Tyrphostin B42 inhibits IL-12-induced tyrosine phosphorylation and activation of Janus kinase-2 and prevents experimental allergic encephalomyelitis

Journal of Immunology

Volumn 162, Issue 10, 1999, Pages 6255-6262

  Bright, John J ^a   Du, Caigan ^a   Sriram, Subramaniam ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; PROTEIN TYROSINE KINASE; TYRPHOSTIN; TYRPHOSTIN B42; UNCLASSIFIED DRUG;

ADOLESCENT; ALLERGIC ENCEPHALOMYELITIS; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; HELPER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0033563170     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Trinchieri, G. 1995. Interleukin 12: a pro-inflammatory cytokine with immuno-regulatory functions that bridge innate resistance and antigen specific adaptive immunity. Annu. Rev. Immunol. 13:251.
2. Constantinescu, C. S., K. Frei, M. Wysocka, G. Trinchieri, U. Malipiero, A. Rostami, and A. Fontana. 1996. Astrocytes and microglia produce interleukin-12 p40. Ann. NY Acad. Sci. 795:328.
3. Cella, M., D. Scheidegger, K. Palmer-Lehmann, P. Lane, and A. Lanzavecchia. 1996. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184:747.
4. Sriskandan, S., T. J. Evana, and J. Cohen. 1996. Bacterial superantigen induced human lymphocyte responses are nitric oxide dependent and mediated by IL-12 and IFN-γ. J. Immunol. 156:2430.
5. Bette, M., S. C. Jin, T. Germann, M. K. Schafer, E. Weihe, E. Rude, and B. Flaischer. 1994. Differential expression of mRNA encoding interleukin-12p35 and p40 subunits in situ. Eur. J. Immunol. 24:2435.
6. Trinchieri, G. 1993. Interleukin-12 and its role in the generation of Th1 cells. Immunol. Today 14:335.
7. Zhang, M., M. K. Gately, E. Wang, J. Gong, S. F. Wolf, S. Lu, R. L. Modlin, and P. F. Barnes. 1994. Interleukin 12 at the site of disease in tuberculosis. J. Clin. Invest. 93:1733.
8. Sieling, P. A., and R. L. Modlin. 1994. Cytokine patterns at the site of mycobacterial infection. Immunobiology 191:378.
9. Piermez, C., M. Yamamura, K. Uyemura, M. Paes-Oliveira, F. Conceicao-Silva, and R. L. Modlin. 1993. Cytokine patterns in the pathogenesis of human leishmaniasis. J. Clin. Invest. 91:1390.
10. Chougnet, C., T. A. Wynn, M. Clerici, A. L. Landay, H. A. Kessler, J. Rusnak, G. P. Melcher, A. Sher, and G. M. Shearer. 1996. Molecular analysis of decreased interleukin-12 production in persons infected with human immunodeficiency virus. J. Infect. Dis. 174:46.
11. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547.
12. Owens, T., and S. Sriram. 1995. The immunology of multiple sclerosis and its animal model, experimental allergic encephalomyelitis. Neurol. Clin. 13:51.
13. Raine, C. S. 1984. Analysis of autoimmune demyelination: its impact on MS. Lab. Invest. 50:608.
14. Scolding, N. J., J. P. Zajicek, and D. A. S. Compston. 1994. The pathogenesis of demyelinating disease. Prog. Neurobiol. 43:143.
15. Windhagen, A., J. Newcombe, F. Dangond, C. Strand, M. Woodroofe, M. L. Cuzner, and D. A. Hafler. 1995. Expression of co-stimulatory molecules B7-1 (CD80) B7-2 (CD86) and IL-12 in MS lesions. J. Exp. Med. 82:1985.
16. Bright, J. J., B. F. Musuro, C. Du, and S. Sriram. 1998. Expression of IL-12 in CNS and lymphoid organs of mice with experimental allergic encephalomyelitis. J. Neuroimmunol. 82:22.
17. Leonard, J. P., K. E. Waldburger, and S. J. Goldman. 1995. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin-12. J. Exp. Med. 181:381.
18. Gubler, U., and D. H. Presky. 1996. Molecular biology of interleukin-12 receptors. Ann. NY Acad. Sci. 795:36.
19. Bacon, C. M., D. W. McVicar, J. R. Ortaldo, R. C. Rees, and J. J. O'Shea. 1995. Interleukin-12 induces tyrosine phosphorylation of Jak-2 and Tyk-2: differential use of Janus tyrosine kinases by interleukin-2 and interleukin-12. J. Exp. Med. 181:399.
20. Bacon, C. M., E. F. Petricoin III, J. R. Ortaldo, R. C. Rees, A. C. Larner, J. A. Johnston, and J. J. O'Shea. 1995. Interleukin 12 induces tyrosine phosphorylation and activation of Stat4 in human lymphocytes. Proc. Natl. Acad. Sci. USA 92:7307.
21. Jacobson, N. G., S. J. Szabo, R. M. Weber-Nordt, Z. Zhong, R. D. Schreiber, J. E. Darnell, and K. M. Murphy. 1995. Interleukin-12 signaling in Th1 cells involves tyrosine phosphorylation of Stat3 and Stat4. J. Exp. Med. 181:1755.
22. Spencer, D., T. J. Wnadless, S. L. Schreiber, and G. R. Crabtree. 1993. Controlling signal transduction with synthetic ligands. Science 262:1019.
23. Hunter, T. 1996. Tyrosine phosphorylation: past, present and future. Biochem. Soc. Trans. 24:307.
24. Levitzki, A., and A. Gazit. 1995. Tyrosine kinase inhibition: an approach to drug development. Science 267:1782.
25. Ito, T., and W.S. May. 1996. Drug development train gathering steam. Nat. Med. 2:403.
26. Levitzki, A. 1992. Tyrphostins: tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction. FASEB. J. 6:3275.
27. Osherov, N., and A. Levitzki. 1997. Tyrphostin AG497 blocks Cdk2 activation. FEBS Lett. 410:187.
28. Esther, A., S. Iftach, and P. Esther. 1994. Inhibition of Moloney murine leukemia virus replication by tyrphostins, tyrosine kinase inhibitors. FEBS Lett. 341:99.
29. Yura, Y., J. Kusaka, H. Tsujimoto, Y. Yoshioka, H. Yoshida, and M. Sato. 1997. Effect of protein tyrosine kinase inhibitors on the replication of herpes simplex virus and the phosphorylation of viral proteins. Intervirology 40:7.
30. Meydan, N., T. Grunberger, H. Dadi, M. Shahar, E. Arpaia, Z. Lapidot, J. S. Leeder, M. Freedman, A. Cohen, A. Gazit, et al. 1996. Inhibition of acute lymphoblastic leukaemia by Jak-2 inhibitor. Nature 379:645.
31. Nielsen, M., K. Kaltoft, M. Nordahl, C. Ropke, C. Geisler, T. Mustelin, P. Dobson, A. Svejgaard, and N. Odum. 1997. Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG 490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines. Proc. Nat. Acad. Sci. USA 94:6764.
32. Bright, J. J., L. D. Kerr, and S. Sriram. 1997. TGF-β inhibits IL-2 induced tyrosine phosphorylation and activation of Jak-1 and Stat5 in T lymphocytes. J. Immunol. 159:175.
33. Su, X., and S. Sriram. 1992. Analysis of TCR Vβ gene usage and encephalitogenicity of myelin basic protein peptide p91-103 reactive T cell clones in SJL mice: lack of evidence for V gene hypothesis. Cell. Immunol. 141:485.
34. Bright, J. J., and S. Sriram. 1998. TGF-β inhibits IL-12-induced activation of Jak-STAT pathway in T lymphocytes. J. Immunol. 161:1772.
35. Bright, J. J., D. J. Topham, B. Nag, P. A. Lodge, and S. Sriram. 1996. Vaccination with peptides from MHC class II β chain hypervariable region causes allele-specific suppression of EAE. J. Neuroimmunol. 67:119.
36. Darnell, J. E., I. M. Kerr, and G. R. Stark. 1994. Jak-Stat pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415.
37. Ihle, J. N. 1996. Signaling by the cytokine receptor superfamily in normal and transformed hematopoietic cells. Cancer Res. 68:23.
38. Chaturvedi, P., M. V. Reddy, and E. P. Reddy. 1998. Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation. Oncogene 16: 1749.
39. Weller, M., D. B. Constam, U. Malipiero, and A. Fontana. 1994. Transforming growth factor-β2 induces apoptosis of murine T cell clones without down-regulating Bcl-2 mRNA expression. Eur. J. Immunol. 24:293.
40. Maruo, S., K. Toyo-oka, M. Oh-hora, X. G. Tai, H. Iwata, H. Takenaka, S. Yamada, S. Ono, S. Hamaoka, M. Kobayashi, et al. 1996. IL-12 produced by antigen presenting cells induces IL-2 independent proliferation of T helper clones. J. Immunol. 156:1748.
41. Hara, T., and A. Miyajima. 1996. Function and signal transduction mediated by the interleukin 3 receptor system in hematopoiesis. Stem Cell 14:605.
42. Thierfelder, W. E., J. M. Van Deursen, K. Yamamoto, R. A. Tripp, S. R. Sarawar, R. T. Carson, M. Y. Sangster, D. A. Vignali, P. C. Doherty, G. C. Grosveld, et al. 1996. Requirement for Stat4 in interleukin-12 mediated responses of natural killer and T cells. Nature 382:171.
43. Constantin, G., S. Brocke, A. Izikson, C. Landanna, and E. C. Butcher. 1998. Tyrphostin AG490, a tyrosine kinase inhibitor, blocks actively induced experimental autoimmune encephalomyelitis. Eur. J. Immunol. 28:3523.
44. Constantin, G., C. Landanna, S. Brocke, and E. C. Butcher. 1999. Inhibition of experimental allergic encephalomyelitis by a tyrosine kinase inhibitor. J. Immunol. 162:1144.