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Platz EA, Leitzmann MF, Visvanathan K, et al.: Statin drugs and risk of advanced prostate cancer. J Natl Cancer Inst 2006, 98:1819-1825. This important publication was the first to solidify the association between statin use and advanced prostate cancer while demonstrating no association between statin use and overall prostate cancer. These researchers also elegantly controlled for use of PSA screening, as this is a potential source of bias and a common criticism of the studies pertaining to advanced prostate cancer.
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Jacobs EJ, Rodriguez C, Bain EB, et al.: Cholesterol-lowering drugs and advanced prostate cancer incidence in a large US cohort. Cancer Epidemiol Biomarkers Prev 2007, 16:2213-2217. This paper furthered the work of Platz et al. [7••], observing an association between statin use and advanced prostate cancer, but not observing an association with overall prostate cancer.
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Flick ED, Habel LA, Chan KA, et al.: Statin use and risk of prostate cancer in the California Men's Health Study Cohort. Cancer Epidemiol Biomarkers Prev 2007, 16:2218-2225. This paper also observed an association between statin use and advanced prostate cancer, observing no association with overall prostate cancer.
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Murtola T, Tammela TLJ, Lahtela J, Auvinen A: Cholesterol-lowering drugs and prostate cancer risk: a population-based case-control study. Cancer Epidemiol Biomarkers Prev 2007, 16:2226-2232. This paper similarly observed an association between statin use and advanced prostate cancer. In particular, given the less prevalent use of PSA screening in the Finnish population, the potential bias introduced by statin users being more likely to participate in screening than non-users was minimized.
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Murtola T, Tammela TLJ, Lahtela J, Auvinen A: Cholesterol-lowering drugs and prostate cancer risk: a population-based case-control study. Cancer Epidemiol Biomarkers Prev 2007, 16:2226-2232. This paper similarly observed an association between statin use and advanced prostate cancer. In particular, given the less prevalent use of PSA screening in the Finnish population, the potential bias introduced by statin users being more likely to participate in screening than non-users was minimized.
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Dale KM, Coleman CI, Henyan NN, et al.: Statins and cancer risk: a meta-analysis. JAMA 2006, 295:74-80. Although not the first published, this paper was the most comprehensive, most rigorous, and received the most press of the three meta-analyses that conducted secondary analyses of the randomized controlled trials of statin use in the prevention of cardiovascular disease. This study found no association between statin use and overall prostate cancer risk.
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