Pore mutations in Shaker K+ channels distinguish between the sites of tetraethylammonium blockade and C-type inactivation

Journal of Physiology

Volumn 499, Issue 2, 1997, Pages 361-367

  Molina, A ^a   Castellano, A G ^a   Lopez Barneo J ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; POTASSIUM CHANNEL; POTASSIUM ION; TETRYLAMMONIUM;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ELECTRIC POTENTIAL; MOLECULAR BIOLOGY; NERVE FIBER C; NONHUMAN; PRIORITY JOURNAL;

EID: 0030993829     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.1997.sp021933     Document Type: Article

References (20)

1. + channel. Science 271, 653-656.
2. BUSCH, A. E., HURST, R. S., NORTH, R. A., ADELMAN, J. P. & KAVANAUGH, M. P. (1991). Current inactivation involves a histidine residue in the pore of the rat lymphocyte potassium channel RGK5. Biochemical and Biophysical Research Communications 179, 1384-1390.
3. + channels. Proceedings of the National Academy of Sciences of the USA 88, 5092-5095.
4. + pores. Pflügers Archiv 422, 354-363.
5. + channels in human T lymphocytes. Biophysical Journal 55, 203-206.
6. HEGINBOTHAM, L. & MACKINNON, R. (1992). The aromatic binding site for tetraethylammonium ions on potassium channels. Neuron 8, 483-491.
7. HILLE, B. (1992). Ionic Channels of Excitable Membranes, 2nd edn. Sinauer Associates Inc., Sunderland, MA, USA.
8. HOSHI, T., ZAGOTTA, W. N. & ALDRICH, R. W. (1990). Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science 250, 533-538.
9. + channels: effects of alterations in the carboxy-terminal region. Neuron 7, 547-556.
10. KAVANAUGH, M. P., HURST, R. S., YAKEL, J., VARNUM, M. D., ADELMAN, J. P. & NORTH, R. A. (1992). Multiple subunits of a voltage-dependent potassium channel contribute to the binding site for tetraethylammonium, Neuron 8, 493-497.
11. KIRSCH, G. E., PASCUAL, J. M. & SHIEH, C.-C. (1995). Functional role of a conserved aspartate in the external mouth of voltage-gated potassium channels. Biophysical Journal 68, 1804-1813.
12. + channel during gating. Neuron 16, 859-867.
13. LÓPEZ-BARNEO, J., HOSHI, T., HEINEMANN, S. H. & ALDRICH, R. W. (1993). Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. Receptors and Channels 1, 61-71.
14. + channels. Science 250, 276-279.
15. + channels. Biophysical Journal 69, 2449-2457.
16. + channel occurs by a cooperative mechanism. Biophysical Journal 69, 896-903.
17. + channel. Proceedings of the National Academy of Sciences of the USA 89, 2466-2470.
18. SCHLIEF, T., SCHÖNHERR, R. & HEINEMANN, S. H. (1996). Modification of C-type inactivating Shaker potassium channels by chloramine-T. Pflügers Archiv 431, 483-493.
19. STÜHMER, W., RUPPERSBERG, J. P., SCHRÖTER, K. H., SAKMANN, B., STOCKER, M., GIESE, K. P., PERSCHKE, A., BAUMANN, A. & PONGS, O. (1989). Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. EMBO Journal 8, 3235-3244.
20. + channel allows inactivation to be modulated by metal binding. Biophysical Journal 66, 1068-1075.