The conformational flexibility of the carboxy terminal residues 105-114 is a key modulator of the catalytic activity and stability of macrophage migration inhibitory factor

Biochemistry

Volumn 47, Issue 40, 2008, Pages 10740-10756

  El Turk, Farah ^a   Cascella, Michele ^a   Ouertatani Sakouhi, Hajer ^a   Narayanan, Raghavendran Lakshmi ^b   Leng, Lin ^c   Bucala, Richard ^c   Zweckstetter, Markus ^b   Rothlisberger, Ursula ^a   Lashuel, Hilal A ^a  

^a EPFL   (Switzerland)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTALLOGRAPHY; FLOW INTERACTIONS; MACROPHAGES; MINERALOGY; MODULATION; MONOMERS; OLIGOMERIZATION; PORT TERMINALS;

BIOCHEMICAL ACTIVITY; CATALYTIC ACTIVITIES; CONFORMATIONAL FLEXIBILITY; HOMOTRIMER; IN-VIVO; INNATE IMMUNITY; INTRA-MOLECULAR INTERACTIONS; MIGRATION INHIBITORY FACTOR; MONOMER-MONOMER INTERFACES; MULTIFUNCTIONAL PROTEINS; POINT MUTATIONS; TERMINAL REGIONS; TERMINAL RESIDUES;

X RAY CRYSTALLOGRAPHY;

DOPACHROME; MACROPHAGE MIGRATION INHIBITION FACTOR;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DELETION MUTANT; FLUORESCENCE SPECTROSCOPY; GEL PERMEATION CHROMATOGRAPHY; LIGHT SCATTERING; MASS SPECTROMETRY; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OLIGOMERIZATION; POINT MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN STABILITY; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS; THERMOSTABILITY; ULTRACENTRIFUGATION; WILD TYPE; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; CHROMATOGRAPHY, GEL; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; HUMANS; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SPECTROMETRY, FLUORESCENCE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; ULTRACENTRIFUGATION;

EID: 53249090254     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800603x     Document Type: Article

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