volumn 392, Issue 6679 SUPPL., 1998, Pages 11-17

  Platt, Jeffrey L ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GRAFT REJECTION; HUMAN; IMMUNE RESPONSE; NONHUMAN; ORGAN TRANSPLANTATION; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; REVIEW; XENOTRANSPLANTATION; ZOONOSIS;

ANIMALS; GRAFT REJECTION; HUMANS; IMMUNE TOLERANCE; IMMUNOSUPPRESSIVE AGENTS; ORGAN TRANSPLANTATION; PAPIO; SPECIES SPECIFICITY; SWINE; TRANSPLANTATION, HETEROLOGOUS; ZOONOSES;

ANIMALIA;

EID: 0032580312     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (56)

1. Guthrie, C. C. Blood-vessel surgery and its applications (Longmans, Green, New York, 1912).
2. Evans, R. W., Orians, C. E. & Ascher, N. L. The potential supply oforgan donors: an assessment of the efficiency of organ procurement efforts in the United States. J. Am. Med. Assoc. 267, 239-246 (1992).
3. Calne, R. Y. Organ transplantation between widely disparate species. Transpl. Proc. 2, 550-556 (1970).
4. Parker, W. et al. Specificity and function of "natural" antibodies in immunodeficient subjects: clues to B- cell lineage and development. J. Clin. Immunol. 17, 311-321 (1997).
5. Good, A. H. et al. Identification of carbohydrate structures that bind human antiporcine antibodies: implications fordiscordant xenografting in humans. Transpl. Proc. 24, 559-562 (1992).
6. Galili, U., Clark, M. R., Shohet, S. B., Buehler, J. & Macher, B. A. Evolutionary relationship between the natural anti-Gal antibody and the Galα1-3Gal epitope in primates. Proc. Natl Acad. Sci. USA 84, 1369-1373 (1987).
7. Platt, J. L. et al. Immunopathology of hyperacute xenograft rejection in a swine-to-primate model. Transplantation 52, 214-220 (1991).
8. Saadi, S., Ihrcke, N. S. & Platt, J. L. in Principles of Immunomodulatory Drug Development in Transplantation and Autoimmunity 1st edn (eds Lieberman, R. & Morris, R.) 31-45 (Raven, New York, 1996).
9. Hourcade, D., Holers, V. M. & Atkinson, J. P. The regulators of complement activation (RCA) gene cluster. Adv. Immunol. 45, 381-416 (1989).
10. Platt, J. L. et al. Transplantation of discordant xenografts: a review of progress. Immunol. Today 11, 450-456 (1990).
11. Cooper, D. K. C. et al. Effects of cyclosporine and antibody adsorption on pig cardiac xenograft survival in the baboon. J. Heart Transpl. 7, 238-246 (1988).
12. Leventhal, J. R. et al. Prolongation of cardiac xenograft survival by depletion of complement. Transplantation 55, 857-866 (1993).
13. Sachs, D. H. & Sablinski, T. Tolerance across discordant xenogeneic barriers. Xenotransplantation 2, 234-239 (1995).
14. Lin, S. S. et al. The role of natural anti-Galα1-3Gal antibodies in hyperacute rejection of pig-to-baboon cardiac xenotransplants. Transpl. Immunol. 5, 212-218 (1997).
15. Sandrin, M. S. et al. Enzymatic remodelling of the carbohydrate surface of a xenogeneic cell substantially reduces human antibody binding and complement-mediated cytolysis. Nature Med. 1, 1261-1267 (1995).
16. Pruitt, S. K. et al. The effect of soluble complement receptor type 1 on hyperacute rejection of porcine xenografts. Transplantation 57, 363-370 (1994).
17. Magee, J. C. et al. Immunoglobulin prevents complement mediated hyperacute rejection in swine-to-primate xenotransplantation. J. Clin. Invest. 96, 2404-2412 (1995).
18. Wagner, E., Platt, J. L. & Frank, M. M. High-dose intravenous immunoglobulin does not affect complement-bacteria interactions. J. Immunol. 160, 1936-1943 (1998).
19. McCurry, K. R. et al. Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury. Nature Med. 1, 423-427 (1995).
20. Cozzi, E. & White, D. J. G. The generation of transgenic pigs as potential organ donors for humans. Nature Med. 1, 964-966 (1995).
21. Leventhal, J. R. et al. The immunopathology of cardiac xenograft rejection in the guinea pig to rat model. Transplantation 56, 1-8 (1993).
22. Bach, P. H., Winkler, H., Ferran, C., Hancock, W. W. & Robson, S. C. Delayed xenograft rejection. Immunol. Today 17, 379-384 (1996).
23. Parker, W. et al. Transplantation of discordant xenografts: 4 challenge revisited. Immunol. Today 17, 373-378 (1996).
24. Nagayasu, T. & Platt, J. L. Progress in xenotransplantation. Graft 1, 19-24 (1998).
25. Saadi, S., Holzkhecht, R. A., Patte, C. P., Stern, D. M. & Platt, J. L. Complement-mediated regulation of tissue factor activity in endothelium. J. Exp. 182, 1807-1814 (1995).
26. Lawson, J. H. & Platt, J. L. Molecular barriers to xenotransplantation. Transplantation 62, 303-310 (1996).
27. Lin, S. S. et al. Xenoreactive antibodies in the pathogenesis of acute vascular xenograft rejection in pig-to-primate xenografts. J. Clin. Invest. (in the press).
28. Cozzi, E. et al. in Xenotransplantation: the Transplantation of Organs and Tissues between Species 2nd edn (eds Cooper, D. K. C., Kemp, E., Platt, J. L. & White, D. J. G.) 665-682 (Springer, Berlin, 1997).
29. McCurry, K. R. et al. Humoral responses in pig-to-baboon cardiac transplantation: implications for the pathogenesis and treatment of acute vascular rejection and for accommodation. Hum. Immunol. 58, 91-105 (1997).
30. Robson, S. C. et al. Thrombin inhibition in an ex vivo model of porcine heart xenograft hyperacute rejection. Transplantation 61, 862-868 (1996).
31. Bach, F. H. et al. Accommodation of vascularized xenografts: expression of "protective genes" by donor endothelial cells in a host Th2 cytokine environment. Nature Med. 3, 196-204 (1997).
32. Zehr, K. J. et al. Neutrophil adhesion and complement inhibition prolongs survival of cardiac xenografts in discordant species. Transplantation 57, 900-906 (1994).
33. Chopek, M. W., Simmons, R. L. & Platt, J. L. ABO incompatible renal transplantation: initial immunopalhologic evaluation. Transpl. Proc. 19, 4553-4557 (1987).
34. Alter, B. J. & Bach, F. H. Cellular basis of the proliferative response of human T cells to mouse xenoantigens. J. Exp. Med. 191, 333-338 (1990).
35. Wrenshall, L. E., Cerra, F. B., Singh, R. K. & Platt, J. L. Heparan sulfate initiates signals in murine macrophages leading to divergent biological outcomes. J. Immunol. 154, 871-880 (1995).
36. Ihrcke, N. S., Wrenshall, L. E., Lindman, B. J. & Platt, J. L. Role of heparan sulfate in immune system-blood vessel interactions. Immunol. Today 14, 500-505 (1993).
37. Moses, R. D., Winn, H. J. & Auchincloss, H. Jr Multiple defects in cell surface molecule interactions across species differences are responsible for diminished xenogeneic T cell responses. Transplantation 53, 203-209 (1992).
38. Zhao, Y. et al. Skin graft tolerance across a discordant xenogeneic barrier. Nature Med. 2, 1211-1216 (1996).
39. Li, H. et al. Mixed xenogeneic chimerism (mouse+rat→mouse) to induce donor-specific tolerance to sequential orsimultaneous islet xenografts. Transplantation 57, 592-598 (1994).
40. Starzl, T. E. et al. Cell migration, chimerism, and graft acceptance. Lancet 339, 1579-1582 (1992).
41. Inverardi, L. et al. Early recognition of a discordant xenogeneic organ by human circulating lymphocytes. J. Immunol. 149, 1416-1423 (1992).
42. Malyguine, A. M. et al. Induction of procoagulant function in porcine endothelial cells by human NK cells. J. Immunol. 159, 4659-4664 (1997).
43. Sablinski, T. et al. Xenotransplantation of pig kidneys to nonhuman primates: I. development of the model. Xenotransplantation 2, 264-270 (1995).
44. Kypson, A. P. et al. Ex vivo adenoviral-mediated gene transfer to the transplanted adult rat heart. J. Thor. Cardiovasc. Surg. (in the press).
45. Daggett, C. W. et al. Total respiratory support from swine lungs in primate recipients. J. Thor. Cardiovasc. Surg. (in the press).
46. Chari, R. S. et al. Treatment ofhepatic failure with ex-vivo pig liver perfusion followed by liver transplantation. N. Engl. J. Med. 331, 234-237 (1994).
47. Akhter, S. A. et al. Restoration of β-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer. Proc. Natl Acad. Sci. USA 94, 12100-12105 (1997).
48. Starzl, T. E. et al. Baboon-to-human liver transplantation. Lancet 341, 65-71 (1993).
49. Patience, C., Takeuchi, Y. & Weiss, R. A. Infection of human cells by an endogenous retrovirus of pigs. Nature Med. 3, 282-286 (1997).
50. Allan, J. S. Xenotransplantation at a crossroads: prevention versus progress. Nature Med. 2, 18-21 (1996).
51. Groth, C. G. et al. Transplantation of porcine fetal pancreas to diabetic patients. Lancet 344, 1402-1404 (1994).
52. Isacson, O. et al. Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificty and distinct growth patterns of glial and axonal fibers. Nature Med. 1, 1189-1194 (1995).
53. Deacon, T. et al. Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease. Nature Med. 3, 350-353 (1997).
54. Sharma, A., Okabe, J. F., Birch, P., Platt, J. L. & Logan, J. S. Reduction in the level of gal (α1,3) gal in transgenic mice and pigs by the expression of an α(1,2) fucosyltransferase. Proc. Natl Acad. Sci. USA 93, 7190-7195 (1996).
55. Charlton, B., Auchincloss, H. Jr & Fathman, C. G. Mechanisms of transplantation tolerance. Annu. Rev. Immunol. 12, 707-734 (1994).
56. Waldmann, H. & Cobbold, S. The use of monoclonal antibodies to achieve immunological tolerance. Immunol. Today 14, 247-251 (1993).