Combined ascorbate and glutathione deficiency leads to decreased cytochrome b 5 expression and impaired reduction of sulfamethoxazole hydroxylamine

Archives of Toxicology

Volumn 84, Issue 8, 2010, Pages 597-607

  Bhusari, Sachin ^a   Abouraya, Mahmoud ^a   Padilla, Marcia L ^a   Pinkerton, Marie E ^b   Drescher, Nicholas J ^a   Sacco, James C ^a   Trepanier, Lauren A ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Antioxidants; Drug hypersensitivity; Guinea pig; NADH hydroxylamine reductase

Indexed keywords

ASCORBIC ACID; BUTHIONINE SULFOXIMINE; CYTOCHROME B5; CYTOCHROME B5 REDUCTASE; GLUTATHIONE; HYDROXYLAMINE; NITROSO DERIVATIVE; SULFAMETHOXAZOLE HYDROXYLAMINE; SULFAMETHOXAZOLE NITROSO; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCORBIC ACID DEFICIENCY; CELL PROLIFERATION; CONTROLLED STUDY; DIET RESTRICTION; DIET SUPPLEMENTATION; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GLUTATHIONE DEFICIENCY; GUINEA PIG; HISTOPATHOLOGY; IMMUNOGENICITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; RISK FACTOR; SPLEEN CELL; T CELL DEPLETION;

ANIMALS; ANTI-INFECTIVE AGENTS; ANTIOXIDANTS; ASCORBIC ACID; ASCORBIC ACID DEFICIENCY; CELL PROLIFERATION; CYTOCHROME-B(5) REDUCTASE; CYTOCHROMES B5; DRUG HYPERSENSITIVITY; GLUTATHIONE; GUINEA PIGS; LIVER; MALE; METABOLIC DETOXICATION, DRUG; SULFAMETHOXAZOLE; T-LYMPHOCYTES;

CAVIA; SUIDAE;

EID: 77956232460     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-010-0530-z     Document Type: Article

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