Ebselen effects on MPTP-induced neurotoxicity

Brain Research

Volumn 1118, Issue 1, 2006, Pages 251-254

  Dhanasekaran, Muralikrishnan ^a   Uthayathas, Subramaniam ^a   Karuppagounder, Senthilkumar S ^a   Parameshwaran, Kodeeswaran ^a   Suppiramaniam, Vishnu ^a   Ebadi, Manuchair ^b   Brown Borg, Holly M ^b  

^a AUBURN UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH DAKOTA SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

Ebselen; Monoamine oxidase; MPTP; Neuroprotection; SH SY5Y cell

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; AMINE OXIDASE (FLAVIN CONTAINING); DOPAMINE; EBSELEN;

AKINESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; TREMOR;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; ANTIOXIDANTS; AZOLES; BRAIN; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE PEROXIDASE; HUMANS; MICE; MICE, INBRED C57BL; MONOAMINE OXIDASE; NEURONS; NEUROPROTECTIVE AGENTS; ORGANOSELENIUM COMPOUNDS; OXIDATIVE STRESS; PARKINSONIAN DISORDERS; TREATMENT OUTCOME; TREMOR;

EID: 33750371842     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2006.08.020     Document Type: Article

References (31)

1. Basma A.N., Heikkila R.E., Saporito M.S., Philbert M., Geller H.M., and Nicklas W.J. 1-Methyl-4-(2′-ethylphenyl)-1,2,3,6-tetrahydropyridine-induced toxicity in PC12 cells is enhanced by preventing glycolysis. J. Neurochem. 58 (1992) 1052-1059
2. Beal M.F., Matthews R.T., Tieleman A., and Shults C.W. Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice. Brain Res. 783 (1998) 109-114
3. Borges V.C., Rocha J.B., and Nogueira C.W. Effect of diphenyl diselenide, diphenyl ditelluride and ebselen on cerebral Na(+), K(+)-ATPase activity in rats. Toxicology 215 (2005) 191-197
4. Burns R.S., Chiueh C.C., Markey S.P., Ebert M.H., Jacobowitz D.M., and Kopin I.J. A primate model of parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc. Natl. Acad. Sci. U. S. A. 80 (1983) 4546-4550
5. Chan P., Langston J.W., Irwin I., DeLanney L.E., and Di Monte D.A. 2-deoxyglucose enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced ATP loss in the mouse brain. J. Neurochem. 61 (1993) 610-616
6. Cohen G., and Kesler N. Monoamine oxidase and mitochondrial respiration. J. Neurochem. 73 (1999) 2310-2315
7. Dawson D.A., Masayasu H., Graham D.I., and Macrae I.M. The neuroprotective efficacy of ebselen (a glutathione peroxidase mimic) on brain damage induced by transient focal cerebral ischaemia in the rat. Neurosci. Lett. 185 (1995) 65-69
8. Haobam R., Sindhu K.M., Chandra G., and Mohanakumar K.P. Swim-test as a function of motor impairment in MPTP model of Parkinson's disease: A comparative study in two mouse strains. Behav. Brain Res. 163 (2005) 159-167
9. Hertel C., Terzi E., Hauser N., Jakob-Rotne R., Seelig J., and Kemp J.A. Inhibition of the electrostatic interaction between β-amyloid peptide and membranes prevents β-amyloid-induced toxicity. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 9412-9416
10. Imai H., Graham D.I., Masayasu H., and Macrae I.M. Antioxidant ebselen reduces oxidative damage in focal cerebral ischemia. Free Radic. Biol. Med. 34 (2003) 56-63
11. Lapchak P.A., and Zivin J.A. Ebselen, a seleno-organic antioxidant, is neuroprotective after embolic strokes in rabbits: Synergism with low-dose tissue plasminogen activator. Stroke 34 (2003) 2013-2018
12. Liu Y., and Schubert D. Steroid hormones block amyloid fibril-induced 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) formazan exocytosis: Relationship to neurotoxicity. J. Neurochem. 71 (1998) 2322-2329
13. Manyam B.V., Dhanasekaran M., and Hare T.A. Neuroprotective effects of the antiparkinson drug Mucuna pruriens. Phytother. Res. 18 (2004) 706-712
14. Marsden C.D., and Parkes J.D. On-off effects in patients with Parkinson's disease on chronic levodopa therapy. Lancet 1 (1976) 292-296
15. Martinovits G., Melamed E., Cohen O., Rosenthal J., and Uzzan A. Systemic administration of antioxidants does not protect mice against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP). Neurosci. Lett. 69 (1986) 192-197
16. Meotti F.C., Borges V.C., Zeni G., Rocha J.B.T., and Nogueira C.W. Potential renal and hepatic toxicity of diphenyl diselenide, diphenyl ditelluride and Ebselen for rats and mice. Toxicol. Lett. 143 (2003) 9-16
17. Mihatsch W., Russ H., Gerlach M., Riederer P., and Przuntek H. Treatment with antioxidants does not prevent loss of dopamine in the striatum of MPTP-treated common marmosets: Preliminary observations. J. Neural Transm. Parkinson's Dis. Dementia Sect. 3 (1991) 73-78
18. Mitra N., Mohanakumar K.P., and Ganguly D.K. Dissociation of serotoninergic and dopaminergic components in acute effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Brain Res. Bull. 28 (1992) 355-364
19. Muralikrishnan D., and Ebadi M. SKF-38393, a dopamine receptor agonist, attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. Brain Res. 892 (2001) 241-247
20. Muralikrishnan D., and Mohanakumar K.P. Neuroprotection by bromocriptine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice. FASEB J. 12 (1998) 905-912
21. Muralikrishnan D., Samantaray S., and Mohanakumar K.P. D-deprenyl protects nigrostriatal neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity. Synapse 50 (2003) 7-13
22. Muralikrishnan D., Ebadi M., and Brown-Borg H.M. Dopamine agonist 3-PPP fails to protect against MPTP-induced toxicity. Neurochem. Res. 29 (2004) 379-384
23. Ogawa A., Yoshimoto T., Kikuchi H., Sano K., Saito I., Yamaguchi T., and Yasuhara H. Ebselen in acute middle cerebral artery occlusion: a placebo-controlled, double-blind clinical trial. Cerebrovasc. Dis. 9 (1999) 112-118
24. Rousselet E., Joubert C., Callebert J., Parain K., Tremblay L., Orieux G., Launay J.M., Cohen-Salmon C., and Hirsch E.C. Behavioral changes are not directly related to striatal monoamine levels, number of nigral neurons, or dose of parkinsonian toxin MPTP in mice. Neurobiol. Dis. 14 (2003) 218-228
25. Schewe T. Molecular actions of ebselen: An antiinflammatory antioxidant. Gen. Pharmacol. 26 (1995) 1153-1169
26. Sedelis M., Schwarting R.K.W., and Huston J.P. Behavioral phenotyping of the MPTP mouse model of Parkinson's disease. Behav. Brain Res. 125 (2001) 109-122
27. Shi H., Liu S., Miyake M., and Liu K.J. Ebselen induced C6 glioma cell death in oxygen and glucose deprivation. Chem. Res. Toxicol. 19 (2006) 655-660
28. Van der Schyf C.J., Castagnoli K., Palmer S., Hazelwood L., and Castagnoli Jr. N. Melatonin fails to protect against long-term MPTP-induced dopamine depletion in mouse striatum. Neurotox. Res. 1 (2000) 261-269
29. Virmani M.A., Caso V., Spadoni A., Rossi S., Russo F., and Gaetani F. The action of acetyl-L-carnitine on the neurotoxicity evoked by amyloid fragments and peroxide on primary rat cortical neurones. Ann. N. Y. Acad. Sci. 939 (2001) 162-178
30. Yamaguchi T., Sano K., Takakura K., Saito I., Shinohara Y., Asano T., and Yasuhara H. Ebselen in acute ischemic stroke: A placebo-controlled, double-blind clinical trial. Ebselen Study Group. Stroke 29 (1998) 12-17
31. Yang C.F., Shen H.M., and Ong C.N. Ebselen induces apoptosis in HepG2 cells through rapid depletion of intracellular thiols. Arch. Biochem. Biophys. 374 (2000) 142-152