Identification of a pharmacophore of SKCa channel blockers

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 20, Issue 6, 2005, Pages 517-523

  Dilly, Sebastien ^a   Graulich, Amaury ^b   Farce, Amaury ^a   Seutin, Vincent ^b   Liegeois, Jean Francois ^b   Chavatte, Philippe ^a  

^a UNIV LILLE   (France)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Apamin; Blockers; Dequalinium; Model; Pharmacophore; SK channels

Indexed keywords

APAMIN; BQ 1; BQ 2; BQ 3; CALCIUM; DEQUALINIUM; LAUDANOSINE; POTASSIUM CHANNEL BLOCKING AGENT; QUINOLINE DERIVATIVE; RECEPTOR SUBTYPE; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; TUBOCURARINE CHLORIDE; UCL 1530; UCL 1684; UCL 1848; UNCLASSIFIED DRUG; AZEPINE DERIVATIVE; BQ1 COMPOUND; BQ2 COMPOUND; BQ3 COMPOUND; CADAVERINE; DRUG DERIVATIVE; MACROCYCLIC COMPOUND;

ARTICLE; BRAIN; CALCIUM CELL LEVEL; CENTRAL NERVOUS SYSTEM; COGNITIVE DEFECT; DEPRESSION; DRUG CONFORMATION; DRUG STRUCTURE; EXCITABILITY; HYPERPOLARIZATION; PARKINSON DISEASE; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; BEE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; MOLECULAR GENETICS; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; APAMIN; AZEPINES; BEES; CADAVERINE; DRUG DESIGN; MACROCYCLIC COMPOUNDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; POTASSIUM CHANNEL BLOCKERS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; QUINOLINES; QUINOLINIUM COMPOUNDS; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33644969875     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360500210989     Document Type: Article

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