메뉴 건너뛰기




Volumn 9, Issue 3, 2008, Pages 189-196

Rationale for statins in the chemoprevention of prostate cancer

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; FINASTERIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; PLACEBO; SILDENAFIL; SIMVASTATIN;

EID: 44449163871     PISSN: 15272737     EISSN: 15346285     Source Type: Journal    
DOI: 10.1007/s11934-008-0034-z     Document Type: Review
Times cited : (21)

References (65)
  • 1
    • 37349049507 scopus 로고    scopus 로고
    • Lamb E: Top 200 Prescription Drugs of 2006. Pharmacy Times, May 2007. Accessible at http://www.pharmacytimes.com/article.cfm?ID=4629. Accessed December 2007.
    • Lamb E: Top 200 Prescription Drugs of 2006. Pharmacy Times, May 2007. Accessible at http://www.pharmacytimes.com/article.cfm?ID=4629. Accessed December 2007.
  • 2
    • 26244432388 scopus 로고    scopus 로고
    • Efficacy and safety of cholesterol-lowering treatment: Prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
    • Baigent C, Keech A, Kearney PM, et al.: Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet 2005, 366:1267-1278.
    • (2005) Lancet , vol.366 , pp. 1267-1278
    • Baigent, C.1    Keech, A.2    Kearney, P.M.3
  • 3
    • 19444364509 scopus 로고    scopus 로고
    • Statins and the risk of colorectal cancer
    • Poynter JN, Gruber SB, Higgins PD, et al.: Statins and the risk of colorectal cancer. N Engl J Med 2005, 352:2184-2192.
    • (2005) N Engl J Med , vol.352 , pp. 2184-2192
    • Poynter, J.N.1    Gruber, S.B.2    Higgins, P.D.3
  • 4
    • 14844292583 scopus 로고    scopus 로고
    • Cancer risk among statin users: A population-based cohort study
    • Friis S, Poulsen AH, Johnsen SP, et al.: Cancer risk among statin users: a population-based cohort study. Int J Cancer 2005, 114:643-647.
    • (2005) Int J Cancer , vol.114 , pp. 643-647
    • Friis, S.1    Poulsen, A.H.2    Johnsen, S.P.3
  • 5
    • 23944487796 scopus 로고    scopus 로고
    • Statins and prostate cancer risk: A case-control study
    • The first paper to observe a significant inverse association between statin use and overall prostate cancer risk. This paper was also the first to suggest statins may preferentially inhibit or prevent aggressive prostate cancer
    • Shannon J, Tewoderos S, Garzotto M, et al.: Statins and prostate cancer risk: a case-control study. Am J Epidemiol 2005, 162:318-325. The first paper to observe a significant inverse association between statin use and overall prostate cancer risk. This paper was also the first to suggest statins may preferentially inhibit or prevent aggressive prostate cancer.
    • (2005) Am J Epidemiol , vol.162 , pp. 318-325
    • Shannon, J.1    Tewoderos, S.2    Garzotto, M.3
  • 7
    • 33845864688 scopus 로고    scopus 로고
    • Platz EA, Leitzmann MF, Visvanathan K, et al.: Statin drugs and risk of advanced prostate cancer. J Natl Cancer Inst 2006, 98:1819-1825. This important publication was the first to solidify the association between statin use and advanced prostate cancer while demonstrating no association between statin use and overall prostate cancer. These researchers also elegantly controlled for use of PSA screening, as this is a potential source of bias and a common criticism of the studies pertaining to advanced prostate cancer.
    • Platz EA, Leitzmann MF, Visvanathan K, et al.: Statin drugs and risk of advanced prostate cancer. J Natl Cancer Inst 2006, 98:1819-1825. This important publication was the first to solidify the association between statin use and advanced prostate cancer while demonstrating no association between statin use and overall prostate cancer. These researchers also elegantly controlled for use of PSA screening, as this is a potential source of bias and a common criticism of the studies pertaining to advanced prostate cancer.
  • 8
    • 38849159872 scopus 로고    scopus 로고
    • Jacobs EJ, Rodriguez C, Bain EB, et al.: Cholesterol-lowering drugs and advanced prostate cancer incidence in a large US cohort. Cancer Epidemiol Biomarkers Prev 2007, 16:2213-2217. This paper furthered the work of Platz et al. [7••], observing an association between statin use and advanced prostate cancer, but not observing an association with overall prostate cancer.
    • Jacobs EJ, Rodriguez C, Bain EB, et al.: Cholesterol-lowering drugs and advanced prostate cancer incidence in a large US cohort. Cancer Epidemiol Biomarkers Prev 2007, 16:2213-2217. This paper furthered the work of Platz et al. [7••], observing an association between statin use and advanced prostate cancer, but not observing an association with overall prostate cancer.
  • 9
    • 38849123455 scopus 로고    scopus 로고
    • Statin use and risk of prostate cancer in the California Men's Health Study Cohort
    • This paper also observed an association between statin use and advanced prostate cancer, observing no association with overall prostate cancer
    • Flick ED, Habel LA, Chan KA, et al.: Statin use and risk of prostate cancer in the California Men's Health Study Cohort. Cancer Epidemiol Biomarkers Prev 2007, 16:2218-2225. This paper also observed an association between statin use and advanced prostate cancer, observing no association with overall prostate cancer.
    • (2007) Cancer Epidemiol Biomarkers Prev , vol.16 , pp. 2218-2225
    • Flick, E.D.1    Habel, L.A.2    Chan, K.A.3
  • 10
    • 38849208358 scopus 로고    scopus 로고
    • Murtola T, Tammela TLJ, Lahtela J, Auvinen A: Cholesterol-lowering drugs and prostate cancer risk: a population-based case-control study. Cancer Epidemiol Biomarkers Prev 2007, 16:2226-2232. This paper similarly observed an association between statin use and advanced prostate cancer. In particular, given the less prevalent use of PSA screening in the Finnish population, the potential bias introduced by statin users being more likely to participate in screening than non-users was minimized.
    • Murtola T, Tammela TLJ, Lahtela J, Auvinen A: Cholesterol-lowering drugs and prostate cancer risk: a population-based case-control study. Cancer Epidemiol Biomarkers Prev 2007, 16:2226-2232. This paper similarly observed an association between statin use and advanced prostate cancer. In particular, given the less prevalent use of PSA screening in the Finnish population, the potential bias introduced by statin users being more likely to participate in screening than non-users was minimized.
  • 12
    • 29944446607 scopus 로고    scopus 로고
    • Statins and cancer risk: A meta-analysis
    • Although not the first published, this paper was the most comprehensive, most rigorous, and received the most press of the three meta-analyses that conducted secondary analyses of the randomized controlled trials of statin use in the prevention of cardiovascular disease. This study found no association between statin use and overall prostate cancer risk
    • Dale KM, Coleman CI, Henyan NN, et al.: Statins and cancer risk: a meta-analysis. JAMA 2006, 295:74-80. Although not the first published, this paper was the most comprehensive, most rigorous, and received the most press of the three meta-analyses that conducted secondary analyses of the randomized controlled trials of statin use in the prevention of cardiovascular disease. This study found no association between statin use and overall prostate cancer risk.
    • (2006) JAMA , vol.295 , pp. 74-80
    • Dale, K.M.1    Coleman, C.I.2    Henyan, N.N.3
  • 13
    • 33846604584 scopus 로고    scopus 로고
    • Statins and risk of cancer: A systematic review and metaanalysis
    • This paper was a unique meta-analysis, contrasting pooled observational study results with secondary analyses of randomized controlled trials of statins in the prevention of cardiovascular disease. This study also observed that statin use was not associated with overall prostate cancer risk
    • Browning DR, Martin RM: Statins and risk of cancer: a systematic review and metaanalysis. Int J Cancer 2007, 120:833-843. This paper was a unique meta-analysis, contrasting pooled observational study results with secondary analyses of randomized controlled trials of statins in the prevention of cardiovascular disease. This study also observed that statin use was not associated with overall prostate cancer risk.
    • (2007) Int J Cancer , vol.120 , pp. 833-843
    • Browning, D.R.1    Martin, R.M.2
  • 14
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • Goldstein JL, Brown MS: Regulation of the mevalonate pathway. Nature 1990, 343:425-430.
    • (1990) Nature , vol.343 , pp. 425-430
    • Goldstein, J.L.1    Brown, M.S.2
  • 15
    • 1542314891 scopus 로고    scopus 로고
    • Current overview of statin-induced myopathy
    • Rosenson RS: Current overview of statin-induced myopathy. Am J Med 2004, 116:408-416.
    • (2004) Am J Med , vol.116 , pp. 408-416
    • Rosenson, R.S.1
  • 16
    • 33845876333 scopus 로고    scopus 로고
    • Risks associated with statin therapy: A systematic overview of randomized clinical trials
    • Kashani A, Phillips CO, Foody JM, et al.: Risks associated with statin therapy: a systematic overview of randomized clinical trials. Circulation 2006, 114:2788-2797.
    • (2006) Circulation , vol.114 , pp. 2788-2797
    • Kashani, A.1    Phillips, C.O.2    Foody, J.M.3
  • 17
    • 0034655284 scopus 로고    scopus 로고
    • Use of cholesterol-lowering medications in the United States from 1991 to 1997
    • Siegel D, Lopez J, Meier J: Use of cholesterol-lowering medications in the United States from 1991 to 1997. Am J Med 2000, 108:496-499.
    • (2000) Am J Med , vol.108 , pp. 496-499
    • Siegel, D.1    Lopez, J.2    Meier, J.3
  • 18
    • 0035422745 scopus 로고    scopus 로고
    • Pleiotropic effects of statins and their clinical significance
    • LaRosa JC: Pleiotropic effects of statins and their clinical significance. Am J Cardiol 2001, 88:291-293.
    • (2001) Am J Cardiol , vol.88 , pp. 291-293
    • LaRosa, J.C.1
  • 19
    • 0037812658 scopus 로고    scopus 로고
    • The influence of finasteride on the development of prostate cancer
    • Thompson IM, Goodman PJ, Tangen CM et al.: The influence of finasteride on the development of prostate cancer. N Engl J Med 2003, 349:215-224.
    • (2003) N Engl J Med , vol.349 , pp. 215-224
    • Thompson, I.M.1    Goodman, P.J.2    Tangen, C.M.3
  • 20
    • 0034726387 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and the risk of cancer: A nested case-control study
    • Blais L, Desgagne A, LeLorier J: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and the risk of cancer: a nested case-control study. Arch Intern Med 2000, 160:2363-2368.
    • (2000) Arch Intern Med , vol.160 , pp. 2363-2368
    • Blais, L.1    Desgagne, A.2    LeLorier, J.3
  • 22
    • 1542329169 scopus 로고    scopus 로고
    • Statin use and cancer risk in the General Practice Research Database
    • Kaye JA, Jick H: Statin use and cancer risk in the General Practice Research Database. Br J Cancer 2004, 90:635-637.
    • (2004) Br J Cancer , vol.90 , pp. 635-637
    • Kaye, J.A.1    Jick, H.2
  • 23
    • 18744387733 scopus 로고    scopus 로고
    • Cyrus-David MS, Weinberg A, Thompson T, Kadmon D: The effect of statins on serum prostate specific antigen levels in a cohort of airline pilots: a preliminary report. J Urol 2005, 173:1923-1925. The first paper to describe an association between statin use and lower PSA levels. Though a small study (n =15), we have recently confirmed this association in our larger, longitudinal study.
    • Cyrus-David MS, Weinberg A, Thompson T, Kadmon D: The effect of statins on serum prostate specific antigen levels in a cohort of airline pilots: a preliminary report. J Urol 2005, 173:1923-1925. The first paper to describe an association between statin use and lower PSA levels. Though a small study (n =15), we have recently confirmed this association in our larger, longitudinal study.
  • 25
    • 0347756695 scopus 로고    scopus 로고
    • Contamination by opportunistic screening in the European Randomized Study of Prostate Cancer Screening
    • Ciatto S, Zappa M, Villers A, et al.: Contamination by opportunistic screening in the European Randomized Study of Prostate Cancer Screening. BJU Int 2003, 92(Suppl 2):97-100.
    • (2003) BJU Int , vol.92 , Issue.SUPPL. 2 , pp. 97-100
    • Ciatto, S.1    Zappa, M.2    Villers, A.3
  • 26
    • 0037038402 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease
    • Youssef S, Stuve O, Patarroyo JC, et al.: The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Nature 2002, 420:78-84.
    • (2002) Nature , vol.420 , pp. 78-84
    • Youssef, S.1    Stuve, O.2    Patarroyo, J.C.3
  • 28
    • 0033529171 scopus 로고    scopus 로고
    • Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase
    • Rao S, Porter DC, Chen X, et al.: Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase. Proc Natl Acad Sci U S A 1999, 96:7797-7802.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 7797-7802
    • Rao, S.1    Porter, D.C.2    Chen, X.3
  • 29
    • 1342289577 scopus 로고    scopus 로고
    • Lovastatin inhibits Rho-regulated expression of E-selectin by TNFalpha and attenuates tumor cell adhesion
    • Nubel T, Dippold W, Kleinert H, et al.: Lovastatin inhibits Rho-regulated expression of E-selectin by TNFalpha and attenuates tumor cell adhesion. Faseb J 2004, 18:140-142.
    • (2004) Faseb J , vol.18 , pp. 140-142
    • Nubel, T.1    Dippold, W.2    Kleinert, H.3
  • 30
    • 0035874879 scopus 로고    scopus 로고
    • Inhibition of epidermal growth factor-induced RhoA translocation and invasion of human pancreatic cancer cells by 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors
    • Kusama T, Mukai M, Iwasaki T, et al.: Inhibition of epidermal growth factor-induced RhoA translocation and invasion of human pancreatic cancer cells by 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors. Cancer Res 2001, 61:4885-4891.
    • (2001) Cancer Res , vol.61 , pp. 4885-4891
    • Kusama, T.1    Mukai, M.2    Iwasaki, T.3
  • 31
    • 0031963951 scopus 로고    scopus 로고
    • Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP
    • Marcelli M, Cunningham GR, Haidacher SJ, et al.: Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP. Cancer Res 1998, 58:76-83.
    • (1998) Cancer Res , vol.58 , pp. 76-83
    • Marcelli, M.1    Cunningham, G.R.2    Haidacher, S.J.3
  • 32
    • 0034777844 scopus 로고    scopus 로고
    • Cerivastatin triggers tumor-specific apoptosis with higher efficacy than lovastatin
    • Wong WW, Tan MM, Xia Z, et al.: Cerivastatin triggers tumor-specific apoptosis with higher efficacy than lovastatin. Clin Cancer Res 2001, 7:2067-2075.
    • (2001) Clin Cancer Res , vol.7 , pp. 2067-2075
    • Wong, W.W.1    Tan, M.M.2    Xia, Z.3
  • 33
    • 28844490054 scopus 로고    scopus 로고
    • Statins and cancer prevention
    • A thorough review that provides the reader with more in-depth analysis of the antineoplastic mechanisms of statins than the scope of the current review allows
    • Demierre MF, Higgins PD, Gruber SB, et al.: Statins and cancer prevention. Nat Rev Cancer 2005, 5:930-942. A thorough review that provides the reader with more in-depth analysis of the antineoplastic mechanisms of statins than the scope of the current review allows.
    • (2005) Nat Rev Cancer , vol.5 , pp. 930-942
    • Demierre, M.F.1    Higgins, P.D.2    Gruber, S.B.3
  • 34
    • 0019761279 scopus 로고
    • Prostatic cholesterol metabolism: Regulation and alteration
    • Schaffner CP: Prostatic cholesterol metabolism: regulation and alteration. Prog Clin Biol Res 1981, 75A:279-324.
    • (1981) Prog Clin Biol Res , vol.75 A , pp. 279-324
    • Schaffner, C.P.1
  • 35
    • 0037015040 scopus 로고    scopus 로고
    • The program of androgen-responsive genes in neoplastic prostate epithelium
    • Nelson PS, Clegg N, Arnold H, et al.: The program of androgen-responsive genes in neoplastic prostate epithelium. Proc Natl Acad Sci U S A 2002, 99:11890-11895.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 11890-11895
    • Nelson, P.S.1    Clegg, N.2    Arnold, H.3
  • 36
    • 0029743674 scopus 로고    scopus 로고
    • Androgens markedly stimulate the accumulation of neutral lipids in the human prostatic adenocarcinoma cell line LNCaP
    • Swinnen JV, Van Veldhoven PP, Esquenet M, et al.: Androgens markedly stimulate the accumulation of neutral lipids in the human prostatic adenocarcinoma cell line LNCaP. Endocrinology 1996, 137:4468-4474.
    • (1996) Endocrinology , vol.137 , pp. 4468-4474
    • Swinnen, J.V.1    Van Veldhoven, P.P.2    Esquenet, M.3
  • 37
    • 0030949124 scopus 로고    scopus 로고
    • Functional rafts in cell membranes
    • Simons K, Ikonen E: Functional rafts in cell membranes. Nature 1997, 387:569-572.
    • (1997) Nature , vol.387 , pp. 569-572
    • Simons, K.1    Ikonen, E.2
  • 39
    • 23044504053 scopus 로고    scopus 로고
    • Membrane rafts as potential sites of nongenomic hormonal signaling in prostate cancer
    • Freeman MR, Cinar B, Lu ML: Membrane rafts as potential sites of nongenomic hormonal signaling in prostate cancer. Trends Endocrinol Metab 2005, 16:273-279.
    • (2005) Trends Endocrinol Metab , vol.16 , pp. 273-279
    • Freeman, M.R.1    Cinar, B.2    Lu, M.L.3
  • 40
    • 0037089486 scopus 로고    scopus 로고
    • Cholesterol-rich lipid rafts mediate akt-regulated survival in prostate cancer cells
    • Zhuang L, Lin J, Lu ML, et al.: Cholesterol-rich lipid rafts mediate akt-regulated survival in prostate cancer cells. Cancer Res 2002, 62:2227-2231.
    • (2002) Cancer Res , vol.62 , pp. 2227-2231
    • Zhuang, L.1    Lin, J.2    Lu, M.L.3
  • 41
    • 33645520326 scopus 로고    scopus 로고
    • Luteinizing hormone receptors translocate to plasma membrane microdomains after binding of human chorionic gonadotropin
    • Smith SM, Lei Y, Liu J, et al.: Luteinizing hormone receptors translocate to plasma membrane microdomains after binding of human chorionic gonadotropin. Endocrinology 2006, 147:1789-1795.
    • (2006) Endocrinology , vol.147 , pp. 1789-1795
    • Smith, S.M.1    Lei, Y.2    Liu, J.3
  • 42
    • 0037340797 scopus 로고    scopus 로고
    • Real-time analysis of the effects of cholesterol on lipid raft behavior using atomic force microscopy
    • Lawrence JC, Saslowsky DE, Edwardson JM, Henderson RM: Real-time analysis of the effects of cholesterol on lipid raft behavior using atomic force microscopy. Biophys J 2003, 84:1827-1832.
    • (2003) Biophys J , vol.84 , pp. 1827-1832
    • Lawrence, J.C.1    Saslowsky, D.E.2    Edwardson, J.M.3    Henderson, R.M.4
  • 43
    • 11144292081 scopus 로고    scopus 로고
    • Phosphorylation of both EGFR and ErbB2 is a reliable predictor of prostate cancer cell proliferation in response to EGF
    • El Sheikh SS, Domin J, Abel P, et al.: Phosphorylation of both EGFR and ErbB2 is a reliable predictor of prostate cancer cell proliferation in response to EGF. Neoplasia 2004, 6:846-853.
    • (2004) Neoplasia , vol.6 , pp. 846-853
    • El Sheikh, S.S.1    Domin, J.2    Abel, P.3
  • 44
    • 24144475549 scopus 로고    scopus 로고
    • Clinical and pathologic significance of activation of signal transducer and activator of transcription 3 in prostate cancer
    • Horinaga M, Okita H, Nakashima J, et al.: Clinical and pathologic significance of activation of signal transducer and activator of transcription 3 in prostate cancer. Urology 2005, 66:671-675.
    • (2005) Urology , vol.66 , pp. 671-675
    • Horinaga, M.1    Okita, H.2    Nakashima, J.3
  • 45
    • 16844372930 scopus 로고    scopus 로고
    • Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts
    • This paper solidified the foundation of basic science evidence in support of a cholesterol-mediated antineoplastic mechanism of action of statins in the setting of prostate cancer and furthered understanding of the role of lipid rafts in prostate cancer cell survival
    • Zhuang L, Kim J, Adam RM, et al.: Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts. J Clin Invest 2005, 115:959-968. This paper solidified the foundation of basic science evidence in support of a cholesterol-mediated antineoplastic mechanism of action of statins in the setting of prostate cancer and furthered understanding of the role of lipid rafts in prostate cancer cell survival.
    • (2005) J Clin Invest , vol.115 , pp. 959-968
    • Zhuang, L.1    Kim, J.2    Adam, R.M.3
  • 46
    • 0033812189 scopus 로고    scopus 로고
    • Effects of high-dose simvastatin on adrenal and gonadal steroidogenesis in men with hypercholesterolemia
    • Dobs AS, Schrott H, Davidson MH, et al.: Effects of high-dose simvastatin on adrenal and gonadal steroidogenesis in men with hypercholesterolemia. Metabolism 2000, 49:1234-1238.
    • (2000) Metabolism , vol.49 , pp. 1234-1238
    • Dobs, A.S.1    Schrott, H.2    Davidson, M.H.3
  • 47
    • 0025877865 scopus 로고
    • The HMG-CoA reductase inhibitor simvastatin suppresses human testicular testosterone synthesis in vitro by a selective inhibitory effect on 17-ketosteroid- oxidoreductase enzyme activity
    • Smals AG, Weusten JJ, Benraad TJ, Kloppenborg PW: The HMG-CoA reductase inhibitor simvastatin suppresses human testicular testosterone synthesis in vitro by a selective inhibitory effect on 17-ketosteroid- oxidoreductase enzyme activity. J Steroid Biochem Mol Biol 1991, 38:465-468.
    • (1991) J Steroid Biochem Mol Biol , vol.38 , pp. 465-468
    • Smals, A.G.1    Weusten, J.J.2    Benraad, T.J.3    Kloppenborg, P.W.4
  • 48
    • 0029950679 scopus 로고    scopus 로고
    • Prospective case control study to determine the effect of lovastatin on serum testosterone and cortisol concentrations in hyperlipidemic nephrotic patients with chronic renal failure
    • Segarra A, Chacon P, Vilardell M, Piera LL: Prospective case control study to determine the effect of lovastatin on serum testosterone and cortisol concentrations in hyperlipidemic nephrotic patients with chronic renal failure. Nephron 1996, 73:186-190.
    • (1996) Nephron , vol.73 , pp. 186-190
    • Segarra, A.1    Chacon, P.2    Vilardell, M.3    Piera, L.L.4
  • 49
    • 0028673301 scopus 로고
    • Effects of long-term simvastatin treatment on testicular and adrenal steroidogenesis in hypercholesterolemic patients
    • Bernini GP, Argenio GF, Gasperi M, et al.: Effects of long-term simvastatin treatment on testicular and adrenal steroidogenesis in hypercholesterolemic patients. J Endocrinol Invest 1994, 17:227-233.
    • (1994) J Endocrinol Invest , vol.17 , pp. 227-233
    • Bernini, G.P.1    Argenio, G.F.2    Gasperi, M.3
  • 50
    • 17444448785 scopus 로고    scopus 로고
    • Does statin therapy influence steroid hormone synthesis?
    • Bohm M, Herrmann W, Wassmann S, et al.: Does statin therapy influence steroid hormone synthesis? Z Kardiol 2004, 93:43-48.
    • (2004) Z Kardiol , vol.93 , pp. 43-48
    • Bohm, M.1    Herrmann, W.2    Wassmann, S.3
  • 51
    • 0033983170 scopus 로고    scopus 로고
    • Effects of simvastatin and pravastatin on gonadal function in male hypercholesterolemic patients
    • Dobs AS, Miller S, Neri G, et al.: Effects of simvastatin and pravastatin on gonadal function in male hypercholesterolemic patients. Metabolism 2000, 49:115-121.
    • (2000) Metabolism , vol.49 , pp. 115-121
    • Dobs, A.S.1    Miller, S.2    Neri, G.3
  • 52
    • 34548081675 scopus 로고    scopus 로고
    • Do statins affect androgen levels in men? Results from the Boston area community health survey
    • One hypothesized mechanism through which statins inhibit prostate cancer was that statins may reduce serum androgen levels. This large population-based cohort study was the first to demonstrate that statin use was not associated with changes in serum androgen levels
    • Hall SA, Page ST, Travison TG, et al.: Do statins affect androgen levels in men? Results from the Boston area community health survey. Cancer Epidemiol Biomarkers Prev 2007, 16:1587-1594. One hypothesized mechanism through which statins inhibit prostate cancer was that statins may reduce serum androgen levels. This large population-based cohort study was the first to demonstrate that statin use was not associated with changes in serum androgen levels.
    • (2007) Cancer Epidemiol Biomarkers Prev , vol.16 , pp. 1587-1594
    • Hall, S.A.1    Page, S.T.2    Travison, T.G.3
  • 53
    • 33749550602 scopus 로고    scopus 로고
    • Persistent intraprostatic androgen concentrations after medical castration in healthy men
    • Page ST, Lin DW, Mostaghel EA, et al.: Persistent intraprostatic androgen concentrations after medical castration in healthy men. J Clin Endocrinol Metab 2006, 91:3850-3856.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 3850-3856
    • Page, S.T.1    Lin, D.W.2    Mostaghel, E.A.3
  • 54
    • 0035140497 scopus 로고    scopus 로고
    • Immunoelectron microscopic localization of 3beta-hydroxysteroid dehydrogenase and type 5 17beta-hydroxysteroid dehydrogenase in the human prostate and mammary gland
    • Pelletier G, Luu-The V, El-Alfy M, et al.: Immunoelectron microscopic localization of 3beta-hydroxysteroid dehydrogenase and type 5 17beta-hydroxysteroid dehydrogenase in the human prostate and mammary gland. J Mol Endocrinol 2001, 26:11-19.
    • (2001) J Mol Endocrinol , vol.26 , pp. 11-19
    • Pelletier, G.1    Luu-The, V.2    El-Alfy, M.3
  • 55
    • 0142124790 scopus 로고    scopus 로고
    • Androgens stimulate coordinated lipogenic gene expression in normal target tissues in vivo
    • Heemers H, Vanderhoydonc F, Roskams T, et al.: Androgens stimulate coordinated lipogenic gene expression in normal target tissues in vivo. Mol Cell Endocrinol 2003, 205:21-31.
    • (2003) Mol Cell Endocrinol , vol.205 , pp. 21-31
    • Heemers, H.1    Vanderhoydonc, F.2    Roskams, T.3
  • 56
    • 10044271037 scopus 로고    scopus 로고
    • SREBP transcription factors: Master regulators of lipid homeostasis
    • Eberle D, Hegarty B, Bossard P, et al.: SREBP transcription factors: master regulators of lipid homeostasis. Biochimie 2004, 86:839-848.
    • (2004) Biochimie , vol.86 , pp. 839-848
    • Eberle, D.1    Hegarty, B.2    Bossard, P.3
  • 57
    • 1542615071 scopus 로고    scopus 로고
    • Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence
    • Ettinger SL, Sobel R, Whitmore TG, et al.: Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence. Cancer Res 2004, 64:2212-2221.
    • (2004) Cancer Res , vol.64 , pp. 2212-2221
    • Ettinger, S.L.1    Sobel, R.2    Whitmore, T.G.3
  • 58
    • 7544219925 scopus 로고    scopus 로고
    • Effects of statins and farnesyltransferase inhibitors on the development and progression of cancer
    • Graaf MR, Richel DJ, van Noorden CJ, Guchelaar HJ: Effects of statins and farnesyltransferase inhibitors on the development and progression of cancer. Cancer Treat Rev 2004, 30:609-641.
    • (2004) Cancer Treat Rev , vol.30 , pp. 609-641
    • Graaf, M.R.1    Richel, D.J.2    van Noorden, C.J.3    Guchelaar, H.J.4
  • 59
    • 3242756036 scopus 로고    scopus 로고
    • Ras signaling in prostate cancer progression
    • Weber MJ, Gioeli D: Ras signaling in prostate cancer progression. J Cell Biochem 2004, 91:13-25.
    • (2004) J Cell Biochem , vol.91 , pp. 13-25
    • Weber, M.J.1    Gioeli, D.2
  • 60
    • 0032562711 scopus 로고    scopus 로고
    • Inhibition of the 3-hydroxy-3- methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells
    • Lee SJ, Ha MJ, Lee J, et al.: Inhibition of the 3-hydroxy-3- methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells. J Biol Chem 1998, 273:10618-10623.
    • (1998) J Biol Chem , vol.273 , pp. 10618-10623
    • Lee, S.J.1    Ha, M.J.2    Lee, J.3
  • 61
    • 33750112905 scopus 로고    scopus 로고
    • Statins, especially atorvastatin, may improve survival following brachytherapy for clinically localized prostate cancer
    • Moyad MA, Merrick GS, Butler WM, et al.: Statins, especially atorvastatin, may improve survival following brachytherapy for clinically localized prostate cancer. Urol Nurs 2006, 26:298-303.
    • (2006) Urol Nurs , vol.26 , pp. 298-303
    • Moyad, M.A.1    Merrick, G.S.2    Butler, W.M.3
  • 62
    • 41749121847 scopus 로고    scopus 로고
    • Statin use and clinical outcomes after high dose radiotherapy for prostate cancer [abstract 203]
    • Shippy AM, Katz MS, Yamada Y, et al.: Statin use and clinical outcomes after high dose radiotherapy for prostate cancer [abstract 203]. Int J Radiat Biol 2007, 69:S113.
    • (2007) Int J Radiat Biol , vol.69
    • Shippy, A.M.1    Katz, M.S.2    Yamada, Y.3
  • 63
    • 34447103784 scopus 로고    scopus 로고
    • Effect of statin therapy on early return of potency after nerve sparing radical retropubic prostatectomy
    • Hong SK, Han BK, Jeong SJ, et al.: Effect of statin therapy on early return of potency after nerve sparing radical retropubic prostatectomy. J Urol 2007, 178:613-616.
    • (2007) J Urol , vol.178 , pp. 613-616
    • Hong, S.K.1    Han, B.K.2    Jeong, S.J.3
  • 64
    • 34247606685 scopus 로고    scopus 로고
    • American Cancer Society, Atlanta, GA: American Cancer Society;
    • American Cancer Society. Cancer Facts & Figures 2007. Atlanta, GA: American Cancer Society; 2007.
    • (2007) Cancer Facts & Figures 2007
  • 65
    • 44449164380 scopus 로고    scopus 로고
    • Exploring causes for declining prostate cancer mortality rates in the United States between 1993 and 2003
    • abstract 203, Anaheim, CA; May 19-24
    • Cox J, Clark S, Colli JL: Exploring causes for declining prostate cancer mortality rates in the United States between 1993 and 2003 [abstract 203]. Proceedings of the American Urological Association Meeting. Anaheim, CA; May 19-24, 2007.
    • (2007) Proceedings of the American Urological Association Meeting
    • Cox, J.1    Clark, S.2    Colli, J.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.