Regulation of lymphoid tyrosine phosphatase activity: Inhibition of the catalytic domain by the proximal interdomain

Biochemistry

Volumn 48, Issue 31, 2009, Pages 7525-7532

  Liu, Yingge ^a   Stanford, Stephanie M ^a   Jog, Sonali P ^a   Fiorillo, Edoardo ^a   Orrú, Valeria ^a   Comai, Lucio ^a   Bottini, Nunzio ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANDIDATE DRUGS; CATALYTIC DOMAINS; INTER-DOMAIN; INTRAMOLECULAR MECHANISM; N-TERMINALS; PHOSPHATASE ACTIVITY; TRUNCATION MUTANTS; TYROSINE PHOSPHATASE;

AMINES; ORGANIC ACIDS;

AMINO ACIDS;

PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE LYP; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME REGULATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE ALIGNMENT; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; ENZYME ACTIVATION; HUMANS; JURKAT CELLS; LYMPHOCYTES; MOLECULAR SEQUENCE DATA; PROTEIN KINASE INHIBITORS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 22;

EID: 68249099691     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900332f     Document Type: Article

References (29)

1. Alonso,A., Sasin, J., Bottini, N., Friedberg, I., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J., and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell 117, 699-711. (Pubitemid 38748887)
2. Mustelin, T., Alonso, A., Bottini, N., Huynh, H., Rahmouni, S., Nika, K., Louis-dit-Sully, C., Tautz, L., Togo, S. H., Bruckner, S., Mena-Duran, A. V., and al-Khouri, A. M. (2004) Protein tyrosine phosphatases in T cell physiology. Mol. Immunol. 41, 687-700.
3. Cohen, S., Dadi, H., Shaoul, E., Sharfe, N., and Roifman, C. M. (1999) Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp. Blood 93, 2013-2024. (Pubitemid 29128504)
4. Cloutier, J. F., and Veillette, A. (1999) Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase. J. Exp. Med. 189, 111-121.
5. Gjorloff-Wingren, A., Saxena, M., Williams, S., Hammi, D., and Mustelin, T. (1999) Characterization of TCR-induced receptor-proximal signaling events negatively regulated by the protein tyrosine phosphatase PEP. Eur. J. Immunol. 29, 3845-3854.
6. Begovich, A. B., Carlton, V. E., Honigberg, L. A., Schrodi, S. J., Chokkalingam, A. P., Alexander, H. C., Ardlie, K. G., Huang, Q., Smith, A. M., Spoerke, J. M., Conn, M. T., Chang, M., Chang, S. Y., Saiki, R. K., Catanese, J. J., Leong, D. U., Garcia, V. E., McAllister, L. B., Jeffery, D. A., Lee, A. T., Batliwalla, F., Remmers, E., Criswell, L. A., Seldin, M. F., Kastner, D. L., Amos, C. I., Sninsky, J. J., and Gregersen, P. K. (2004) A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am. J. Hum. Genet. 75, 330-337.
7. Vang, T., Congia, M., Macis, M. D., Musumeci, L., Orru, V., Zavattari, P., Nika, K., Tautz, L., Tasken, K., Cucca, F., Mustelin, T., and Bottini, N. (2005) Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat. Genet. 37, 1317-1319.
8. Hill, R. J., Zozulya, S., Lu, Y. L., Ward, K., Gishizky, M., and Jallal, B. (2002) The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation. Exp. Hematol. 30, 237-244.
9. Wu, J., Katrekar, A., Honigberg, L. A., Smith, A. M., Conn, M. T., Tang, J., Jeffery, D., Mortara, K., Sampang, J., Williams, S. R., Buggy, J., and Clark, J. M. (2006) Identification of substrates of human protein-tyrosine phosphatase PTPN22. J. Biol. Chem. 281, 11002-11010.
10. Bottini, N., Musumeci, L., Alonso, A., Rahmouni, S., Nika, K., Rostamkhani, M., MacMurray, J., Meloni, G. F., Lucarelli, P., Pellecchia, M., Eisenbarth, G. S., Comings, D., and Mustelin, T. (2004) A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat. Genet. 36, 337-338.
11. Smyth, D., Cooper, J. D., Collins, J. E., Heward, J. M., Franklyn, J. A., Howson, J. M., Vella, A., Nutland, S., Rance, H. E., Maier, L., Barratt, B. J., Guja, C., Ionescu-Tirgoviste, C., Savage, D. A., Dunger, D. B., Widmer, B., Strachan, D. P., Ring, S. M., Walker, N., Clayton, D. G., Twells, R. C., Gough, S. C., and Todd, J. A. (2004) Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Diabetes 53, 3020-3023. (Pubitemid 39425931)
12. Todd, J. A., Walker, N.M., Cooper, J. D., Smyth, D. J., Downes, K., Plagnol, V., Bailey, R., Nejentsev, S., Field, S. F., Payne, F., Lowe, C. E., Szeszko, J. S., Hafler, J. P., Zeitels, L., Yang, J. H., Vella, A., Nutland, S., Stevens, H. E., Schuilenburg, H., Coleman, G., Maisuria, M., Meadows,W., Smink, L. J., Healy, B., Burren, O. S., Lam, A. A., Ovington, N. R., Allen, J., Adlem, E., Leung, H. T., Wallace, C., Howson, J. M., Guja, C., Ionescu-Tirgoviste, C., Simmonds, M. J., Heward, J.M.,Gough, S.C.,Dunger, D. B.,Wicker,L. S., andClayton, D. G. (2007)Robust associations of four newchromosome regions from genome-wide analyses of type 1 diabetes. Nat. Genet. 39, 857-864.
13. Zoledziewska, M., Perra, C., Orru, V., Moi, L., Frongia, P., Congia, M., Bottini, N., and Cucca, F. (2008) Further evidence of a primary, causal association of the PTPN22 620W variant with type 1 diabetes. Diabetes 57, 229-234.
14. Gregersen, P. K. (2005) Pathways to gene identification in rheumatoid arthritis: PTPN22 and beyond. Immunol. Rev. 204, 74-86.
15. Orozco, G., Sanchez, E., Gonzalez-Gay, M. A., Lopez-Nevot, M. A., Torres, B., Caliz, R., Ortego-Centeno, N., Jimenez-Alonso, J., Pascual-Salcedo, D., Balsa, A., de Pablo, R., Nunez-Roldan, A., Gonzalez-Escribano, M. F., and Martin, J. (2005) Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus. Arthritis Rheum. 52, 219-224. (Pubitemid 40129251)
16. Bottini, N., Vang, T., Cucca, F., and Mustelin, T. (2006) Role of PTPN22 in type 1 diabetes and other autoimmune diseases. Semin. Immunol. 18, 207-213.
17. Gregersen, P. K., Lee, H. S., Batliwalla, F., and Begovich,A. B. (2006) PTPN22: Ssetting thresholds for autoimmunity. Semin. Immunol. 18, 214-223.
18. Rieck, M., Arechiga, A., Onengut-Gumuscu, S., Greenbaum, C., Concannon, P., and Buckner, J. H. (2007) Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes. J. Immunol. 179, 4704-4710.
19. Yu,X., Sun, J. P.,He, Y.,Guo,X., Liu, S., Zhou, B.,Hudmon, A., and Zhang, Z. Y. (2007) Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases. Proc. Natl. Acad. Sci. U.S.A. 104, 19767-19772.
20. Saito, K., Williams, S., Bulankina, A., Honing, S., and Mustelin, T. (2007) Association of protein-tyrosine phosphatase MEG2 via its Sec14p homology domain with vesicle-trafficking proteins. J. Biol. Chem. 282, 15170-15178.
21. Shaw, J. P., Utz, P. J., Durand, D. B., Toole, J. J., Emmel, E. A., and Crabtree, G. R. (1988) Identification of a putative regulator of early T cell activation genes. Science 241, 202-205.
22. Kung, P., Goldstein, G., Reinherz, E. L., and Schlossman, S. F. (1979) Monoclonal antibodies defining distinctive human T cell surface antigens. Science 206, 347-349. (Pubitemid 10244191)
23. Montalibet, J., Skorey, K. I., and Kennedy, B. P. (2005) Protein tyrosine phosphatase: Enzymatic assays. Methods 35, 2-8. (Pubitemid 39647573)
24. Thompson, J. D., Higgins, D. G., and Gibson, T. J. (1994) CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22, 4673-4680.
25. Chenna, R., Sugawara, H., Koike, T., Lopez, R., Gibson, T. J., Higgins, D. G., and Thompson, J. D. (2003) Multiple sequence alignment with the Clustal series of programs. Nucleic Acids Res. 31, 3497-3500. (Pubitemid 37442184)
26. Taylor, J. R. (1997) An introduction to error analysis , 2nd ed., University Science Books, Sausalito, CA.
27. Hao, L., Tiganis, T., Tonks, N. K., and Charbonneau, H. (1997) The noncatalytic C-terminal segment of the T cell protein tyrosine phosphatase regulates activity via an intramolecular mechanism. J. Biol. Chem. 272, 29322-29329.
28. Pei, D., Lorenz, U., Klingmuller, U., Neel, B. G., and Walsh, C. T. (1994) Intramolecular regulation of protein tyrosine phosphatase SH-PTP1: A new function for Src homology 2 domains. Biochemistry 33, 15483-15493.
29. Barr, A. J., Ugochukwu, E., Lee, W. H., King, O. N., Filippakopoulos, P., Alfano, I., Savitsky, P., Burgess-Brown, N. A., Muller, S., and Knapp, S. (2009) Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell 136, 352-363.