Lack of CIITA expression is central to the absence of antigen presentation functions of trophoblast cells and is caused by methylation of the IFN-γ inducible promoter (PIV) of CIITA

Human Immunology

Volumn 61, Issue 9, 2000, Pages 850-862

  Van den Elsen, Peter J ^a   Van der Stoep, Nienke ^a   Viëtor, Henk E ^b   Wilson, Louis ^a   Van Zutphen, Marlijn ^a   Gobin, Sam J P ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

CIITA; IFN ; MHC; Transcription; Trophoblast cells

Indexed keywords

GAMMA INTERFERON; HLA B ANTIGEN; HLA C ANTIGEN; HLA DP ANTIGEN; HLA DQ ANTIGEN; HLA DR ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TRANSACTIVATOR PROTEIN;

ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; CHORION VILLUS; CONTROLLED STUDY; FETUS; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; METHYLATION; PRIORITY JOURNAL; PROMOTER REGION; TROPHOBLAST;

ANTIGEN PRESENTATION; CELL LINE; CELL LINE, TRANSFORMED; CHORIOCARCINOMA; CHORIONIC VILLI; DNA METHYLATION; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HELA CELLS; HLA ANTIGENS; HUMAN; INTERFERON TYPE II; K562 CELLS; PROMOTER REGIONS (GENETICS); SUPPORT, NON-U.S. GOV'T; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFECTION; TROPHOBLASTS;

EID: 0033789216     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0198-8859(00)00159-2     Document Type: Article

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