Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation

Molecular Pharmacology

Volumn 62, Issue 3, 2002, Pages 628-637

  Naisbitt, Dean J ^a   Farrell, John ^a   Gordon, S Fraser ^a   Maggs, James L ^a   Burkhart, Christoph ^b   Pichler, Werner J ^b   Pirmohamed, Munir ^a   Park, B Kevin ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AZO COMPOUND; AZOXY DERIVATIVE; CD4 ANTIGEN; CD8 ANTIGEN; CELL PROTEIN; DIMER; DRUG METABOLITE; HYDROXYLAMINE; NITROSO DERIVATIVE; SULFAMETHOXAZOLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; APOPTOSIS; ARTICLE; CELL ASSAY; CELL DEATH; CELL PROLIFERATION; CELL SURFACE; CHEMICAL REACTION; CONTROLLED STUDY; COVALENT BOND; DOSE RESPONSE; DRUG BINDING; DRUG BLOOD LEVEL; DRUG CYTOTOXICITY; DRUG DEGRADATION; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG SENSITIZATION; DRUG TRANSFORMATION; FLOW CYTOMETRY; HAPTENATION; HYPERSENSITIVITY REACTION; IMMUNOGENICITY; IMMUNOSTIMULATION; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MALE; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SPLEEN CELL; T LYMPHOCYTE;

ANIMALS; ANTI-INFECTIVE AGENTS; ANTIGEN-PRESENTING CELLS; CELL DIVISION; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; NITROSO COMPOUNDS; RATS; RATS, INBRED LEW; SULFAMETHOXAZOLE; T-LYMPHOCYTES;

EID: 0036765861     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.62.3.628     Document Type: Article

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