Calcium- and FK506-independent interaction between the immunophilin FKBP51 and calcineurin

Journal of Cellular Biochemistry

Volumn 84, Issue 3, 2002, Pages 460-471

  Li, Ta Kai ^a   Baksh, Shairaz ^a   Cristillo, Anthony D ^a   Bierer, Barbara E ^a,b  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Calcineurin; Cyclosporin; FKBPs; Immunophilin; Immunosuppression; Rapamycin; Transplantation

Indexed keywords

CALCINEURIN; CYCLOSPORIN; FK 506 BINDING PROTEIN; FK 506 BINDING PROTEIN 51; IMMUNOPHILIN; IMMUNOSUPPRESSIVE AGENT; RAPAMYCIN; TACROLIMUS; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATTLE; CELL LYSATE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG PROTEIN BINDING; GENE DELETION; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; T LYMPHOCYTE;

ANIMALIA; BOS TAURUS; BOVINAE; MURINAE;

EID: 0035702976     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.10026     Document Type: Article

References (60)

1. Dysregulated expression of androgen-responsive and nonresponsive genes in the androgen-independent prostate cancer xenograft model CWR22-RR1
2. Analysis of FKBP51/FKBP52 chimeras and mutants for Hsp90 binding and association with progesterone receptor complexes
3. Genes newly identified as regulated by glucocorticoids in murine thymocytes
4. FKBP51, a novel T-cell-specific immunophihn capable of calcineurin inhibition
5. Tissue distribution and abundance of human FKBP51, an FK506-binding protein that can mediate calcineurin inhibition
6. FK506, and rapamycin: Binding to immunophilins and biological action
7. Partial deletions of the cytoplasmic domain of CD2 result in a partial defect in signal transduction
8. Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein
9. 2+ flux
10. Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands
11. Mechanism of TGF receptor inhibition by FKBP12
12. Glucocorticoids inhibit calcium- and calcineurin-dependent activation of the human IL-4 promoter
13. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
14. Association of protein kinase A and protein phosphatase 2B with a common anchoring protein
15. The immunophilins FK506 binding protein and cyclophilin, are discretely localized in the brain: Relationship to calcineurin
16. Squirrel monkey immunophilin FKBP51 is a potent inhibitor of glucocorticoid receptor binding
17. Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins
18. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A
19. FK506 binding protein 12 mediates sensitivity to both FK506 and rapamycin in murine mast cells
20. DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways
21. Peptidylproline cis-trans-isomerases: Immunophilins
22. Identification and characterization of a highly conserved calcineurin binding protein CBP1/calcipressin, in Cryptococcus neoformans
23. Quantitative assessment of complex formation of nuclear-receptor accessory proteins
24. Evidence that the hormone-binding domain of the mouse glucocorticoid receptor directly represses DNA binding activity in a major portion of receptors that are "misfolded" after removal of hsp90
25. FK506 binding to the 56-kilodalton immunophilin (Hsp56) in the glucocorticoid receptor heterocomplex has no effect on receptor folding or function
26. Molecular cloning of a 25-kDa high affinity rapamycin binding protein FKBP25
27. The involvement of p23, hsp90, and immunophilins in the assembly of progesterone receptor complexes
28. AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region
29. Structure-function relationships in the FK506-binding protein (FKBP) family of peptidylprolyl cis-trans isomerases
30. Novel progesterone target genes identified by an improved differential display technique suggest that progestin-induced growth inhibition of breast cancer cells coincides with enhancement of differentiation
31. A conserved family of calcineurin regulators
32. Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein
33. Regulation of the calmodulin-stimulated protein phosphatase, calcineurin
34. Cain, a novel physiologic protein inhibitor of calcineurin
35. Calcium/calmodulin kinase inhibitors and immunosuppressant macrolides rapamycin and FK506 inhibit progestin- and glucocorticosteroid receptor-mediated transcription in human breast cancer T47D cells
36. A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange
37. Association of p59fyn with the T lymphocyte costimulatory receptor CD2
38. Inhibition of calcineurin phosphatase activity by a calcineurin B homologous protein
39. Calcineurin is a common target of cyclophilin cyclosporin A and FKBP-FK506 complexes
40. Cellular functions of immunophilins
41. A viral mechanism for inhibition of the cellular phosphatase calcineurin
42. A pathway of multichaperone interactions common to diverse regulatory proteins: Estrogen receptor. Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor
43. Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor
44. Potentiation of glucocorticoid receptor-mediated gene expression by the immunophilin ligands FK506 and rapamycin
45. Immunolocalization of calcineurin and FKBP12, the FK506-binding protein, in Hassall's corpuscles of human thymus and epidermis
46. Efficient selection for high-expression transfectants with a novel eukaryotic vector
47. FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin
48. Glucocorticoids regulate calcineurin-dependent trans-activating pathways for interleukin-2 gene transcription in human T lymphoytes
49. Regulation of calcineurin phosphatase activity and interaction with the FK-506/FK-506 binding protein complex
50. Steroid receptor interactions with heat shock protein and immunophilin chaperones
51. Transcription factors of the NFAT family: Regulation and function
52. Glucocorticoid resistance in the squirrel monkey is associated with overexpression of the immunophilin FKBP51
53. Regulation of the protein phosphatase calcineurin by redox: Implications for catalysis and signal transduction
54. Protein folding and the regulation of signaling pathways
55. Cloning and expression of a mouse cDNA endocing p59, an immunophilin that associates with the glucocorticoid receptor
56. High brain densities of the immunophilin FKBP colocalized with calcineurin
57. Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes
58. Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506
59. Identification and characterization of an immunophilin expressed during the clonal expansion phase of adipocyte differentiation
60. Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90